Best TWAS P=2.27e-11 · Best GWAS P=1.71e-09 conditioned to 0.982
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.1 | 6.2 | 5.6e-10 | -0.43 | 0.28 | 0.72 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -6.0 | -5.8 | 5.2e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -5.6 | -5.3 | 1.5e-07 | 0.94 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -5.6 | -5.8 | 7.3e-09 | 0.94 | 0.03 | 0.89 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -5.6 | 6.7 | 2.3e-11 | -0.90 | 0.05 | 0.95 | TRUE |
| 6 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.7 | -5.8 | 6.8e-09 | 0.52 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 4.1 | -5.7 | 1.2e-08 | 0.71 | 0.01 | 0.61 | FALSE |