Hub : Genes

AMZ1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.189	0.0340	2.2e-12	0.121	0.128	0.134	0.131	0.120	1.5e-14	2.8e-15	5.7e-16	1.2e-15	2.0e-14
2	ROSMAP	Brain Pre-frontal Cortex	0.086	0.0236	2.1e-05	0.048	0.030	0.043	0.039	0.044	8.3e-07	7.6e-05	2.5e-06	8.9e-06	2.4e-06
3	TCGA	Esophageal Carcinoma	0.179	0.0850	2.6e-03	0.050	0.046	0.009	NA	0.034	1.1e-02	1.4e-02	1.7e-01	NA	3.1e-02
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.334	0.0890	1.0e-05	0.201	0.099	0.133	NA	0.190	1.1e-11	2.6e-06	4.7e-08	NA	4.5e-11
5	TCGA	Brain Lower Grade Glioma	0.040	0.0189	5.9e-04	0.038	0.019	0.022	NA	0.022	3.3e-05	2.6e-03	1.5e-03	NA	1.3e-03
6	TCGA	Lung Adenocarcinoma	0.267	0.0764	6.5e-09	0.083	0.079	0.095	NA	0.092	6.1e-10	1.4e-09	3.1e-11	NA	7.0e-11
7	TCGA	Lung Squamous Cell Carcinoma	0.141	0.0473	1.3e-06	0.060	0.057	0.065	NA	0.054	2.2e-07	4.8e-07	7.4e-08	NA	9.5e-07
8	TCGA	Pancreatic Adenocarcinoma	0.174	0.0780	2.5e-03	0.108	0.065	0.102	NA	0.093	2.9e-05	1.1e-03	5.0e-05	NA	1.1e-04
9	TCGA	Prostate Adenocarcinoma	0.076	0.0346	2.5e-04	0.009	0.046	0.043	NA	0.033	3.8e-02	1.3e-05	2.6e-05	NA	2.2e-04
10	TCGA	Thyroid Carcinoma	0.317	0.0730	9.1e-15	0.036	0.187	0.200	NA	0.170	1.7e-04	6.4e-18	3.3e-19	NA	2.7e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	1.7	-1.3	-1.2	0.9	-0.6	-0.5	0.1	0.4	-0.5	-1.2	0.5
Bipolar Disorder or Schizophrenia	0.5	1.2	6.2	-0.5	-1.1	0.7	-0.6	0.4	0.6	0.1	-0.7	-2.5	-1.6
Depressed Affect (Nagel 2018)	2.9	6.1	13.5	-0.1	1.6	-3.0	3.5	2.3	2.0	1.7	3.7	2.9	1.5
Depression (Nagel 2018)	0.9	1.4	2.4	1.4	1.3	-1.2	1.2	1.5	0.9	1.5	1.3	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.6	-1.3	-0.2	-1.9	0.2	-0.6	-0.2	-2.3	0.8	2.4	0.6
Neuroticism (Nagel 2018)	2.8	6.6	13.9	0.6	1.9	-3.3	3.4	2.2	2.1	1.6	3.7	3.1	1.9
Schizophrenia (2018)	0.6	1.3	6.3	0.4	-0.4	0.2	-0.4	0.9	0.5	-0.2	-0.5	-2.3	-2.5
Schizophrenia vs Biploar Disorder	0.7	1.0	2.1	0.8	-0.6	1.2	1.1	-1.2	1.4	1.4	0.6	-0.3	-0.3
Worry (Nagel 2018)	1.9	3.9	8.8	1.4	1.0	-1.2	3.0	0.9	2.8	2.5	2.8	1.3	1.3
Alzheimer’s Disease (in mother)	1.0	1.2	4.1	-0.0	-1.0	1.2	-0.9	-2.0	0.4	-0.9	-1.3	-1.0	-0.9
Alzheimer’s Disease (in father)	1.3	1.4	5.3	1.9	0.9	0.1	0.7	-0.0	1.7	2.3	0.5	-0.5	0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	1.9	0.4	0.5	-0.0	-1.3	1.4	0.8	-0.4	-0.6	-0.1
Crohns Disease (2017)	0.3	0.7	4.4	2.1	1.1	0.1	-0.3	0.7	-0.5	0.1	0.0	-0.3	-0.2
Irritable Bowel Disease (IBD)	3.3	7.9	28.0	3.9	5.3	-2.5	1.0	2.1	0.9	2.5	2.4	2.5	2.0
Ulcerative Colitis (UC)	6.2	11.6	39.9	3.4	6.3	-3.8	1.5	2.3	1.0	3.0	3.2	3.9	2.7
Major Depression (MDD)	0.0	0.1	0.4	0.4	0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.4	4.6	10.2	-1.9	-3.2	2.6	-1.5	-1.8	0.6	-1.4	-2.0	-3.0	-2.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.7	-0.5	-0.2	-0.9	-0.5	-0.5	-0.4	-1.6	0.0	0.9	-0.0
Breast Cancer	0.7	1.6	3.4	-0.9	1.3	-1.2	1.0	1.9	0.1	1.0	1.7	1.1	1.6
Ovarian Cancer	0.9	1.1	4.5	-1.2	-1.5	2.1	1.1	-0.6	-0.2	0.8	0.6	-0.1	0.8
Prostate Cancer	0.5	0.7	2.3	1.4	-0.5	0.8	0.6	-1.5	1.1	0.2	0.1	-0.0	0.6
Age at First Birth	1.3	2.0	7.0	-1.0	-1.6	2.4	-0.8	-2.6	0.2	0.3	-1.3	-0.3	-1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	-1.0	-1.0	0.7	-1.2	0.0	0.6	0.1	-1.1	-1.4	0.1
Coronary Artery Disease (CAD)	0.9	1.1	5.1	-2.3	-0.8	-0.2	1.1	-0.9	0.2	-0.2	0.8	1.3	0.8
Crohns Disease (2012)	0.2	0.4	1.7	0.7	0.6	1.0	0.2	-0.1	0.2	1.3	0.2	-0.3	0.1
Mean Putamen Volume	1.6	1.8	4.7	-1.2	1.1	-2.1	0.7	1.9	0.1	0.3	1.1	0.8	2.2
Fasting Glucose	0.5	0.7	1.6	-1.1	-0.5	-1.1	0.6	0.3	1.3	-0.5	0.7	0.8	0.5
HbA1C	0.5	0.6	1.2	-0.5	0.4	-1.1	-1.1	1.0	-0.6	-0.6	-0.8	-0.7	0.5
HDL Cholesterol	0.4	0.6	3.8	-1.9	-0.9	0.6	-0.0	-0.2	-0.6	-0.6	-0.3	0.0	0.8
LDL Cholesterol	0.4	0.6	3.3	0.1	-1.3	0.3	0.4	-0.4	0.3	-0.1	0.0	-0.9	-1.8
Lupus	0.4	0.6	2.7	-0.6	-0.3	1.1	0.8	-0.6	0.1	1.7	0.7	0.1	0.5
Neuroticism (2016)	1.4	2.0	5.7	1.4	2.0	-2.4	1.1	1.8	0.3	0.2	1.3	1.4	0.2
Primary Biliary Cirrhosis	0.8	1.2	2.0	0.7	1.1	-0.7	1.3	0.7	1.1	1.4	1.2	0.8	1.4
Rheumatoid Arthritis	2.7	3.7	9.5	1.9	1.8	-3.1	2.1	2.5	0.3	0.9	2.4	1.6	0.7
Schizophrenia (2014)	0.6	1.4	5.9	0.7	-0.7	0.6	0.1	0.5	1.2	0.8	-0.0	-2.4	-2.2
Triglycerides	0.1	0.1	0.5	0.6	0.2	-0.1	-0.2	0.7	-0.0	0.1	-0.2	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	0.5	0.5	-1.0	-0.3	0.9	-0.2	-0.9	-0.2	-1.1	-1.1
Ulcerative Colitis	8.0	11.6	32.6	3.8	5.7	-3.3	2.2	2.7	1.3	3.9	3.5	3.2	2.5
Blood Eosinophil Count	0.8	6.3	19.0	-1.2	-4.4	3.1	-1.1	-2.6	0.2	-2.4	-2.3	-2.2	-2.9
Blood Platelet Count	6.5	75.0	163.8	-4.6	-12.8	11.4	-4.1	-9.4	-1.5	-5.5	-7.5	-10.5	-11.5
Blood Red Count	0.4	4.0	9.3	1.0	-2.7	1.7	-1.0	-3.0	1.2	-2.1	-2.2	-1.7	-2.1
Blood White Count	3.7	27.2	57.5	-0.6	-7.5	7.6	-1.6	-7.1	1.9	-1.6	-3.8	-6.3	-6.7
Heel T-Score	3.0	23.7	49.3	-1.0	-7.0	7.0	-2.3	-6.4	0.3	-1.8	-4.2	-5.7	-6.3
BMI	0.3	1.6	4.0	2.0	1.8	-2.0	-0.2	1.8	0.4	-0.2	0.0	-0.7	-1.1
Height	19.6	378.4	1122.2	18.2	33.5	-27.1	6.6	22.2	0.2	12.6	14.9	19.2	17.6
Waist Hip Ratio (WHR)	0.4	2.0	9.1	1.8	-0.5	-0.3	0.1	-0.1	0.8	-1.5	-0.5	-1.9	-3.0
Systolic Blood Pressure	0.6	2.8	8.9	-2.3	-2.8	3.0	-0.3	-2.0	0.3	-1.0	-0.8	-0.2	0.4
Smoking Status	0.3	0.7	2.2	0.8	0.8	-0.7	-0.2	1.5	-1.0	-0.0	-0.0	-0.7	-1.3
Allergy or Eczema	3.1	8.1	21.7	3.3	4.7	-4.2	1.1	3.0	0.5	1.6	1.9	2.5	2.8
Cardiovascular Disease	1.4	4.6	10.3	-0.2	-2.9	2.4	-1.3	-2.4	0.1	-2.1	-2.0	-2.5	-3.2
Hypothyroidism (self reported)	0.9	2.1	4.6	-1.5	-1.4	1.4	-1.7	0.0	-1.5	-1.0	-2.0	-2.1	-0.3
Respiratory disease	0.6	1.3	3.6	1.3	1.9	-1.8	0.3	1.7	-0.1	0.4	0.6	0.7	0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	4.2	2.0	1.3	-0.2	-1.2	-0.7	-0.3	0.2	-0.6	-0.3	-1.7
Lung FEV1/FVC ratio	4.4	22.2	58.5	-4.0	-7.7	5.4	-2.4	-5.1	0.5	-2.7	-4.2	-5.8	-5.3
Lung FVC	1.0	5.2	22.4	-4.7	-3.6	2.5	0.3	-2.3	0.5	-1.8	-0.3	0.2	0.9
Neuroticism	1.9	4.5	10.5	1.2	2.4	-3.2	2.0	2.5	1.2	1.1	2.5	2.6	1.5
Chronotype (morning person)	0.8	1.9	4.9	-0.4	1.2	-0.8	1.6	0.4	0.6	1.9	1.6	2.2	1.7
Hair Pigment	0.2	5.1	13.6	-3.7	-2.1	1.2	1.4	-2.6	2.6	0.5	1.2	2.4	2.9
Tanning	0.2	1.9	5.3	-0.7	-0.6	0.4	-0.5	1.4	-2.3	-1.5	-0.6	-1.7	-2.1
Hand grip strength (left)	2.9	7.7	25.8	2.6	3.7	-3.8	0.8	5.1	0.0	2.0	2.0	0.9	2.6
Number of treatments/medications taken	1.8	3.3	7.1	1.4	2.6	-2.7	0.8	1.4	1.3	0.6	1.2	2.1	2.5
Average weekly spirits intake	1.3	1.6	8.5	2.9	2.1	-0.7	0.4	1.0	0.1	1.2	0.6	-0.0	-0.4
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.1	-0.3	-0.8	0.4	0.6	-0.6	-0.2	0.6	0.9	0.3
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.7	1.2	1.9	-2.2	1.6	1.3	0.7	1.4	1.9	1.5	0.5
Hearing difficulty/problems: Yes	1.7	2.6	5.4	2.2	2.3	-1.2	1.7	0.3	1.9	1.6	1.8	1.4	0.8
Relative age of first facial hair	1.1	2.2	7.1	-2.2	-0.6	0.5	0.4	-1.5	0.5	-0.0	0.4	2.6	2.7
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	9.1	3.0	2.4	-1.9	1.4	1.5	0.6	1.7	1.5	0.5	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.2	1.3	2.0	-0.9	0.1	1.0	-0.1	1.0	0.4	0.5	1.6
Ever had hysterectomy (womb removed)	1.2	1.3	2.8	0.6	0.9	-0.0	1.5	-0.1	1.1	1.6	1.4	1.1	1.7
Systolic blood pressure, automated reading	0.2	0.6	1.7	-0.4	-0.7	1.3	-0.9	-0.4	-0.4	-0.4	-1.0	-0.7	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.8	0.0	0.1	-0.2	-0.8	0.9	-0.0	-0.1	-0.4	-0.9
Angina	0.5	0.7	2.0	1.3	0.8	-1.0	0.8	1.4	0.1	0.1	0.8	0.1	0.1
Medication for hormone replacement therapy	2.8	3.2	4.8	1.8	2.1	-0.9	1.7	0.6	1.3	2.2	2.0	2.1	2.2
Vitamin and mineral supplements	1.0	1.4	4.2	-1.0	-1.5	0.6	-0.3	-0.3	-1.4	-0.8	-0.7	-1.7	-2.0
Supplements: Zinc	2.2	2.4	6.6	0.3	2.3	-1.9	-0.9	1.3	-0.7	0.3	0.2	2.2	2.6
Medication: Co-codamol	0.8	0.9	2.0	0.9	-0.5	1.3	0.6	-1.0	1.4	1.4	0.3	-0.9	-0.7
Medication: Metformin	0.6	0.9	2.6	1.5	1.2	-0.1	-1.6	-0.8	0.0	0.1	-1.0	0.5	-0.7
Diabetes (father)	0.7	0.9	5.3	1.0	0.7	0.1	0.3	0.7	0.1	2.3	0.4	-0.5	0.9
Diabetes (mother)	1.0	1.2	2.7	-0.4	-1.3	0.7	-0.6	-1.6	0.1	-1.5	-1.2	-0.8	-1.6
Severe depression (siblings)	1.5	1.7	5.7	-0.1	-1.7	1.4	-0.6	-0.7	-0.4	-0.1	-1.0	-2.4	-1.9
Pack years adult smoking proportion	1.3	1.9	5.6	2.2	0.8	-1.4	1.2	2.4	0.9	1.1	0.9	-1.3	-0.5
Impedance of leg (right)	0.3	1.6	6.4	0.3	-1.6	2.1	0.5	-2.5	-0.0	0.9	-0.1	0.3	-1.0
Leg fat-free mass (left)	11.3	59.7	187.7	7.9	13.7	-11.8	1.7	9.7	0.0	3.1	5.0	6.3	5.9
Trunk fat percentage	5.8	23.3	69.2	6.6	8.3	-7.4	1.5	5.2	0.9	1.8	3.1	3.9	2.7
Hand grip strength (right)	2.2	6.0	16.9	2.7	3.6	-3.4	0.4	4.1	0.0	2.2	1.5	0.5	2.1
Townsend deprivation index at recruitment	0.5	0.7	2.3	1.0	1.5	-1.3	0.3	0.1	-0.0	0.3	0.8	0.9	-0.6
Current tobacco smoking	0.3	0.4	1.2	0.6	-0.1	0.9	0.5	-0.4	0.2	1.1	0.2	-0.9	-0.9
Average weekly fortified wine intake	0.4	0.4	1.5	0.7	0.5	-1.2	0.1	1.1	0.3	0.2	0.1	-0.8	0.0
Maternal smoking around birth	0.6	0.8	4.8	2.2	1.2	-0.7	-0.1	0.8	-0.5	-0.3	-0.3	-0.2	-0.7
Fed-up feelings	1.3	2.4	6.7	0.3	1.0	-2.1	2.6	1.0	0.7	0.4	2.6	1.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	4.1	1.3	1.5	-1.7	0.9	2.0	-0.1	1.5	1.2	-0.2	0.1
Relative age voice broke	1.1	1.6	7.7	-0.6	0.6	0.0	-0.0	-0.7	-0.1	0.6	0.5	2.6	2.8
Taking other prescription medications	1.1	1.7	4.7	1.6	2.2	-2.2	0.0	1.6	-0.1	-0.0	0.5	1.3	1.1
Age when periods started (menarche)	0.6	1.5	4.2	0.6	2.0	-1.9	-0.1	2.0	-1.1	-0.1	0.7	1.1	0.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.2	-0.2	0.6	-0.2	1.9	0.3	1.5	1.2	1.7	1.4	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	5.8	1.3	-1.6	0.9	0.1	-0.5	1.1	-0.2	-0.3	-1.9	-2.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	5.1	0.2	0.4	-2.2	-0.2	1.3	-1.2	-1.1	0.3	0.6	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	1.1	-1.0	-0.6	0.3	0.3	0.4	-0.6	0.4	0.3	-0.5	-0.3
Serious illness, injury or assault to yourself	1.5	1.8	4.8	1.8	2.1	-2.2	0.1	2.0	-0.7	0.1	0.7	0.4	-0.2
High blood pressure	0.3	0.9	3.8	0.7	-0.6	0.2	-0.6	-0.2	0.4	-2.0	-1.0	-1.2	-1.2
Hayfever, allergic rhinitis or eczema	2.5	5.5	15.9	1.4	3.6	-4.0	0.9	2.3	-0.4	0.4	1.8	2.9	2.6
Multivitamins +/- minerals	1.3	1.6	4.3	0.9	1.3	0.2	0.7	-0.2	1.3	1.7	1.0	1.8	2.1
Stomach or abdominal pain in last month	2.1	2.7	12.9	3.6	2.8	-0.9	0.2	-0.3	0.6	1.4	0.7	1.5	0.2
Supplements: Glucosamine	0.3	0.3	1.2	0.2	0.4	0.4	-1.1	-0.1	-0.0	0.0	-1.0	0.0	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.3	-0.5	-0.4	-0.0	0.9	-1.5	0.8	0.2	0.8	1.2	-0.1
Medication: Atenolol	2.3	2.8	6.4	1.2	-0.2	0.7	-2.1	0.1	-1.9	-2.4	-2.0	-1.6	-2.5
Medication: Levothyroxine sodium	0.3	0.4	1.9	-0.6	0.4	-0.2	-0.3	1.0	-0.6	0.7	-0.3	0.2	1.4
Sitting height	16.9	120.3	342.2	8.3	18.5	-15.4	4.3	11.7	0.3	7.1	9.0	12.3	10.8
Chronic bronchitis/emphysema (father)	1.4	1.7	5.1	2.3	1.6	-1.0	-1.4	0.3	-1.0	-1.7	-1.2	0.8	0.1
High blood pressure (mother)	0.7	0.9	3.7	-0.9	-1.5	0.3	-0.7	-0.9	-0.5	-1.9	-0.8	-0.2	-0.4
Body mass index (BMI)	0.7	3.0	9.9	3.1	2.4	-2.7	0.2	2.2	0.6	-0.3	0.4	-0.5	-0.7
Impedance of leg (left)	0.4	1.7	7.3	0.1	-1.8	2.1	0.6	-2.7	0.0	0.9	-0.0	0.2	-1.2
Leg predicted mass (left)	11.1	58.7	185.0	8.0	13.6	-11.7	1.7	9.7	-0.0	3.1	4.9	6.1	5.8
Trunk fat mass	9.6	41.1	125.4	8.3	11.2	-9.5	2.0	7.2	1.0	2.9	4.3	5.1	4.0
Waist circumference	4.7	17.0	54.2	6.3	7.4	-6.4	0.7	4.9	0.2	1.0	2.1	2.2	0.9
Number of incorrect matches in round	0.4	0.7	1.9	1.1	0.4	0.4	-0.9	0.5	0.3	0.3	-0.8	-1.1	-1.4
Past tobacco smoking	0.7	1.2	4.3	-1.1	-1.5	1.6	0.2	-2.1	1.0	0.4	-0.0	0.6	0.6
Alcohol usually taken with meals	0.3	0.5	1.7	-0.7	0.8	-0.6	-1.3	0.4	-0.3	-0.9	-0.6	0.4	0.5
Nervous feelings	1.6	2.9	7.0	2.0	1.1	-1.3	2.2	0.4	2.6	1.9	2.2	1.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	8.0	0.9	2.1	-2.8	1.9	2.1	0.9	0.5	2.1	2.5	2.3
Hearing difficulty/problems with background noise	1.5	2.4	7.2	0.6	1.8	-0.8	1.7	-0.4	1.1	1.2	2.0	2.7	1.5
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	-1.5	-0.3	-0.4	0.4	0.7	-0.8	0.6	0.4	0.4	0.6
Had menopause	0.3	0.4	1.2	-0.2	0.6	-0.5	-1.0	0.2	-0.3	-1.1	-0.9	-0.0	0.7
Had other major operations	0.9	1.1	3.6	1.8	1.9	-1.2	-0.8	-0.0	0.0	-0.6	-0.0	1.4	0.5
Forced vital capacity (FVC)	3.6	13.7	37.7	2.0	6.1	-5.6	1.0	4.5	-1.2	1.3	2.9	4.1	3.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.5	1.3	-1.8	1.4	0.3	-0.9	1.3	0.3	-0.4	-2.0	-2.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	6.5	2.5	2.0	-1.6	1.0	1.0	0.4	0.8	1.2	0.5	0.4
Qualifications: None of the above	1.0	2.1	7.3	0.4	0.2	-0.4	2.7	1.0	1.9	1.5	2.2	1.1	0.9
Financial difficulties in last 2 years	2.0	2.7	6.8	2.2	1.6	-2.6	1.8	0.4	0.5	1.1	2.1	1.9	-0.4
Mouth/teeth dental problems	3.2	5.0	13.0	-1.0	-2.5	3.6	-1.9	-2.5	-0.8	-1.1	-2.3	-2.6	-2.3
Heart attack	0.4	0.5	1.8	1.4	0.7	-0.3	-0.6	0.3	-0.4	-0.5	-0.2	-0.3	-1.2
Allergy	2.9	6.6	18.1	-2.5	-4.2	4.2	-0.5	-2.7	0.8	-0.0	-1.6	-2.9	-2.3
Pain all over the body in last month	1.0	1.1	2.5	-0.2	0.5	-1.5	1.4	0.5	0.5	0.7	1.6	1.5	0.7
Diabetes (self-reported)	0.5	0.8	2.7	1.6	1.2	-0.9	-0.9	-0.6	0.2	-0.2	-0.4	0.3	-1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.2	-0.3	0.7	-0.9	1.1	0.7	0.9	0.7	1.0	1.0	1.5
Medication: Ramipril	0.4	0.5	2.7	0.6	0.6	-1.6	0.0	0.7	0.8	-0.4	0.1	0.4	0.4
Medication: Simvastatin	1.6	2.4	4.7	1.6	-0.7	1.6	-1.7	-1.8	0.6	-0.8	-1.9	-1.8	-2.2
Fluid intelligence score	0.5	1.1	3.1	-0.4	0.9	-1.8	-0.3	0.3	-0.9	-1.7	0.5	1.7	0.4
Illnesses of siblings	2.0	2.8	5.8	-2.4	-1.4	0.6	2.4	-1.4	1.7	1.2	2.1	1.5	1.2
Neuroticism score	1.4	2.9	5.7	0.6	1.1	-2.4	2.2	1.2	1.3	0.9	2.4	2.4	1.1
Weight	10.5	51.8	161.3	8.9	12.7	-10.8	2.0	8.5	0.6	3.4	4.7	5.5	4.7
Impedance of arm (right)	1.3	6.1	15.5	2.6	3.9	-2.8	0.9	1.2	0.4	1.9	1.9	3.9	2.5
Arm fat percentage (right)	2.1	8.1	25.2	5.0	4.8	-4.4	0.3	3.2	0.4	-0.2	1.0	1.3	0.4
Trunk fat-free mass	8.7	49.7	158.8	7.7	12.6	-10.3	1.6	8.8	0.0	3.7	4.5	5.2	5.6
Hip circumference	8.4	36.2	112.4	6.9	10.6	-8.8	1.7	6.9	0.2	3.3	4.0	5.1	4.4
Time employed in main current job	0.9	1.0	2.5	-0.3	-0.3	-0.5	-1.6	0.3	-1.5	-1.2	-1.3	-0.7	-0.9
Alcohol intake versus 10 years previously	1.7	2.5	7.0	-1.9	-2.6	1.7	-0.5	-1.7	0.4	-0.3	-0.8	-1.6	-2.1
Father’s age at death	1.5	2.0	5.3	-0.9	-1.1	-0.1	2.3	-1.6	1.9	0.9	1.8	1.5	0.5
Worrier / anxious feelings	1.6	3.1	5.4	2.0	1.4	-1.3	2.2	0.9	2.2	2.3	2.0	1.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	16.0	2.2	3.2	-4.0	2.3	2.6	0.9	1.4	2.8	2.5	1.7
Falls in the last year	0.1	0.2	0.6	0.6	0.2	-0.1	-0.6	-0.8	0.1	-0.4	-0.6	0.1	-0.1
Hair/balding pattern: Pattern 3	0.6	0.8	1.9	0.5	-0.6	0.6	-1.0	-1.0	-0.4	-1.1	-1.0	-0.9	-1.4
Number of live births	0.8	1.1	2.3	0.4	1.5	-1.5	0.3	1.5	-0.2	-0.5	0.5	1.2	1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	12.0	0.2	2.7	-3.5	0.3	2.5	-1.0	-0.1	1.3	1.9	1.7
Pulse rate	0.4	0.6	1.7	-1.3	-1.0	-1.1	-0.3	-0.6	0.2	-1.2	-0.4	0.4	-0.3
Happiness	1.1	1.4	5.2	0.3	1.1	-2.3	-0.7	1.6	-1.0	-1.6	-0.1	-0.2	-0.9
Noisy workplace	2.1	2.6	9.9	1.2	1.7	-3.1	1.5	2.3	0.4	0.8	1.8	0.9	0.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.8	-0.2	-1.6	2.2	-1.4	-2.1	-0.9	0.3	-1.4	-1.3	-1.3
Serious illness, injury or assault of a close relative in last 2 years	5.6	6.5	12.1	-0.5	1.4	-1.0	3.4	-0.5	3.0	3.5	3.4	3.2	2.5
Mouth/teeth dental problems: Dentures	1.4	2.3	5.4	0.1	0.6	-1.4	1.8	0.7	2.3	0.8	1.8	1.8	2.3
Asthma	0.5	1.0	3.3	0.4	1.6	-1.2	-0.1	0.4	-1.1	-0.7	0.4	1.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.4	5.8	0.5	2.2	-1.9	1.6	1.8	0.1	2.4	2.2	2.0	2.1
Medication: Cholesterol lowering	3.0	4.6	12.8	1.7	-0.6	2.2	-2.5	-0.7	-0.9	-0.7	-2.6	-3.2	-3.6
Depression (self-reported)	1.1	1.3	3.6	1.9	1.4	-1.3	0.7	1.3	0.7	1.6	0.9	0.1	0.4
Medication: Lansoprazole	0.9	1.0	3.2	0.2	1.3	-1.8	-0.1	1.2	-0.9	-1.2	0.5	0.9	0.6
Prospective memory result	0.4	0.5	1.2	-0.7	-0.7	0.9	-0.9	-0.8	0.0	0.1	-1.1	-0.4	-0.2
Lung cancer (father)	0.4	0.4	1.2	0.6	0.3	-0.0	-0.9	0.5	-0.1	-0.7	-1.0	-1.1	-0.1
Illnesses of mother	2.7	3.3	15.4	-0.9	1.2	0.2	1.9	1.0	0.5	3.9	2.3	1.2	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.8	0.7	2.5	-2.8	-0.2	1.8	-0.8	-0.0	0.8	1.6	1.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.8	1.3	1.4	-0.4	-0.2	0.5	-0.9	0.2	0.2	0.1	-0.7
Impedance of arm (left)	2.2	10.0	25.6	2.4	5.1	-3.8	1.1	2.2	-0.0	2.1	2.5	4.9	3.6
Arm fat mass (right)	4.6	19.1	58.1	6.4	7.6	-6.9	0.8	5.3	0.7	1.0	2.3	2.5	1.8
Trunk predicted mass	8.7	49.5	158.8	7.8	12.6	-10.2	1.6	8.8	0.1	3.7	4.5	5.2	5.5
Standing height	17.5	173.4	533.6	13.1	23.1	-18.2	4.1	14.4	0.2	8.4	9.7	13.0	11.8
Length of working week for main job	0.6	0.6	2.9	1.5	0.6	0.3	0.5	0.4	0.2	1.7	0.2	-0.5	-0.4
Exposure to tobacco smoke at home	1.4	1.6	6.2	1.5	2.5	-0.9	-0.6	2.0	-1.2	0.9	0.0	-0.5	-0.4
Breastfed as a baby	0.5	0.7	1.7	-1.0	-0.3	0.7	0.3	-0.3	-0.1	1.3	0.5	-1.0	-1.3
Tense / ‘highly strung’	2.0	3.4	7.0	0.5	1.4	-2.6	1.9	1.3	1.9	0.9	2.2	2.2	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	10.1	2.1	2.0	-1.4	2.7	-0.7	3.0	2.8	2.8	3.2	2.3
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	1.4	0.3	-0.4	0.7	0.9	1.0	0.5	0.6	-1.4	-1.5
Birth weight of first child	3.6	6.6	15.9	1.8	3.4	-2.9	1.6	4.0	0.4	2.5	2.5	0.8	3.2
Peak expiratory flow (PEF)	0.9	2.1	4.8	-0.8	-0.7	-0.6	-1.3	0.7	-1.8	-2.2	-1.3	-1.9	-2.1
Pulse wave reflection index	0.5	0.6	1.7	1.2	0.5	0.7	-0.6	-0.4	-1.3	-0.4	-0.5	-0.1	-1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.6	0.5	1.2	-1.5	0.6	0.5	-0.3	0.0	0.7	1.9	1.5
Loud music exposure frequency	1.8	1.9	7.8	1.1	1.4	-0.8	1.5	1.3	-0.1	2.8	1.7	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	11.4	-0.9	-2.2	3.4	-1.3	-3.3	-0.7	0.4	-1.7	-1.4	-1.9
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	10.8	1.9	2.8	-3.3	0.9	2.4	-0.5	1.2	1.4	1.7	0.7
Blood clot in the leg (DVT)	1.5	1.9	5.6	2.4	2.1	-1.7	0.7	1.0	0.4	0.8	1.2	1.1	1.0
Medication: Paracetamol	1.1	1.8	5.2	2.3	2.1	-2.0	0.3	1.5	0.0	1.0	0.7	0.6	0.4
Headache pain in last month	3.5	6.0	10.1	2.9	3.0	-3.1	2.3	1.5	1.3	1.9	3.2	2.6	1.5
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	7.7	-0.5	0.8	-1.6	1.9	-0.1	0.9	1.2	2.2	2.8	2.6
Glaucoma (self-reported)	3.1	3.7	6.8	-2.3	-2.6	1.7	-1.6	-2.1	-1.1	-2.1	-1.9	-1.2	-2.0
Gout (self-reported)	0.6	0.8	1.9	-0.2	0.8	-1.2	-0.6	1.1	-1.0	-0.5	0.0	0.8	1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.3	-1.1	-0.4	0.7	-0.9	0.2	-1.0	0.0	-1.0	-0.6	0.6
Medication: Amlodipine	0.7	1.0	2.2	0.0	-1.4	0.9	0.1	-0.9	1.5	-1.3	-0.5	-1.1	-1.2
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.4	-1.4	-0.5	-0.6	-1.7	0.1	-1.6	-2.3	-1.4	-0.7	-0.3
Birth weight	8.3	18.1	49.7	0.8	5.8	-5.2	1.8	4.5	-0.1	1.8	3.6	5.4	7.0
Chronic bronchitis/emphysema (mother)	1.2	1.5	3.2	1.8	0.4	-1.2	-0.8	1.6	-1.4	-1.6	-0.9	-0.1	-1.2
High blood pressure (siblings)	1.4	2.0	4.2	0.9	0.2	-0.0	-2.0	0.7	-1.4	-1.6	-1.9	-1.6	-1.8
Forced vital capacity (FVC), Best measure	3.4	12.5	34.8	2.2	5.9	-5.1	0.8	3.7	-0.7	1.5	2.7	4.1	4.2
Body fat percentage	3.5	13.7	39.8	5.9	6.3	-5.6	1.1	3.9	0.7	0.9	2.2	2.6	1.3
Leg fat percentage (right)	0.8	3.0	17.2	4.1	2.4	-1.9	0.2	1.2	0.5	-0.1	0.2	-0.3	-1.4
Arm fat-free mass (right)	8.1	41.6	127.7	6.6	11.3	-9.6	2.0	7.8	0.3	3.2	4.5	5.5	5.3
Exposure to tobacco smoke outside home	0.4	0.5	1.8	1.3	1.2	-0.7	-0.5	0.8	-0.6	-0.4	-0.4	0.0	-0.1
Comparative body size at age 10	0.9	2.4	8.1	-1.2	0.5	-0.1	1.2	1.0	1.5	2.5	1.6	0.7	2.8
Number of full brothers	3.1	3.9	13.0	1.4	2.5	-2.5	-1.6	2.4	-3.6	-1.4	-0.5	0.6	-1.0
Worry too long after embarrassment	1.3	2.1	5.8	0.6	1.6	-2.2	0.9	0.6	0.5	0.4	1.3	2.4	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	10.5	3.2	2.1	-2.2	0.5	0.8	2.3	0.6	0.7	0.2	-0.3
Wheeze or whistling in the chest in last year	2.1	3.7	10.8	3.1	3.3	-1.8	1.2	1.4	0.2	1.6	1.6	2.1	0.9
Number of children fathered	1.3	1.5	4.2	1.1	1.0	0.5	-1.5	0.4	-2.0	-1.6	-1.5	-0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	-1.0	-1.3	1.1	-0.7	-0.6	-1.0	-0.7	-1.0	-0.7	-1.1
Age at first live birth	1.6	2.8	6.3	-0.9	-1.7	2.1	-1.7	-1.2	-0.6	-0.5	-1.8	-2.5	-2.2
Pulse wave peak to peak time	0.4	0.5	2.0	-0.4	0.2	-0.9	0.3	0.5	0.8	0.1	0.4	0.7	1.4
Health satisfaction	3.0	3.9	9.1	3.0	1.9	-2.4	-1.8	1.4	-2.1	-2.4	-1.2	-0.2	-1.9
Shortness of breath walking on level ground	1.7	2.0	6.1	1.8	2.0	-2.5	0.2	0.9	-0.9	-1.2	0.6	1.8	-0.1
Qualifications: College or University degree	0.6	2.0	4.8	0.5	-1.0	1.0	-1.9	-0.9	-1.0	-0.4	-2.0	-2.2	-1.9
Eye problems/disorders: None of the above	1.0	1.2	3.4	1.4	1.4	-0.9	-0.6	1.8	-1.9	-0.2	-0.2	-0.4	-0.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.7	0.2	1.0	-1.0	1.3	-0.0	1.0	1.6	1.3	1.2	1.1
Emphysema/chronic bronchitis	3.4	3.9	7.5	1.8	2.5	-2.5	2.1	2.5	0.8	1.2	2.7	1.4	0.7
Medication for pain relief, constipation, heartburn	1.1	1.8	5.7	-1.5	-2.4	2.1	0.2	-1.4	0.2	-0.5	-0.5	-1.2	-1.3
Neck or shoulder pain in last month	0.4	0.5	1.1	1.0	0.4	-0.1	1.0	0.6	0.7	0.2	1.0	0.2	0.9
Medication: Blood pressure	0.5	0.9	3.0	0.1	-0.3	0.1	-1.3	0.2	-0.2	-1.7	-1.4	-0.9	-1.1
Angina (self-reported)	0.5	0.6	1.6	1.3	0.7	-0.9	0.9	1.1	0.4	0.1	0.9	0.2	0.1
Migraine (self-reported)	1.4	1.7	3.4	-0.6	-1.0	1.3	-1.9	-0.7	-1.3	-0.5	-1.8	-1.6	-1.5
Medication: Ibuprofen	2.7	3.2	5.0	0.7	2.2	-1.8	1.8	1.5	0.6	2.1	2.2	2.2	2.0
Medication: Allopurinol	0.9	1.2	3.5	0.1	1.5	-1.5	-0.1	1.1	-0.8	-0.2	0.6	1.9	1.3
Medication: Omeprazole	0.1	0.2	0.7	0.8	0.2	-0.3	0.2	0.1	0.4	0.5	0.1	-0.6	-0.3
Medication: Seretide 50 evohaler	0.6	0.7	2.2	-0.6	-0.3	-0.0	-1.0	-0.1	-1.3	-1.5	-1.1	-0.3	-0.4
Mean time to correctly identify matches	1.5	2.9	9.8	-1.5	-2.7	1.8	-0.9	-0.8	1.2	-0.3	-1.4	-3.1	-1.3
Heart disease (mother)	2.8	3.4	11.0	0.9	-0.9	0.0	-1.9	-0.9	-0.5	-3.3	-2.2	-1.6	-3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.8	1.3	0.8	-0.5	-0.7	0.0	-0.1	-0.1	-0.7	-0.4	0.9
Whole body fat mass	7.1	29.7	90.8	7.5	9.5	-8.3	1.5	6.1	0.9	2.0	3.4	4.0	3.0
Leg fat mass (right)	3.8	14.8	44.7	6.2	6.7	-5.7	0.9	4.4	0.7	1.2	2.0	2.0	1.3
Arm predicted mass (right)	8.5	43.6	134.6	6.9	11.6	-9.9	1.8	8.2	0.1	3.2	4.5	5.3	5.2
Pulse rate, automated reading	0.3	1.0	4.4	-1.9	-2.1	0.4	0.4	-0.8	0.9	-0.5	-0.2	-0.4	0.0
Alcohol intake frequency.	0.2	0.4	1.6	0.6	0.3	-1.0	0.2	0.1	1.3	-0.0	0.5	0.4	0.5
Comparative height size at age 10	11.1	61.3	204.5	9.6	14.3	-10.8	1.7	9.5	-0.4	5.0	4.9	5.8	5.1
Number of full sisters	0.4	0.5	1.4	-1.1	-0.3	-1.2	-0.5	0.8	-0.1	-0.8	-0.4	-0.2	-0.3
Suffer from ‘nerves’	1.6	2.6	4.0	1.7	1.5	-1.1	1.9	-0.1	2.0	1.8	2.0	1.7	1.3
Overall health rating	3.4	7.2	19.6	4.4	4.0	-4.1	1.6	2.5	0.9	0.8	2.2	2.0	0.9
Chest pain or discomfort	0.7	1.0	3.0	1.7	1.1	-1.6	0.0	-0.2	-0.1	-0.1	0.4	1.5	-0.7
Had major operations	4.9	5.7	11.6	3.1	3.4	-3.3	1.8	2.3	-0.1	1.4	2.6	2.8	0.7
Age at last live birth	1.1	1.6	3.3	-1.1	-1.8	1.8	-1.0	-1.4	-0.2	-0.4	-0.9	-1.6	-1.6
Family relationship satisfaction	0.6	0.7	3.1	-0.1	-0.9	-0.5	-0.2	0.3	0.4	-1.0	-0.5	-1.3	-1.8
Leg pain on walking	0.9	1.2	5.2	1.5	0.3	-2.3	0.4	1.6	0.3	-0.8	0.3	-0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	0.3	0.0	-0.8	-0.6	1.1	-1.4	-1.5	-0.6	-0.5	-0.4
Commuting to job workplace: Car/motor vehicle	1.6	1.8	5.3	-0.3	-1.6	2.3	0.9	-2.3	1.1	0.3	-0.1	-0.7	-1.4
Illness, injury, bereavement, stress in last 2 years	4.6	5.6	11.9	-1.4	-2.9	3.4	-2.6	-2.1	-1.1	-2.0	-3.1	-2.6	-0.7
Medication: Aspirin	0.5	0.7	2.0	0.9	0.7	-0.3	-0.0	-1.1	1.4	-0.3	0.4	1.2	0.7
Supplements: Vitamin C	0.6	0.7	1.7	-0.3	1.0	-1.3	-1.0	1.0	-0.8	-1.2	-0.4	0.4	0.1
Knee pain experienced in last month	3.0	4.6	10.8	2.0	3.1	-3.3	1.5	2.2	0.7	1.3	2.2	2.4	1.3
Hypertension (Self-reported)	0.4	1.0	3.6	0.8	-0.5	0.2	-0.8	-0.0	0.2	-1.9	-1.1	-1.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.5	1.6	1.2	-1.0	-1.9	1.0	-2.1	-1.3	-1.6	-0.6	-0.7
Illnesses of father: Heart disease	0.3	0.4	2.0	-0.5	-0.3	0.3	-0.0	-1.2	0.5	-0.1	0.3	1.4	0.4
Illnesses of siblings: Diabetes	1.0	1.2	2.4	0.4	-0.4	0.9	-1.3	-0.1	-1.1	-1.0	-1.5	-1.5	-1.5
Smoking status: Previous	0.8	1.2	4.2	0.9	1.5	-1.7	0.0	2.0	-1.0	-0.8	0.2	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	9.3	19.2	55.7	4.1	7.5	-6.1	1.7	4.8	-0.1	2.9	3.5	4.5	3.9
Whole body fat-free mass	9.8	55.9	176.9	8.0	13.3	-11.2	1.7	9.4	0.1	3.5	4.8	5.8	5.8
Leg fat-free mass (right)	10.7	57.2	179.6	7.6	13.4	-11.6	1.7	9.5	-0.0	3.1	5.0	6.3	5.8
Arm fat percentage (left)	2.3	9.3	27.7	4.9	5.3	-4.8	0.3	3.6	0.1	-0.0	1.2	1.7	0.9
Average weekly red wine intake	0.3	0.4	0.8	-0.3	0.9	-0.8	0.7	0.6	0.4	0.7	0.8	0.1	0.6
Handedness (chirality/laterality): Left-handed	2.1	2.6	7.5	0.7	1.3	-2.7	1.6	2.5	0.5	0.3	1.8	1.1	1.6
Mood swings	1.7	3.1	8.7	-0.5	-0.2	-0.7	3.0	-0.5	2.3	2.0	2.7	2.1	0.5
Loneliness, isolation	2.4	3.3	11.1	-0.9	1.3	-3.3	1.4	3.0	-0.3	0.1	1.8	1.7	1.3
Long-standing illness, disability or infirmity	1.2	1.8	5.2	0.9	1.4	-2.3	0.8	1.1	0.7	0.6	1.5	1.9	1.3
Ever had bowel cancer screening	0.7	0.8	2.6	0.3	1.6	-1.1	-0.7	0.6	-0.8	0.4	-0.3	1.1	1.0
Diabetes diagnosed by doctor	0.9	1.5	5.9	2.3	2.4	-1.3	-1.1	0.2	0.1	0.1	-0.3	0.7	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.5	0.7	0.9	0.9	0.1	-0.4	-0.7	1.6	0.3	0.2	-0.3
Friendships satisfaction	0.6	0.7	2.7	-0.3	-1.0	-0.4	0.0	-1.4	0.7	-1.6	-0.1	0.9	-0.3
Qualifications: nursing, teaching	0.7	1.1	2.2	-0.7	-0.9	1.5	-1.1	-1.4	0.6	0.5	-1.0	-1.5	-0.5
Commuting to job workplace: Walk	1.1	1.2	4.3	0.4	1.0	-1.4	-0.9	2.1	-1.5	0.3	-0.2	-0.7	-0.7
Eye problems/disorders: Cataract	0.9	1.1	3.3	-1.8	-0.7	-0.5	0.7	-0.5	1.0	0.4	0.7	1.3	1.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.5	0.3	1.7	-1.3	-0.4	2.1	-1.5	-0.1	-0.0	0.0	0.5
Medication for cholesterol	0.5	0.8	2.0	-0.9	-0.8	0.8	-0.6	0.7	-1.3	0.1	-0.6	-1.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	15.1	3.1	3.0	-3.9	0.5	2.8	0.7	0.6	0.9	0.7	1.1
Back pain experienced in last month	1.6	2.3	6.0	2.0	2.5	-2.4	-0.2	2.4	-1.0	-0.7	0.4	0.7	0.2
Mineral and other dietary supplements	2.2	3.0	10.9	0.9	-1.4	1.8	-0.7	-0.9	-1.2	-0.3	-1.3	-3.0	-3.3
Breast cancer (self-reported)	2.4	2.8	8.4	-2.6	-1.0	-0.3	-2.1	-0.3	-2.1	-2.9	-1.7	0.0	-0.5
Asthma (self-reported)	0.5	0.9	3.2	0.7	1.6	-1.0	-0.1	0.2	-1.1	-0.4	0.3	1.8	0.7
Osteoporosis (self-reported)	0.6	0.7	4.0	-2.0	-0.6	-0.2	0.7	0.2	0.1	0.2	0.7	0.3	1.2
Osteoarthritis (self-reported)	0.3	0.3	1.1	-0.6	-1.1	0.3	0.6	-0.2	0.2	0.9	0.2	-0.5	-0.5
Medication: Aspirin	0.4	0.5	1.1	1.0	0.8	-0.5	-0.3	-0.7	1.0	-0.8	0.1	1.0	0.5
Medication: Gliclazide	0.6	0.7	2.3	1.4	1.5	-0.6	-0.2	-0.4	-0.1	1.0	0.1	1.0	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	-1.0	-1.0	0.9	1.0	0.2	0.8	1.1	0.5	-1.1	0.1
Smoking status: Current	0.3	0.5	1.3	0.5	-0.1	1.0	0.2	-0.5	0.0	1.1	-0.0	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.8	19.3	-3.9	-4.4	2.8	-1.5	-2.8	-0.5	-2.2	-2.2	-1.7	-1.4
Whole body water mass	9.4	53.8	171.6	7.8	13.1	-11.0	1.6	9.2	-0.0	3.4	4.7	5.7	5.7
Leg predicted mass (right)	10.7	57.1	179.6	7.5	13.4	-11.6	1.6	9.5	0.0	3.1	4.9	6.2	5.8
Arm fat mass (left)	5.0	20.5	62.5	6.3	7.9	-7.1	1.1	5.4	0.6	1.2	2.6	3.0	2.2
Number of self-reported non-cancer illnesses	1.1	1.8	6.6	2.6	1.9	-2.2	-0.3	1.8	0.2	-0.4	-0.0	-0.1	0.2
Average weekly champagne plus white wine intake	0.9	1.2	4.8	-0.1	0.2	-0.3	-1.7	0.3	-2.2	-1.3	-1.4	-0.3	-0.7
Miserableness	2.8	4.9	11.4	-0.6	0.9	-2.4	3.1	1.1	1.6	1.5	3.4	3.3	1.9
Guilty feelings	0.7	1.1	4.0	-0.5	0.5	-2.0	0.7	1.6	-0.1	-0.1	1.1	1.3	0.7
Wears glasses or contact lenses	0.2	0.3	0.7	0.5	0.8	0.3	-0.2	-0.5	0.5	0.3	-0.1	0.6	0.8
Ever taken oral contraceptive pill	0.3	0.3	1.0	0.6	-0.1	0.2	-0.5	-1.0	0.4	-0.7	-0.6	-0.1	0.2
Hearing aid user	1.7	1.9	4.5	-0.9	0.1	-0.4	1.8	-0.3	2.1	1.2	1.4	1.8	2.0
Mother’s age at death	1.0	1.3	6.0	-0.9	0.4	-0.3	0.9	-0.2	1.3	0.7	0.9	1.5	2.5
Financial situation satisfaction	0.5	0.6	2.6	0.4	0.2	-1.6	0.7	1.1	-0.7	-0.4	0.7	0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.7	0.9	3.5	0.8	0.5	-0.7	0.6	1.0	1.4	1.9	0.7	-0.1	0.1
Commuting to job workplace: Public transport	2.8	3.3	8.0	1.8	2.6	-2.8	-1.5	2.6	-2.2	-0.2	-0.2	-0.1	-0.7
Eye problems/disorders: Glaucoma	1.7	2.0	3.5	-1.8	-1.9	1.3	-1.2	-1.7	-0.3	-1.9	-1.4	-0.5	-1.1
Medication: Blood pressure	0.4	0.7	2.6	1.4	0.0	-0.5	-0.4	-0.8	0.8	-1.6	-0.5	0.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.4	1.0	-0.3	0.1	0.1	-1.0	0.9	-0.4	0.1	0.1	-1.6
Supplements: Fish oil (including cod liver oil)	5.0	6.5	17.8	-1.2	1.5	-2.1	2.5	1.4	2.2	2.1	2.9	3.5	4.2
High cholesterol (Self-reported)	2.8	5.0	11.2	0.5	-2.0	2.9	-2.1	-2.5	-0.1	-1.0	-2.7	-2.7	-3.3
Medication: Bendroflumethiazide	0.1	0.2	1.2	0.2	-0.2	-0.2	-0.1	0.5	-0.4	-1.1	-0.4	-0.3	-0.4
Medication: Paracetamol	1.8	2.8	8.6	1.7	2.5	-2.9	0.2	2.1	0.0	0.4	1.0	1.4	1.6
Medication: Lisinopril	0.6	0.8	4.9	-0.5	-0.7	0.2	0.9	-1.0	2.2	0.1	0.5	0.6	0.6
Medication: Atorvastatin	1.1	1.3	5.2	0.7	-0.7	1.3	-0.7	-1.4	-0.2	-0.5	-0.8	-1.5	-2.3
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.1	0.9	-1.0	-0.6	0.9	-1.2	-0.7	0.1	0.7	0.0
Alcohol drinker status: Never	1.3	1.5	4.6	-0.1	0.4	-2.0	1.0	0.5	2.1	1.0	1.5	1.2	0.6
Ever smoked	0.4	0.7	2.6	0.2	0.8	-1.3	0.6	1.6	-0.5	0.6	0.7	-0.2	-0.7
Basal metabolic rate	10.3	57.0	179.6	8.3	13.4	-11.4	1.8	9.4	0.1	3.4	4.9	5.8	5.5
Leg fat percentage (left)	0.7	2.7	15.0	3.9	2.0	-1.9	0.2	1.0	0.5	-0.2	0.2	-0.4	-1.6
Arm fat-free mass (left)	7.6	38.5	116.6	6.8	10.8	-9.6	1.8	7.9	0.3	2.8	4.2	4.5	4.4
Number of operations (self-reported)	5.9	8.7	29.7	4.7	5.4	-4.1	0.3	3.1	0.0	0.7	1.7	2.1	0.6
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.8	-0.4	-0.7	0.2	0.0	-0.1	-0.2	0.2	0.1	-0.5
Irritability	0.8	1.4	3.8	0.1	0.3	-1.9	1.5	0.6	1.3	0.2	1.5	1.5	1.1
Risk taking	0.7	1.0	2.4	0.2	1.1	-1.3	-1.6	1.1	-0.1	-1.5	-1.0	-0.5	0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.0	0.3	-0.4	1.4	-0.6	-1.0	-0.2	0.3	-0.8	-0.7	0.0
Fractured/broken bones in last 5 years	1.1	1.4	7.0	0.5	1.4	-2.6	0.1	1.5	-0.4	-1.4	0.7	0.7	0.2
Age started oral contraceptive pill	0.4	0.5	1.1	0.2	1.1	-0.9	-0.4	0.7	1.1	-0.1	-0.0	0.1	0.9
Diastolic blood pressure, automated reading	0.8	2.6	7.1	-0.7	-2.6	1.1	-1.4	-1.0	-0.5	-2.7	-2.0	-1.6	-0.3
Ever depressed for a whole week	1.5	1.9	4.4	1.2	1.2	-1.0	1.9	0.8	1.2	2.1	1.9	0.4	1.3
Unable to work because of sickness or disability	0.1	0.2	0.5	0.7	0.5	-0.3	0.4	0.3	0.1	0.7	0.4	-0.2	-0.3
Commuting to job workplace: Cycle	0.6	0.7	2.8	0.3	0.8	-0.2	0.9	-0.2	0.9	1.7	1.0	0.8	0.4
Myopia	0.6	0.9	2.0	1.4	0.6	-0.0	-1.3	0.1	-0.9	-1.2	-1.2	-0.5	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.6	-1.0	0.7	-0.1	0.8	0.2	-0.3	2.1	1.2	1.4	1.5
Cholesterol lowering medication	0.7	1.0	4.2	0.7	-0.9	0.1	0.2	-2.1	1.5	-0.6	-0.2	-0.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.9	0.6	-0.6	-0.3	0.6	-0.4	-0.3	-0.2	-0.5	-0.8
Pain experienced in last month	2.0	3.3	7.9	-2.6	-2.8	2.6	-0.9	-1.5	-0.5	-0.7	-1.6	-2.1	-0.5
Supplements: Calcium	0.4	0.5	1.9	-0.6	-0.4	-0.2	-0.6	0.3	-0.8	-1.4	-0.5	0.5	0.7
Basal cell carcinoma (self-reported)	0.6	0.8	2.1	-0.8	-0.2	-0.7	1.5	-0.3	0.8	0.2	1.4	1.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	1.1	0.7	-0.4	-0.6	0.3	-0.6	-0.7	-0.2	-0.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	5.2	2.3	1.9	-1.7	0.3	0.9	0.0	0.2	0.7	0.9	0.7
Heart disease (siblings)	1.7	2.1	4.8	2.2	2.2	-1.0	-1.9	1.2	-1.6	-1.0	-1.4	0.2	0.3
Alcohol drinker status: Previous	1.4	1.5	6.2	2.5	1.8	-1.5	0.9	0.9	0.8	0.8	1.0	0.4	0.2
Pack years of smoking	1.2	1.8	6.5	1.9	0.7	-1.3	1.0	2.5	0.9	1.0	0.8	-1.5	-0.5
Impedance of whole body	0.6	3.1	12.1	1.5	2.2	-1.2	1.1	-0.1	0.2	1.8	1.7	3.5	1.8
Leg fat mass (left)	3.8	14.8	44.4	6.0	6.7	-5.8	1.0	4.5	0.6	1.2	2.1	2.0	1.2
Arm predicted mass (left)	7.7	39.2	121.0	6.9	11.0	-9.4	1.9	7.8	0.4	3.1	4.3	4.6	4.5