Hub : Genes

AMZ1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.189 0.0340 2.2e-12 0.121 0.128 0.134 0.131 0.120 1.5e-14 2.8e-15 5.7e-16 1.2e-15 2.0e-14
2 ROSMAP Brain Pre-frontal Cortex 0.086 0.0236 2.1e-05 0.048 0.030 0.043 0.039 0.044 8.3e-07 7.6e-05 2.5e-06 8.9e-06 2.4e-06
3 TCGA Esophageal Carcinoma 0.179 0.0850 2.6e-03 0.050 0.046 0.009 NA 0.034 1.1e-02 1.4e-02 1.7e-01 NA 3.1e-02
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.334 0.0890 1.0e-05 0.201 0.099 0.133 NA 0.190 1.1e-11 2.6e-06 4.7e-08 NA 4.5e-11
5 TCGA Brain Lower Grade Glioma 0.040 0.0189 5.9e-04 0.038 0.019 0.022 NA 0.022 3.3e-05 2.6e-03 1.5e-03 NA 1.3e-03
6 TCGA Lung Adenocarcinoma 0.267 0.0764 6.5e-09 0.083 0.079 0.095 NA 0.092 6.1e-10 1.4e-09 3.1e-11 NA 7.0e-11
7 TCGA Lung Squamous Cell Carcinoma 0.141 0.0473 1.3e-06 0.060 0.057 0.065 NA 0.054 2.2e-07 4.8e-07 7.4e-08 NA 9.5e-07
8 TCGA Pancreatic Adenocarcinoma 0.174 0.0780 2.5e-03 0.108 0.065 0.102 NA 0.093 2.9e-05 1.1e-03 5.0e-05 NA 1.1e-04
9 TCGA Prostate Adenocarcinoma 0.076 0.0346 2.5e-04 0.009 0.046 0.043 NA 0.033 3.8e-02 1.3e-05 2.6e-05 NA 2.2e-04
10 TCGA Thyroid Carcinoma 0.317 0.0730 9.1e-15 0.036 0.187 0.200 NA 0.170 1.7e-04 6.4e-18 3.3e-19 NA 2.7e-16

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.4 0.7 1.7 -1.3 -1.2 0.9 -0.6 -0.5 0.1 0.4 -0.5 -1.2 0.5
Bipolar Disorder or Schizophrenia 0.5 1.2 6.2 -0.5 -1.1 0.7 -0.6 0.4 0.6 0.1 -0.7 -2.5 -1.6
Depressed Affect (Nagel 2018) 2.9 6.1 13.5 -0.1 1.6 -3.0 3.5 2.3 2.0 1.7 3.7 2.9 1.5
Depression (Nagel 2018) 0.9 1.4 2.4 1.4 1.3 -1.2 1.2 1.5 0.9 1.5 1.3 -0.1 -0.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.6 -1.3 -0.2 -1.9 0.2 -0.6 -0.2 -2.3 0.8 2.4 0.6
Neuroticism (Nagel 2018) 2.8 6.6 13.9 0.6 1.9 -3.3 3.4 2.2 2.1 1.6 3.7 3.1 1.9
Schizophrenia (2018) 0.6 1.3 6.3 0.4 -0.4 0.2 -0.4 0.9 0.5 -0.2 -0.5 -2.3 -2.5
Schizophrenia vs Biploar Disorder 0.7 1.0 2.1 0.8 -0.6 1.2 1.1 -1.2 1.4 1.4 0.6 -0.3 -0.3
Worry (Nagel 2018) 1.9 3.9 8.8 1.4 1.0 -1.2 3.0 0.9 2.8 2.5 2.8 1.3 1.3
Alzheimer’s Disease (in mother) 1.0 1.2 4.1 -0.0 -1.0 1.2 -0.9 -2.0 0.4 -0.9 -1.3 -1.0 -0.9
Alzheimer’s Disease (in father) 1.3 1.4 5.3 1.9 0.9 0.1 0.7 -0.0 1.7 2.3 0.5 -0.5 0.4
Alzheimer’s Disease (including proxy) 0.6 0.9 3.7 1.9 0.4 0.5 -0.0 -1.3 1.4 0.8 -0.4 -0.6 -0.1
Crohns Disease (2017) 0.3 0.7 4.4 2.1 1.1 0.1 -0.3 0.7 -0.5 0.1 0.0 -0.3 -0.2
Irritable Bowel Disease (IBD) 3.3 7.9 28.0 3.9 5.3 -2.5 1.0 2.1 0.9 2.5 2.4 2.5 2.0
Ulcerative Colitis (UC) 6.2 11.6 39.9 3.4 6.3 -3.8 1.5 2.3 1.0 3.0 3.2 3.9 2.7
Major Depression (MDD) 0.0 0.1 0.4 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 2.4 4.6 10.2 -1.9 -3.2 2.6 -1.5 -1.8 0.6 -1.4 -2.0 -3.0 -2.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.7 -0.5 -0.2 -0.9 -0.5 -0.5 -0.4 -1.6 0.0 0.9 -0.0
Breast Cancer 0.7 1.6 3.4 -0.9 1.3 -1.2 1.0 1.9 0.1 1.0 1.7 1.1 1.6
Ovarian Cancer 0.9 1.1 4.5 -1.2 -1.5 2.1 1.1 -0.6 -0.2 0.8 0.6 -0.1 0.8
Prostate Cancer 0.5 0.7 2.3 1.4 -0.5 0.8 0.6 -1.5 1.1 0.2 0.1 -0.0 0.6
Age at First Birth 1.3 2.0 7.0 -1.0 -1.6 2.4 -0.8 -2.6 0.2 0.3 -1.3 -0.3 -1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.1 -1.0 -1.0 0.7 -1.2 0.0 0.6 0.1 -1.1 -1.4 0.1
Coronary Artery Disease (CAD) 0.9 1.1 5.1 -2.3 -0.8 -0.2 1.1 -0.9 0.2 -0.2 0.8 1.3 0.8
Crohns Disease (2012) 0.2 0.4 1.7 0.7 0.6 1.0 0.2 -0.1 0.2 1.3 0.2 -0.3 0.1
Mean Putamen Volume 1.6 1.8 4.7 -1.2 1.1 -2.1 0.7 1.9 0.1 0.3 1.1 0.8 2.2
Fasting Glucose 0.5 0.7 1.6 -1.1 -0.5 -1.1 0.6 0.3 1.3 -0.5 0.7 0.8 0.5
HbA1C 0.5 0.6 1.2 -0.5 0.4 -1.1 -1.1 1.0 -0.6 -0.6 -0.8 -0.7 0.5
HDL Cholesterol 0.4 0.6 3.8 -1.9 -0.9 0.6 -0.0 -0.2 -0.6 -0.6 -0.3 0.0 0.8
LDL Cholesterol 0.4 0.6 3.3 0.1 -1.3 0.3 0.4 -0.4 0.3 -0.1 0.0 -0.9 -1.8
Lupus 0.4 0.6 2.7 -0.6 -0.3 1.1 0.8 -0.6 0.1 1.7 0.7 0.1 0.5
Neuroticism (2016) 1.4 2.0 5.7 1.4 2.0 -2.4 1.1 1.8 0.3 0.2 1.3 1.4 0.2
Primary Biliary Cirrhosis 0.8 1.2 2.0 0.7 1.1 -0.7 1.3 0.7 1.1 1.4 1.2 0.8 1.4
Rheumatoid Arthritis 2.7 3.7 9.5 1.9 1.8 -3.1 2.1 2.5 0.3 0.9 2.4 1.6 0.7
Schizophrenia (2014) 0.6 1.4 5.9 0.7 -0.7 0.6 0.1 0.5 1.2 0.8 -0.0 -2.4 -2.2
Triglycerides 0.1 0.1 0.5 0.6 0.2 -0.1 -0.2 0.7 -0.0 0.1 -0.2 -0.5 -0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.2 0.5 0.5 -1.0 -0.3 0.9 -0.2 -0.9 -0.2 -1.1 -1.1
Ulcerative Colitis 8.0 11.6 32.6 3.8 5.7 -3.3 2.2 2.7 1.3 3.9 3.5 3.2 2.5
Blood Eosinophil Count 0.8 6.3 19.0 -1.2 -4.4 3.1 -1.1 -2.6 0.2 -2.4 -2.3 -2.2 -2.9
Blood Platelet Count 6.5 75.0 163.8 -4.6 -12.8 11.4 -4.1 -9.4 -1.5 -5.5 -7.5 -10.5 -11.5
Blood Red Count 0.4 4.0 9.3 1.0 -2.7 1.7 -1.0 -3.0 1.2 -2.1 -2.2 -1.7 -2.1
Blood White Count 3.7 27.2 57.5 -0.6 -7.5 7.6 -1.6 -7.1 1.9 -1.6 -3.8 -6.3 -6.7
Heel T-Score 3.0 23.7 49.3 -1.0 -7.0 7.0 -2.3 -6.4 0.3 -1.8 -4.2 -5.7 -6.3
BMI 0.3 1.6 4.0 2.0 1.8 -2.0 -0.2 1.8 0.4 -0.2 0.0 -0.7 -1.1
Height 19.6 378.4 1122.2 18.2 33.5 -27.1 6.6 22.2 0.2 12.6 14.9 19.2 17.6
Waist Hip Ratio (WHR) 0.4 2.0 9.1 1.8 -0.5 -0.3 0.1 -0.1 0.8 -1.5 -0.5 -1.9 -3.0
Systolic Blood Pressure 0.6 2.8 8.9 -2.3 -2.8 3.0 -0.3 -2.0 0.3 -1.0 -0.8 -0.2 0.4
Smoking Status 0.3 0.7 2.2 0.8 0.8 -0.7 -0.2 1.5 -1.0 -0.0 -0.0 -0.7 -1.3
Allergy or Eczema 3.1 8.1 21.7 3.3 4.7 -4.2 1.1 3.0 0.5 1.6 1.9 2.5 2.8
Cardiovascular Disease 1.4 4.6 10.3 -0.2 -2.9 2.4 -1.3 -2.4 0.1 -2.1 -2.0 -2.5 -3.2
Hypothyroidism (self reported) 0.9 2.1 4.6 -1.5 -1.4 1.4 -1.7 0.0 -1.5 -1.0 -2.0 -2.1 -0.3
Respiratory disease 0.6 1.3 3.6 1.3 1.9 -1.8 0.3 1.7 -0.1 0.4 0.6 0.7 0.9
Type 2 Diabetes (T2D) (2018) 0.6 1.1 4.2 2.0 1.3 -0.2 -1.2 -0.7 -0.3 0.2 -0.6 -0.3 -1.7
Lung FEV1/FVC ratio 4.4 22.2 58.5 -4.0 -7.7 5.4 -2.4 -5.1 0.5 -2.7 -4.2 -5.8 -5.3
Lung FVC 1.0 5.2 22.4 -4.7 -3.6 2.5 0.3 -2.3 0.5 -1.8 -0.3 0.2 0.9
Neuroticism 1.9 4.5 10.5 1.2 2.4 -3.2 2.0 2.5 1.2 1.1 2.5 2.6 1.5
Chronotype (morning person) 0.8 1.9 4.9 -0.4 1.2 -0.8 1.6 0.4 0.6 1.9 1.6 2.2 1.7
Hair Pigment 0.2 5.1 13.6 -3.7 -2.1 1.2 1.4 -2.6 2.6 0.5 1.2 2.4 2.9
Tanning 0.2 1.9 5.3 -0.7 -0.6 0.4 -0.5 1.4 -2.3 -1.5 -0.6 -1.7 -2.1
Hand grip strength (left) 2.9 7.7 25.8 2.6 3.7 -3.8 0.8 5.1 0.0 2.0 2.0 0.9 2.6
Number of treatments/medications taken 1.8 3.3 7.1 1.4 2.6 -2.7 0.8 1.4 1.3 0.6 1.2 2.1 2.5
Average weekly spirits intake 1.3 1.6 8.5 2.9 2.1 -0.7 0.4 1.0 0.1 1.2 0.6 -0.0 -0.4
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.1 -0.3 -0.8 0.4 0.6 -0.6 -0.2 0.6 0.9 0.3
Frequency of depressed mood in last 2 weeks 1.6 2.3 4.7 1.2 1.9 -2.2 1.6 1.3 0.7 1.4 1.9 1.5 0.5
Hearing difficulty/problems: Yes 1.7 2.6 5.4 2.2 2.3 -1.2 1.7 0.3 1.9 1.6 1.8 1.4 0.8
Relative age of first facial hair 1.1 2.2 7.1 -2.2 -0.6 0.5 0.4 -1.5 0.5 -0.0 0.4 2.6 2.7
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 9.1 3.0 2.4 -1.9 1.4 1.5 0.6 1.7 1.5 0.5 0.7
Ever used hormone-replacement therapy (HRT) 0.9 1.2 4.2 1.3 2.0 -0.9 0.1 1.0 -0.1 1.0 0.4 0.5 1.6
Ever had hysterectomy (womb removed) 1.2 1.3 2.8 0.6 0.9 -0.0 1.5 -0.1 1.1 1.6 1.4 1.1 1.7
Systolic blood pressure, automated reading 0.2 0.6 1.7 -0.4 -0.7 1.3 -0.9 -0.4 -0.4 -0.4 -1.0 -0.7 0.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 0.8 0.0 0.1 -0.2 -0.8 0.9 -0.0 -0.1 -0.4 -0.9
Angina 0.5 0.7 2.0 1.3 0.8 -1.0 0.8 1.4 0.1 0.1 0.8 0.1 0.1
Medication for hormone replacement therapy 2.8 3.2 4.8 1.8 2.1 -0.9 1.7 0.6 1.3 2.2 2.0 2.1 2.2
Vitamin and mineral supplements 1.0 1.4 4.2 -1.0 -1.5 0.6 -0.3 -0.3 -1.4 -0.8 -0.7 -1.7 -2.0
Supplements: Zinc 2.2 2.4 6.6 0.3 2.3 -1.9 -0.9 1.3 -0.7 0.3 0.2 2.2 2.6
Medication: Co-codamol 0.8 0.9 2.0 0.9 -0.5 1.3 0.6 -1.0 1.4 1.4 0.3 -0.9 -0.7
Medication: Metformin 0.6 0.9 2.6 1.5 1.2 -0.1 -1.6 -0.8 0.0 0.1 -1.0 0.5 -0.7
Diabetes (father) 0.7 0.9 5.3 1.0 0.7 0.1 0.3 0.7 0.1 2.3 0.4 -0.5 0.9
Diabetes (mother) 1.0 1.2 2.7 -0.4 -1.3 0.7 -0.6 -1.6 0.1 -1.5 -1.2 -0.8 -1.6
Severe depression (siblings) 1.5 1.7 5.7 -0.1 -1.7 1.4 -0.6 -0.7 -0.4 -0.1 -1.0 -2.4 -1.9
Pack years adult smoking proportion 1.3 1.9 5.6 2.2 0.8 -1.4 1.2 2.4 0.9 1.1 0.9 -1.3 -0.5
Impedance of leg (right) 0.3 1.6 6.4 0.3 -1.6 2.1 0.5 -2.5 -0.0 0.9 -0.1 0.3 -1.0
Leg fat-free mass (left) 11.3 59.7 187.7 7.9 13.7 -11.8 1.7 9.7 0.0 3.1 5.0 6.3 5.9
Trunk fat percentage 5.8 23.3 69.2 6.6 8.3 -7.4 1.5 5.2 0.9 1.8 3.1 3.9 2.7
Hand grip strength (right) 2.2 6.0 16.9 2.7 3.6 -3.4 0.4 4.1 0.0 2.2 1.5 0.5 2.1
Townsend deprivation index at recruitment 0.5 0.7 2.3 1.0 1.5 -1.3 0.3 0.1 -0.0 0.3 0.8 0.9 -0.6
Current tobacco smoking 0.3 0.4 1.2 0.6 -0.1 0.9 0.5 -0.4 0.2 1.1 0.2 -0.9 -0.9
Average weekly fortified wine intake 0.4 0.4 1.5 0.7 0.5 -1.2 0.1 1.1 0.3 0.2 0.1 -0.8 0.0
Maternal smoking around birth 0.6 0.8 4.8 2.2 1.2 -0.7 -0.1 0.8 -0.5 -0.3 -0.3 -0.2 -0.7
Fed-up feelings 1.3 2.4 6.7 0.3 1.0 -2.1 2.6 1.0 0.7 0.4 2.6 1.8 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 4.1 1.3 1.5 -1.7 0.9 2.0 -0.1 1.5 1.2 -0.2 0.1
Relative age voice broke 1.1 1.6 7.7 -0.6 0.6 0.0 -0.0 -0.7 -0.1 0.6 0.5 2.6 2.8
Taking other prescription medications 1.1 1.7 4.7 1.6 2.2 -2.2 0.0 1.6 -0.1 -0.0 0.5 1.3 1.1
Age when periods started (menarche) 0.6 1.5 4.2 0.6 2.0 -1.9 -0.1 2.0 -1.1 -0.1 0.7 1.1 0.8
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.2 -0.2 0.6 -0.2 1.9 0.3 1.5 1.2 1.7 1.4 2.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 5.8 1.3 -1.6 0.9 0.1 -0.5 1.1 -0.2 -0.3 -1.9 -2.4
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 5.1 0.2 0.4 -2.2 -0.2 1.3 -1.2 -1.1 0.3 0.6 -0.5
Qualifications: CSEs or equivalent 0.2 0.3 1.1 -1.0 -0.6 0.3 0.3 0.4 -0.6 0.4 0.3 -0.5 -0.3
Serious illness, injury or assault to yourself 1.5 1.8 4.8 1.8 2.1 -2.2 0.1 2.0 -0.7 0.1 0.7 0.4 -0.2
High blood pressure 0.3 0.9 3.8 0.7 -0.6 0.2 -0.6 -0.2 0.4 -2.0 -1.0 -1.2 -1.2
Hayfever, allergic rhinitis or eczema 2.5 5.5 15.9 1.4 3.6 -4.0 0.9 2.3 -0.4 0.4 1.8 2.9 2.6
Multivitamins +/- minerals 1.3 1.6 4.3 0.9 1.3 0.2 0.7 -0.2 1.3 1.7 1.0 1.8 2.1
Stomach or abdominal pain in last month 2.1 2.7 12.9 3.6 2.8 -0.9 0.2 -0.3 0.6 1.4 0.7 1.5 0.2
Supplements: Glucosamine 0.3 0.3 1.2 0.2 0.4 0.4 -1.1 -0.1 -0.0 0.0 -1.0 0.0 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.3 -0.5 -0.4 -0.0 0.9 -1.5 0.8 0.2 0.8 1.2 -0.1
Medication: Atenolol 2.3 2.8 6.4 1.2 -0.2 0.7 -2.1 0.1 -1.9 -2.4 -2.0 -1.6 -2.5
Medication: Levothyroxine sodium 0.3 0.4 1.9 -0.6 0.4 -0.2 -0.3 1.0 -0.6 0.7 -0.3 0.2 1.4
Sitting height 16.9 120.3 342.2 8.3 18.5 -15.4 4.3 11.7 0.3 7.1 9.0 12.3 10.8
Chronic bronchitis/emphysema (father) 1.4 1.7 5.1 2.3 1.6 -1.0 -1.4 0.3 -1.0 -1.7 -1.2 0.8 0.1
High blood pressure (mother) 0.7 0.9 3.7 -0.9 -1.5 0.3 -0.7 -0.9 -0.5 -1.9 -0.8 -0.2 -0.4
Body mass index (BMI) 0.7 3.0 9.9 3.1 2.4 -2.7 0.2 2.2 0.6 -0.3 0.4 -0.5 -0.7
Impedance of leg (left) 0.4 1.7 7.3 0.1 -1.8 2.1 0.6 -2.7 0.0 0.9 -0.0 0.2 -1.2
Leg predicted mass (left) 11.1 58.7 185.0 8.0 13.6 -11.7 1.7 9.7 -0.0 3.1 4.9 6.1 5.8
Trunk fat mass 9.6 41.1 125.4 8.3 11.2 -9.5 2.0 7.2 1.0 2.9 4.3 5.1 4.0
Waist circumference 4.7 17.0 54.2 6.3 7.4 -6.4 0.7 4.9 0.2 1.0 2.1 2.2 0.9
Number of incorrect matches in round 0.4 0.7 1.9 1.1 0.4 0.4 -0.9 0.5 0.3 0.3 -0.8 -1.1 -1.4
Past tobacco smoking 0.7 1.2 4.3 -1.1 -1.5 1.6 0.2 -2.1 1.0 0.4 -0.0 0.6 0.6
Alcohol usually taken with meals 0.3 0.5 1.7 -0.7 0.8 -0.6 -1.3 0.4 -0.3 -0.9 -0.6 0.4 0.5
Nervous feelings 1.6 2.9 7.0 2.0 1.1 -1.3 2.2 0.4 2.6 1.9 2.2 1.1 0.7
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.8 8.0 0.9 2.1 -2.8 1.9 2.1 0.9 0.5 2.1 2.5 2.3
Hearing difficulty/problems with background noise 1.5 2.4 7.2 0.6 1.8 -0.8 1.7 -0.4 1.1 1.2 2.0 2.7 1.5
Hair/balding pattern: Pattern 2 0.4 0.5 2.2 -1.5 -0.3 -0.4 0.4 0.7 -0.8 0.6 0.4 0.4 0.6
Had menopause 0.3 0.4 1.2 -0.2 0.6 -0.5 -1.0 0.2 -0.3 -1.1 -0.9 -0.0 0.7
Had other major operations 0.9 1.1 3.6 1.8 1.9 -1.2 -0.8 -0.0 0.0 -0.6 -0.0 1.4 0.5
Forced vital capacity (FVC) 3.6 13.7 37.7 2.0 6.1 -5.6 1.0 4.5 -1.2 1.3 2.9 4.1 3.9
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.5 1.3 -1.8 1.4 0.3 -0.9 1.3 0.3 -0.4 -2.0 -2.4
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 6.5 2.5 2.0 -1.6 1.0 1.0 0.4 0.8 1.2 0.5 0.4
Qualifications: None of the above 1.0 2.1 7.3 0.4 0.2 -0.4 2.7 1.0 1.9 1.5 2.2 1.1 0.9
Financial difficulties in last 2 years 2.0 2.7 6.8 2.2 1.6 -2.6 1.8 0.4 0.5 1.1 2.1 1.9 -0.4
Mouth/teeth dental problems 3.2 5.0 13.0 -1.0 -2.5 3.6 -1.9 -2.5 -0.8 -1.1 -2.3 -2.6 -2.3
Heart attack 0.4 0.5 1.8 1.4 0.7 -0.3 -0.6 0.3 -0.4 -0.5 -0.2 -0.3 -1.2
Allergy 2.9 6.6 18.1 -2.5 -4.2 4.2 -0.5 -2.7 0.8 -0.0 -1.6 -2.9 -2.3
Pain all over the body in last month 1.0 1.1 2.5 -0.2 0.5 -1.5 1.4 0.5 0.5 0.7 1.6 1.5 0.7
Diabetes (self-reported) 0.5 0.8 2.7 1.6 1.2 -0.9 -0.9 -0.6 0.2 -0.2 -0.4 0.3 -1.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.2 -0.3 0.7 -0.9 1.1 0.7 0.9 0.7 1.0 1.0 1.5
Medication: Ramipril 0.4 0.5 2.7 0.6 0.6 -1.6 0.0 0.7 0.8 -0.4 0.1 0.4 0.4
Medication: Simvastatin 1.6 2.4 4.7 1.6 -0.7 1.6 -1.7 -1.8 0.6 -0.8 -1.9 -1.8 -2.2
Fluid intelligence score 0.5 1.1 3.1 -0.4 0.9 -1.8 -0.3 0.3 -0.9 -1.7 0.5 1.7 0.4
Illnesses of siblings 2.0 2.8 5.8 -2.4 -1.4 0.6 2.4 -1.4 1.7 1.2 2.1 1.5 1.2
Neuroticism score 1.4 2.9 5.7 0.6 1.1 -2.4 2.2 1.2 1.3 0.9 2.4 2.4 1.1
Weight 10.5 51.8 161.3 8.9 12.7 -10.8 2.0 8.5 0.6 3.4 4.7 5.5 4.7
Impedance of arm (right) 1.3 6.1 15.5 2.6 3.9 -2.8 0.9 1.2 0.4 1.9 1.9 3.9 2.5
Arm fat percentage (right) 2.1 8.1 25.2 5.0 4.8 -4.4 0.3 3.2 0.4 -0.2 1.0 1.3 0.4
Trunk fat-free mass 8.7 49.7 158.8 7.7 12.6 -10.3 1.6 8.8 0.0 3.7 4.5 5.2 5.6
Hip circumference 8.4 36.2 112.4 6.9 10.6 -8.8 1.7 6.9 0.2 3.3 4.0 5.1 4.4
Time employed in main current job 0.9 1.0 2.5 -0.3 -0.3 -0.5 -1.6 0.3 -1.5 -1.2 -1.3 -0.7 -0.9
Alcohol intake versus 10 years previously 1.7 2.5 7.0 -1.9 -2.6 1.7 -0.5 -1.7 0.4 -0.3 -0.8 -1.6 -2.1
Father’s age at death 1.5 2.0 5.3 -0.9 -1.1 -0.1 2.3 -1.6 1.9 0.9 1.8 1.5 0.5
Worrier / anxious feelings 1.6 3.1 5.4 2.0 1.4 -1.3 2.2 0.9 2.2 2.3 2.0 1.2 1.4
Frequency of tiredness / lethargy in last 2 weeks 3.9 6.3 16.0 2.2 3.2 -4.0 2.3 2.6 0.9 1.4 2.8 2.5 1.7
Falls in the last year 0.1 0.2 0.6 0.6 0.2 -0.1 -0.6 -0.8 0.1 -0.4 -0.6 0.1 -0.1
Hair/balding pattern: Pattern 3 0.6 0.8 1.9 0.5 -0.6 0.6 -1.0 -1.0 -0.4 -1.1 -1.0 -0.9 -1.4
Number of live births 0.8 1.1 2.3 0.4 1.5 -1.5 0.3 1.5 -0.2 -0.5 0.5 1.2 1.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 12.0 0.2 2.7 -3.5 0.3 2.5 -1.0 -0.1 1.3 1.9 1.7
Pulse rate 0.4 0.6 1.7 -1.3 -1.0 -1.1 -0.3 -0.6 0.2 -1.2 -0.4 0.4 -0.3
Happiness 1.1 1.4 5.2 0.3 1.1 -2.3 -0.7 1.6 -1.0 -1.6 -0.1 -0.2 -0.9
Noisy workplace 2.1 2.6 9.9 1.2 1.7 -3.1 1.5 2.3 0.4 0.8 1.8 0.9 0.1
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.8 -0.2 -1.6 2.2 -1.4 -2.1 -0.9 0.3 -1.4 -1.3 -1.3
Serious illness, injury or assault of a close relative in last 2 years 5.6 6.5 12.1 -0.5 1.4 -1.0 3.4 -0.5 3.0 3.5 3.4 3.2 2.5
Mouth/teeth dental problems: Dentures 1.4 2.3 5.4 0.1 0.6 -1.4 1.8 0.7 2.3 0.8 1.8 1.8 2.3
Asthma 0.5 1.0 3.3 0.4 1.6 -1.2 -0.1 0.4 -1.1 -0.7 0.4 1.8 0.8
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.4 5.8 0.5 2.2 -1.9 1.6 1.8 0.1 2.4 2.2 2.0 2.1
Medication: Cholesterol lowering 3.0 4.6 12.8 1.7 -0.6 2.2 -2.5 -0.7 -0.9 -0.7 -2.6 -3.2 -3.6
Depression (self-reported) 1.1 1.3 3.6 1.9 1.4 -1.3 0.7 1.3 0.7 1.6 0.9 0.1 0.4
Medication: Lansoprazole 0.9 1.0 3.2 0.2 1.3 -1.8 -0.1 1.2 -0.9 -1.2 0.5 0.9 0.6
Prospective memory result 0.4 0.5 1.2 -0.7 -0.7 0.9 -0.9 -0.8 0.0 0.1 -1.1 -0.4 -0.2
Lung cancer (father) 0.4 0.4 1.2 0.6 0.3 -0.0 -0.9 0.5 -0.1 -0.7 -1.0 -1.1 -0.1
Illnesses of mother 2.7 3.3 15.4 -0.9 1.2 0.2 1.9 1.0 0.5 3.9 2.3 1.2 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 7.8 0.7 2.5 -2.8 -0.2 1.8 -0.8 -0.0 0.8 1.6 1.5
Pulse wave Arterial Stiffness index 0.5 0.5 1.8 1.3 1.4 -0.4 -0.2 0.5 -0.9 0.2 0.2 0.1 -0.7
Impedance of arm (left) 2.2 10.0 25.6 2.4 5.1 -3.8 1.1 2.2 -0.0 2.1 2.5 4.9 3.6
Arm fat mass (right) 4.6 19.1 58.1 6.4 7.6 -6.9 0.8 5.3 0.7 1.0 2.3 2.5 1.8
Trunk predicted mass 8.7 49.5 158.8 7.8 12.6 -10.2 1.6 8.8 0.1 3.7 4.5 5.2 5.5
Standing height 17.5 173.4 533.6 13.1 23.1 -18.2 4.1 14.4 0.2 8.4 9.7 13.0 11.8
Length of working week for main job 0.6 0.6 2.9 1.5 0.6 0.3 0.5 0.4 0.2 1.7 0.2 -0.5 -0.4
Exposure to tobacco smoke at home 1.4 1.6 6.2 1.5 2.5 -0.9 -0.6 2.0 -1.2 0.9 0.0 -0.5 -0.4
Breastfed as a baby 0.5 0.7 1.7 -1.0 -0.3 0.7 0.3 -0.3 -0.1 1.3 0.5 -1.0 -1.3
Tense / ‘highly strung’ 2.0 3.4 7.0 0.5 1.4 -2.6 1.9 1.3 1.9 0.9 2.2 2.2 2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 3.8 5.8 10.1 2.1 2.0 -1.4 2.7 -0.7 3.0 2.8 2.8 3.2 2.3
Hair/balding pattern: Pattern 4 0.4 0.9 2.2 1.4 0.3 -0.4 0.7 0.9 1.0 0.5 0.6 -1.4 -1.5
Birth weight of first child 3.6 6.6 15.9 1.8 3.4 -2.9 1.6 4.0 0.4 2.5 2.5 0.8 3.2
Peak expiratory flow (PEF) 0.9 2.1 4.8 -0.8 -0.7 -0.6 -1.3 0.7 -1.8 -2.2 -1.3 -1.9 -2.1
Pulse wave reflection index 0.5 0.6 1.7 1.2 0.5 0.7 -0.6 -0.4 -1.3 -0.4 -0.5 -0.1 -1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.6 0.5 1.2 -1.5 0.6 0.5 -0.3 0.0 0.7 1.9 1.5
Loud music exposure frequency 1.8 1.9 7.8 1.1 1.4 -0.8 1.5 1.3 -0.1 2.8 1.7 0.7 0.8
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 11.4 -0.9 -2.2 3.4 -1.3 -3.3 -0.7 0.4 -1.7 -1.4 -1.9
Mouth/teeth dental problems: Bleeding gums 2.8 3.6 10.8 1.9 2.8 -3.3 0.9 2.4 -0.5 1.2 1.4 1.7 0.7
Blood clot in the leg (DVT) 1.5 1.9 5.6 2.4 2.1 -1.7 0.7 1.0 0.4 0.8 1.2 1.1 1.0
Medication: Paracetamol 1.1 1.8 5.2 2.3 2.1 -2.0 0.3 1.5 0.0 1.0 0.7 0.6 0.4
Headache pain in last month 3.5 6.0 10.1 2.9 3.0 -3.1 2.3 1.5 1.3 1.9 3.2 2.6 1.5
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 7.7 -0.5 0.8 -1.6 1.9 -0.1 0.9 1.2 2.2 2.8 2.6
Glaucoma (self-reported) 3.1 3.7 6.8 -2.3 -2.6 1.7 -1.6 -2.1 -1.1 -2.1 -1.9 -1.2 -2.0
Gout (self-reported) 0.6 0.8 1.9 -0.2 0.8 -1.2 -0.6 1.1 -1.0 -0.5 0.0 0.8 1.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.3 -1.1 -0.4 0.7 -0.9 0.2 -1.0 0.0 -1.0 -0.6 0.6
Medication: Amlodipine 0.7 1.0 2.2 0.0 -1.4 0.9 0.1 -0.9 1.5 -1.3 -0.5 -1.1 -1.2
Medication: Ventolin 100micrograms inhaler 1.2 1.6 5.4 -1.4 -0.5 -0.6 -1.7 0.1 -1.6 -2.3 -1.4 -0.7 -0.3
Birth weight 8.3 18.1 49.7 0.8 5.8 -5.2 1.8 4.5 -0.1 1.8 3.6 5.4 7.0
Chronic bronchitis/emphysema (mother) 1.2 1.5 3.2 1.8 0.4 -1.2 -0.8 1.6 -1.4 -1.6 -0.9 -0.1 -1.2
High blood pressure (siblings) 1.4 2.0 4.2 0.9 0.2 -0.0 -2.0 0.7 -1.4 -1.6 -1.9 -1.6 -1.8
Forced vital capacity (FVC), Best measure 3.4 12.5 34.8 2.2 5.9 -5.1 0.8 3.7 -0.7 1.5 2.7 4.1 4.2
Body fat percentage 3.5 13.7 39.8 5.9 6.3 -5.6 1.1 3.9 0.7 0.9 2.2 2.6 1.3
Leg fat percentage (right) 0.8 3.0 17.2 4.1 2.4 -1.9 0.2 1.2 0.5 -0.1 0.2 -0.3 -1.4
Arm fat-free mass (right) 8.1 41.6 127.7 6.6 11.3 -9.6 2.0 7.8 0.3 3.2 4.5 5.5 5.3
Exposure to tobacco smoke outside home 0.4 0.5 1.8 1.3 1.2 -0.7 -0.5 0.8 -0.6 -0.4 -0.4 0.0 -0.1
Comparative body size at age 10 0.9 2.4 8.1 -1.2 0.5 -0.1 1.2 1.0 1.5 2.5 1.6 0.7 2.8
Number of full brothers 3.1 3.9 13.0 1.4 2.5 -2.5 -1.6 2.4 -3.6 -1.4 -0.5 0.6 -1.0
Worry too long after embarrassment 1.3 2.1 5.8 0.6 1.6 -2.2 0.9 0.6 0.5 0.4 1.3 2.4 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 10.5 3.2 2.1 -2.2 0.5 0.8 2.3 0.6 0.7 0.2 -0.3
Wheeze or whistling in the chest in last year 2.1 3.7 10.8 3.1 3.3 -1.8 1.2 1.4 0.2 1.6 1.6 2.1 0.9
Number of children fathered 1.3 1.5 4.2 1.1 1.0 0.5 -1.5 0.4 -2.0 -1.6 -1.5 -0.9 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.8 -1.0 -1.3 1.1 -0.7 -0.6 -1.0 -0.7 -1.0 -0.7 -1.1
Age at first live birth 1.6 2.8 6.3 -0.9 -1.7 2.1 -1.7 -1.2 -0.6 -0.5 -1.8 -2.5 -2.2
Pulse wave peak to peak time 0.4 0.5 2.0 -0.4 0.2 -0.9 0.3 0.5 0.8 0.1 0.4 0.7 1.4
Health satisfaction 3.0 3.9 9.1 3.0 1.9 -2.4 -1.8 1.4 -2.1 -2.4 -1.2 -0.2 -1.9
Shortness of breath walking on level ground 1.7 2.0 6.1 1.8 2.0 -2.5 0.2 0.9 -0.9 -1.2 0.6 1.8 -0.1
Qualifications: College or University degree 0.6 2.0 4.8 0.5 -1.0 1.0 -1.9 -0.9 -1.0 -0.4 -2.0 -2.2 -1.9
Eye problems/disorders: None of the above 1.0 1.2 3.4 1.4 1.4 -0.9 -0.6 1.8 -1.9 -0.2 -0.2 -0.4 -0.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.7 0.2 1.0 -1.0 1.3 -0.0 1.0 1.6 1.3 1.2 1.1
Emphysema/chronic bronchitis 3.4 3.9 7.5 1.8 2.5 -2.5 2.1 2.5 0.8 1.2 2.7 1.4 0.7
Medication for pain relief, constipation, heartburn 1.1 1.8 5.7 -1.5 -2.4 2.1 0.2 -1.4 0.2 -0.5 -0.5 -1.2 -1.3
Neck or shoulder pain in last month 0.4 0.5 1.1 1.0 0.4 -0.1 1.0 0.6 0.7 0.2 1.0 0.2 0.9
Medication: Blood pressure 0.5 0.9 3.0 0.1 -0.3 0.1 -1.3 0.2 -0.2 -1.7 -1.4 -0.9 -1.1
Angina (self-reported) 0.5 0.6 1.6 1.3 0.7 -0.9 0.9 1.1 0.4 0.1 0.9 0.2 0.1
Migraine (self-reported) 1.4 1.7 3.4 -0.6 -1.0 1.3 -1.9 -0.7 -1.3 -0.5 -1.8 -1.6 -1.5
Medication: Ibuprofen 2.7 3.2 5.0 0.7 2.2 -1.8 1.8 1.5 0.6 2.1 2.2 2.2 2.0
Medication: Allopurinol 0.9 1.2 3.5 0.1 1.5 -1.5 -0.1 1.1 -0.8 -0.2 0.6 1.9 1.3
Medication: Omeprazole 0.1 0.2 0.7 0.8 0.2 -0.3 0.2 0.1 0.4 0.5 0.1 -0.6 -0.3
Medication: Seretide 50 evohaler 0.6 0.7 2.2 -0.6 -0.3 -0.0 -1.0 -0.1 -1.3 -1.5 -1.1 -0.3 -0.4
Mean time to correctly identify matches 1.5 2.9 9.8 -1.5 -2.7 1.8 -0.9 -0.8 1.2 -0.3 -1.4 -3.1 -1.3
Heart disease (mother) 2.8 3.4 11.0 0.9 -0.9 0.0 -1.9 -0.9 -0.5 -3.3 -2.2 -1.6 -3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.8 1.3 0.8 -0.5 -0.7 0.0 -0.1 -0.1 -0.7 -0.4 0.9
Whole body fat mass 7.1 29.7 90.8 7.5 9.5 -8.3 1.5 6.1 0.9 2.0 3.4 4.0 3.0
Leg fat mass (right) 3.8 14.8 44.7 6.2 6.7 -5.7 0.9 4.4 0.7 1.2 2.0 2.0 1.3
Arm predicted mass (right) 8.5 43.6 134.6 6.9 11.6 -9.9 1.8 8.2 0.1 3.2 4.5 5.3 5.2
Pulse rate, automated reading 0.3 1.0 4.4 -1.9 -2.1 0.4 0.4 -0.8 0.9 -0.5 -0.2 -0.4 0.0
Alcohol intake frequency. 0.2 0.4 1.6 0.6 0.3 -1.0 0.2 0.1 1.3 -0.0 0.5 0.4 0.5
Comparative height size at age 10 11.1 61.3 204.5 9.6 14.3 -10.8 1.7 9.5 -0.4 5.0 4.9 5.8 5.1
Number of full sisters 0.4 0.5 1.4 -1.1 -0.3 -1.2 -0.5 0.8 -0.1 -0.8 -0.4 -0.2 -0.3
Suffer from ‘nerves’ 1.6 2.6 4.0 1.7 1.5 -1.1 1.9 -0.1 2.0 1.8 2.0 1.7 1.3
Overall health rating 3.4 7.2 19.6 4.4 4.0 -4.1 1.6 2.5 0.9 0.8 2.2 2.0 0.9
Chest pain or discomfort 0.7 1.0 3.0 1.7 1.1 -1.6 0.0 -0.2 -0.1 -0.1 0.4 1.5 -0.7
Had major operations 4.9 5.7 11.6 3.1 3.4 -3.3 1.8 2.3 -0.1 1.4 2.6 2.8 0.7
Age at last live birth 1.1 1.6 3.3 -1.1 -1.8 1.8 -1.0 -1.4 -0.2 -0.4 -0.9 -1.6 -1.6
Family relationship satisfaction 0.6 0.7 3.1 -0.1 -0.9 -0.5 -0.2 0.3 0.4 -1.0 -0.5 -1.3 -1.8
Leg pain on walking 0.9 1.2 5.2 1.5 0.3 -2.3 0.4 1.6 0.3 -0.8 0.3 -0.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.2 0.3 0.0 -0.8 -0.6 1.1 -1.4 -1.5 -0.6 -0.5 -0.4
Commuting to job workplace: Car/motor vehicle 1.6 1.8 5.3 -0.3 -1.6 2.3 0.9 -2.3 1.1 0.3 -0.1 -0.7 -1.4
Illness, injury, bereavement, stress in last 2 years 4.6 5.6 11.9 -1.4 -2.9 3.4 -2.6 -2.1 -1.1 -2.0 -3.1 -2.6 -0.7
Medication: Aspirin 0.5 0.7 2.0 0.9 0.7 -0.3 -0.0 -1.1 1.4 -0.3 0.4 1.2 0.7
Supplements: Vitamin C 0.6 0.7 1.7 -0.3 1.0 -1.3 -1.0 1.0 -0.8 -1.2 -0.4 0.4 0.1
Knee pain experienced in last month 3.0 4.6 10.8 2.0 3.1 -3.3 1.5 2.2 0.7 1.3 2.2 2.4 1.3
Hypertension (Self-reported) 0.4 1.0 3.6 0.8 -0.5 0.2 -0.8 -0.0 0.2 -1.9 -1.1 -1.3 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 4.5 1.6 1.2 -1.0 -1.9 1.0 -2.1 -1.3 -1.6 -0.6 -0.7
Illnesses of father: Heart disease 0.3 0.4 2.0 -0.5 -0.3 0.3 -0.0 -1.2 0.5 -0.1 0.3 1.4 0.4
Illnesses of siblings: Diabetes 1.0 1.2 2.4 0.4 -0.4 0.9 -1.3 -0.1 -1.1 -1.0 -1.5 -1.5 -1.5
Smoking status: Previous 0.8 1.2 4.2 0.9 1.5 -1.7 0.0 2.0 -1.0 -0.8 0.2 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 9.3 19.2 55.7 4.1 7.5 -6.1 1.7 4.8 -0.1 2.9 3.5 4.5 3.9
Whole body fat-free mass 9.8 55.9 176.9 8.0 13.3 -11.2 1.7 9.4 0.1 3.5 4.8 5.8 5.8
Leg fat-free mass (right) 10.7 57.2 179.6 7.6 13.4 -11.6 1.7 9.5 -0.0 3.1 5.0 6.3 5.8
Arm fat percentage (left) 2.3 9.3 27.7 4.9 5.3 -4.8 0.3 3.6 0.1 -0.0 1.2 1.7 0.9
Average weekly red wine intake 0.3 0.4 0.8 -0.3 0.9 -0.8 0.7 0.6 0.4 0.7 0.8 0.1 0.6
Handedness (chirality/laterality): Left-handed 2.1 2.6 7.5 0.7 1.3 -2.7 1.6 2.5 0.5 0.3 1.8 1.1 1.6
Mood swings 1.7 3.1 8.7 -0.5 -0.2 -0.7 3.0 -0.5 2.3 2.0 2.7 2.1 0.5
Loneliness, isolation 2.4 3.3 11.1 -0.9 1.3 -3.3 1.4 3.0 -0.3 0.1 1.8 1.7 1.3
Long-standing illness, disability or infirmity 1.2 1.8 5.2 0.9 1.4 -2.3 0.8 1.1 0.7 0.6 1.5 1.9 1.3
Ever had bowel cancer screening 0.7 0.8 2.6 0.3 1.6 -1.1 -0.7 0.6 -0.8 0.4 -0.3 1.1 1.0
Diabetes diagnosed by doctor 0.9 1.5 5.9 2.3 2.4 -1.3 -1.1 0.2 0.1 0.1 -0.3 0.7 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.5 0.7 0.9 0.9 0.1 -0.4 -0.7 1.6 0.3 0.2 -0.3
Friendships satisfaction 0.6 0.7 2.7 -0.3 -1.0 -0.4 0.0 -1.4 0.7 -1.6 -0.1 0.9 -0.3
Qualifications: nursing, teaching 0.7 1.1 2.2 -0.7 -0.9 1.5 -1.1 -1.4 0.6 0.5 -1.0 -1.5 -0.5
Commuting to job workplace: Walk 1.1 1.2 4.3 0.4 1.0 -1.4 -0.9 2.1 -1.5 0.3 -0.2 -0.7 -0.7
Eye problems/disorders: Cataract 0.9 1.1 3.3 -1.8 -0.7 -0.5 0.7 -0.5 1.0 0.4 0.7 1.3 1.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 4.5 0.3 1.7 -1.3 -0.4 2.1 -1.5 -0.1 -0.0 0.0 0.5
Medication for cholesterol 0.5 0.8 2.0 -0.9 -0.8 0.8 -0.6 0.7 -1.3 0.1 -0.6 -1.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.8 4.5 15.1 3.1 3.0 -3.9 0.5 2.8 0.7 0.6 0.9 0.7 1.1
Back pain experienced in last month 1.6 2.3 6.0 2.0 2.5 -2.4 -0.2 2.4 -1.0 -0.7 0.4 0.7 0.2
Mineral and other dietary supplements 2.2 3.0 10.9 0.9 -1.4 1.8 -0.7 -0.9 -1.2 -0.3 -1.3 -3.0 -3.3
Breast cancer (self-reported) 2.4 2.8 8.4 -2.6 -1.0 -0.3 -2.1 -0.3 -2.1 -2.9 -1.7 0.0 -0.5
Asthma (self-reported) 0.5 0.9 3.2 0.7 1.6 -1.0 -0.1 0.2 -1.1 -0.4 0.3 1.8 0.7
Osteoporosis (self-reported) 0.6 0.7 4.0 -2.0 -0.6 -0.2 0.7 0.2 0.1 0.2 0.7 0.3 1.2
Osteoarthritis (self-reported) 0.3 0.3 1.1 -0.6 -1.1 0.3 0.6 -0.2 0.2 0.9 0.2 -0.5 -0.5
Medication: Aspirin 0.4 0.5 1.1 1.0 0.8 -0.5 -0.3 -0.7 1.0 -0.8 0.1 1.0 0.5
Medication: Gliclazide 0.6 0.7 2.3 1.4 1.5 -0.6 -0.2 -0.4 -0.1 1.0 0.1 1.0 -0.5
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 -1.0 -1.0 0.9 1.0 0.2 0.8 1.1 0.5 -1.1 0.1
Smoking status: Current 0.3 0.5 1.3 0.5 -0.1 1.0 0.2 -0.5 0.0 1.1 -0.0 -1.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.2 6.8 19.3 -3.9 -4.4 2.8 -1.5 -2.8 -0.5 -2.2 -2.2 -1.7 -1.4
Whole body water mass 9.4 53.8 171.6 7.8 13.1 -11.0 1.6 9.2 -0.0 3.4 4.7 5.7 5.7
Leg predicted mass (right) 10.7 57.1 179.6 7.5 13.4 -11.6 1.6 9.5 0.0 3.1 4.9 6.2 5.8
Arm fat mass (left) 5.0 20.5 62.5 6.3 7.9 -7.1 1.1 5.4 0.6 1.2 2.6 3.0 2.2
Number of self-reported non-cancer illnesses 1.1 1.8 6.6 2.6 1.9 -2.2 -0.3 1.8 0.2 -0.4 -0.0 -0.1 0.2
Average weekly champagne plus white wine intake 0.9 1.2 4.8 -0.1 0.2 -0.3 -1.7 0.3 -2.2 -1.3 -1.4 -0.3 -0.7
Miserableness 2.8 4.9 11.4 -0.6 0.9 -2.4 3.1 1.1 1.6 1.5 3.4 3.3 1.9
Guilty feelings 0.7 1.1 4.0 -0.5 0.5 -2.0 0.7 1.6 -0.1 -0.1 1.1 1.3 0.7
Wears glasses or contact lenses 0.2 0.3 0.7 0.5 0.8 0.3 -0.2 -0.5 0.5 0.3 -0.1 0.6 0.8
Ever taken oral contraceptive pill 0.3 0.3 1.0 0.6 -0.1 0.2 -0.5 -1.0 0.4 -0.7 -0.6 -0.1 0.2
Hearing aid user 1.7 1.9 4.5 -0.9 0.1 -0.4 1.8 -0.3 2.1 1.2 1.4 1.8 2.0
Mother’s age at death 1.0 1.3 6.0 -0.9 0.4 -0.3 0.9 -0.2 1.3 0.7 0.9 1.5 2.5
Financial situation satisfaction 0.5 0.6 2.6 0.4 0.2 -1.6 0.7 1.1 -0.7 -0.4 0.7 0.5 -0.3
Tinnitus: Yes, now most or all of the time 0.7 0.9 3.5 0.8 0.5 -0.7 0.6 1.0 1.4 1.9 0.7 -0.1 0.1
Commuting to job workplace: Public transport 2.8 3.3 8.0 1.8 2.6 -2.8 -1.5 2.6 -2.2 -0.2 -0.2 -0.1 -0.7
Eye problems/disorders: Glaucoma 1.7 2.0 3.5 -1.8 -1.9 1.3 -1.2 -1.7 -0.3 -1.9 -1.4 -0.5 -1.1
Medication: Blood pressure 0.4 0.7 2.6 1.4 0.0 -0.5 -0.4 -0.8 0.8 -1.6 -0.5 0.0 -0.7
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.4 1.0 -0.3 0.1 0.1 -1.0 0.9 -0.4 0.1 0.1 -1.6
Supplements: Fish oil (including cod liver oil) 5.0 6.5 17.8 -1.2 1.5 -2.1 2.5 1.4 2.2 2.1 2.9 3.5 4.2
High cholesterol (Self-reported) 2.8 5.0 11.2 0.5 -2.0 2.9 -2.1 -2.5 -0.1 -1.0 -2.7 -2.7 -3.3
Medication: Bendroflumethiazide 0.1 0.2 1.2 0.2 -0.2 -0.2 -0.1 0.5 -0.4 -1.1 -0.4 -0.3 -0.4
Medication: Paracetamol 1.8 2.8 8.6 1.7 2.5 -2.9 0.2 2.1 0.0 0.4 1.0 1.4 1.6
Medication: Lisinopril 0.6 0.8 4.9 -0.5 -0.7 0.2 0.9 -1.0 2.2 0.1 0.5 0.6 0.6
Medication: Atorvastatin 1.1 1.3 5.2 0.7 -0.7 1.3 -0.7 -1.4 -0.2 -0.5 -0.8 -1.5 -2.3
Illnesses of father: High blood pressure 0.4 0.5 1.5 -0.1 0.9 -1.0 -0.6 0.9 -1.2 -0.7 0.1 0.7 0.0
Alcohol drinker status: Never 1.3 1.5 4.6 -0.1 0.4 -2.0 1.0 0.5 2.1 1.0 1.5 1.2 0.6
Ever smoked 0.4 0.7 2.6 0.2 0.8 -1.3 0.6 1.6 -0.5 0.6 0.7 -0.2 -0.7
Basal metabolic rate 10.3 57.0 179.6 8.3 13.4 -11.4 1.8 9.4 0.1 3.4 4.9 5.8 5.5
Leg fat percentage (left) 0.7 2.7 15.0 3.9 2.0 -1.9 0.2 1.0 0.5 -0.2 0.2 -0.4 -1.6
Arm fat-free mass (left) 7.6 38.5 116.6 6.8 10.8 -9.6 1.8 7.9 0.3 2.8 4.2 4.5 4.4
Number of operations (self-reported) 5.9 8.7 29.7 4.7 5.4 -4.1 0.3 3.1 0.0 0.7 1.7 2.1 0.6
Average weekly beer plus cider intake 0.1 0.2 0.6 -0.8 -0.4 -0.7 0.2 0.0 -0.1 -0.2 0.2 0.1 -0.5
Irritability 0.8 1.4 3.8 0.1 0.3 -1.9 1.5 0.6 1.3 0.2 1.5 1.5 1.1
Risk taking 0.7 1.0 2.4 0.2 1.1 -1.3 -1.6 1.1 -0.1 -1.5 -1.0 -0.5 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.0 0.3 -0.4 1.4 -0.6 -1.0 -0.2 0.3 -0.8 -0.7 0.0
Fractured/broken bones in last 5 years 1.1 1.4 7.0 0.5 1.4 -2.6 0.1 1.5 -0.4 -1.4 0.7 0.7 0.2
Age started oral contraceptive pill 0.4 0.5 1.1 0.2 1.1 -0.9 -0.4 0.7 1.1 -0.1 -0.0 0.1 0.9
Diastolic blood pressure, automated reading 0.8 2.6 7.1 -0.7 -2.6 1.1 -1.4 -1.0 -0.5 -2.7 -2.0 -1.6 -0.3
Ever depressed for a whole week 1.5 1.9 4.4 1.2 1.2 -1.0 1.9 0.8 1.2 2.1 1.9 0.4 1.3
Unable to work because of sickness or disability 0.1 0.2 0.5 0.7 0.5 -0.3 0.4 0.3 0.1 0.7 0.4 -0.2 -0.3
Commuting to job workplace: Cycle 0.6 0.7 2.8 0.3 0.8 -0.2 0.9 -0.2 0.9 1.7 1.0 0.8 0.4
Myopia 0.6 0.9 2.0 1.4 0.6 -0.0 -1.3 0.1 -0.9 -1.2 -1.2 -0.5 -1.1
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.6 -1.0 0.7 -0.1 0.8 0.2 -0.3 2.1 1.2 1.4 1.5
Cholesterol lowering medication 0.7 1.0 4.2 0.7 -0.9 0.1 0.2 -2.1 1.5 -0.6 -0.2 -0.1 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.9 0.9 0.6 -0.6 -0.3 0.6 -0.4 -0.3 -0.2 -0.5 -0.8
Pain experienced in last month 2.0 3.3 7.9 -2.6 -2.8 2.6 -0.9 -1.5 -0.5 -0.7 -1.6 -2.1 -0.5
Supplements: Calcium 0.4 0.5 1.9 -0.6 -0.4 -0.2 -0.6 0.3 -0.8 -1.4 -0.5 0.5 0.7
Basal cell carcinoma (self-reported) 0.6 0.8 2.1 -0.8 -0.2 -0.7 1.5 -0.3 0.8 0.2 1.4 1.1 -0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.7 1.1 0.7 -0.4 -0.6 0.3 -0.6 -0.7 -0.2 -0.2 -1.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 5.2 2.3 1.9 -1.7 0.3 0.9 0.0 0.2 0.7 0.9 0.7
Heart disease (siblings) 1.7 2.1 4.8 2.2 2.2 -1.0 -1.9 1.2 -1.6 -1.0 -1.4 0.2 0.3
Alcohol drinker status: Previous 1.4 1.5 6.2 2.5 1.8 -1.5 0.9 0.9 0.8 0.8 1.0 0.4 0.2
Pack years of smoking 1.2 1.8 6.5 1.9 0.7 -1.3 1.0 2.5 0.9 1.0 0.8 -1.5 -0.5
Impedance of whole body 0.6 3.1 12.1 1.5 2.2 -1.2 1.1 -0.1 0.2 1.8 1.7 3.5 1.8
Leg fat mass (left) 3.8 14.8 44.4 6.0 6.7 -5.8 1.0 4.5 0.6 1.2 2.1 2.0 1.2
Arm predicted mass (left) 7.7 39.2 121.0 6.9 11.0 -9.4 1.9 7.8 0.4 3.1 4.3 4.6 4.5