[Hub]/) : Traits : Leg fat-free mass (right) :

chr6:25,266,147-26,689,223

Best TWAS P=6.65e-16 · Best GWAS P=1.41e-30 conditioned to 1.25e-19

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous U91328.19 0.40 0.46 lasso 8 0.46 4.2e-41 -5.8 5.7 1.1e-08 -0.32 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum U91328.19 0.21 0.25 lasso 8 0.27 3.7e-14 -5.8 6.1 1.3e-09 -0.35 1.00 0.00 FALSE
3 GTEx Adrenal Gland U91328.19 0.28 0.12 lasso 10 0.14 1.3e-05 -6.2 7.7 1.6e-14 -0.42 0.94 0.00 FALSE
4 GTEx Artery Aorta U91328.19 0.32 0.24 lasso 7 0.25 8.3e-14 -6.3 6.6 3.3e-11 -0.38 1.00 0.00 FALSE
5 GTEx Artery Tibial U91328.19 0.26 0.32 lasso 5 0.31 1.6e-24 -5.8 6.1 1.1e-09 -0.34 1.00 0.00 FALSE
6 GTEx Brain Caudate basal ganglia U91328.19 0.23 0.16 lasso 10 0.16 3.1e-05 -6.3 6.2 8.0e-10 -0.33 0.62 0.16 FALSE
7 GTEx Brain Cerebellar Hemisphere U91328.19 0.47 0.33 enet 44 0.26 2.8e-07 -6.0 7.2 4.2e-13 -0.24 0.98 0.00 FALSE
8 GTEx Brain Cerebellum U91328.19 0.13 0.15 lasso 2 0.09 1.1e-03 -6.0 5.9 4.3e-09 -0.26 0.35 0.04 FALSE
9 GTEx Brain Cortex U91328.19 0.36 0.14 lasso 10 0.15 7.1e-05 -5.7 6.2 4.2e-10 -0.31 0.64 0.04 FALSE
10 GTEx Brain Frontal Cortex BA9 U91328.19 0.17 0.16 lasso 4 0.18 1.8e-05 -5.7 5.9 3.2e-09 -0.31 0.43 0.08 FALSE
11 GTEx Breast Mammary Tissue U91328.19 0.38 0.39 lasso 5 0.38 2.2e-20 -5.8 6.0 1.5e-09 -0.33 1.00 0.00 FALSE
12 GTEx Breast Mammary Tissue (Male) U91328.19 0.35 0.15 enet 25 0.15 2.9e-04 -5.8 5.4 8.0e-08 -0.26 0.38 0.04 FALSE
13 GTEx Breast Mammary Tissue (Female) U91328.19 0.39 0.27 lasso 6 0.23 1.4e-07 -5.8 6.1 1.0e-09 -0.31 0.95 0.00 FALSE
14 GTEx Cells Transformed fibroblasts U91328.19 0.58 0.62 lasso 8 0.60 6.2e-56 -5.8 5.9 3.9e-09 -0.32 1.00 0.00 FALSE
15 GTEx Esophagus Gastroesophageal Junction U91328.20 0.16 0.13 enet 16 0.13 2.0e-05 -4.3 7.0 2.4e-12 -0.42 0.31 0.34 FALSE
16 GTEx Esophagus Gastroesophageal Junction U91328.19 0.28 0.07 lasso 7 0.21 4.3e-08 -5.7 5.8 6.6e-09 -0.33 0.71 0.02 FALSE
17 GTEx Esophagus Mucosa U91328.19 0.45 0.42 lasso 7 0.44 6.3e-32 -5.8 6.6 5.5e-11 -0.36 1.00 0.00 FALSE
18 GTEx Esophagus Muscularis TRIM38 0.06 0.04 lasso 4 0.02 1.7e-02 -6.3 6.5 7.6e-11 -0.34 0.49 0.10 FALSE
19 GTEx Esophagus Muscularis U91328.19 0.36 0.30 lasso 10 0.30 1.7e-18 -6.3 6.5 8.2e-11 -0.38 1.00 0.00 FALSE
20 GTEx Heart Atrial Appendage U91328.19 0.25 0.17 enet 6 0.13 2.0e-06 -5.8 6.0 1.7e-09 -0.34 0.99 0.00 FALSE
21 GTEx Heart Left Ventricle U91328.19 0.20 0.18 lasso 5 0.15 2.4e-08 -5.8 5.4 5.5e-08 -0.29 0.99 0.00 FALSE
22 GTEx Lung U91328.19 0.20 0.22 enet 15 0.24 2.9e-18 -6.4 6.7 1.6e-11 -0.35 1.00 0.00 FALSE
23 GTEx Muscle Skeletal U91328.19 0.28 0.26 enet 15 0.32 1.3e-31 -5.8 6.0 2.7e-09 -0.33 1.00 0.00 FALSE
24 GTEx Nerve Tibial U91328.19 0.46 0.38 lasso 10 0.36 1.4e-26 -5.8 5.8 5.5e-09 -0.32 1.00 0.00 FALSE
25 GTEx Ovary U91328.19 0.37 0.17 enet 18 0.34 4.7e-09 -5.7 8.1 6.6e-16 -0.39 0.74 0.04 TRUE
26 GTEx Prostate U91328.19 0.30 0.39 lasso 2 0.37 3.0e-10 -5.8 5.8 8.0e-09 -0.32 0.95 0.02 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic U91328.19 0.39 0.37 lasso 11 0.34 2.4e-19 -5.8 6.3 2.2e-10 -0.34 1.00 0.00 FALSE
28 GTEx Skin Sun Exposed Lower leg U91328.19 0.29 0.34 lasso 6 0.34 5.6e-29 -5.8 6.2 4.8e-10 -0.32 1.00 0.00 FALSE
29 GTEx Thyroid TRIM38 0.14 0.16 lasso 4 0.17 8.5e-13 -4.5 5.2 2.1e-07 -0.27 1.00 0.00 FALSE
30 GTEx Thyroid U91328.19 0.21 0.17 lasso 5 0.17 6.4e-13 -5.8 5.5 4.4e-08 -0.31 1.00 0.00 FALSE
31 GTEx Uterus U91328.19 0.38 0.05 enet 21 0.04 6.2e-02 -6.4 5.8 5.1e-09 -0.36 0.12 0.38 FALSE
32 GTEx Vagina U91328.19 0.45 0.27 lasso 4 0.26 9.4e-07 -5.8 5.7 1.2e-08 -0.31 0.65 0.02 FALSE
33 METSIM Adipose U91328.19 0.19 0.24 lasso 23 0.25 1.7e-36 -5.8 6.5 8.1e-11 -0.33 1.00 0.00 FALSE
34 METSIM Adipose U91328.20 0.07 0.04 bslmm 658 0.04 8.9e-07 -2.7 6.7 2.0e-11 -0.19 0.96 0.00 FALSE
35 YFS Blood TRIM38 0.37 0.31 bslmm 672 0.34 3.8e-115 -6.3 -6.6 5.1e-11 0.29 1.00 0.00 FALSE