[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr6:25,266,147-26,689,223

Best TWAS P=6.65e-16 · Best GWAS P=1.41e-30 conditioned to 1.25e-19

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Ovary	U91328.19	0.37	0.17	enet	18	0.34	4.7e-09	-5.7	8.1	6.6e-16	-0.39	0.74	0.04	TRUE
3	GTEx	Adrenal Gland	U91328.19	0.28	0.12	lasso	10	0.14	1.3e-05	-6.2	7.7	1.6e-14	-0.42	0.94	0.00	FALSE
7	GTEx	Brain Cerebellar Hemisphere	U91328.19	0.47	0.33	enet	44	0.26	2.8e-07	-6.0	7.2	4.2e-13	-0.24	0.98	0.00	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	U91328.20	0.16	0.13	enet	16	0.13	2.0e-05	-4.3	7.0	2.4e-12	-0.42	0.31	0.34	FALSE
22	GTEx	Lung	U91328.19	0.20	0.22	enet	15	0.24	2.9e-18	-6.4	6.7	1.6e-11	-0.35	1.00	0.00	FALSE
34	METSIM	Adipose	U91328.20	0.07	0.04	bslmm	658	0.04	8.9e-07	-2.7	6.7	2.0e-11	-0.19	0.96	0.00	FALSE
4	GTEx	Artery Aorta	U91328.19	0.32	0.24	lasso	7	0.25	8.3e-14	-6.3	6.6	3.3e-11	-0.38	1.00	0.00	FALSE
35	YFS	Blood	TRIM38	0.37	0.31	bslmm	672	0.34	3.8e-115	-6.3	-6.6	5.1e-11	0.29	1.00	0.00	FALSE
17	GTEx	Esophagus Mucosa	U91328.19	0.45	0.42	lasso	7	0.44	6.3e-32	-5.8	6.6	5.5e-11	-0.36	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	TRIM38	0.06	0.04	lasso	4	0.02	1.7e-02	-6.3	6.5	7.6e-11	-0.34	0.49	0.10	FALSE
33	METSIM	Adipose	U91328.19	0.19	0.24	lasso	23	0.25	1.7e-36	-5.8	6.5	8.1e-11	-0.33	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	U91328.19	0.36	0.30	lasso	10	0.30	1.7e-18	-6.3	6.5	8.2e-11	-0.38	1.00	0.00	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	U91328.19	0.39	0.37	lasso	11	0.34	2.4e-19	-5.8	6.3	2.2e-10	-0.34	1.00	0.00	FALSE
9	GTEx	Brain Cortex	U91328.19	0.36	0.14	lasso	10	0.15	7.1e-05	-5.7	6.2	4.2e-10	-0.31	0.64	0.04	FALSE
28	GTEx	Skin Sun Exposed Lower leg	U91328.19	0.29	0.34	lasso	6	0.34	5.6e-29	-5.8	6.2	4.8e-10	-0.32	1.00	0.00	FALSE
6	GTEx	Brain Caudate basal ganglia	U91328.19	0.23	0.16	lasso	10	0.16	3.1e-05	-6.3	6.2	8.0e-10	-0.33	0.62	0.16	FALSE
13	GTEx	Breast Mammary Tissue (Female)	U91328.19	0.39	0.27	lasso	6	0.23	1.4e-07	-5.8	6.1	1.0e-09	-0.31	0.95	0.00	FALSE
5	GTEx	Artery Tibial	U91328.19	0.26	0.32	lasso	5	0.31	1.6e-24	-5.8	6.1	1.1e-09	-0.34	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	U91328.19	0.21	0.25	lasso	8	0.27	3.7e-14	-5.8	6.1	1.3e-09	-0.35	1.00	0.00	FALSE
11	GTEx	Breast Mammary Tissue	U91328.19	0.38	0.39	lasso	5	0.38	2.2e-20	-5.8	6.0	1.5e-09	-0.33	1.00	0.00	FALSE
20	GTEx	Heart Atrial Appendage	U91328.19	0.25	0.17	enet	6	0.13	2.0e-06	-5.8	6.0	1.7e-09	-0.34	0.99	0.00	FALSE
23	GTEx	Muscle Skeletal	U91328.19	0.28	0.26	enet	15	0.32	1.3e-31	-5.8	6.0	2.7e-09	-0.33	1.00	0.00	FALSE
10	GTEx	Brain Frontal Cortex BA9	U91328.19	0.17	0.16	lasso	4	0.18	1.8e-05	-5.7	5.9	3.2e-09	-0.31	0.43	0.08	FALSE
14	GTEx	Cells Transformed fibroblasts	U91328.19	0.58	0.62	lasso	8	0.60	6.2e-56	-5.8	5.9	3.9e-09	-0.32	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	U91328.19	0.13	0.15	lasso	2	0.09	1.1e-03	-6.0	5.9	4.3e-09	-0.26	0.35	0.04	FALSE
31	GTEx	Uterus	U91328.19	0.38	0.05	enet	21	0.04	6.2e-02	-6.4	5.8	5.1e-09	-0.36	0.12	0.38	FALSE
24	GTEx	Nerve Tibial	U91328.19	0.46	0.38	lasso	10	0.36	1.4e-26	-5.8	5.8	5.5e-09	-0.32	1.00	0.00	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	U91328.19	0.28	0.07	lasso	7	0.21	4.3e-08	-5.7	5.8	6.6e-09	-0.33	0.71	0.02	FALSE
26	GTEx	Prostate	U91328.19	0.30	0.39	lasso	2	0.37	3.0e-10	-5.8	5.8	8.0e-09	-0.32	0.95	0.02	FALSE
1	GTEx	Adipose Subcutaneous	U91328.19	0.40	0.46	lasso	8	0.46	4.2e-41	-5.8	5.7	1.1e-08	-0.32	1.00	0.00	FALSE
32	GTEx	Vagina	U91328.19	0.45	0.27	lasso	4	0.26	9.4e-07	-5.8	5.7	1.2e-08	-0.31	0.65	0.02	FALSE
30	GTEx	Thyroid	U91328.19	0.21	0.17	lasso	5	0.17	6.4e-13	-5.8	5.5	4.4e-08	-0.31	1.00	0.00	FALSE
21	GTEx	Heart Left Ventricle	U91328.19	0.20	0.18	lasso	5	0.15	2.4e-08	-5.8	5.4	5.5e-08	-0.29	0.99	0.00	FALSE
12	GTEx	Breast Mammary Tissue (Male)	U91328.19	0.35	0.15	enet	25	0.15	2.9e-04	-5.8	5.4	8.0e-08	-0.26	0.38	0.04	FALSE
29	GTEx	Thyroid	TRIM38	0.14	0.16	lasso	4	0.17	8.5e-13	-4.5	5.2	2.1e-07	-0.27	1.00	0.00	FALSE