Best TWAS P=7.96e-08 · Best GWAS P=2.05e-09 conditioned to 1.13e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | PRMT6 | 0.29 | 0.24 | lasso | 7 | 0.19 | 1.4e-09 | 4.9 | -5.2 | 2.3e-07 | -0.09 | 0.45 | 0.55 | FALSE |
| 2 | GTEx | Liver | PRMT6 | 0.60 | 0.52 | lasso | 6 | 0.58 | 1.0e-19 | 4.9 | -5.2 | 2.0e-07 | -0.08 | 0.43 | 0.57 | FALSE |
| 3 | GTEx | Muscle Skeletal | PRMT6 | 0.32 | 0.16 | enet | 13 | 0.16 | 2.8e-15 | 5.0 | -5.4 | 8.0e-08 | -0.08 | 0.43 | 0.57 | TRUE |
| 4 | GTEx | Thyroid | PRMT6 | 0.19 | 0.17 | enet | 14 | 0.19 | 1.7e-14 | 5.0 | -5.2 | 1.6e-07 | -0.08 | 0.43 | 0.57 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | PRMT6 | 0.33 | 0.26 | lasso | 3 | 0.25 | 2.0e-08 | 4.9 | -5.1 | 2.9e-07 | -0.09 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRMT6 | 0.09 | 0.08 | blup | 36 | 0.08 | 3.3e-06 | 5.0 | -5.3 | 1.4e-07 | -0.09 | 0.01 | 0.99 | FALSE |