[Hub]/) : Traits : Leg fat-free mass (right) :

chr12:101,575,652-103,148,974

Best TWAS P=2.83e-08 · Best GWAS P=2.67e-12 conditioned to 5.41e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC53 0.21 0.15 blup 448 0.19 2.4e-22 3.9 -5.2 2.1e-07 0.08 0.27 0.73 FALSE
2 GTEx Cells Transformed fibroblasts CCDC53 0.10 0.18 lasso 1 0.17 1.5e-12 5.4 -5.4 5.6e-08 0.13 0.04 0.96 FALSE
3 GTEx Heart Left Ventricle CCDC53 0.14 0.20 lasso 4 0.18 9.6e-10 5.5 -5.2 2.4e-07 0.14 0.04 0.96 FALSE
4 GTEx Spleen CCDC53 0.25 0.19 lasso 11 0.16 5.8e-05 5.5 -5.4 7.6e-08 0.12 0.06 0.88 FALSE
5 METSIM Adipose DRAM1 0.12 0.03 enet 24 0.08 1.1e-12 3.5 5.3 1.2e-07 0.06 0.03 0.97 FALSE
6 YFS Blood DRAM1 0.33 0.13 enet 101 0.19 1.6e-58 5.6 5.5 2.8e-08 0.10 0.01 0.99 TRUE
7 The Cancer Genome Atlas Colon Adenocarcinoma CCDC53 0.07 0.07 blup 55 0.06 1.3e-04 4.7 -5.2 1.6e-07 0.09 0.05 0.94 FALSE
8 The Cancer Genome Atlas Stomach Adenocarcinoma CCDC53 0.04 0.07 lasso 4 0.06 2.1e-05 5.5 -5.4 5.3e-08 0.13 0.02 0.98 TRUE