[Hub]/) : Traits : Leg fat-free mass (right) :

chr12:106,649,988-108,064,952

Best TWAS P=2.57e-10 · Best GWAS P=9.07e-10 conditioned to 0.625

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous C12orf23 0.07 0.02 lasso 4 0.02 5.5e-03 -6.1 5.6 2.0e-08 -0.90 0.01 0.96 FALSE
2 GTEx Adipose Subcutaneous RP11-412D9.4 0.22 0.13 lasso 5 0.13 5.1e-11 -5.9 6.3 2.6e-10 -0.94 0.01 0.99 TRUE
3 GTEx Artery Tibial C12orf23 0.15 0.10 enet 21 0.15 8.1e-12 5.9 5.3 9.0e-08 -0.80 0.04 0.96 FALSE
4 GTEx Artery Tibial RP11-412D9.4 0.06 0.05 lasso 3 0.06 2.9e-05 -6.1 6.2 4.3e-10 -0.93 0.01 0.99 FALSE
5 GTEx Breast Mammary Tissue RP11-412D9.4 0.23 0.26 lasso 4 0.26 9.7e-14 -6.1 6.0 2.6e-09 -0.97 0.00 1.00 FALSE
6 GTEx Breast Mammary Tissue (Female) RP11-412D9.4 0.20 0.14 lasso 4 0.13 9.0e-05 -6.1 5.6 2.5e-08 -0.95 0.01 0.97 FALSE
7 GTEx Cells Transformed fibroblasts RP11-412D9.4 0.12 0.10 lasso 4 0.09 2.1e-07 -5.9 6.2 5.1e-10 -0.91 0.01 0.99 FALSE
8 GTEx Colon Sigmoid RP11-412D9.4 0.17 0.06 lasso 3 0.07 1.4e-03 5.4 5.4 5.3e-08 -0.78 0.06 0.68 FALSE
9 GTEx Lung C12orf23 0.04 0.03 lasso 2 0.02 9.9e-03 -5.1 5.3 1.2e-07 -0.76 0.04 0.88 FALSE
10 GTEx Nerve Tibial C12orf23 0.09 0.12 enet 10 0.12 1.1e-08 -6.1 6.2 4.1e-10 -0.97 0.00 1.00 FALSE
11 GTEx Nerve Tibial RP11-412D9.4 0.18 0.18 enet 11 0.20 5.6e-14 -5.9 6.1 9.7e-10 -0.95 0.01 0.99 FALSE
12 GTEx Pancreas RP11-412D9.4 0.09 0.06 enet 12 0.06 1.2e-03 -6.1 5.6 2.7e-08 -0.85 0.01 0.96 FALSE
13 GTEx Skin Sun Exposed Lower leg C12orf23 0.06 0.04 lasso 3 0.03 8.0e-04 -6.1 6.3 2.9e-10 -0.98 0.00 0.99 FALSE
14 GTEx Testis RP11-412D9.4 0.25 0.24 lasso 5 0.20 3.7e-09 -6.1 6.2 6.8e-10 -0.99 0.00 1.00 FALSE
15 GTEx Thyroid RP11-412D9.4 0.10 0.10 enet 7 0.12 9.3e-10 5.9 6.3 3.9e-10 -0.95 0.01 0.99 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma C12orf23 0.03 0.05 enet 7 0.05 2.2e-10 5.3 5.4 6.7e-08 -0.81 0.13 0.87 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma MTERFD3 0.02 0.01 lasso 4 0.01 1.3e-03 -5.8 6.1 1.3e-09 -0.89 0.02 0.91 FALSE
18 The Cancer Genome Atlas Colon Adenocarcinoma MTERFD3 0.08 0.06 lasso 6 0.05 7.1e-04 -5.8 5.8 7.2e-09 -0.90 0.01 0.79 FALSE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C12orf23 0.03 0.01 blup 50 0.01 2.2e-02 -6.1 5.4 7.9e-08 -0.86 0.01 0.84 FALSE
20 The Cancer Genome Atlas Pancreatic Adenocarcinoma C12orf23 0.06 0.05 enet 8 0.05 5.0e-03 -6.1 5.8 6.8e-09 -0.93 0.01 0.76 FALSE