Best TWAS P=8.9e-10 · Best GWAS P=1.53e-12 conditioned to 1.86e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | 5.1 | 5.2 | 2.5e-07 | 0.09 | 0.96 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CHRNB1 | 0.19 | 0.11 | lasso | 2 | 0.13 | 7.3e-09 | 5.1 | 5.2 | 1.5e-07 | 0.08 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Prostate | RP11-104H15.8 | 0.54 | 0.01 | enet | 1 | 0.06 | 1.6e-02 | -6.1 | -6.1 | 8.9e-10 | -0.07 | 0.06 | 0.21 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | EFNB3 | 0.05 | 0.05 | enet | 6 | 0.05 | 2.5e-06 | -4.4 | 5.4 | 6.8e-08 | 0.04 | 0.80 | 0.17 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EFNB3 | 0.07 | 0.04 | blup | 34 | 0.04 | 4.0e-05 | -5.9 | 5.3 | 9.2e-08 | -0.07 | 0.16 | 0.07 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EFNB3 | 0.06 | 0.03 | lasso | 4 | 0.05 | 1.0e-05 | -5.9 | 5.5 | 2.9e-08 | -0.14 | 0.84 | 0.08 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SENP3 | 0.07 | 0.04 | enet | 9 | 0.03 | 2.7e-04 | 2.0 | 5.2 | 2.0e-07 | -0.05 | 0.44 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SHBG | 0.04 | 0.00 | blup | 59 | 0.02 | 4.4e-03 | -2.4 | -5.2 | 1.9e-07 | 0.07 | 0.04 | 0.06 | FALSE |