TWAS hub - SHBG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0459	0.0243	0.0016	0.017	0.020	0.006	NA	0.024	0.0043	0.00190	0.0570	NA	0.00081
2	TCGA	Prostate Adenocarcinoma	0.0426	0.0259	0.0055	0.007	0.028	0.018	NA	0.010	0.0540	0.00054	0.0048	NA	0.02800
3	TCGA	Thyroid Carcinoma	0.0390	0.0200	0.0057	0.005	0.020	0.007	NA	0.009	0.1100	0.00440	0.0640	NA	0.04000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Amlodipine	16.1	22.5	29.1	3.8	4.9	5.4
High blood pressure	10.9	30.3	45.0	4.0	6.7	5.5
Had other major operations	10.5	12.9	13.2	3.5	3.6	3.6
Medication: Blood pressure	10.4	19.8	22.6	3.8	4.8	4.7
Deep venous thrombosis (DVT) (self-reported)	10.4	13.3	15.8	4.0	3.7	3.3
Hypertension (Self-reported)	10.3	28.7	40.8	4.0	6.4	5.4
Medication: Bendroflumethiazide	9.8	14.9	19.0	2.7	4.3	4.4
Blood clot in the leg (DVT)	9.4	12.1	15.1	3.9	3.5	3.0
Medication: Allopurinol	9.3	12.4	13.5	3.4	3.5	3.7
Number of operations (self-reported)	8.0	11.9	17.5	3.5	4.2	2.4
Systolic Blood Pressure	7.8	38.9	59.6	3.2	6.8	7.7
Vascular/heart problems diagnosed by doctor	7.6	20.8	30.9	-3.3	-5.6	-4.5
Waist Hip Ratio (WHR)	6.9	30.8	43.7	-6.6	-5.4	-4.5
High blood pressure (siblings)	6.9	9.9	15.8	2.8	4.0	2.5
Systolic blood pressure, automated reading	6.8	19.7	29.4	1.8	5.2	5.4
Length of working week for main job	6.6	7.3	9.2	-2.8	-2.2	-3.0
Alcohol usually taken with meals	6.3	10.1	13.6	-2.5	-3.7	-3.2
High blood pressure (mother)	5.6	7.9	11.5	2.3	3.4	2.6
Impedance of arm (left)	5.5	25.5	45.5	3.0	4.7	6.7
Cardiovascular Disease	5.4	18.0	22.8	3.4	4.8	4.4
Impedance of arm (right)	5.4	25.4	43.4	2.7	5.0	6.6
Eye problems/disorders: Diabetes related eye disease	5.3	5.9	7.6	-2.6	-2.8	-1.8
Medication: Blood pressure	5.3	9.3	13.2	2.3	3.6	3.0
Gout (self-reported)	5.2	7.2	9.4	2.4	3.1	2.5
Trunk predicted mass	5.0	28.4	68.9	-2.6	-3.1	-8.3
Respiratory disease	4.9	10.9	15.1	-3.3	-2.6	-3.9
Trunk fat-free mass	4.8	27.7	67.7	-2.5	-3.0	-8.2
Arm fat percentage (left)	4.6	18.2	23.4	4.1	4.8	3.8
Medication: Lisinopril	4.6	6.0	7.9	2.5	2.8	2.0
Basal cell carcinoma (self-reported)	4.6	5.4	7.7	2.8	2.2	1.9
Lung FVC	4.5	22.7	40.6	6.4	4.3	3.0
Wears glasses or contact lenses	4.5	5.2	6.5	-1.8	-2.4	-2.6
Alcohol intake versus 10 years previously	4.4	6.5	8.2	-2.9	-2.7	-2.0
Major Depression (MDD)	4.1	5.0	10.3	3.2	1.6	1.4
Trunk fat percentage	4.1	16.3	24.2	3.4	4.9	3.7
Arm fat-free mass (left)	4.1	20.9	50.8	-2.2	-2.6	-7.1
Arm predicted mass (left)	4.1	20.7	50.1	-2.2	-2.7	-7.1
Mean time to correctly identify matches	3.9	7.4	9.5	-3.1	-3.0	-2.0
Pulse rate, automated reading	3.9	12.6	17.2	-3.1	-3.3	-4.2
Arm fat percentage (right)	3.8	15.1	21.3	3.7	4.6	3.3
Arm predicted mass (right)	3.8	19.6	47.6	-1.9	-2.8	-6.9
Body Mass Index (BMI) (2010)	3.7	5.0	9.4	3.1	1.7	1.7
Taking other prescription medications	3.7	5.7	7.8	2.6	2.8	1.6
Body fat percentage	3.6	14.3	20.2	3.2	4.5	3.5
Illnesses of father: High blood pressure	3.6	4.4	4.6	2.1	2.1	2.1
Guilty feelings	3.5	5.3	6.5	2.5	2.4	1.9
Mother’s age at death	3.5	4.4	7.4	-1.6	-1.9	-2.7
Arm fat-free mass (right)	3.4	17.4	43.8	-1.7	-2.4	-6.6
Number of self-reported non-cancer illnesses	3.4	5.8	9.1	1.9	3.0	2.1
Heart attack	3.3	4.2	8.7	-1.4	-3.0	-1.3
Whole body fat-free mass	3.3	18.8	50.7	-1.3	-2.0	-7.1
Blood Eosinophil Count	3.2	24.5	49.4	7.0	4.3	2.4
Number of treatments/medications taken	3.2	5.7	7.1	2.7	2.6	1.8
Chronic bronchitis/emphysema (father)	3.2	3.8	5.3	-2.0	-1.4	-2.3
Time employed in main current job	3.2	3.7	7.7	-2.8	-1.6	-1.1
Whole body water mass	3.2	18.2	49.3	-1.3	-1.9	-7.0
Height	3.1	60.6	134.6	-5.4	-4.3	-11.6
Medication: Co-codamol	3.1	3.5	5.1	1.5	1.8	2.2
Medication for cholesterol	3.1	4.8	6.4	-1.9	-2.1	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.2	13.5	3.7	1.4	1.8
Impedance of whole body	3.0	15.3	35.3	1.2	3.0	5.9
Qualifications: nursing, teaching	2.9	4.4	7.8	-1.4	-1.9	-2.8
Medication: Atenolol	2.8	3.5	4.0	1.6	1.9	2.0
Prospective memory result	2.8	3.4	7.2	0.7	1.6	2.7
Heart attack/myocardial infarction (self-reported)	2.8	3.6	7.7	-1.3	-2.8	-1.2
Hand grip strength (right)	2.7	7.3	17.2	-0.8	-2.0	-4.2
Qualifications: A levels/AS levels or equivalent	2.7	6.0	9.5	-1.2	-2.6	-3.1
Fasting Glucose	2.6	3.1	7.8	-2.8	-0.9	-0.7
Number of live births	2.6	3.6	9.0	1.2	0.7	3.0
Happiness	2.6	3.1	3.5	1.7	1.8	1.9
Birth weight of first child	2.6	4.6	10.7	-1.5	-1.0	-3.3
Ever depressed for a whole week	2.6	3.2	6.0	2.4	1.9	0.5
Standing height	2.5	24.4	57.2	-3.3	-2.3	-7.6
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	5.4	2.3	2.1	1.4
Basal metabolic rate	2.4	13.4	38.1	-0.8	-1.2	-6.2
Blood Red Count	2.3	22.5	31.9	4.8	5.7	3.6
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	3.2	-1.4	-1.5	-1.8
Relative age of first facial hair	2.2	4.6	8.0	2.8	2.1	1.3
Hair/balding pattern: Pattern 4	2.0	4.8	4.9	-2.1	-2.2	-2.2
Peak expiratory flow (PEF)	2.0	4.6	9.8	0.7	-1.9	-3.1
Pulse wave reflection index	2.0	2.4	3.9	2.0	1.7	0.8
Average weekly red wine intake	2.0	2.9	4.5	-0.9	-2.1	-1.8
Medication: Metformin	1.9	2.6	3.7	-1.9	-1.4	-1.5
Illnesses of siblings	1.9	2.7	5.1	-0.8	-2.3	-1.6
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.7	1.9	1.7	-0.1
Diastolic blood pressure, automated reading	1.9	5.8	16.2	1.0	4.0	0.6
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	4.6	0.4	-1.9	-2.2
Chest pain or discomfort	1.8	2.5	3.4	-1.3	-1.9	-1.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.3	1.5	1.1	1.8
Asthma (self-reported)	1.8	3.7	5.6	-1.7	-1.6	-2.4
Leg predicted mass (right)	1.8	9.6	28.5	0.4	-0.3	-5.3
Hand grip strength (left)	1.7	4.4	12.4	-0.4	-0.8	-3.5
Ever had hysterectomy (womb removed)	1.7	2.0	3.0	1.1	1.7	1.3
Sitting height	1.7	11.8	30.4	-2.0	-0.9	-5.5
Hearing difficulty/problems with background noise	1.7	2.7	5.1	-0.5	-1.6	-2.3
Leg fat-free mass (right)	1.7	9.1	27.1	0.4	-0.2	-5.2
Reaction Time	1.6	3.0	4.3	-1.9	-2.1	-1.0
Neuroticism (2016)	1.6	2.3	2.9	1.3	1.7	1.5
Smoking Status	1.6	3.8	6.0	2.5	1.8	1.5
Neuroticism	1.6	3.8	8.1	2.9	1.6	1.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	2.8	1.5	1.3	1.7
Diabetes (mother)	1.6	2.0	3.3	-1.8	-1.0	-1.3
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.4	1.9	1.5	0.0
Asthma	1.6	3.3	5.3	-1.5	-1.5	-2.3
Glaucoma (self-reported)	1.6	1.9	3.4	1.8	1.2	0.9
Leg fat percentage (right)	1.6	5.6	7.3	1.8	2.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.5	-0.4	-0.5	-3.1
Alcohol drinker status: Never	1.6	1.9	2.1	1.2	1.5	1.4
Crohns Disease (2012)	1.5	2.4	2.9	-1.6	-1.7	-1.3
HDL Cholesterol	1.5	2.5	4.9	2.2	1.6	0.0
BMI	1.5	9.0	12.5	3.3	3.5	1.9
Diabetes (father)	1.5	1.8	2.3	-1.4	-1.2	-1.5
Leg fat-free mass (left)	1.5	7.7	22.8	0.6	0.0	-4.8
Leg predicted mass (left)	1.5	7.7	22.8	0.6	0.0	-4.8
Trunk fat mass	1.5	6.5	12.9	2.3	3.6	1.0
Knee pain experienced in last month	1.5	2.3	2.8	1.5	1.7	1.4
Supplements: Calcium	1.5	1.7	2.7	-0.4	-1.5	-1.6
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.3	-2.1	-1.6	-1.1
Supplements: Glucosamine	1.4	1.8	4.1	-0.9	-0.6	-2.0
Had menopause	1.4	1.8	4.7	-2.2	-0.8	0.1
Leg fat percentage (left)	1.4	4.9	6.8	1.7	2.6	2.2
Depression (Nagel 2018)	1.3	2.0	3.0	1.7	0.9	1.5
Relative age voice broke	1.3	2.0	3.8	1.9	1.4	-0.4
Qualifications: CSEs or equivalent	1.3	1.7	3.0	1.2	0.8	1.7
Multivitamins +/- minerals	1.3	1.7	3.1	1.1	0.9	-1.8
Arm fat mass (right)	1.3	5.4	10.3	2.4	3.2	0.5
Long-standing illness, disability or infirmity	1.3	2.0	3.1	1.5	1.8	0.9
Arm fat mass (left)	1.3	5.4	9.5	2.5	3.1	0.6
Miserableness	1.3	2.2	4.5	2.1	1.0	1.1
Financial situation satisfaction	1.3	1.6	3.3	1.8	1.0	0.6
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.3	-0.3	-1.5	-1.5
Crohns Disease (2017)	1.2	2.7	4.0	-2.0	-1.8	-1.0
Vitamin and mineral supplements	1.2	1.7	2.5	-1.6	-0.8	1.4
Impedance of leg (right)	1.2	6.0	16.6	-0.7	1.0	4.1
Townsend deprivation index at recruitment	1.2	1.6	2.8	0.2	1.4	1.7
Forced vital capacity (FVC)	1.2	4.5	10.4	1.7	-0.3	-3.2
Medication: Cholesterol lowering	1.2	1.8	2.9	-0.6	-1.5	-1.7
Whole body fat mass	1.2	5.0	10.0	2.2	3.2	0.7
Myopia	1.2	1.7	2.7	1.6	1.5	0.6
Coronary Artery Disease (CAD)	1.1	1.3	3.4	-0.6	-0.4	-1.8
Sensitivity / hurt feelings	1.1	1.9	5.5	2.3	0.4	0.0
Hip circumference	1.1	4.9	8.3	2.5	2.9	-0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.9	7.2	2.1	-0.3	-2.7
Medication: Atorvastatin	1.1	1.3	2.8	-1.0	-1.7	-0.6
Unable to work because of sickness or disability	1.1	1.4	3.1	-0.3	-1.8	-0.9
Serious illness, injury or assault to yourself	1.0	1.3	1.5	-1.1	-1.1	-1.2
Impedance of leg (left)	1.0	4.7	12.5	-1.0	0.7	3.5
Medication: Simvastatin	1.0	1.4	2.1	1.4	1.2	0.9
Birth weight	1.0	2.2	5.7	0.8	-0.6	-2.4
Eye problems/disorders: None of the above	1.0	1.2	2.5	-1.6	-1.0	-0.2
Eye problems/disorders: Cataract	1.0	1.2	3.0	1.7	0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.6	-0.6	-0.0	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.8	-0.5	-2.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.0	-1.0	-1.4	-0.8
Neuroticism score	0.9	1.8	4.0	2.0	1.1	0.4
Falls in the last year	0.9	1.3	1.7	1.3	1.0	1.0
Noisy workplace	0.9	1.1	1.7	1.3	0.8	1.0
Lung cancer (father)	0.9	1.1	1.9	0.8	1.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.2	1.8	-0.1	-2.3
Forced vital capacity (FVC), Best measure	0.9	3.5	6.2	2.0	0.6	-2.5
Comparative body size at age 10	0.9	2.4	5.5	2.3	0.3	-1.3
Commuting to job workplace: Walk	0.9	1.0	1.6	-1.3	-0.6	-1.0
Average weekly champagne plus white wine intake	0.9	1.2	3.5	0.4	1.9	-0.4
Cholesterol lowering medication	0.9	1.3	1.7	1.0	1.1	1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	-0.9	0.8	-1.4
Worry (Nagel 2018)	0.8	1.7	2.4	1.4	0.9	1.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	1.1	0.6	1.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.8	2.0	1.2	0.8
HbA1C	0.8	0.9	1.6	-1.0	-1.2	0.0
Lupus	0.8	1.3	2.7	0.4	1.6	1.0
Rheumatoid Arthritis	0.8	1.1	1.7	-0.1	-1.2	-1.3
Hearing difficulty/problems: Yes	0.8	1.3	3.1	-0.2	-0.8	-1.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.7	0.8	1.3	0.8
Number of incorrect matches in round	0.8	1.3	1.8	0.8	1.3	1.2
Tense / ‘highly strung’	0.8	1.4	2.1	0.4	1.5	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.6	1.3	1.2	0.3
Mood swings	0.8	1.4	4.0	2.0	0.3	-0.0
Back pain experienced in last month	0.8	1.2	3.0	0.7	-0.3	-1.7
Eye problems/disorders: Glaucoma	0.8	1.0	2.1	1.4	0.4	0.9
Ever smoked	0.8	1.4	2.2	-0.6	-1.3	-1.5
Alcohol drinker status: Previous	0.8	0.9	2.0	0.8	1.4	0.1
Blood Platelet Count	0.7	8.5	12.7	-2.8	-3.6	-2.2
Fed-up feelings	0.7	1.2	1.8	1.4	0.9	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.1	1.0	1.1	0.8
Body mass index (BMI)	0.7	3.0	4.6	2.1	2.1	0.3
Qualifications: None of the above	0.7	1.5	2.8	-0.4	1.3	1.7
Pain all over the body in last month	0.7	0.7	1.2	0.9	0.5	1.1
Weight	0.7	3.5	9.1	0.6	1.1	-3.0
Father’s age at death	0.7	1.0	1.7	-0.8	-0.8	-1.3
Breastfed as a baby	0.7	0.9	1.4	1.2	0.8	0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	1.4	0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.4	-1.0	-1.2	-1.0
Angina (self-reported)	0.7	0.9	1.4	-0.2	-1.1	-1.2
Medication: Omeprazole	0.7	0.9	1.3	-0.7	0.9	-1.1
Had major operations	0.7	0.8	2.2	0.2	1.5	0.4
Medication: Gliclazide	0.7	0.8	1.8	-0.2	0.7	1.4
Neuroticism (Nagel 2018)	0.6	1.4	3.6	1.9	-0.2	0.8
Age at First Birth	0.6	0.8	1.6	0.1	-0.9	-1.2
Triglycerides	0.6	0.9	2.7	-0.1	0.3	1.6
Age when periods started (menarche)	0.6	1.5	2.2	-0.7	1.5	1.4
Medication: Ramipril	0.6	0.8	1.8	1.3	0.6	0.5
Exposure to tobacco smoke outside home	0.6	0.8	2.0	-1.4	-0.3	-0.6
Leg fat mass (right)	0.6	2.2	4.1	1.5	2.0	-0.0
Diabetes diagnosed by doctor	0.6	1.0	1.5	-1.2	-0.8	-1.0
Breast cancer (self-reported)	0.6	0.8	1.3	-1.1	-0.8	-0.6
Osteoporosis (self-reported)	0.6	0.7	0.9	1.0	0.8	0.8
Ever taken oral contraceptive pill	0.6	0.7	2.0	-0.1	-1.4	-0.3
High cholesterol (Self-reported)	0.6	1.0	1.8	1.4	-0.4	-1.0
Commuting to job workplace: Cycle	0.6	0.7	1.2	1.1	0.3	-0.9
Leg fat mass (left)	0.6	2.2	4.3	1.5	2.1	-0.1
Bipolar Disorder (2018)	0.5	0.8	1.2	0.9	-1.1	-0.6
Ovarian Cancer	0.5	0.6	1.4	1.2	0.7	-0.3
Heel T-Score	0.5	3.7	9.9	1.0	-3.1	0.4
Allergy or Eczema	0.5	1.3	1.9	-0.8	-1.1	-1.4
Angina	0.5	0.7	1.1	-0.2	-1.0	-1.0
Pack years adult smoking proportion	0.5	0.8	1.1	1.0	0.5	1.0
Average weekly fortified wine intake	0.5	0.6	1.1	-0.6	-0.6	-1.1
Pulse rate	0.5	0.8	1.1	-0.8	-0.8	-1.1
Depression (self-reported)	0.5	0.6	1.0	0.1	-0.8	-1.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	1.0	-0.0	1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	1.3	0.4	0.4
Medication: Seretide 50 evohaler	0.5	0.6	0.9	0.9	0.9	-0.3
Heart disease (mother)	0.5	0.6	1.7	-0.2	-0.3	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	-0.5	-1.0	-0.8
Alcohol intake frequency.	0.5	1.3	1.7	-1.0	1.3	1.1
Number of full sisters	0.5	0.6	0.8	-0.9	-0.0	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	-0.7	0.3	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	0.1	0.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	0.8	0.9	0.9	0.8
Irritability	0.5	0.8	1.0	0.9	-0.7	-1.0
Risk taking	0.5	0.7	1.2	0.8	0.4	1.1
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.1	1.2	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.7	1.6	-0.4	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-0.4	1.1	0.4
Alzheimer’s Disease (in father)	0.4	0.5	0.7	-0.3	-0.9	-0.8
Lung FEV1/FVC ratio	0.4	1.9	4.5	1.1	-2.1	-0.3
Stomach or abdominal pain in last month	0.4	0.4	1.1	0.4	-0.2	1.1
Financial difficulties in last 2 years	0.4	0.6	1.5	0.6	1.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.6	0.5	0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	1.1	0.7	0.2
Medication: Paracetamol	0.4	0.7	2.0	0.3	0.3	1.4
Number of full brothers	0.4	0.5	1.1	1.1	0.6	0.2
Worry too long after embarrassment	0.4	0.7	1.5	-0.5	-0.4	-1.2
Number of children fathered	0.4	0.4	1.1	0.2	-1.0	-0.5
Comparative height size at age 10	0.4	2.4	5.0	-1.1	-1.0	-2.2
Supplements: Vitamin C	0.4	0.5	0.7	0.3	-0.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.5	0.6	-0.9
Smoking status: Current	0.4	0.7	1.0	1.0	0.5	0.9
Hearing aid user	0.4	0.4	0.8	0.1	-0.7	-0.9
Pain experienced in last month	0.4	0.7	1.5	-1.2	-0.1	0.7
Pack years of smoking	0.4	0.5	1.1	0.7	0.3	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.8	1.3	0.7	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.6	0.3	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.5	-0.8	-1.2	-0.5
Prostate Cancer	0.3	0.4	0.7	-0.8	0.1	-0.7
Mean Putamen Volume	0.3	0.3	0.5	-0.6	0.2	-0.7
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.5	0.9	0.5
Ulcerative Colitis	0.3	0.5	1.0	0.0	-0.6	-1.0
Blood White Count	0.3	2.3	5.1	-0.7	-1.2	-2.2
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.9	0.1	-0.4
Severe depression (siblings)	0.3	0.3	0.8	-0.4	0.3	-0.9
Current tobacco smoking	0.3	0.6	1.1	1.0	0.2	0.7
Waist circumference	0.3	1.1	2.9	-0.2	0.6	-1.7
Nervous feelings	0.3	0.5	0.9	-0.6	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.1	0.2	-1.5	-0.1
Worrier / anxious feelings	0.3	0.6	1.3	1.1	-0.2	0.6
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.8	-0.7	0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.4	-1.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.7	-0.1	-0.9
Medication: Lansoprazole	0.3	0.3	0.8	0.9	0.1	0.4
Loud music exposure frequency	0.3	0.3	0.5	0.4	-0.4	0.7
Health satisfaction	0.3	0.3	0.8	0.2	0.4	-0.9
Emphysema/chronic bronchitis	0.3	0.3	0.6	-0.8	0.3	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	0.1	-1.2	-0.4
Neck or shoulder pain in last month	0.3	0.5	1.2	0.2	-1.1	-0.4
Family relationship satisfaction	0.3	0.4	0.7	-0.3	0.8	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.6	-0.4	-0.7
Medication: Aspirin	0.3	0.4	0.6	-0.5	0.6	0.8
Mineral and other dietary supplements	0.3	0.3	1.0	0.1	-0.1	1.0
Medication: Aspirin	0.3	0.4	0.6	-0.5	0.6	0.8
Age started oral contraceptive pill	0.3	0.4	0.9	0.1	0.6	0.9
Heart disease (siblings)	0.3	0.3	0.5	-0.3	-0.7	-0.7
Chronotype (morning person)	0.2	0.5	1.0	0.2	0.6	1.0
Medication for hormone replacement therapy	0.2	0.2	0.4	0.3	-0.4	-0.7
Supplements: Zinc	0.2	0.2	0.4	0.5	-0.0	-0.6
Maternal smoking around birth	0.2	0.3	0.8	0.1	-0.5	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	-0.3	-1.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.6	-0.4	0.4
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.4	-0.5	0.8
Past tobacco smoking	0.2	0.4	0.7	-0.2	0.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.0	-0.7	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.2	-0.1	0.9
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	0.2	-0.0
Allergy	0.2	0.6	0.8	0.6	0.9	0.7
Diabetes (self-reported)	0.2	0.3	0.4	-0.5	-0.5	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	-0.3	-0.2
Headache pain in last month	0.2	0.3	0.7	0.9	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.2	-0.6	-0.5
Shortness of breath walking on level ground	0.2	0.3	0.8	0.9	-0.2	-0.2
Medication: Ibuprofen	0.2	0.3	0.4	-0.7	-0.1	-0.7
Age at last live birth	0.2	0.3	0.5	-0.2	-0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.8	0.3	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.5	0.8	-0.0
Average weekly beer plus cider intake	0.2	0.2	0.4	-0.5	-0.2	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.7	0.0	-0.3
Schizophrenia (2018)	0.1	0.3	0.9	0.2	0.9	0.2
Breast Cancer	0.1	0.3	0.3	0.6	-0.6	-0.5
LDL Cholesterol	0.1	0.2	0.3	-0.5	-0.3	0.3
Schizophrenia (2014)	0.1	0.2	0.2	0.4	0.4	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.6	0.0	0.0
Hypothyroidism (self reported)	0.1	0.3	0.6	0.4	-0.2	0.8
Hair Pigment	0.1	2.2	3.5	-0.4	1.9	1.7
Average weekly spirits intake	0.1	0.2	0.3	0.6	-0.0	-0.4
Fluid intelligence score	0.1	0.2	0.5	0.7	0.0	-0.0
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.3	0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.1	0.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.5	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.1	0.5	-0.6
Age at first live birth	0.1	0.1	0.1	-0.2	0.4	-0.3
Pulse wave peak to peak time	0.1	0.2	0.2	0.1	-0.5	-0.5
Qualifications: College or University degree	0.1	0.4	1.1	-0.3	-0.1	-1.0
Migraine (self-reported)	0.1	0.2	0.3	0.4	0.5	0.1
Suffer from ‘nerves’	0.1	0.1	0.2	0.5	0.2	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.3	0.6	-0.2	-0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.6	-0.2	0.3
Loneliness, isolation	0.1	0.1	0.3	0.6	0.1	-0.1
Ever had bowel cancer screening	0.1	0.1	0.3	-0.5	0.3	-0.1
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.5	0.5	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.3	-0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.3	0.6	-0.2
Medication: Paracetamol	0.1	0.1	0.4	0.0	-0.1	0.6
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	-0.3	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.4	0.6	0.7	0.8	0.2
Illnesses of mother	0.0	0.0	0.1	0.0	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	-0.3	-0.1
Overall health rating	0.0	0.1	0.2	0.5	0.0	-0.0
Leg pain on walking	0.0	0.0	0.1	-0.3	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.4	-0.1	-0.0
Smoking status: Previous	0.0	0.0	0.1	-0.0	-0.0	-0.3
Friendships satisfaction	0.0	0.0	0.1	0.1	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.0	0.3	0.1

Hub : Genes

SHBG

Models

Trait associations