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chr20:42,816,319-44,279,989

Best TWAS P=1.8e-12 · Best GWAS P=1.59e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Brain Cerebellum	YWHAB	0.43	0.19	lasso	7	0.16	1.7e-05	6.6	-7.0	1.8e-12	-0.97	0.01	0.98	TRUE
6	GTEx	Artery Aorta	YWHAB	0.29	0.17	lasso	5	0.15	1.3e-08	6.7	-6.9	4.0e-12	-0.99	0.01	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	YWHAB	0.42	0.22	lasso	4	0.18	2.3e-05	6.6	-6.9	4.1e-12	-0.99	0.01	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	YWHAB	0.19	0.07	lasso	4	0.05	1.1e-03	6.6	-6.9	5.2e-12	-0.99	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	YWHAB	0.07	0.06	lasso	2	0.06	1.3e-04	6.6	-6.8	8.8e-12	-0.99	0.01	0.98	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	YWHAB	0.33	0.24	lasso	4	0.26	1.6e-14	6.6	-6.8	1.2e-11	-0.96	0.01	0.99	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	YWHAB	0.56	0.58	bslmm	418	0.59	7.7e-94	6.7	-6.8	1.2e-11	-1.00	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	YWHAB	0.07	0.06	lasso	6	0.06	3.1e-07	6.6	-6.8	1.2e-11	-0.96	0.01	0.99	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	YWHAB	0.22	0.11	lasso	3	0.07	6.5e-03	6.6	-6.7	1.6e-11	-0.97	0.01	0.95	FALSE
19	GTEx	Lung	YWHAB	0.10	0.04	lasso	4	0.04	6.5e-04	6.7	-6.7	1.6e-11	-0.99	0.01	0.98	FALSE
7	GTEx	Artery Tibial	YWHAB	0.17	0.15	lasso	3	0.16	3.5e-12	6.7	-6.7	1.7e-11	-1.00	0.01	0.99	FALSE
25	GTEx	Thyroid	YWHAB	0.22	0.18	lasso	2	0.17	5.3e-13	6.7	-6.7	1.7e-11	-1.00	0.01	0.99	FALSE
17	GTEx	Esophagus Mucosa	YWHAB	0.25	0.27	enet	7	0.27	4.2e-18	6.7	-6.7	1.8e-11	-0.99	0.01	0.99	FALSE
23	GTEx	Skin Sun Exposed Lower leg	YWHAB	0.17	0.18	lasso	2	0.17	4.7e-14	6.7	-6.7	1.9e-11	-1.00	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	YWHAB	0.13	0.17	lasso	2	0.15	2.8e-12	6.7	-6.7	2.0e-11	-1.00	0.01	0.99	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	YWHAB	0.27	0.12	enet	13	0.18	1.2e-06	6.2	-6.7	2.4e-11	-0.95	0.01	0.99	FALSE
20	GTEx	Muscle Skeletal	YWHAB	0.09	0.07	lasso	5	0.07	4.5e-07	6.6	-6.7	2.6e-11	-0.98	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	YWHAB	0.06	0.07	enet	6	0.09	7.4e-11	5.6	-6.7	2.7e-11	-0.94	0.01	0.99	FALSE
5	GTEx	Adrenal Gland	YWHAB	0.23	0.15	lasso	3	0.10	1.4e-04	6.7	-6.7	2.8e-11	-1.00	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	PABPC1L	0.20	0.21	lasso	3	0.21	5.5e-23	6.6	-6.6	3.0e-11	-0.99	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	PABPC1L	0.08	0.14	lasso	4	0.14	4.2e-14	6.6	-6.6	3.0e-11	-0.99	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PABPC1L	0.17	0.16	lasso	1	0.15	8.0e-18	6.6	-6.6	3.4e-11	-0.99	0.01	0.99	FALSE
28	NTR	Blood	YWHAB	0.16	0.19	lasso	5	0.19	2.2e-58	6.6	-6.6	3.4e-11	-0.99	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	YWHAB	0.04	0.05	enet	10	0.03	2.3e-03	6.2	-6.6	3.4e-11	-0.88	0.01	0.92	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	YWHAB	0.12	0.13	lasso	5	0.12	4.3e-12	6.6	-6.6	3.6e-11	-0.99	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC1L	0.02	0.02	lasso	4	0.02	2.2e-04	6.6	-6.6	3.8e-11	-0.99	0.01	0.99	FALSE
24	GTEx	Testis	YWHAB	0.23	0.23	enet	14	0.23	1.8e-10	6.7	-6.6	4.5e-11	-0.97	0.00	0.99	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	YWHAB	0.04	0.03	lasso	5	0.04	2.9e-05	6.3	-6.5	7.7e-11	-0.93	0.01	0.97	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	YWHAB	0.31	0.18	lasso	5	0.14	9.9e-06	6.3	-6.5	7.9e-11	-0.95	0.01	0.99	FALSE
21	GTEx	Nerve Tibial	YWHAB	0.21	0.24	lasso	2	0.23	3.3e-16	6.3	-6.5	9.4e-11	-0.94	0.02	0.98	FALSE
31	YFS	Blood	YWHAB	0.07	0.06	lasso	4	0.07	6.8e-21	6.3	6.5	9.4e-11	0.95	0.02	0.98	FALSE
18	GTEx	Esophagus Muscularis	YWHAB	0.16	0.11	lasso	3	0.14	1.5e-08	5.6	-6.4	1.3e-10	-0.92	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	PABPC1L	0.32	0.07	lasso	8	0.07	1.9e-03	6.6	-6.3	2.3e-10	-0.88	0.01	0.94	FALSE
26	GTEx	Whole Blood	YWHAB	0.20	0.10	lasso	9	0.10	1.6e-09	6.7	-6.3	2.7e-10	-0.98	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Esophageal Carcinoma	YWHAB	0.15	0.14	lasso	5	0.10	4.6e-04	6.2	-6.3	3.6e-10	-0.85	0.02	0.88	FALSE
11	GTEx	Breast Mammary Tissue	YWHAB	0.18	0.09	lasso	6	0.08	5.2e-05	6.7	-6.2	7.9e-10	-0.97	0.01	0.99	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	PABPC1L	0.24	0.21	lasso	3	0.21	8.1e-27	6.6	-6.2	7.9e-10	-0.98	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	YWHAB	0.29	0.20	enet	21	0.26	1.5e-19	6.5	-5.8	6.5e-09	-0.84	0.01	0.99	FALSE
15	GTEx	Colon Sigmoid	YWHAB	0.27	0.14	lasso	4	0.10	1.7e-04	6.6	-5.8	6.7e-09	-0.94	0.01	0.98	FALSE
13	GTEx	Cells Transformed fibroblasts	PABPC1L	0.12	0.03	enet	22	0.08	2.0e-06	3.4	5.4	8.1e-08	0.72	0.04	0.95	FALSE
27	METSIM	Adipose	TOMM34	0.34	0.09	enet	73	0.16	2.5e-23	-4.5	5.1	2.9e-07	0.27	1.00	0.00	FALSE