[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr2:23,453,834-25,040,082

Best TWAS P=1.82e-12 · Best GWAS P=2.59e-15 conditioned to 0.000271

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-6.5	7.0	1.8e-12	-0.52	0.24	0.35	TRUE
13	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	6.5	-6.2	7.5e-10	0.41	0.35	0.26	TRUE
1	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-7.4	6.8	9.2e-12	-0.61	0.12	0.88	FALSE
8	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-6.6	-6.8	1.1e-11	0.56	0.20	0.36	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-6.5	6.5	5.8e-11	-0.57	0.12	0.72	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-5.0	-6.3	3.5e-10	0.61	0.26	0.27	FALSE
9	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	2.2	-6.2	4.1e-10	0.64	0.04	0.94	FALSE
10	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-4.9	-6.1	9.8e-10	0.62	0.97	0.03	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	-6.3	-6.0	1.6e-09	0.54	0.08	0.32	FALSE
6	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	2.2	-5.9	3.3e-09	0.29	0.11	0.09	FALSE
15	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-5.1	-5.5	4.2e-08	0.40	0.33	0.67	FALSE
7	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	-5.0	-5.3	8.7e-08	0.56	0.99	0.00	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFN4	0.09	0.07	blup	43	0.08	5.3e-09	-4.9	-5.3	8.8e-08	0.55	0.00	0.99	FALSE
14	METSIM	Adipose	PFN4	0.04	0.01	blup	306	0.03	1.9e-05	-4.9	-5.3	1.4e-07	0.56	0.43	0.32	FALSE
2	GTEx	Adipose Visceral Omentum	PFN4	0.08	0.02	enet	14	0.04	3.1e-03	-5.0	-5.3	1.5e-07	0.56	0.07	0.29	FALSE
4	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-5.2	-5.2	1.6e-07	0.18	0.22	0.11	FALSE
11	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	-5.0	-5.2	1.6e-07	0.52	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-5.0	5.2	2.1e-07	-0.58	0.41	0.10	FALSE
12	GTEx	Nerve Tibial	PFN4	0.25	0.16	lasso	5	0.20	3.8e-14	-5.0	-5.2	2.3e-07	0.52	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFN4	0.10	0.07	enet	5	0.08	5.5e-09	-4.9	-5.1	2.7e-07	0.51	0.00	0.99	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	-5.0	-5.1	2.7e-07	0.52	0.00	0.99	FALSE