TWAS
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Traits
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Traits
:
Leg fat-free mass (right)
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chr3:40,537,829-42,251,329
Best TWAS P=1.01e-10 · Best GWAS P=9.04e-12 conditioned to 0.0058
40.6M
40.8M
41M
41.2M
41.4M
41.6M
41.8M
42M
42.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Nerve Tibial
CTNNB1
0.05
0.00
enet
4
0.00
2.0e-01
6.4
6.5
1.0e-10
0.80
0.07
0.56
TRUE
3
NTR
Blood
CTNNB1
0.04
0.04
lasso
6
0.04
4.6e-13
6.3
-6.5
1.1e-10
-0.75
0.18
0.82
FALSE
1
GTEx
Artery Coronary
CTNNB1
0.30
0.00
lasso
4
0.01
1.0e-01
6.2
-6.2
4.4e-10
-0.70
0.04
0.26
FALSE
4
The Cancer Genome Atlas
Liver Hepatocellular Carcinoma
ULK4
0.12
0.03
blup
256
0.05
1.9e-03
2.9
5.4
8.4e-08
0.35
0.24
0.08
FALSE