Hub : Genes

CTNNB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.3000 0.1260 6.3e-03 -0.002 NA -0.006 NA 0.015 3.9e-01 NA 6.0e-01 NA 1.0e-01
2 GTEx Nerve Tibial 0.0471 0.0249 9.8e-03 0.001 NA 0.003 NA 0.002 2.5e-01 NA 2.0e-01 NA 2.3e-01
3 NTR Blood 0.0350 0.0110 1.7e-10 0.043 0.033 0.038 0.036 0.041 7.6e-14 8.8e-11 2.7e-12 8.3e-12 4.6e-13
4 TCGA Brain Lower Grade Glioma 0.0706 0.0340 2.9e-03 0.013 0.027 0.028 NA 0.014 1.2e-02 3.9e-04 3.0e-04 NA 8.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.4 3.8 8.5 -1.1 1.9 -1.3 2.9
Bipolar Disorder or Schizophrenia 0.9 2.3 3.7 -1.2 1.2 -1.6 1.9
Depressed Affect (Nagel 2018) 0.2 0.5 1.2 0.1 1.1 0.2 0.9
Depression (Nagel 2018) 2.8 4.1 7.0 -1.5 2.7 -1.4 2.3
Intelligence (Savage-Jansen 2018) 4.6 14.1 26.3 -5.1 2.1 -4.9 1.4
Neuroticism (Nagel 2018) 0.2 0.5 1.3 0.7 1.2 0.4 0.1
Schizophrenia (2018) 0.2 0.4 0.9 -0.7 0.0 -1.0 0.1
Schizophrenia vs Biploar Disorder 2.6 3.5 8.2 1.3 -2.9 1.6 -1.2
Worry (Nagel 2018) 0.9 1.8 3.9 1.5 0.2 1.1 -2.0
Alzheimer’s Disease (in mother) 0.8 1.0 2.1 -1.0 0.8 -1.4 0.5
Alzheimer’s Disease (in father) 1.2 1.3 3.3 0.3 -0.8 1.0 1.8
Alzheimer’s Disease (including proxy) 1.0 1.5 2.8 -1.4 0.1 -0.9 1.7
Crohns Disease (2017) 1.0 2.2 4.6 -2.1 0.9 -1.9 -0.1
Irritable Bowel Disease (IBD) 2.5 6.0 13.5 -3.7 0.9 -3.1 -0.1
Ulcerative Colitis (UC) 2.7 5.1 11.9 -3.4 0.4 -2.9 -0.3
Major Depression (MDD) 1.0 1.2 2.7 0.7 1.1 -0.5 1.6
Reaction Time 3.1 6.0 9.4 -2.6 3.1 -2.8 -0.4
Verbal and Numeric Reasoning (VNR) 3.0 7.2 14.7 -3.8 1.2 -3.5 0.8
Breast Cancer 0.4 0.9 1.3 0.7 -1.1 1.1 -0.8
Ovarian Cancer 0.6 0.8 1.9 -0.8 0.7 -0.4 1.4
Prostate Cancer 2.0 2.8 4.4 -2.1 1.7 -1.9 0.6
Age at First Birth 4.5 6.6 9.5 -3.0 2.5 -3.1 1.3
Bipolar Disorder (2011) 5.3 5.2 7.8 -1.8 2.4 -1.9 2.8
Body Mass Index (BMI) (2010) 1.4 2.0 4.4 -1.3 2.1 -1.3 0.2
Coronary Artery Disease (CAD) 0.5 0.6 0.9 -0.8 0.9 -1.0 0.5
Crohns Disease (2012) 1.1 1.8 3.8 -1.3 1.9 -1.3 -0.3
Mean Putamen Volume 0.4 0.4 1.0 0.9 0.0 1.0 -0.0
Fasting Glucose 1.7 2.0 6.2 -0.7 -0.7 -0.9 -2.5
HbA1C 1.5 1.6 3.0 -0.9 1.3 -1.7 1.0
HDL Cholesterol 0.2 0.3 0.5 -0.7 -0.7 -0.4 0.4
LDL Cholesterol 0.8 1.2 2.1 1.2 -1.5 1.0 -0.4
Lupus 0.4 0.7 1.3 0.5 -0.8 0.6 -1.2
Neuroticism (2016) 0.1 0.1 0.4 0.2 -0.0 0.2 0.6
Primary Biliary Cirrhosis 0.6 0.9 2.4 0.8 -0.8 0.3 1.5
Rheumatoid Arthritis 0.4 0.5 1.2 -1.1 -0.0 -0.0 0.9
Schizophrenia (2014) 0.2 0.4 1.5 -0.3 -0.3 -0.0 1.2
Triglycerides 0.3 0.6 1.4 0.6 1.2 0.1 -0.7
Type 2 Diabetes (T2D) (2012) 1.0 1.1 4.0 -0.4 2.0 -0.6 0.1
Ulcerative Colitis 0.9 1.4 3.5 -1.9 -0.2 -1.4 0.2
Blood Eosinophil Count 0.7 5.5 10.1 -1.9 2.5 -3.2 1.5
Blood Platelet Count 0.1 1.3 2.0 1.4 -1.2 1.2 0.3
Blood Red Count 0.7 7.0 9.2 -2.4 2.9 -2.2 3.0
Blood White Count 0.5 3.8 9.5 3.1 -0.7 2.2 0.5
Heel T-Score 5.3 42.3 61.9 -5.3 5.2 -7.9 -7.3
BMI 3.4 19.6 26.7 -4.5 5.2 -5.0 2.7
Height 4.0 77.6 121.0 -11.0 8.0 -10.8 3.1
Waist Hip Ratio (WHR) 0.1 0.5 1.1 -0.6 1.1 -0.8 -0.1
Systolic Blood Pressure 1.9 9.5 18.7 -3.7 2.4 -4.3 -0.1
Smoking Status 0.4 1.1 3.0 -1.0 1.7 -0.5 0.0
Allergy or Eczema 1.2 3.3 5.4 -2.3 0.5 -1.8 2.0
Cardiovascular Disease 0.8 2.7 3.7 -1.6 1.6 -1.9 1.4
Hypothyroidism (self reported) 0.2 0.5 1.0 -0.8 0.4 -0.3 1.0
Respiratory disease 0.1 0.3 0.9 -0.3 0.9 -0.5 -0.0
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 0.1 -0.1 -0.1 -0.1
Lung FEV1/FVC ratio 2.3 11.8 19.7 -4.4 2.5 -3.9 2.5
Lung FVC 0.3 1.4 3.3 -1.8 -0.3 -0.8 1.3
Neuroticism 0.8 2.0 6.5 -0.6 2.6 -0.8 -0.6
Chronotype (morning person) 0.5 1.0 3.3 -0.1 -1.8 0.1 -0.9
Hair Pigment 0.0 0.7 2.0 -0.4 0.6 -0.6 1.4
Tanning 0.4 5.0 6.2 2.1 -2.1 2.5 -2.3
Hand grip strength (left) 0.2 0.6 1.5 -1.2 0.2 -1.0 0.0
Number of treatments/medications taken 0.3 0.6 0.8 -0.8 0.9 -0.4 0.9
Average weekly spirits intake 0.6 0.8 1.7 -1.3 0.6 -1.0 0.1
Sensitivity / hurt feelings 1.4 2.5 5.9 2.4 -0.5 1.8 -0.8
Frequency of depressed mood in last 2 weeks 1.5 2.1 5.0 -1.1 2.2 -0.7 1.3
Hearing difficulty/problems: Yes 0.4 0.6 1.9 0.0 1.4 -0.5 -0.3
Relative age of first facial hair 0.1 0.3 0.5 0.4 0.7 -0.2 -0.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.4 -0.6 0.9 -0.1 1.5
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.1 -0.3 0.0 0.3 -0.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.2 0.1 1.1 -0.1 0.7
Systolic blood pressure, automated reading 2.9 8.5 14.9 -3.8 1.8 -3.9 -1.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.1 1.1 -0.7 0.9 0.1
Angina 0.1 0.1 0.3 -0.5 -0.2 0.5 0.2
Medication for hormone replacement therapy 1.1 1.2 2.2 1.1 -1.5 1.1 0.3
Vitamin and mineral supplements 2.4 3.2 4.9 2.2 -2.1 1.9 -0.5
Supplements: Zinc 0.9 0.9 3.0 0.6 1.7 0.0 0.6
Medication: Co-codamol 0.4 0.4 0.7 -0.4 0.7 -0.6 0.8
Medication: Metformin 0.2 0.2 0.8 -0.2 0.9 -0.4 -0.1
Diabetes (father) 0.9 1.1 3.1 1.8 -0.1 1.1 -0.0
Diabetes (mother) 0.8 1.0 3.1 0.8 -0.3 0.6 -1.8
Severe depression (siblings) 0.5 0.6 1.8 0.5 1.3 0.5 0.3
Pack years adult smoking proportion 0.2 0.3 0.8 0.2 -0.5 0.2 0.9
Impedance of leg (right) 0.8 3.8 6.4 2.1 -2.5 1.9 -0.6
Leg fat-free mass (left) 6.7 35.4 44.2 -6.4 6.6 -6.6 3.5
Trunk fat percentage 5.4 21.7 30.3 -5.0 5.5 -5.5 1.3
Hand grip strength (right) 0.9 2.5 5.3 -2.3 0.6 -1.7 1.1
Townsend deprivation index at recruitment 1.6 2.2 3.8 2.0 -1.4 1.7 -0.0
Current tobacco smoking 0.6 0.9 2.0 1.1 -0.6 1.4 -0.3
Average weekly fortified wine intake 0.0 0.0 0.1 -0.0 0.3 0.2 0.2
Maternal smoking around birth 4.1 6.0 8.3 2.2 -2.6 2.9 -2.0
Fed-up feelings 0.4 0.7 2.3 -0.0 1.5 -0.2 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 5.1 -1.3 2.1 -1.7 2.3
Relative age voice broke 0.1 0.2 0.6 0.1 0.8 -0.3 -0.2
Taking other prescription medications 1.5 2.3 4.3 1.6 -0.7 2.1 1.4
Age when periods started (menarche) 0.7 1.8 3.5 1.2 -1.9 1.5 0.4
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 3.7 1.7 -0.5 1.9 0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 13.3 -0.9 1.1 -1.8 -3.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.1 -0.4 0.5 -0.3
Qualifications: CSEs or equivalent 2.0 2.6 5.3 2.3 -0.3 2.1 0.8
Serious illness, injury or assault to yourself 0.6 0.7 2.1 -0.3 0.9 -0.2 1.4
High blood pressure 0.9 2.6 4.4 -1.5 1.9 -2.1 0.1
Hayfever, allergic rhinitis or eczema 1.5 3.2 5.4 -2.3 0.8 -1.9 1.7
Multivitamins +/- minerals 1.2 1.5 3.5 -1.3 1.9 -0.9 -0.2
Stomach or abdominal pain in last month 0.0 0.1 0.2 0.2 -0.1 0.4 -0.1
Supplements: Glucosamine 3.1 4.0 6.8 -2.6 1.7 -2.4 0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -0.1 1.0 -1.0 -0.3
Medication: Atenolol 0.1 0.1 0.2 -0.4 -0.2 -0.3 0.4
Medication: Levothyroxine sodium 0.6 1.0 2.7 -0.9 -0.4 -0.3 1.6
Sitting height 5.5 39.3 60.9 -7.6 5.7 -7.8 2.4
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 0.2 -0.3 -0.0 0.3
High blood pressure (mother) 2.0 2.8 4.5 -1.5 2.1 -1.9 0.8
Body mass index (BMI) 2.4 10.3 14.8 -3.2 3.9 -3.6 1.7
Impedance of leg (left) 0.9 4.4 5.9 2.4 -2.4 2.1 -1.4
Leg predicted mass (left) 6.9 36.4 45.3 -6.5 6.7 -6.7 3.6
Trunk fat mass 6.9 29.5 41.1 -5.9 6.2 -6.4 2.0
Waist circumference 4.6 16.8 25.1 -4.3 5.0 -4.4 2.0
Number of incorrect matches in round 3.5 5.8 10.8 3.3 -1.2 2.9 -1.6
Past tobacco smoking 3.5 6.5 10.6 2.8 -3.3 2.6 -0.7
Alcohol usually taken with meals 3.7 6.0 9.2 -3.0 2.5 -2.9 -0.2
Nervous feelings 0.6 1.2 2.9 0.8 1.1 0.0 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.7 0.9 0.9 0.9 1.3
Hearing difficulty/problems with background noise 2.5 4.0 7.1 -2.0 2.1 -2.7 -0.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 0.2 0.1 0.3 0.5
Had menopause 0.2 0.3 0.4 -0.6 0.6 -0.5 -0.2
Had other major operations 0.7 0.8 1.7 0.9 -0.9 1.3 -0.0
Forced vital capacity (FVC) 4.1 15.7 25.0 -5.0 3.3 -4.8 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 7.3 -0.5 1.1 -1.3 -2.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.6 -0.7 0.6 -1.2 -1.0
Qualifications: None of the above 2.6 5.6 11.6 3.4 -1.8 2.7 0.2
Financial difficulties in last 2 years 0.5 0.7 1.4 -0.1 1.2 -0.6 0.9
Mouth/teeth dental problems 0.4 0.6 0.8 0.9 -0.9 0.9 0.1
Heart attack 0.6 0.8 2.9 -0.4 -0.3 0.3 1.7
Allergy 1.0 2.4 4.3 2.1 -1.2 1.8 -0.8
Pain all over the body in last month 1.8 1.9 5.1 2.3 0.0 1.6 -0.5
Diabetes (self-reported) 0.2 0.3 0.9 -0.1 0.9 -0.6 -0.4
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 4.2 -1.5 1.7 -1.3 2.0
Medication: Ramipril 1.5 1.9 4.6 -1.0 2.1 -1.3 -0.5
Medication: Simvastatin 1.8 2.7 5.2 2.3 -0.5 2.3 -0.4
Fluid intelligence score 0.7 1.5 2.9 -1.7 -0.4 -1.3 1.1
Illnesses of siblings 0.1 0.1 0.2 0.1 0.3 0.3 0.5
Neuroticism score 0.5 1.1 2.8 0.4 1.7 -0.0 -1.2
Weight 6.9 33.8 45.0 -6.3 6.4 -6.7 3.1
Impedance of arm (right) 0.1 0.3 0.5 -0.0 0.7 -0.3 -0.7
Arm fat percentage (right) 3.7 14.6 23.3 -3.8 4.8 -4.4 1.2
Trunk fat-free mass 4.2 23.8 31.6 -5.5 4.9 -5.6 3.2
Hip circumference 5.2 22.2 30.0 -4.9 5.5 -5.3 2.6
Time employed in main current job 1.0 1.1 1.6 -1.2 1.1 -0.6 1.3
Alcohol intake versus 10 years previously 0.1 0.1 0.4 -0.1 -0.3 0.1 0.6
Father’s age at death 0.0 0.1 0.2 0.1 -0.4 0.1 -0.2
Worrier / anxious feelings 0.8 1.5 4.8 -0.2 0.8 -0.6 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.5 0.7 1.6 0.2 1.3
Falls in the last year 1.5 2.1 4.4 -1.2 1.4 -0.8 2.1
Hair/balding pattern: Pattern 3 0.7 1.0 1.1 -1.0 1.1 -1.0 1.0
Number of live births 3.0 4.2 8.4 2.5 -1.3 2.9 0.5
Forced expiratory volume in 1-second (FEV1) 5.3 17.9 29.7 -5.5 3.3 -5.1 2.3
Pulse rate 7.7 13.0 22.3 -4.6 2.9 -4.7 -0.2
Happiness 2.4 2.9 4.5 -1.9 1.3 -2.1 -1.2
Noisy workplace 3.2 4.0 6.2 2.5 -1.7 2.5 -0.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.3 -1.0 -0.2 -1.1 0.9
Serious illness, injury or assault of a close relative in last 2 years 3.5 4.0 8.0 1.6 -2.8 2.1 0.8
Mouth/teeth dental problems: Dentures 1.0 1.7 3.6 -1.9 0.7 -1.2 1.2
Asthma 0.2 0.3 0.5 0.7 -0.7 0.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 3.5 -0.3 1.9 -0.5 -0.9
Medication: Cholesterol lowering 0.3 0.4 0.6 0.7 0.8 0.7 -0.4
Depression (self-reported) 0.5 0.6 1.5 1.2 0.4 0.7 -0.5
Medication: Lansoprazole 2.5 2.9 4.4 1.9 -1.8 2.1 0.5
Prospective memory result 0.1 0.1 0.1 -0.4 -0.2 -0.1 -0.4
Lung cancer (father) 0.5 0.6 1.2 -0.8 1.1 -0.4 -0.7
Illnesses of mother 0.5 0.6 1.4 0.4 -1.2 0.8 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 6.1 19.5 31.0 -5.6 3.2 -5.1 3.3
Pulse wave Arterial Stiffness index 2.6 3.1 7.3 -2.7 1.2 -1.9 0.4
Impedance of arm (left) 0.2 0.8 1.3 -0.5 1.1 -0.8 -0.9
Arm fat mass (right) 5.7 23.3 32.9 -5.0 5.7 -5.6 2.1
Trunk predicted mass 4.1 23.5 31.1 -5.4 4.8 -5.6 3.2
Standing height 4.1 41.0 56.1 -7.5 6.4 -7.5 3.3
Length of working week for main job 1.3 1.4 2.0 0.7 -1.4 1.4 -1.1
Exposure to tobacco smoke at home 3.3 3.7 4.9 1.8 -2.2 2.2 1.4
Breastfed as a baby 5.7 7.1 10.5 -3.2 2.8 -3.1 0.5
Tense / ‘highly strung’ 0.5 0.8 2.2 1.5 0.2 1.1 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 6.7 -1.2 2.6 -2.4 0.2
Hair/balding pattern: Pattern 4 8.9 21.5 31.3 -5.6 4.3 -5.6 2.2
Birth weight of first child 3.2 5.7 10.4 -3.2 1.4 -1.9 2.6
Peak expiratory flow (PEF) 1.6 3.8 6.4 -2.5 1.1 -2.5 1.2
Pulse wave reflection index 0.1 0.1 0.4 0.1 -0.4 0.6 -0.0
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.2 0.3 0.6 -0.1 -1.1
Loud music exposure frequency 0.2 0.3 0.6 0.2 0.5 -0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.6 0.5 -0.7 0.8 0.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.7 0.3 0.8 -0.6 -0.2
Blood clot in the leg (DVT) 0.8 1.0 1.6 -1.1 1.1 -1.2 -0.3
Medication: Paracetamol 0.2 0.4 1.1 0.2 -0.1 0.5 -1.0
Headache pain in last month 1.1 1.9 3.2 1.8 -0.9 1.7 -0.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 -0.2 -1.1 -0.2 0.3
Glaucoma (self-reported) 0.4 0.5 1.1 -1.0 0.2 -0.8 -0.3
Gout (self-reported) 0.4 0.5 1.5 0.4 -0.6 1.2 -0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.1 -0.9 -1.0 -0.2 1.4
Medication: Amlodipine 4.2 5.9 8.1 -2.0 2.9 -2.1 2.7
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.5 1.1 -1.6 0.8 1.0
Birth weight 0.4 0.9 1.6 -1.3 -0.7 -0.8 0.9
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.8 1.9 -0.0 1.9 -0.7
High blood pressure (siblings) 1.0 1.4 2.8 -1.2 0.5 -1.7 -1.1
Forced vital capacity (FVC), Best measure 4.7 17.3 25.0 -5.0 3.3 -4.9 3.2
Body fat percentage 4.1 16.2 22.8 -4.2 4.8 -4.8 1.4
Leg fat percentage (right) 1.8 6.5 9.7 -2.3 3.1 -3.1 1.2
Arm fat-free mass (right) 4.8 24.7 32.1 -5.6 5.0 -5.7 3.2
Exposure to tobacco smoke outside home 3.4 4.5 5.9 2.3 -2.4 2.4 1.1
Comparative body size at age 10 0.6 1.6 2.9 -1.4 1.3 -1.7 0.5
Number of full brothers 1.2 1.5 3.4 1.1 0.4 1.9 -1.0
Worry too long after embarrassment 2.4 4.0 11.4 -0.8 3.4 -2.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 4.0 5.2 10.0 3.2 -1.2 2.4 -1.9
Wheeze or whistling in the chest in last year 1.5 2.7 3.4 1.7 -1.1 1.8 1.9
Number of children fathered 1.1 1.2 1.9 1.0 -1.4 0.7 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.5 -0.1 -0.1 -0.4 -1.2
Age at first live birth 4.0 7.0 11.5 -2.9 2.8 -3.4 -0.6
Pulse wave peak to peak time 1.7 2.0 5.2 2.3 -0.8 1.5 0.1
Health satisfaction 2.7 3.5 5.7 -1.9 2.4 -1.9 1.1
Shortness of breath walking on level ground 0.6 0.7 1.2 0.8 1.1 0.3 0.9
Qualifications: College or University degree 1.5 4.7 8.5 -2.9 1.6 -2.7 0.1
Eye problems/disorders: None of the above 0.5 0.6 0.9 0.9 -0.9 0.8 0.2
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.6 1.9 0.4 1.4 -1.3
Emphysema/chronic bronchitis 0.7 0.8 1.2 1.1 -0.6 1.1 0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 0.5 -1.0 -0.0 0.2
Neck or shoulder pain in last month 1.7 2.4 4.7 2.1 -0.5 2.2 0.4
Medication: Blood pressure 0.5 0.8 2.1 -0.8 1.4 -0.7 0.3
Angina (self-reported) 0.1 0.1 0.4 -0.4 -0.2 0.6 -0.0
Migraine (self-reported) 0.4 0.5 1.7 -0.5 0.4 0.1 1.3
Medication: Ibuprofen 0.3 0.3 1.1 0.2 1.0 0.1 -0.5
Medication: Allopurinol 0.1 0.2 0.3 -0.6 0.1 0.6 0.4
Medication: Omeprazole 0.7 0.9 1.8 1.3 -0.2 1.1 -0.6
Medication: Seretide 50 evohaler 0.3 0.4 1.2 0.5 -0.1 0.1 -1.1
Mean time to correctly identify matches 5.0 9.5 13.2 -3.6 3.5 -3.5 -0.0
Heart disease (mother) 0.9 1.2 2.3 1.4 -1.5 0.6 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.0 0.3 0.1 0.0
Whole body fat mass 6.0 25.1 34.3 -5.3 5.7 -5.9 2.1
Leg fat mass (right) 4.7 18.3 25.0 -4.3 4.9 -5.0 2.4
Arm predicted mass (right) 5.0 25.6 35.0 -5.7 5.1 -5.9 3.0
Pulse rate, automated reading 5.1 16.5 29.5 -5.2 3.0 -5.4 0.0
Alcohol intake frequency. 0.9 2.2 3.3 1.6 -1.8 1.6 0.7
Comparative height size at age 10 2.7 14.9 25.1 -4.5 3.6 -5.0 1.0
Number of full sisters 0.9 1.1 1.9 1.2 -1.4 1.0 -0.5
Suffer from ‘nerves’ 0.3 0.4 1.1 0.0 1.0 -0.1 -0.8
Overall health rating 0.5 1.2 2.3 1.5 0.4 1.5 0.3
Chest pain or discomfort 0.3 0.4 1.1 0.0 -0.1 1.1 0.8
Had major operations 0.2 0.2 0.8 0.3 0.3 0.0 0.9
Age at last live birth 0.4 0.6 1.9 0.2 1.4 -0.6 -0.5
Family relationship satisfaction 0.1 0.1 0.2 -0.2 0.2 -0.5 0.1
Leg pain on walking 3.4 4.2 10.5 -1.5 3.2 -1.8 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.3 -0.7 0.6 -1.2 -0.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.4 1.6 -0.7 0.9 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.0 -0.3 -1.3 -0.4 -1.4
Medication: Aspirin 0.1 0.2 0.3 0.4 0.6 0.4 0.0
Supplements: Vitamin C 0.9 1.1 1.7 -1.3 0.9 -1.3 -0.5
Knee pain experienced in last month 1.4 2.1 5.9 -0.8 1.2 -0.7 2.4
Hypertension (Self-reported) 0.9 2.6 4.3 -1.6 1.8 -2.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 0.4 -0.2 0.8 0.1
Illnesses of father: Heart disease 0.5 0.7 0.9 -0.6 0.7 -1.0 0.9
Illnesses of siblings: Diabetes 0.8 1.0 2.5 0.6 -1.6 1.0 0.3
Smoking status: Previous 4.1 6.1 11.5 -2.4 3.4 -2.6 0.7
Forced expiratory volume in 1-second (FEV1), predicted 6.1 12.6 16.8 -3.5 4.1 -4.0 2.3
Whole body fat-free mass 5.1 29.0 37.5 -5.9 5.7 -6.1 3.4
Leg fat-free mass (right) 6.2 33.1 41.8 -6.2 6.5 -6.5 3.1
Arm fat percentage (left) 3.9 15.6 24.0 -4.0 4.9 -4.7 1.1
Average weekly red wine intake 1.9 2.8 5.1 -2.2 1.4 -1.9 -0.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.1 -0.9 0.6 -1.1 -0.1
Mood swings 0.2 0.4 1.5 0.1 1.2 0.3 -0.2
Loneliness, isolation 0.1 0.2 0.5 0.7 0.3 0.1 -0.1
Long-standing illness, disability or infirmity 0.2 0.3 0.5 0.6 0.7 0.4 0.5
Ever had bowel cancer screening 0.4 0.5 0.9 -1.0 1.0 -0.3 -0.2
Diabetes diagnosed by doctor 0.2 0.3 0.5 0.5 0.5 -0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.9 0.3 -0.4 0.3 -1.7
Friendships satisfaction 0.6 0.8 1.3 -1.1 0.6 -1.1 -0.5
Qualifications: nursing, teaching 0.5 0.7 2.9 -0.1 -0.0 -0.3 -1.7
Commuting to job workplace: Walk 0.5 0.6 1.4 0.3 -0.8 1.2 0.4
Eye problems/disorders: Cataract 0.3 0.3 1.0 -0.5 1.0 -0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 3.8 -1.5 2.0 -1.5 0.8
Medication for cholesterol 0.7 1.0 1.5 1.2 -0.8 1.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 4.9 -1.0 2.2 -1.0 0.8
Back pain experienced in last month 2.1 3.1 7.6 -1.4 2.8 -1.7 -0.0
Mineral and other dietary supplements 1.4 1.8 3.2 1.2 -1.8 1.4 -0.8
Breast cancer (self-reported) 2.5 2.9 4.2 1.4 -1.8 2.1 -1.5
Asthma (self-reported) 0.2 0.4 0.6 0.6 -0.7 0.3 -0.7
Osteoporosis (self-reported) 8.9 11.0 18.9 3.6 -3.5 4.4 0.2
Osteoarthritis (self-reported) 0.8 1.1 1.7 -0.8 1.2 -0.7 1.3
Medication: Aspirin 0.2 0.3 0.7 0.7 0.0 0.8 0.3
Medication: Gliclazide 1.9 2.1 3.9 -2.0 1.1 -1.7 0.7
Illnesses of father: None of the above (group 1) 1.3 1.5 2.9 0.8 -0.6 1.5 -1.7
Smoking status: Current 0.8 1.3 2.7 1.3 -0.8 1.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.5 -1.9 1.1 -1.4 0.5
Whole body water mass 5.3 30.5 39.2 -6.1 5.8 -6.3 3.4
Leg predicted mass (right) 6.1 32.7 41.6 -6.2 6.4 -6.4 3.1
Arm fat mass (left) 6.1 25.0 34.2 -5.4 5.7 -5.8 2.0
Number of self-reported non-cancer illnesses 0.8 1.3 2.8 -0.2 1.5 -0.2 1.7
Average weekly champagne plus white wine intake 1.4 1.9 5.1 -0.9 -1.3 0.3 -2.3
Miserableness 0.6 1.0 1.8 1.2 0.4 1.3 -0.8
Guilty feelings 0.2 0.3 1.0 0.1 1.0 -0.0 0.3
Wears glasses or contact lenses 1.9 2.2 3.7 -1.9 1.0 -1.9 0.4
Ever taken oral contraceptive pill 0.4 0.4 0.9 0.6 -0.7 0.2 -0.9
Hearing aid user 0.2 0.2 0.7 -0.3 0.8 -0.2 -0.1
Mother’s age at death 1.0 1.3 1.8 -1.3 1.1 -1.2 0.8
Financial situation satisfaction 0.9 1.1 2.0 -0.8 1.2 -1.4 -0.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 -0.8 0.6 -0.9 0.4
Commuting to job workplace: Public transport 0.9 1.1 2.9 -1.7 0.7 -0.8 0.4
Eye problems/disorders: Glaucoma 0.2 0.3 0.7 -0.4 -0.4 -0.0 -0.8
Medication: Blood pressure 2.0 3.9 5.5 -2.3 2.1 -2.4 0.6
Pain type(s) experienced in last month: Hip pain 2.4 3.0 5.9 -1.8 2.4 -1.6 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.3 0.3 1.2 -0.2 0.9
High cholesterol (Self-reported) 0.4 0.6 1.4 0.8 0.2 1.2 -0.6
Medication: Bendroflumethiazide 2.2 3.4 5.9 -2.2 1.6 -2.4 -0.6
Medication: Paracetamol 0.6 1.0 1.8 0.7 -0.9 1.3 -0.9
Medication: Lisinopril 0.5 0.6 1.5 0.1 0.9 -0.2 1.2
Medication: Atorvastatin 2.1 2.6 4.9 -2.2 1.8 -1.4 0.6
Illnesses of father: High blood pressure 0.7 0.9 1.6 -0.7 0.6 -1.3 1.1
Alcohol drinker status: Never 1.0 1.2 2.3 1.2 -0.6 0.9 -1.5
Ever smoked 6.2 10.9 17.5 -4.2 3.4 -3.7 0.9
Basal metabolic rate 5.9 32.5 41.9 -6.2 6.1 -6.5 3.5
Leg fat percentage (left) 1.6 5.8 9.7 -2.1 3.1 -3.0 0.5
Arm fat-free mass (left) 4.8 24.3 31.8 -5.5 5.1 -5.6 3.1
Number of operations (self-reported) 0.7 1.0 2.5 0.6 0.6 1.0 1.6
Average weekly beer plus cider intake 0.3 0.4 0.7 0.8 0.6 0.1 0.8
Irritability 2.6 4.4 8.9 -2.2 3.0 -1.9 -0.4
Risk taking 0.2 0.3 0.8 0.2 -0.4 0.9 -0.5
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.2 -1.5 0.8 -1.2 -0.8
Fractured/broken bones in last 5 years 1.4 1.8 3.1 -1.2 1.1 -1.2 1.8
Age started oral contraceptive pill 1.1 1.3 2.1 -1.3 1.4 -1.2 0.1
Diastolic blood pressure, automated reading 5.6 17.3 28.5 -5.3 3.7 -4.9 1.8
Ever depressed for a whole week 1.3 1.6 2.3 -1.3 1.2 -1.5 -1.0
Unable to work because of sickness or disability 0.7 0.9 2.8 -0.2 1.7 -0.9 -0.3
Commuting to job workplace: Cycle 2.7 3.3 6.7 -2.6 0.8 -1.9 1.5
Myopia 2.9 4.2 6.7 -2.0 2.4 -2.6 0.6
Vascular/heart problems diagnosed by doctor 0.9 2.4 3.6 1.4 -1.9 1.9 -0.6
Cholesterol lowering medication 0.3 0.4 0.6 -0.6 0.8 0.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.4 0.6 0.3 0.4 -0.4
Pain experienced in last month 0.2 0.3 0.9 -0.4 -1.0 -0.4 -0.1
Supplements: Calcium 1.6 1.8 2.7 1.1 -1.2 1.6 1.4
Basal cell carcinoma (self-reported) 0.7 0.8 3.0 -0.2 -0.1 0.5 -1.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.1 -0.6 -0.3 0.2 1.7
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 1.5 -1.0 1.2 -1.2 0.0
Heart disease (siblings) 0.9 1.1 2.1 1.1 -0.7 1.4 0.7
Alcohol drinker status: Previous 0.8 0.9 1.9 1.4 -0.8 0.9 0.6
Pack years of smoking 0.2 0.3 0.9 -0.1 -0.9 0.1 0.7
Impedance of whole body 0.1 0.5 1.2 0.6 -0.3 0.4 -1.1
Leg fat mass (left) 4.3 16.8 23.5 -4.0 4.8 -4.8 2.0
Arm predicted mass (left) 5.0 25.6 32.5 -5.7 5.2 -5.7 3.3