[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr5:175,756,956-177,591,495

Best TWAS P=1.7e-10 · Best GWAS P=1.26e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MXD3	0.16	0.05	enet	13	0.06	1.7e-05	5.9	5.5	4.8e-08	0.77	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	MXD3	0.33	0.06	lasso	6	0.05	9.1e-04	5.9	5.4	7.8e-08	0.84	0.02	0.94	FALSE
3	GTEx	Artery Tibial	MXD3	0.12	0.13	enet	5	0.12	7.0e-10	5.9	6.0	2.1e-09	0.89	0.02	0.98	FALSE
4	GTEx	Brain Cerebellum	MXD3	0.28	0.31	lasso	2	0.30	1.6e-09	5.9	5.9	3.1e-09	0.87	0.02	0.98	FALSE
5	GTEx	Brain Cortex	MXD3	0.47	0.20	lasso	10	0.22	7.7e-07	5.9	5.1	2.8e-07	0.78	0.03	0.82	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	MXD3	0.24	0.14	enet	10	0.25	2.9e-07	5.9	5.5	4.8e-08	0.83	0.02	0.92	FALSE
7	GTEx	Breast Mammary Tissue	MXD3	0.26	0.08	lasso	5	0.10	1.3e-05	5.9	5.6	2.0e-08	0.86	0.00	0.99	FALSE
8	GTEx	Colon Sigmoid	MXD3	0.35	0.27	lasso	9	0.29	6.3e-11	5.9	6.0	2.2e-09	0.90	0.02	0.98	FALSE
9	GTEx	Colon Transverse	PRELID1	0.31	0.28	lasso	4	0.26	1.1e-12	5.9	-6.0	1.5e-09	-0.90	0.02	0.98	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	MXD3	0.17	0.12	lasso	3	0.08	9.5e-04	5.9	5.4	7.9e-08	0.78	0.02	0.75	FALSE
11	GTEx	Esophagus Mucosa	MXD3	0.16	0.14	lasso	8	0.15	1.7e-10	5.9	5.5	3.2e-08	0.85	0.02	0.98	FALSE
12	GTEx	Esophagus Muscularis	MXD3	0.27	0.20	enet	10	0.24	1.6e-14	5.9	6.0	1.5e-09	0.91	0.02	0.98	FALSE
13	GTEx	Heart Atrial Appendage	MXD3	0.33	0.15	enet	24	0.16	1.5e-07	5.9	5.3	9.9e-08	0.76	0.00	1.00	FALSE
14	GTEx	Heart Left Ventricle	MXD3	0.17	0.03	lasso	3	0.03	1.5e-02	5.9	5.8	7.9e-09	0.86	0.03	0.82	FALSE
15	GTEx	Liver	PRELID1	0.22	0.25	lasso	3	0.24	2.4e-07	6.4	-6.4	1.7e-10	-0.98	0.00	1.00	TRUE
16	GTEx	Lung	MXD3	0.20	0.12	lasso	10	0.12	1.8e-09	5.9	6.0	1.8e-09	0.85	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	MXD3	0.26	0.17	lasso	7	0.28	6.9e-20	5.9	6.1	8.3e-10	0.87	0.02	0.98	FALSE
18	GTEx	Pituitary	MXD3	0.25	0.20	lasso	6	0.16	7.5e-05	5.7	6.1	9.0e-10	0.74	0.03	0.92	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	MXD3	0.22	0.18	lasso	3	0.17	1.8e-09	5.9	6.2	4.1e-10	0.94	0.01	0.99	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PRELID1	0.06	0.02	enet	5	0.03	3.4e-03	5.9	-6.1	9.7e-10	-0.92	0.01	0.99	FALSE
21	GTEx	Skin Sun Exposed Lower leg	MXD3	0.19	0.14	lasso	6	0.12	4.2e-10	6.4	5.8	4.9e-09	0.91	0.00	1.00	FALSE
22	GTEx	Small Intestine Terminal Ileum	PRELID1	0.47	0.16	enet	10	0.13	7.6e-04	6.4	-6.4	2.0e-10	-0.94	0.00	0.96	FALSE
23	GTEx	Testis	DBN1	0.10	0.00	lasso	6	0.00	4.6e-01	5.6	-5.3	1.1e-07	-0.66	0.03	0.54	FALSE
24	GTEx	Thyroid	MXD3	0.31	0.17	lasso	8	0.24	1.1e-18	5.9	6.0	1.9e-09	0.91	0.00	1.00	FALSE
25	METSIM	Adipose	MXD3	0.18	0.18	lasso	3	0.21	1.3e-30	5.9	5.7	1.3e-08	0.86	0.03	0.97	FALSE
26	METSIM	Adipose	ZNF346	0.04	0.00	blup	373	0.03	9.6e-05	5.2	5.3	1.0e-07	0.38	0.26	0.63	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FGFR4	0.08	0.06	blup	46	0.07	2.5e-08	5.0	-6.0	2.3e-09	-0.39	0.11	0.88	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRELID1	0.24	0.11	lasso	5	0.10	1.2e-11	6.2	-6.1	1.1e-09	-0.88	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRELID1	0.33	0.08	enet	4	0.08	2.7e-05	5.9	-6.1	1.2e-09	-0.90	0.01	0.97	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	FGFR4	0.06	0.02	enet	7	0.05	1.2e-06	-2.8	-5.6	2.4e-08	-0.27	0.26	0.33	TRUE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PRELID1	0.08	0.10	lasso	4	0.07	2.9e-04	5.4	-5.6	1.8e-08	-0.83	0.01	0.94	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	MXD3	0.04	0.02	blup	41	0.02	5.6e-04	4.7	5.6	1.8e-08	0.79	0.10	0.62	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	MXD3	0.04	0.02	blup	40	0.03	2.8e-04	5.9	6.0	2.5e-09	0.84	0.04	0.91	FALSE