TWAS hub - FGFR4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0340	1.1e-04	0.000	0.019	0.000	0.019	0.001	3.0e-01	1.9e-03	3.3e-01	2.1e-03	2.4e-01
2	GTEx	Artery Aorta	0.2080	0.0670	3.3e-04	0.025	NA	0.042	NA	0.083	1.6e-02	NA	2.3e-03	NA	2.5e-05
3	GTEx	Artery Tibial	0.0701	0.0298	3.6e-03	-0.002	NA	0.001	NA	-0.003	4.8e-01	NA	2.6e-01	NA	7.8e-01
4	GTEx	Brain Caudate basal ganglia	0.1450	0.0680	4.7e-03	0.211	NA	0.050	NA	0.107	1.0e-06	NA	1.5e-02	NA	5.5e-04
5	GTEx	Brain Cerebellar Hemisphere	0.4090	0.0980	3.7e-09	0.364	NA	0.212	NA	0.380	3.0e-10	NA	3.9e-06	NA	9.6e-11
6	GTEx	Brain Cerebellum	0.3720	0.0970	2.2e-07	0.113	NA	0.082	NA	0.105	3.3e-04	NA	2.1e-03	NA	5.3e-04
7	GTEx	Brain Cortex	0.2980	0.0960	2.2e-04	0.094	NA	0.239	NA	0.111	1.5e-03	NA	3.0e-07	NA	5.6e-04
8	GTEx	Brain Nucleus accumbens basal ganglia	0.1720	0.0760	3.2e-03	0.043	NA	0.015	NA	0.044	2.7e-02	NA	1.3e-01	NA	2.5e-02
9	GTEx	Brain Putamen basal ganglia	0.1850	0.0910	5.5e-03	0.066	NA	0.026	NA	0.061	1.2e-02	NA	8.0e-02	NA	1.5e-02
10	GTEx	Esophagus Mucosa	0.1770	0.0460	1.4e-07	0.162	NA	0.159	NA	0.157	5.9e-11	NA	9.2e-11	NA	1.1e-10
11	GTEx	Nerve Tibial	0.4363	0.0504	0.0e+00	0.478	NA	0.465	NA	0.474	7.9e-38	NA	1.8e-36	NA	2.1e-37
12	GTEx	Pituitary	0.2970	0.1040	5.6e-03	0.206	NA	0.036	NA	0.111	6.9e-06	NA	4.4e-02	NA	1.0e-03
13	GTEx	Skin Not Sun Exposed Suprapubic	0.1910	0.0710	2.3e-03	0.113	NA	0.110	NA	0.114	9.3e-07	NA	1.3e-06	NA	8.3e-07
14	GTEx	Skin Sun Exposed Lower leg	0.0920	0.0300	8.6e-05	0.109	NA	0.117	NA	0.115	2.5e-09	NA	7.1e-10	NA	9.9e-10
15	GTEx	Whole Blood	0.0570	0.0260	2.4e-03	0.012	NA	0.002	NA	0.007	2.7e-02	NA	2.0e-01	NA	6.4e-02
16	ROSMAP	Brain Pre-frontal Cortex	0.2641	0.0441	0.0e+00	0.137	0.160	0.192	0.157	0.207	2.8e-17	4.5e-20	4.0e-24	9.8e-20	4.5e-26
17	TCGA	Head and Neck Squamous Cell Carcinoma	0.0829	0.0310	1.6e-06	0.058	0.070	0.059	NA	0.058	4.4e-07	2.5e-08	3.4e-07	NA	3.8e-07
18	TCGA	Brain Lower Grade Glioma	0.0559	0.0244	2.8e-05	0.024	0.035	0.053	NA	0.032	9.1e-04	7.2e-05	1.2e-06	NA	1.5e-04
19	TCGA	Prostate Adenocarcinoma	0.1108	0.0408	1.5e-06	0.038	0.045	0.059	NA	0.055	7.6e-05	1.6e-05	8.7e-07	NA	1.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Financial difficulties in last 2 years	8.6	11.6	22.9	4.7	3.2	4.7	3.2	2.8	2.8	3.6	2.4	1.6	3.5	3.4	3.2	3.3	3.5	3.0	4.8	3.6	3.6	1.9
Height	7.5	145.3	489.8	-9.5	-5.1	-14.4	-1.8	-2.4	-3.5	0.5	-1.5	-2.5	-20.3	-22.1	-18.1	-18.8	-13.4	-2.3	-17.8	-9.5	-11.5	9.8
Had menopause	6.1	7.6	30.9	-5.2	-1.8	-3.6	-1.6	-2.1	-2.2	-1.9	-1.7	-0.9	-1.9	-2.3	-1.8	-2.3	-2.7	-1.7	-4.7	0.3	-5.6	-0.6
Standing height	5.9	58.4	196.2	-5.4	-3.9	-9.4	-1.3	-2.2	-2.4	1.5	-1.6	-0.4	-12.6	-14.0	-11.6	-12.2	-8.1	-1.8	-11.2	-5.1	-6.0	8.2
Comparative height size at age 10	5.4	29.6	96.8	-4.9	-2.6	-6.5	-1.2	-1.6	-1.8	0.4	-1.3	-0.2	-9.2	-9.8	-7.9	-8.6	-6.3	-1.2	-7.5	-5.2	-5.7	2.5
Waist Hip Ratio (WHR)	3.9	17.4	70.2	2.1	-0.3	-4.1	1.2	1.0	1.0	1.8	1.1	-0.8	-7.5	-8.4	-7.2	-6.9	-2.9	1.2	-5.1	0.3	-1.4	6.0
Ever had hysterectomy (womb removed)	3.9	4.4	12.5	3.5	1.0	2.4	2.0	2.0	1.5	2.0	1.3	0.1	2.0	2.0	1.5	1.6	3.0	1.5	2.6	2.6	2.6	1.8
Comparative body size at age 10	3.9	10.6	29.1	4.1	1.5	4.5	0.8	0.7	1.1	2.2	0.9	1.9	4.1	4.5	5.0	4.4	4.0	0.8	5.4	2.8	4.1	0.6
Trunk fat-free mass	3.5	20.3	56.0	-4.9	-2.6	-5.0	-0.8	-1.8	-1.8	-0.1	-1.0	0.6	-7.2	-7.5	-5.8	-6.3	-5.5	-1.1	-5.7	-6.5	-5.7	0.0
Trunk predicted mass	3.5	19.9	54.9	-4.8	-2.6	-4.9	-0.8	-1.8	-1.9	-0.0	-1.1	0.5	-7.2	-7.4	-5.7	-6.3	-5.4	-1.2	-5.7	-6.5	-5.6	0.2
Medication: Omeprazole	3.4	4.1	11.5	-1.6	-0.8	-2.2	0.4	0.6	0.1	-0.2	0.7	0.7	-3.4	-3.3	-3.0	-2.7	-2.5	0.4	-2.5	-3.4	-1.9	-0.8
Supplements: Calcium	3.4	3.8	9.6	3.1	2.7	2.2	2.4	2.5	2.3	1.6	2.2	0.7	1.3	1.0	0.2	0.6	1.2	2.5	1.9	2.3	1.8	1.0
Supplements: Vitamin C	3.3	3.9	11.0	2.1	0.4	2.4	0.8	0.4	0.2	-0.8	0.1	-0.5	3.2	3.1	2.9	2.5	2.5	0.4	3.3	2.2	2.1	0.4
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	9.7	-0.7	-1.4	-2.0	0.6	0.8	0.4	-2.4	0.5	2.0	-2.9	-2.8	-3.1	-2.9	-2.8	0.6	-1.8	-2.4	-1.8	-1.6
Whole body fat-free mass	3.0	17.1	40.4	-4.9	-2.6	-4.7	-1.1	-2.1	-2.1	-0.6	-1.4	0.5	-6.2	-6.4	-4.8	-5.4	-5.1	-1.5	-5.1	-6.3	-5.7	-0.9
Whole body water mass	3.0	16.9	39.4	-4.8	-2.8	-4.6	-1.2	-2.1	-2.1	-0.8	-1.5	0.6	-6.2	-6.3	-4.8	-5.4	-5.1	-1.6	-5.1	-6.3	-5.7	-1.0
Average weekly beer plus cider intake	3.0	4.3	10.0	1.8	2.0	3.2	1.8	1.9	2.1	3.0	2.1	1.3	2.1	2.3	2.2	2.7	1.9	2.1	2.7	0.3	1.1	-0.8
Impedance of leg (left)	2.9	13.9	112.4	5.0	0.6	0.7	1.7	2.2	2.1	3.9	2.0	0.3	-0.9	-1.9	-2.0	-1.1	2.6	1.8	-0.8	6.9	5.0	10.6
Birth weight of first child	2.8	5.2	15.5	-2.4	-1.4	-3.3	-0.9	-0.2	-0.3	-0.8	-0.2	-1.0	-3.1	-3.0	-2.7	-3.4	-3.9	-0.7	-2.6	-3.3	-2.2	-1.5
Arm predicted mass (left)	2.8	14.0	35.9	-4.1	-3.0	-4.4	-1.4	-2.2	-2.3	-0.6	-1.5	0.4	-5.8	-6.0	-4.5	-4.8	-4.2	-1.7	-5.0	-5.1	-4.8	0.5
Arm fat-free mass (right)	2.7	13.9	35.6	-4.1	-2.4	-4.2	-1.1	-1.9	-1.9	-0.7	-1.3	0.6	-5.8	-6.0	-4.6	-5.0	-4.4	-1.4	-5.0	-5.3	-5.0	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	12.1	1.8	1.6	2.4	0.9	0.8	1.1	0.8	1.1	1.8	2.2	2.3	1.7	2.0	2.1	1.0	2.8	1.4	3.5	1.4
Arm predicted mass (right)	2.7	14.0	35.8	-4.2	-2.4	-4.2	-1.1	-2.0	-2.0	-0.8	-1.4	0.5	-5.8	-6.0	-4.5	-5.0	-4.4	-1.5	-5.0	-5.3	-4.9	0.0
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	12.0	2.9	0.0	1.5	0.4	0.5	0.2	1.0	0.3	-0.4	1.7	1.4	0.7	1.4	2.6	0.2	2.2	2.1	3.1	3.5
Number of full brothers	2.6	3.3	7.5	2.7	2.0	2.5	1.6	1.2	1.8	2.2	1.7	1.1	1.4	1.3	1.5	1.6	1.9	1.6	2.2	2.0	2.1	1.3
Basal metabolic rate	2.6	14.4	34.5	-4.3	-2.7	-4.3	-1.2	-2.1	-2.1	-0.6	-1.4	0.7	-5.8	-5.9	-4.4	-4.9	-4.5	-1.6	-4.9	-5.6	-5.2	-0.7
Arm fat-free mass (left)	2.6	13.1	34.6	-3.6	-2.6	-4.2	-1.1	-1.9	-2.0	-0.3	-1.3	0.4	-5.7	-5.9	-4.6	-4.7	-4.0	-1.5	-4.9	-5.1	-4.7	0.4
Impedance of leg (right)	2.5	12.2	104.0	4.3	0.7	0.3	1.2	1.8	1.6	3.8	1.6	0.5	-1.5	-2.5	-2.2	-1.5	2.2	1.3	-1.4	6.3	4.7	10.2
Wheeze or whistling in the chest in last year	2.5	4.5	12.9	-0.5	0.3	-1.9	0.1	0.0	0.1	-1.5	0.3	-1.7	-3.4	-3.1	-3.0	-2.7	-2.8	0.3	-2.1	-3.6	-2.5	-2.6
Leg predicted mass (right)	2.5	13.4	36.4	-4.9	-2.8	-4.2	-1.5	-2.4	-2.3	-1.6	-1.9	0.3	-4.6	-4.5	-3.2	-4.1	-4.5	-1.9	-4.0	-6.0	-5.6	-2.8
Leg predicted mass (left)	2.4	12.5	31.7	-4.7	-2.7	-4.1	-1.7	-2.5	-2.6	-1.4	-2.1	0.4	-4.5	-4.5	-3.0	-3.9	-4.1	-2.1	-4.1	-5.6	-5.4	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	16.9	-0.5	-1.5	-2.5	-1.0	-1.0	-0.9	0.5	-0.8	0.7	-3.7	-4.1	-3.1	-3.5	-2.2	-1.0	-2.9	-1.6	-0.1	3.5
Leg fat-free mass (right)	2.4	12.9	35.6	-4.8	-2.7	-4.1	-1.4	-2.3	-2.2	-1.5	-1.8	0.4	-4.6	-4.5	-3.1	-4.0	-4.5	-1.8	-3.9	-6.0	-5.6	-2.8
Financial situation satisfaction	2.4	3.0	7.7	2.3	1.6	2.1	1.8	1.8	1.3	1.8	1.3	0.4	1.4	1.1	0.5	1.2	2.0	1.6	2.0	1.9	2.0	2.8
Vitamin and mineral supplements	2.3	3.1	8.8	-2.1	-1.8	-2.5	-2.1	-1.7	-1.8	-1.1	-1.4	-2.1	-1.5	-1.5	-1.7	-1.1	-1.4	-1.8	-3.0	-0.8	-2.0	0.2
Leg fat-free mass (left)	2.3	12.3	31.5	-4.7	-2.6	-4.0	-1.7	-2.5	-2.5	-1.4	-2.0	0.4	-4.5	-4.4	-3.0	-3.8	-4.1	-2.1	-4.0	-5.6	-5.3	-2.4
Forced vital capacity (FVC)	2.3	8.9	25.8	-2.3	-1.6	-3.9	-1.4	-0.9	-1.0	0.9	-0.6	-1.3	-4.7	-5.1	-3.9	-5.0	-3.7	-1.0	-4.0	-2.7	-2.8	2.4
Heart disease (mother)	2.3	2.7	8.7	-1.3	-1.2	-1.9	0.0	-0.4	-0.1	-1.3	-0.2	-1.8	-1.8	-1.7	-1.7	-1.7	-1.9	-0.1	-2.4	-1.7	-3.0	-2.7
Had other major operations	2.2	2.7	7.8	1.5	0.0	2.0	0.3	0.3	0.1	-0.2	-0.0	0.4	2.3	2.4	2.3	2.8	2.6	-0.0	2.4	1.6	2.0	1.5
Angina (self-reported)	2.2	2.9	8.3	1.2	2.1	2.1	2.9	2.8	2.7	1.0	2.4	1.6	0.2	0.3	0.5	0.3	-0.3	2.7	1.6	0.2	1.2	-0.1
Fluid intelligence score	2.1	4.3	15.7	-1.8	-1.4	-4.0	-1.9	-2.3	-1.9	-1.4	-1.8	0.7	-2.1	-2.3	-2.0	-2.8	-2.5	-2.2	-2.2	-2.0	-0.7	0.1
Chest pain or discomfort	2.1	3.0	6.3	1.8	2.2	1.9	2.4	2.5	2.3	2.5	2.3	1.9	0.8	0.9	0.6	0.9	0.7	2.4	1.6	0.4	0.6	-0.2
Knee pain experienced in last month	2.1	3.2	5.8	0.5	0.9	-0.4	2.4	1.7	2.2	1.7	2.2	1.6	-2.4	-2.3	-2.1	-2.4	-2.0	2.3	-0.7	-1.1	-1.3	-1.4
Body Mass Index (BMI) (2010)	2.0	2.7	8.6	0.0	-0.2	1.7	-1.1	-1.0	-1.0	0.3	-0.9	-0.5	2.8	2.9	2.9	2.8	2.3	-1.0	2.0	0.9	1.1	-0.2
Angina	2.0	2.7	7.9	1.0	2.1	2.0	2.8	2.7	2.6	0.9	2.3	1.6	-0.1	0.0	0.2	-0.1	-0.6	2.6	1.4	-0.2	1.0	-0.4
Medication: Metformin	2.0	2.8	7.3	-1.7	-0.7	-1.7	-1.2	-0.9	-1.0	-1.6	-1.1	-1.1	-1.9	-1.7	-1.5	-1.5	-2.3	-1.0	-1.9	-2.7	-2.0	-2.5
Hearing aid user	2.0	2.3	6.0	-1.0	-1.3	-0.1	-2.5	-1.8	-2.1	-0.6	-1.9	-2.1	1.6	1.7	1.6	1.8	1.7	-2.1	0.3	0.3	0.1	0.4
Coronary Artery Disease (CAD)	1.9	2.3	6.8	-1.5	-2.6	-1.4	-1.6	-1.7	-1.7	-2.6	-1.9	-0.6	-1.3	-1.0	-0.1	-0.9	-1.0	-1.8	-1.3	-1.3	-1.1	-1.1
Hearing difficulty/problems: Yes	1.9	3.0	5.8	2.2	1.3	1.6	2.3	2.4	2.4	2.1	2.1	1.6	0.8	0.9	1.0	1.1	0.3	2.0	2.4	0.5	2.2	0.1
Depression (self-reported)	1.9	2.3	5.4	0.2	1.6	2.0	0.4	0.8	1.0	0.6	1.1	1.8	2.1	2.3	2.3	2.3	1.9	0.9	2.0	1.1	0.6	0.1
Medication: Paracetamol	1.9	3.2	16.9	4.1	-0.4	1.3	1.5	1.7	1.2	0.4	1.3	0.4	1.0	0.7	-0.6	0.5	1.7	1.4	1.6	1.8	3.5	3.0
High blood pressure (siblings)	1.9	2.7	8.0	1.7	-0.4	1.4	-0.7	-0.7	-0.5	0.5	-1.3	-0.6	1.9	1.9	2.2	1.9	2.4	-0.8	1.3	2.8	2.7	2.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.2	-1.8	-1.0	-1.6	-1.7	-1.1	-1.2	-2.0	-1.5	-1.4	-1.5	-1.4	-1.1	-1.7	-1.5	-1.3	-2.0	-1.6	-1.6	-1.2
Age at First Birth	1.8	2.7	7.6	-2.8	-1.2	-2.3	-0.3	-0.9	-0.7	-1.5	-0.4	-0.1	-1.8	-1.9	-2.4	-2.0	-1.9	-0.6	-2.5	-0.9	-2.1	0.4
Forced vital capacity (FVC), Best measure	1.8	6.6	17.8	-2.4	-1.8	-3.6	-1.6	-1.0	-1.0	0.9	-0.8	-0.9	-3.9	-4.2	-2.9	-4.2	-3.0	-1.0	-3.4	-2.2	-2.4	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.2	0.2	1.4	0.2	2.0	2.1	1.8	1.3	2.3	1.0	-1.7	-1.6	-1.8	-1.7	-0.9	2.1	-0.5	-1.3	-0.5	-0.4
Illnesses of father: Heart disease	1.8	2.6	4.2	1.9	0.3	2.0	1.9	1.1	2.1	0.8	1.2	1.7	1.7	1.9	1.7	1.7	1.7	1.7	1.8	1.6	1.5	-0.5
Friendships satisfaction	1.8	2.2	7.5	-1.5	-0.6	-2.1	-0.7	-0.8	-0.8	-1.1	-1.0	-0.7	-2.1	-2.2	-1.7	-2.7	-2.3	-0.8	-1.6	-1.1	-0.8	0.2
Heart disease (siblings)	1.8	2.2	5.5	0.7	1.4	1.0	2.3	1.7	2.2	1.0	2.2	1.0	-1.8	-1.6	-1.4	-1.0	-1.3	2.2	-0.8	-0.5	-0.9	-1.6
Neuroticism (2016)	1.7	2.4	7.4	1.5	1.0	1.3	0.1	-0.3	0.0	1.0	-0.0	-2.7	2.0	2.1	1.7	1.4	2.3	0.0	1.9	1.5	1.8	2.0
Lung FEV1/FVC ratio	1.7	8.8	40.7	1.8	-0.4	1.0	-1.3	-1.0	-1.0	0.0	-1.1	0.3	4.0	3.3	2.0	2.8	3.9	-1.4	1.7	6.2	4.5	6.4
Current tobacco smoking	1.7	2.7	8.2	2.6	1.0	2.9	2.0	1.5	1.5	1.1	1.2	0.5	0.8	0.8	0.9	1.5	1.7	1.7	2.2	0.7	2.4	1.8
Number of full sisters	1.7	2.1	7.5	1.3	-1.3	0.8	-1.4	-1.4	-1.0	-0.4	-1.3	-1.0	1.0	0.9	0.8	1.1	1.6	-1.4	0.7	2.2	2.7	2.7
Eye problems/disorders: Cataract	1.7	2.0	4.5	-1.4	-1.8	-1.5	-2.1	-2.1	-1.9	-1.1	-2.1	-1.0	-0.7	-0.9	-0.6	-1.1	-0.9	-2.0	-0.9	-0.6	-0.0	1.0
Osteoporosis (self-reported)	1.7	2.1	4.0	1.8	1.8	1.2	1.8	2.0	1.9	1.6	1.8	1.1	0.5	0.2	0.5	0.2	0.4	1.9	1.3	1.7	1.6	1.6
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.8	-1.2	-1.0	-1.6	-0.0	0.1	-0.2	-0.7	0.2	0.9	-2.3	-2.3	-2.4	-1.9	-1.7	-0.2	-2.2	-2.1	-0.9	-0.1
Ulcerative Colitis (UC)	1.6	3.0	12.2	-1.0	-1.1	-1.3	-0.9	-0.7	-0.4	-1.4	-0.5	0.7	-2.8	-2.2	-1.2	-1.9	-1.7	-0.7	-1.5	-3.0	-2.3	-3.5
Allergy or Eczema	1.6	4.1	16.6	-0.1	-1.3	-1.6	-0.6	-0.5	-0.1	-2.8	-0.1	-0.5	-2.9	-2.6	-2.1	-2.5	-2.7	-0.3	-1.7	-2.8	-2.2	-4.1
Qualifications: CSEs or equivalent	1.6	2.1	5.5	0.7	0.2	0.9	-1.1	-1.0	-0.9	2.0	-0.8	-0.9	1.7	1.9	1.8	2.0	2.3	-1.1	1.2	1.5	2.1	1.3
Serious illness, injury or assault to yourself	1.6	2.0	8.1	-1.0	-2.9	-2.0	-1.1	-1.4	-1.4	-1.0	-1.3	1.6	-1.4	-1.4	-1.1	-1.2	-1.0	-1.4	-0.7	-1.9	-0.0	-0.1
Number of incorrect matches in round	1.6	2.7	12.4	-3.3	1.0	-1.5	1.2	0.5	0.7	0.2	0.8	0.7	-1.8	-1.7	-1.6	-1.3	-2.0	0.9	-1.9	-1.4	-3.5	-0.9
Allergy	1.6	3.8	19.4	-0.5	-1.0	0.1	-1.9	-1.5	-2.0	1.0	-1.9	-1.5	2.2	1.9	1.9	1.8	2.4	-1.9	0.4	2.5	1.9	4.4
Prospective memory result	1.6	2.0	5.6	1.2	2.3	2.2	1.8	1.9	2.4	1.2	1.9	-0.7	0.7	0.7	-0.1	0.8	0.8	2.4	0.7	0.6	-0.1	-0.2
Medication: Amlodipine	1.6	2.2	6.3	-1.2	-1.4	-1.3	-1.5	-1.6	-2.0	-2.5	-1.7	-1.2	-0.2	-0.1	-1.0	-0.5	-1.0	-1.5	-1.8	-1.3	-1.5	-2.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.4	0.2	0.1	-0.7	1.9	0.7	0.9	0.9	1.3	0.1	-2.2	-2.1	-2.3	-1.8	-1.2	1.1	-1.3	-1.8	-1.5	-0.8
Medication: Aspirin	1.6	2.1	5.3	0.3	0.5	-0.5	1.1	1.0	0.4	-0.7	0.4	0.3	-2.1	-2.2	-2.3	-2.1	-2.3	0.7	-2.0	-1.2	-1.5	-2.0
Depression (Nagel 2018)	1.5	2.3	6.4	2.1	2.2	1.6	2.1	1.7	1.2	1.4	1.4	0.0	0.6	0.3	-0.0	0.6	1.0	1.3	1.1	2.2	1.8	2.5
Asthma	1.5	2.9	20.3	-0.1	0.9	0.3	1.8	1.5	1.8	-0.5	1.6	0.2	-1.1	-0.7	-0.9	-0.8	-1.7	2.0	0.2	-2.5	-2.4	-4.5
Smoking status: Current	1.5	2.3	6.9	2.4	0.9	2.6	2.1	1.5	1.5	1.0	1.3	0.9	0.5	0.6	0.6	1.2	1.3	1.7	1.9	0.3	2.2	1.7
Medication: Paracetamol	1.5	2.4	11.4	3.4	-0.8	1.5	1.0	1.5	1.0	0.7	1.0	0.3	0.9	0.8	0.2	0.6	1.5	1.1	1.9	1.1	3.2	2.2
Impedance of whole body	1.5	7.7	68.0	3.1	0.4	-0.4	0.5	1.1	0.9	2.5	0.7	-0.1	-0.7	-1.6	-1.7	-1.4	1.4	0.6	-1.3	5.8	3.8	8.2
Ulcerative Colitis	1.4	2.0	11.0	-0.5	-0.1	-0.4	0.3	0.7	0.5	-0.4	0.3	0.3	-2.3	-1.9	-1.2	-1.3	-1.5	0.4	-1.1	-2.1	-2.3	-3.3
Hayfever, allergic rhinitis or eczema	1.4	3.0	11.5	-0.0	-0.5	-1.2	0.5	0.4	0.9	-1.6	1.0	0.9	-2.6	-2.4	-2.2	-2.3	-2.5	0.8	-1.1	-2.3	-1.7	-3.4
Heart attack	1.4	1.8	5.2	1.2	2.3	2.1	1.1	1.2	1.3	1.7	0.7	0.7	0.9	0.8	1.1	0.6	1.5	1.2	1.7	0.9	1.7	1.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	13.4	-1.3	-1.5	-3.2	-1.9	-1.3	-1.2	0.8	-0.9	-1.4	-2.8	-3.2	-2.4	-3.4	-2.2	-1.5	-2.8	-0.4	-0.7	3.7
Medication: Ibuprofen	1.4	1.7	7.9	2.1	-1.3	1.1	0.3	0.2	0.4	-0.0	0.3	0.9	1.1	1.0	0.2	0.7	1.3	0.2	1.3	1.8	2.8	2.5
Medication: Aspirin	1.4	1.8	5.3	0.2	0.6	-0.6	0.9	0.7	0.3	-0.9	0.1	-0.0	-1.9	-2.1	-2.2	-2.0	-2.3	0.5	-2.0	-1.1	-1.4	-1.7
Irritable Bowel Disease (IBD)	1.3	3.1	11.1	-1.4	-1.8	-1.3	-1.8	-1.7	-1.5	-2.0	-1.6	0.0	-2.0	-1.3	-0.6	-0.9	-1.0	-1.7	-1.4	-2.8	-2.2	-3.3
Fasting Glucose	1.3	1.6	6.6	1.6	1.1	1.2	0.2	0.4	-0.1	-0.3	0.3	-0.8	1.5	1.1	0.3	1.0	1.2	0.0	0.9	2.3	2.4	2.6
Lupus	1.3	2.0	5.6	1.5	1.8	0.9	2.3	2.4	2.2	1.4	1.7	2.0	-0.4	-0.3	-0.1	-0.1	0.1	2.0	1.5	-0.7	0.5	0.7
Medication: Atenolol	1.3	1.6	5.5	1.6	2.0	1.6	1.1	0.5	0.9	1.2	0.5	0.3	0.8	0.7	1.0	0.8	1.6	0.8	0.7	2.4	1.6	1.5
Weight	1.3	6.4	15.1	-2.6	-2.4	-3.1	-1.1	-1.8	-1.9	-0.7	-1.3	0.8	-3.8	-3.9	-2.9	-2.9	-2.2	-1.5	-3.7	-2.9	-3.7	0.4
Birth weight	1.3	2.9	9.1	-3.0	-2.2	-1.7	-2.6	-2.1	-1.7	-2.1	-2.0	-0.5	-0.5	-0.4	0.4	-0.8	-1.6	-2.1	-1.1	-2.0	-1.3	-0.7
Qualifications: College or University degree	1.3	4.2	12.3	-3.2	-1.4	-3.2	-1.1	-1.3	-1.3	-2.5	-1.4	1.0	-1.6	-1.7	-1.3	-2.8	-3.5	-1.2	-1.9	-2.0	-2.1	-1.9
Mean time to correctly identify matches	1.3	2.5	7.4	-2.3	-0.7	-1.5	-0.4	-0.5	-0.8	-1.8	-0.5	-1.6	-1.6	-1.7	-1.9	-1.1	-2.0	-0.5	-2.5	-1.7	-2.7	-1.5
Asthma (self-reported)	1.3	2.5	17.5	0.3	1.0	0.5	1.7	1.5	1.9	-0.2	1.7	0.2	-0.9	-0.5	-0.7	-0.6	-1.2	2.1	0.5	-2.2	-2.1	-4.2
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.3	1.1	1.1	1.4	2.1	2.0	1.6	-0.0	1.9	0.6	-0.4	-0.1	0.5	-0.2	-0.1	2.0	1.8	-1.3	0.4	-1.2
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.3	1.1	2.1	2.0	1.0	0.9	1.0	1.4	0.4	0.4	1.0	1.0	1.2	0.8	1.7	0.9	1.6	1.1	1.8	1.6
Verbal and Numeric Reasoning (VNR)	1.2	2.8	12.5	-0.7	0.6	-3.0	-0.0	-0.3	0.1	-0.2	-0.2	0.3	-2.4	-2.6	-2.2	-3.5	-2.8	-0.1	-1.5	-1.7	-0.6	-0.2
High blood pressure (mother)	1.2	1.7	5.9	1.7	-0.6	0.5	-0.7	-0.7	-0.3	-1.0	-0.5	-1.9	1.5	1.6	1.3	1.0	2.0	-0.4	1.0	2.4	1.7	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	8.8	1.9	-1.8	0.1	-0.2	-0.6	-0.4	-0.3	-0.4	0.3	0.7	0.4	-0.5	0.2	0.8	-0.5	0.3	1.8	2.5	3.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	16.2	-1.4	-1.8	-2.8	-2.5	-1.7	-1.6	0.7	-1.5	-1.4	-1.8	-2.2	-1.2	-2.5	-1.4	-2.0	-2.1	0.0	-0.0	4.0
Worry too long after embarrassment	1.2	2.0	5.5	-2.3	-0.6	-2.2	-0.9	-1.7	-1.7	-2.1	-1.4	-1.3	-0.3	-0.4	-0.8	-1.6	-1.2	-1.6	-1.8	0.2	-1.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.3	1.2	-0.3	1.4	-0.4	-0.6	-0.5	0.4	-0.6	-0.3	1.5	1.6	1.3	1.9	2.1	-0.8	0.9	1.6	1.6	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.7	1.6	1.2	1.3	1.5	1.2	1.4	1.5	1.3	1.0	0.6	0.4	0.3	0.4	0.7	1.4	1.1	1.2	1.1	1.3
Miserableness	1.2	2.0	8.8	3.0	1.3	1.8	0.7	0.6	0.5	1.3	0.4	0.6	1.0	1.0	1.2	1.5	2.1	0.6	1.4	1.9	1.7	1.5
Reaction Time	1.1	2.1	8.6	-2.1	-0.2	-1.2	-0.1	-0.2	-0.2	-0.8	-0.1	-1.7	-1.4	-1.4	-1.2	-0.9	-2.2	-0.1	-2.0	-1.5	-2.9	-2.2
Smoking Status	1.1	2.6	9.6	1.7	1.6	3.1	1.4	1.3	1.1	1.4	1.3	0.9	1.1	1.2	1.7	1.9	2.3	1.4	2.0	0.7	1.6	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	9.5	-2.0	-0.9	-0.8	0.4	-0.2	-0.2	-0.4	0.3	-0.1	-1.0	-0.9	-0.7	-0.7	-1.2	0.1	-1.1	-0.9	-3.1	-2.2
Hand grip strength (right)	1.1	2.9	6.3	-2.0	-1.5	-2.3	-0.6	-1.0	-0.9	0.2	-0.7	0.1	-2.4	-2.5	-2.0	-2.4	-2.3	-0.9	-1.8	-2.5	-2.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.9	1.7	1.7	1.3	1.2	1.3	0.8	1.1	1.0	-0.2	0.1	-0.0	0.2	0.2	0.8	1.0	1.0	1.5	2.0	2.4
Multivitamins +/- minerals	1.1	1.4	5.0	0.9	1.0	1.5	0.6	0.5	0.4	1.2	0.3	0.6	1.4	1.6	1.9	1.4	1.3	0.4	2.2	0.1	1.7	-0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.9	-2.0	-1.5	-1.1	-1.5	-0.9	-1.2	-1.3	-1.0	0.2	-0.7	-0.7	-0.7	-0.6	-1.1	-1.1	-1.4	-1.0	-1.6	-1.0
Chronic bronchitis/emphysema (father)	1.1	1.3	4.2	-1.5	-0.8	-1.7	-1.1	-0.9	-1.2	-0.7	-1.5	-2.1	-0.4	-0.4	-0.7	-0.3	-0.3	-1.0	-1.0	-1.5	-1.8	-0.1
Time employed in main current job	1.1	1.3	4.1	-1.3	0.9	-1.1	-0.7	-0.8	-0.7	-0.7	-0.7	-1.7	-1.3	-1.3	-1.6	-0.9	-1.2	-0.5	-2.0	-1.1	-1.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.8	0.4	1.0	1.2	0.5	0.1	0.2	-0.4	0.5	-0.2	2.2	2.2	1.2	1.5	1.4	0.3	0.6	2.0	0.2	0.0
Age at first live birth	1.1	1.9	4.6	-1.7	0.2	-0.9	1.1	1.1	1.4	-0.4	1.3	0.3	-1.5	-1.6	-2.0	-1.9	-2.1	1.3	-1.4	-1.3	-1.8	-0.8
Back pain experienced in last month	1.1	1.5	10.0	1.5	-1.2	0.6	0.4	-0.3	-0.6	0.1	-0.4	-0.4	0.9	0.7	0.7	0.3	1.8	-0.2	1.1	1.6	2.3	3.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.8	-1.4	0.6	-1.1	-0.1	0.8	0.4	-0.3	0.7	0.7	-1.7	-1.7	-1.6	-1.5	-1.4	0.4	-1.5	-1.1	-1.7	-0.7
Myopia	1.1	1.6	5.5	0.4	2.4	0.7	1.5	2.0	2.1	-0.7	1.1	0.3	0.8	0.9	1.0	0.4	-1.0	1.8	1.4	0.6	0.5	-1.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.7	-0.5	-0.5	0.6	-1.4	-1.6	-1.4	-1.3	-1.3	0.1	1.5	1.5	1.1	1.5	0.9	-1.5	0.1	0.8	0.7	0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	6.7	-0.5	-0.2	0.1	-1.1	-1.2	-0.9	-0.3	-0.9	0.3	1.6	1.4	0.6	1.2	1.0	-1.1	-0.2	2.2	1.4	2.6
Hypothyroidism (self reported)	1.0	2.2	4.2	-2.0	-0.9	-2.0	-0.2	-0.5	-0.3	-0.8	-0.0	-0.3	-2.0	-1.8	-2.0	-2.0	-2.0	-0.2	-2.0	-1.9	-2.0	-1.5
Respiratory disease	1.0	2.2	17.0	0.5	0.3	0.2	1.0	1.0	1.0	-1.4	1.0	-1.1	-0.9	-0.4	-0.6	-0.6	-1.7	1.3	0.5	-2.5	-2.0	-4.1
Average weekly spirits intake	1.0	1.2	3.6	-0.4	-0.7	-1.6	-0.4	-0.7	-0.7	-1.1	-0.3	0.0	-1.5	-1.5	-1.8	-1.3	-1.7	-0.7	-1.2	-1.9	-0.2	-0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.7	0.7	2.2	1.4	1.5	1.3	1.0	0.9	1.1	0.9	0.7	0.6	0.5	0.6	0.9	1.1	1.2	1.7	1.3	1.7
Severe depression (siblings)	1.0	1.1	3.1	0.8	-0.3	0.9	-1.0	-0.7	-1.0	-0.6	-0.7	-0.4	1.2	1.2	1.8	1.3	1.3	-1.0	1.3	0.9	1.4	1.1
Hearing difficulty/problems with background noise	1.0	1.6	4.5	-0.0	-0.4	-1.0	2.1	2.0	1.6	0.7	1.6	0.4	-1.3	-1.1	-1.8	-1.0	-1.5	1.5	-0.7	-1.5	-0.8	-0.3
Peak expiratory flow (PEF)	1.0	2.2	6.9	-0.9	-0.2	-2.6	-1.9	-1.6	-1.1	0.2	-0.9	-0.6	-1.8	-2.0	-1.4	-2.1	-1.2	-1.6	-1.9	-0.3	-0.3	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.2	0.7	0.3	0.1	2.1	1.2	0.9	0.2	1.4	-0.2	-1.2	-1.4	-1.8	-1.2	-0.9	1.4	-0.9	-0.6	-1.1	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	8.4	2.9	0.5	1.9	1.9	1.0	1.3	-0.2	1.2	1.3	0.5	0.7	0.0	0.9	1.2	1.5	1.1	1.0	0.9	-1.4
Average weekly champagne plus white wine intake	1.0	1.4	3.4	-0.7	1.2	-0.2	1.7	1.5	1.5	0.5	1.3	0.8	-1.1	-1.1	-0.8	-1.4	-1.0	1.4	-0.5	-1.1	-1.8	-1.6
Ever taken oral contraceptive pill	1.0	1.1	4.5	0.3	1.7	0.7	1.6	1.5	1.4	-0.3	1.4	2.1	0.1	0.2	0.2	-0.1	-0.1	1.3	0.9	-0.3	0.2	-0.8
Medication: Bendroflumethiazide	1.0	1.6	6.6	1.5	1.1	1.7	0.7	1.2	1.3	0.4	0.7	0.6	1.2	1.0	0.9	1.3	1.7	1.2	0.9	2.6	0.8	1.4
Cholesterol lowering medication	1.0	1.5	4.3	0.4	-1.9	-1.5	-0.0	-0.8	-0.4	0.1	-0.6	0.0	-1.9	-1.8	-2.1	-1.8	-1.4	-0.5	-1.6	-1.4	0.3	-0.1
Pack years of smoking	1.0	1.5	5.9	0.9	0.9	-0.5	1.3	0.8	0.6	0.3	0.9	-0.9	-1.8	-2.0	-2.4	-1.7	-1.6	1.0	-1.5	-0.8	-0.7	0.5
Sensitivity / hurt feelings	0.9	1.5	3.8	-0.8	-0.4	-1.6	-0.4	-0.7	-1.1	-1.9	-0.7	-1.9	-1.2	-1.4	-1.4	-1.8	-1.4	-1.0	-1.5	-0.2	-0.5	1.0
Supplements: Zinc	0.9	1.0	3.5	-0.7	-1.1	-0.2	-0.9	-1.3	-1.2	-1.9	-1.4	-1.4	0.7	0.8	0.6	0.6	0.8	-1.3	0.3	0.6	0.6	0.5
Fed-up feelings	0.9	1.7	3.6	1.9	1.5	1.6	1.7	1.2	1.1	1.0	1.0	0.1	0.9	1.1	1.0	0.6	1.5	1.2	1.7	1.3	1.7	1.3
Taking other prescription medications	0.9	1.4	4.9	-0.5	-1.1	-0.9	0.4	0.0	0.2	-1.2	0.5	0.1	-1.8	-1.6	-1.6	-1.6	-1.3	0.4	-0.8	-2.2	-0.8	-1.8
Past tobacco smoking	0.9	1.6	4.6	-0.7	-0.6	-2.1	-0.9	-0.6	-0.9	-0.6	-1.0	-0.7	-1.2	-1.4	-2.1	-1.8	-1.9	-1.1	-2.0	-0.6	-0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	1.0	1.6	0.8	1.8	1.8	1.4	1.6	1.7	0.7	-0.5	-0.6	-0.8	-0.2	0.2	1.6	0.6	0.3	0.6	1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.2	2.0	-0.3	1.0	1.6	1.0	1.6	0.5	1.6	1.4	-0.4	-0.4	-1.0	-0.4	-0.1	1.5	0.3	0.6	1.2	-0.2
Number of live births	0.9	1.3	4.0	2.0	0.4	0.7	2.0	1.8	1.4	1.6	1.3	-1.0	-0.7	-0.8	-0.8	-0.8	0.5	1.8	0.5	0.0	-0.4	0.6
Loud music exposure frequency	0.9	0.9	3.1	1.4	0.5	1.1	-0.6	-0.6	-0.1	0.1	-0.3	0.5	1.2	1.4	0.9	1.6	1.8	-0.1	1.1	0.7	1.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.7	-1.7	-0.9	-1.7	-0.4	-0.7	-0.5	-1.7	-0.2	-0.3	-1.6	-1.5	-1.6	-1.4	-1.9	-0.6	-1.7	-1.7	-1.4	-1.6
Exposure to tobacco smoke outside home	0.9	1.3	7.9	0.0	-1.4	-0.1	-1.0	-1.4	-1.0	0.4	-1.0	0.6	0.6	0.5	-0.3	0.4	1.0	-1.3	-0.4	1.6	1.3	2.8
Neck or shoulder pain in last month	0.9	1.3	3.8	1.8	-0.3	1.6	0.1	-0.0	0.0	-0.6	-0.2	1.9	1.1	1.0	1.0	1.2	1.1	0.1	1.5	1.0	2.0	1.0
Pulse rate, automated reading	0.9	2.8	6.5	-0.3	-2.1	-1.8	-1.1	-0.8	-1.2	-2.5	-1.0	-0.9	-2.3	-2.0	-2.1	-2.0	-2.0	-1.1	-1.7	-2.3	-1.0	-0.9
Age at last live birth	0.9	1.4	4.9	0.5	0.5	0.9	2.0	1.9	2.1	1.0	2.0	-0.4	-0.0	-0.2	-1.1	-0.6	-0.4	2.2	0.3	0.4	-0.1	0.7
Leg pain on walking	0.9	1.1	3.7	-0.5	-1.2	-0.4	-1.9	-1.9	-1.4	-1.0	-1.0	-1.0	-0.4	-0.2	-0.3	0.3	-0.2	-1.5	-0.7	-1.6	-0.2	-0.8
Eye problems/disorders: Glaucoma	0.9	1.1	6.1	-0.6	0.8	0.4	0.7	0.6	0.8	-1.1	1.0	0.7	-0.9	-0.8	-0.3	-0.7	-1.6	0.8	-0.1	-1.5	-1.4	-2.5
Number of operations (self-reported)	0.9	1.3	8.5	2.2	-1.1	0.6	0.6	0.2	-0.2	-0.1	-0.1	0.6	0.3	0.1	-0.1	0.6	1.7	-0.1	1.0	1.0	2.1	2.9
Age started oral contraceptive pill	0.9	1.1	2.9	-0.6	1.7	-1.0	0.6	1.0	0.6	-0.7	0.7	-0.7	-1.1	-1.3	-1.6	-1.4	-1.3	0.8	-1.5	0.1	-1.4	-0.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	11.3	-1.1	-0.1	-3.2	-0.3	-0.5	0.4	0.3	-0.2	0.8	-2.0	-2.2	-2.0	-3.4	-2.3	-0.2	-1.4	-0.5	0.1	0.8
Alzheimer’s Disease (in father)	0.8	0.8	7.6	0.6	0.4	-0.1	0.2	0.2	0.3	1.1	0.1	-0.4	0.5	0.2	-0.4	-0.0	0.3	0.0	-0.4	1.8	1.4	2.8
BMI	0.8	4.6	19.0	-0.2	-1.6	1.8	-1.2	-1.5	-1.2	-1.8	-1.1	1.5	2.7	3.3	3.5	3.3	1.7	-1.1	2.2	-0.7	-0.7	-4.4
Medication: Co-codamol	0.8	0.9	3.2	-0.1	0.8	1.8	0.7	1.1	0.6	-0.3	0.9	-0.0	1.1	1.3	1.2	1.3	0.6	0.7	1.5	-0.2	1.1	-0.4
Diabetes (father)	0.8	1.0	5.9	-0.6	1.7	-0.3	0.5	0.8	0.4	0.5	0.5	0.6	-0.8	-0.5	-0.3	-0.7	-1.3	0.7	0.1	-1.7	-0.8	-2.4
Diabetes (mother)	0.8	1.0	2.5	0.7	-0.6	0.6	-0.4	-1.0	-0.5	-0.5	-0.8	-1.1	1.4	1.6	1.4	1.6	1.3	-0.8	0.8	0.8	1.3	-0.1
Pack years adult smoking proportion	0.8	1.2	4.9	0.9	0.6	-0.6	0.9	0.4	0.3	-0.1	0.5	-1.1	-1.6	-1.8	-2.2	-1.5	-1.3	0.6	-1.5	-0.6	-0.8	0.6
Relative age voice broke	0.8	1.2	3.0	-1.7	-0.3	-1.7	-1.3	-1.2	-0.9	-1.1	-1.0	-0.3	-1.0	-1.0	-0.1	-1.6	-1.4	-1.2	-0.7	-1.1	0.3	0.1
Impedance of arm (right)	0.8	3.9	29.8	2.0	0.6	-0.2	0.0	0.5	0.3	2.3	0.1	-0.0	0.1	-0.5	-0.4	-0.6	1.4	0.1	-0.5	4.8	2.9	5.5
Alcohol intake versus 10 years previously	0.8	1.3	3.6	1.4	1.4	1.8	0.5	0.7	0.7	0.1	0.5	1.6	1.0	0.9	0.9	1.1	1.0	0.6	1.3	1.3	1.9	0.7
Noisy workplace	0.8	1.0	3.7	0.8	-0.3	1.4	-0.8	-0.4	-0.3	-0.4	-0.5	-1.1	1.5	1.5	0.9	1.9	1.8	-0.3	0.6	1.0	0.6	-0.0
Lung cancer (father)	0.8	0.9	3.9	0.9	2.0	1.1	0.3	0.8	1.2	1.2	0.8	0.7	0.9	0.9	0.7	0.5	0.5	0.9	1.1	0.6	1.1	0.4
Pulse wave reflection index	0.8	1.0	3.3	1.7	1.1	1.4	0.9	0.7	0.4	1.6	0.6	0.6	0.7	0.5	0.5	0.8	0.8	0.6	1.2	1.1	1.8	0.6
Eye problems/disorders: None of the above	0.8	0.9	2.7	0.6	-0.2	0.4	0.6	0.4	0.4	0.3	0.4	0.3	1.4	1.5	1.1	1.3	1.7	0.2	1.1	1.5	1.3	0.6
Medication for pain relief, constipation, heartburn	0.8	1.4	7.6	-2.8	1.0	0.2	-1.3	-0.5	-0.4	0.3	-0.6	-0.1	0.6	0.9	2.1	1.0	0.0	-0.6	0.3	-0.5	-2.0	-1.8
Osteoarthritis (self-reported)	0.8	1.1	3.3	0.4	-0.8	0.1	1.8	1.7	1.2	-0.2	1.6	0.8	-1.0	-1.0	-1.3	-1.1	-0.5	1.6	0.3	-0.9	-0.2	0.0
Illnesses of father: High blood pressure	0.8	1.0	2.7	-0.9	-0.9	-0.6	-1.3	-1.3	-1.6	-1.2	-1.4	-1.4	0.8	0.9	0.6	0.4	1.0	-1.3	0.5	0.3	0.2	0.5
Major Depression (MDD)	0.7	0.8	1.9	0.0	0.6	1.3	1.1	0.8	1.3	1.3	1.1	1.4	0.3	0.4	0.6	0.0	0.7	1.1	1.3	0.3	0.6	-0.8
Ovarian Cancer	0.7	1.0	2.5	-1.4	0.0	-1.1	-1.0	-0.8	-1.1	-1.6	-1.5	-0.2	-0.8	-0.8	-0.9	-1.3	-1.3	-1.3	-0.8	-0.8	0.1	0.0
Blood Eosinophil Count	0.7	5.1	30.0	-1.1	-0.4	-1.9	0.3	-0.3	-0.5	-2.5	-1.0	-1.6	-2.6	-1.9	-1.8	-2.8	-2.5	-0.3	-2.2	-2.6	-3.6	-5.5
Hand grip strength (left)	0.7	1.8	4.3	-1.3	-0.1	-1.3	0.4	0.3	0.2	1.2	0.3	0.8	-2.0	-2.1	-2.1	-2.0	-1.8	0.2	-1.6	-1.3	-2.0	0.5
Townsend deprivation index at recruitment	0.7	1.0	3.0	1.7	0.3	1.1	1.0	0.7	0.9	1.3	0.6	0.4	0.9	1.0	0.2	1.1	1.6	1.0	1.1	0.8	0.8	0.5
Average weekly fortified wine intake	0.7	0.8	2.5	0.7	-0.8	-0.3	-1.5	-0.6	-0.9	-1.0	-0.6	-0.2	0.5	0.1	-0.6	0.1	0.2	-1.0	-0.6	1.6	1.4	1.4
Maternal smoking around birth	0.7	1.0	5.2	2.3	0.1	1.0	0.8	0.1	0.5	1.0	0.2	0.2	0.5	0.3	-0.1	0.7	1.4	0.5	0.7	1.6	0.9	2.0
Waist circumference	0.7	2.6	8.4	-0.4	-1.8	-2.0	-0.4	-1.1	-1.0	-0.7	-0.5	0.7	-2.8	-2.9	-2.2	-2.0	-0.9	-0.7	-2.4	-1.2	-2.3	0.6
Hip circumference	0.7	3.2	7.2	-2.6	-2.6	-1.5	-2.0	-2.7	-2.6	-1.4	-2.2	0.1	-0.5	-0.3	0.2	0.1	-0.3	-2.5	-1.6	-1.7	-2.4	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.0	0.7	1.2	0.9	0.4	0.7	0.0	-0.2	0.3	-0.5	1.7	1.7	1.4	1.5	1.2	0.4	1.7	1.1	1.4	0.9
Falls in the last year	0.7	1.0	3.5	1.2	-0.0	0.2	1.9	1.6	1.6	0.7	1.7	0.1	-0.3	-0.3	-0.7	-0.6	-0.6	1.7	0.0	0.6	-0.7	-0.4
Hair/balding pattern: Pattern 3	0.7	1.0	2.7	0.3	0.3	1.6	0.8	0.9	0.5	-0.3	1.0	0.8	1.5	1.6	1.2	1.6	1.2	0.7	1.3	-0.2	0.3	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	3.0	1.2	0.2	-0.4	-0.0	0.1	-0.3	0.9	-0.4	0.6	-1.6	-1.7	-1.4	-1.6	-0.6	-0.1	-0.6	-0.3	0.8	0.4
Impedance of arm (left)	0.7	3.1	25.6	1.3	0.6	-0.8	-0.3	0.2	-0.1	1.4	-0.3	-0.3	-0.3	-0.9	-0.9	-1.1	0.6	-0.3	-1.1	4.2	2.2	5.1
Smoking status: Previous	0.7	1.1	4.3	0.2	0.7	1.4	0.2	0.3	0.4	0.5	0.7	0.1	1.2	1.4	2.1	1.6	1.7	0.6	1.5	0.8	0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.7	-0.7	-0.2	0.7	-0.4	-0.9	-0.6	-0.6	-0.8	-0.7	1.4	1.5	1.9	1.5	0.9	-0.7	0.5	1.1	-0.1	0.1
Qualifications: nursing, teaching	0.7	1.1	3.8	-1.6	-0.1	-1.6	0.3	0.7	0.5	-0.5	0.5	1.4	-0.7	-0.8	-1.2	-1.4	-1.9	0.3	-0.8	-1.2	-0.8	-0.5
Mineral and other dietary supplements	0.7	1.0	4.0	-0.5	-2.0	-1.3	-1.3	-0.9	-1.0	-1.3	-0.8	-1.2	-0.2	-0.3	-0.8	-0.1	-0.7	-1.1	-1.5	0.2	-0.5	0.6
Medication: Atorvastatin	0.7	0.9	2.2	1.5	-0.2	1.0	0.7	1.2	1.2	0.3	0.8	1.0	0.7	0.7	0.1	0.3	0.9	1.1	1.1	1.1	1.5	0.9
Ever smoked	0.7	1.3	4.5	0.3	0.1	1.9	0.7	0.3	0.7	0.5	0.5	1.1	1.2	1.4	2.1	1.9	1.4	0.9	1.7	0.5	0.4	-0.0
Schizophrenia (2018)	0.6	1.2	2.6	0.7	1.6	0.6	1.2	1.4	1.1	1.0	1.5	1.1	1.1	0.9	0.8	0.7	0.5	1.2	1.4	1.5	0.1	1.1
Crohns Disease (2017)	0.6	1.2	3.6	-1.2	-1.5	-0.7	-1.4	-1.9	-1.6	-1.2	-1.6	-0.2	-0.3	0.0	0.1	0.2	0.1	-1.7	-0.6	-1.2	-0.7	-1.0
Prostate Cancer	0.6	0.8	2.8	-0.3	0.1	-0.5	-0.2	0.2	0.1	-0.1	0.2	-1.7	-0.9	-0.8	-1.0	-0.8	-1.3	0.0	-1.3	-1.3	-1.5	-1.4
Rheumatoid Arthritis	0.6	0.9	4.7	2.2	0.4	0.7	0.9	0.5	1.0	2.1	0.7	0.9	-0.7	-0.8	-0.8	-0.3	0.3	1.0	-0.1	0.7	0.3	0.2
Blood Red Count	0.6	6.0	51.6	-0.1	-0.1	-0.6	-0.0	-0.2	-0.6	-1.2	-0.2	-0.2	-2.6	-1.8	-1.6	-1.4	-2.3	-0.1	-2.4	-3.5	-4.7	-7.2
Cardiovascular Disease	0.6	2.0	10.9	2.8	-1.5	0.8	-0.5	-1.2	-0.8	0.1	-1.3	-0.2	1.2	1.0	0.7	1.3	2.2	-0.6	0.2	3.3	0.9	1.3
Age when periods started (menarche)	0.6	1.3	7.0	-2.1	0.8	-1.3	-0.1	0.2	0.1	-0.1	0.0	-0.4	-1.1	-1.1	-1.1	-1.2	-1.1	0.1	-2.2	-0.4	-2.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	7.6	0.6	1.5	1.3	1.1	1.0	1.6	1.3	1.4	1.0	0.5	0.7	0.7	1.0	0.0	1.2	0.6	-0.9	-0.9	-2.8
Medication: Levothyroxine sodium	0.6	1.0	2.1	-1.4	-0.6	-1.2	-0.8	-0.8	-1.0	-1.5	-0.8	-0.9	-0.6	-0.5	-0.6	-0.8	-1.4	-0.9	-1.0	-1.0	-0.7	-1.4
Sitting height	0.6	4.0	9.3	-3.0	-2.1	-1.9	-2.5	-2.9	-2.8	-1.3	-2.5	-0.4	-1.2	-1.7	-0.9	-1.3	-1.3	-2.5	-2.2	-1.9	-2.2	0.8
Body mass index (BMI)	0.6	2.7	12.0	-0.2	-0.7	1.2	-0.6	-1.0	-0.9	-1.4	-0.7	1.0	2.0	2.5	2.6	2.8	1.6	-0.8	1.4	-0.7	-1.1	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	14.4	0.2	1.0	0.6	0.7	0.4	1.1	0.1	1.1	0.3	-0.1	0.2	-0.0	0.7	-0.3	0.9	-0.3	-1.5	-1.9	-3.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	0.2	0.5	0.9	0.8	1.3	1.5	-0.4	1.5	0.9	-0.6	-0.5	0.0	-0.0	-0.4	1.5	0.9	-0.5	0.0	-0.3
Qualifications: None of the above	0.6	1.2	4.7	2.2	-0.2	1.9	1.4	1.1	1.2	0.9	1.4	-1.1	-0.5	-0.4	-0.8	0.9	0.7	1.5	0.3	-0.9	-0.3	-0.6
Arm fat percentage (right)	0.6	2.3	8.1	0.8	-0.5	1.4	-0.5	-0.6	-0.7	-0.4	-0.4	1.3	2.1	2.4	2.8	2.6	2.2	-0.6	1.6	1.2	0.1	-1.7
Worrier / anxious feelings	0.6	1.1	2.4	-0.9	1.6	-0.8	1.0	1.2	0.5	-0.1	0.8	0.8	-1.0	-1.2	-1.5	-1.5	-1.4	0.8	-1.1	-0.2	-1.3	0.3
Pulse rate	0.6	1.0	3.3	-0.2	-0.5	-0.8	0.1	0.8	0.7	-1.8	0.2	0.6	-1.1	-0.9	-1.4	-1.4	-1.7	0.5	-0.9	-1.4	-0.5	-1.3
Medication: Lansoprazole	0.6	0.7	2.6	0.1	0.8	1.1	1.1	1.3	1.6	0.0	1.5	0.4	0.1	0.1	-0.6	0.1	0.6	1.6	-0.2	-0.2	-0.4	-0.5
Illnesses of mother	0.6	0.8	3.4	-0.2	1.3	0.6	0.7	1.5	1.3	0.9	0.6	1.8	0.1	0.0	0.1	-0.2	-0.8	1.0	1.1	-0.4	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.7	0.1	0.5	-0.5	-1.2	-0.9	-0.9	0.6	-1.3	0.7	1.0	0.8	0.7	-0.0	0.2	-1.2	0.3	1.6	1.6	1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.9	-0.4	0.2	0.0	-1.2	-1.1	-1.2	-0.8	-1.0	-2.0	0.7	0.7	0.5	1.0	0.7	-1.2	-0.2	0.2	-0.6	-0.3
Blood clot in the leg (DVT)	0.6	0.8	7.0	1.2	-0.1	0.5	-0.2	-0.2	-0.2	-0.1	-0.1	0.9	-0.3	-0.7	-1.1	-0.4	-0.0	-0.1	-0.4	1.1	1.4	2.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.9	-1.1	0.7	-0.9	0.7	0.6	0.8	0.5	0.9	1.5	-0.9	-0.7	-0.7	-1.0	-1.5	0.7	-0.0	-2.0	-0.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	6.0	0.5	0.9	1.3	0.4	0.7	0.8	0.4	0.4	-1.1	0.2	0.6	1.0	0.9	0.2	0.7	0.7	-0.5	-0.8	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.1	0.6	0.6	1.0	1.4	1.5	1.2	1.2	1.0	0.7	0.1	0.2	0.6	0.4	0.2	1.4	0.9	0.2	-0.3	-0.7
Had major operations	0.6	0.7	1.7	1.3	0.9	0.8	1.3	1.2	1.0	1.3	1.0	0.8	0.0	0.0	0.1	0.3	0.1	0.9	0.6	0.1	0.8	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.9	0.3	-1.7	-0.6	-0.8	-0.7	-1.0	-1.1	-0.8	0.5	0.4	0.3	0.1	0.5	0.7	-1.1	-0.2	0.6	0.5	1.6
Medication: Gliclazide	0.6	0.7	5.1	-0.8	-0.2	0.1	-0.8	-0.1	-0.3	-0.2	-0.4	-0.8	0.3	0.6	0.5	0.8	-0.4	-0.3	-0.2	-1.3	-1.4	-2.3
Leg fat percentage (left)	0.6	2.2	7.9	2.6	-0.2	1.3	0.8	0.4	0.4	0.6	0.7	1.6	1.2	1.2	1.2	1.9	2.8	0.4	0.8	2.8	1.3	1.9
Irritability	0.6	1.1	2.9	1.2	1.0	0.7	-0.4	-0.5	-0.6	0.3	-0.5	0.1	1.2	1.1	0.8	1.3	1.6	-0.7	0.5	1.7	1.5	1.6
Risk taking	0.6	0.9	2.3	1.5	-0.4	0.8	-0.8	-0.9	-0.7	-0.8	-0.9	0.4	0.8	0.6	1.1	1.4	1.0	-0.7	1.0	1.4	1.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	6.0	1.2	-0.0	0.6	-0.4	-0.3	-0.3	-0.1	-0.3	1.2	-0.1	-0.4	-0.7	-0.2	0.1	-0.3	-0.1	1.1	1.7	2.5
Mean Putamen Volume	0.5	0.5	1.2	1.0	-0.8	-0.2	0.7	1.0	0.7	0.1	0.8	0.0	-0.8	-1.0	-1.1	-1.0	-0.8	0.9	-0.2	-0.5	-0.3	0.0
HDL Cholesterol	0.5	0.9	2.9	-1.5	-0.4	-1.4	0.0	-0.6	-0.6	-0.4	-0.7	-0.2	-0.9	-0.8	-0.4	-0.9	-1.3	-0.5	-1.0	-1.4	-1.7	-0.7
Blood Platelet Count	0.5	6.3	12.8	1.1	2.4	2.6	2.8	2.0	2.6	3.2	1.9	1.7	2.6	2.8	2.3	2.4	2.7	2.1	2.9	3.6	2.6	2.1
Systolic blood pressure, automated reading	0.5	1.4	4.4	1.6	-1.2	1.0	-0.4	-0.7	-0.7	0.1	-1.0	-0.3	1.6	1.7	1.4	1.1	2.1	-0.5	1.5	1.5	1.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.2	-0.8	-0.5	-0.9	-0.3	-0.6	-0.2	-0.9	-0.7	-0.9	-0.9	-0.5	-0.6	-0.9	-0.5	-1.2	-0.5	-1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.5	0.4	0.1	1.1	0.2	-0.1	0.1	-0.2	0.6	0.6	1.3	1.5	1.3	1.6	0.9	0.2	1.1	0.5	0.6	0.1
Hair/balding pattern: Pattern 4	0.5	1.3	5.4	-0.4	-2.3	-1.3	-1.5	-1.3	-1.1	-0.6	-1.0	-1.1	-0.7	-1.1	-1.1	-0.7	-0.6	-1.3	-1.7	0.2	-0.7	1.1
Hypertension (Self-reported)	0.5	1.5	5.8	1.8	-1.2	0.4	-0.9	-1.5	-1.6	-1.0	-1.5	-1.3	0.8	0.7	0.5	1.1	1.6	-1.0	-0.4	2.4	-0.2	0.4
Arm fat percentage (left)	0.5	2.1	7.1	0.6	-0.4	1.2	-0.5	-0.7	-0.8	-0.8	-0.5	1.4	2.0	2.3	2.7	2.4	1.9	-0.7	1.4	0.9	-0.1	-1.9
Commuting to job workplace: Public transport	0.5	0.6	3.3	-1.4	0.3	-0.8	-0.4	-0.4	-0.4	-1.2	-0.4	1.8	0.0	-0.0	0.4	-0.6	-0.9	-0.4	-0.1	0.0	-0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	4.0	0.4	2.0	0.9	1.3	0.9	0.8	1.4	0.6	0.7	0.1	0.1	0.2	0.0	0.9	1.1	0.7	0.1	-0.1	0.1
Breast Cancer	0.4	1.0	6.0	0.9	0.2	0.4	-0.2	-0.5	-0.3	1.0	-0.4	-0.1	0.7	0.4	0.1	0.6	1.6	-0.3	-0.5	2.3	0.7	2.4
Crohns Disease (2012)	0.4	0.7	3.7	-1.1	-1.9	-0.4	-0.8	-0.9	-1.0	-1.2	-0.6	-0.1	-0.4	-0.2	-0.3	-0.2	-0.4	-0.8	-0.7	-0.5	-1.2	-0.6
HbA1C	0.4	0.5	2.4	0.4	1.0	0.2	0.7	1.6	0.8	0.7	1.0	0.5	-0.6	-0.5	-0.4	-0.2	0.0	1.0	0.0	-0.2	-0.7	-0.6
Blood White Count	0.4	2.8	18.8	0.1	0.2	-0.4	1.1	0.4	1.0	0.4	0.3	0.6	-1.9	-1.2	-2.1	-1.6	-0.9	0.8	-1.0	-3.3	-2.2	-4.3
Heel T-Score	0.4	3.5	24.1	0.2	-0.9	1.3	-1.2	-1.3	-0.6	-2.5	-0.4	0.4	1.7	2.4	1.7	2.9	0.6	-1.0	1.2	-2.6	0.4	-4.9
Neuroticism	0.4	0.9	3.1	-0.1	0.0	-0.8	-1.2	-1.2	-1.7	-0.9	-1.3	-1.4	-0.1	-0.2	0.1	-0.4	-0.0	-1.4	-0.4	0.1	0.4	1.8
Relative age of first facial hair	0.4	0.8	3.5	-1.9	-0.2	-0.8	-0.9	-0.9	-0.6	-1.2	-0.6	-0.2	-0.6	-0.5	0.8	-0.7	-0.9	-0.7	0.3	-1.5	-0.3	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	-0.7	0.5	0.2	0.6	1.1	0.6	0.7	0.9	0.9	-0.3	-0.2	-0.2	-0.3	-0.6	0.9	-0.1	-0.7	0.6	0.3
High blood pressure	0.4	1.0	2.9	1.5	-1.1	-0.1	-0.8	-1.4	-1.4	-1.4	-1.3	-1.3	0.2	0.0	-0.3	0.4	0.9	-0.9	-0.9	1.7	-0.6	0.3
Alcohol usually taken with meals	0.4	0.7	1.7	-1.2	0.4	-0.1	0.2	0.6	0.5	0.1	0.5	1.3	-0.5	-0.6	-0.8	-0.7	-1.3	0.6	-1.3	0.5	-1.1	-1.3
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	-0.7	-0.3	-0.8	-0.7	-1.1	-0.8	-1.4	-0.9	0.9	-0.1	-0.2	-0.6	-0.2	-0.4	-1.0	-0.9	0.4	-0.3	0.2
Father’s age at death	0.4	0.5	2.3	-1.5	-0.4	-1.1	0.0	-0.1	-0.3	-1.1	-0.0	0.5	-0.3	-0.2	-0.5	-0.1	-0.4	-0.1	-0.5	-1.1	-1.3	-1.0
Length of working week for main job	0.4	0.5	2.2	0.6	1.0	0.4	0.7	0.7	0.4	0.9	0.4	1.5	-0.6	-0.6	-1.0	-0.1	0.1	0.5	-0.4	-0.2	-0.1	0.6
Tense / ‘highly strung’	0.4	0.6	2.0	-0.3	1.2	1.0	1.4	1.0	0.6	0.6	0.8	0.4	0.6	0.7	0.4	0.6	0.3	1.0	0.6	-0.2	-0.8	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.9	0.4	-0.8	0.3	-0.1	0.0	-0.1	0.2	0.3	0.8	0.8	0.8	0.8	1.1	0.6	-0.0	0.8	1.0	0.5	1.4
Gout (self-reported)	0.4	0.5	2.1	1.1	-1.5	0.1	-0.7	-0.8	-0.3	-1.5	-0.1	0.4	-0.1	-0.2	-0.1	0.3	-0.3	-0.4	-0.7	0.7	-0.6	-1.0
Leg fat percentage (right)	0.4	1.6	6.4	2.1	-0.1	1.1	0.5	0.2	0.0	0.6	0.4	1.6	0.8	0.8	1.0	1.6	2.5	0.1	0.3	2.5	1.0	1.8
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.1	-1.0	0.0	-0.2	-0.2	-0.5	-0.4	-0.8	-0.6	-0.7	-0.8	-0.7	-1.1	-0.4	-0.9	-0.5	-1.1	0.2	-0.5	-0.5
Medication: Blood pressure	0.4	0.8	3.7	1.6	-0.3	1.2	-0.4	-0.3	-0.5	-0.5	-0.6	-0.6	0.8	0.7	0.6	0.8	1.4	-0.3	0.3	1.9	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.0	-1.2	0.1	0.1	-0.1	-0.1	-0.0	-1.1	0.4	-0.6	0.5	0.8	1.1	0.6	-0.2	-0.1	0.6	-0.1	-0.6	-1.7
Family relationship satisfaction	0.4	0.5	2.4	0.4	1.5	0.8	0.9	1.0	0.7	1.0	0.6	0.2	-0.0	0.0	0.0	-0.3	-0.3	1.0	0.7	-0.1	0.3	-0.3
Medication for cholesterol	0.4	0.6	3.5	-0.5	1.9	0.6	-0.0	0.8	0.5	1.0	0.5	0.4	0.7	0.7	1.1	0.7	0.2	0.2	1.1	-0.2	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.5	-1.2	0.4	-0.1	-1.1	-0.1	-0.4	-0.8	-0.4	0.1	1.6	1.6	1.4	0.8	0.8	-0.6	0.0	1.3	-0.2	1.0
Mother’s age at death	0.4	0.5	2.1	-1.4	0.1	-0.9	-1.2	-0.3	-0.7	-0.0	-0.7	0.3	0.8	0.6	0.2	0.1	-0.2	-0.9	-0.4	0.4	0.5	1.2
Ever depressed for a whole week	0.4	0.5	1.7	0.2	0.3	1.0	0.6	1.0	1.0	-0.1	1.0	0.6	0.1	0.1	0.5	0.2	-0.0	1.1	1.3	-0.2	0.7	0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	1.2	1.5	0.6	0.7	1.2	0.9	-0.3	1.0	0.5	0.8	0.8	0.9	0.4	0.7	0.7	1.5	1.4	0.1	0.3
Schizophrenia (2014)	0.3	0.6	1.7	0.3	1.1	0.6	0.6	0.9	0.7	0.4	0.8	0.6	1.0	0.9	0.9	0.8	0.5	0.6	1.0	1.3	-0.1	1.1
Chronotype (morning person)	0.3	0.6	2.4	1.4	-0.2	1.3	0.5	0.2	0.2	0.6	-0.1	0.8	0.0	0.1	0.5	1.4	1.6	0.2	-0.2	1.0	0.8	0.3
Number of treatments/medications taken	0.3	0.6	2.9	1.7	-0.7	0.6	1.3	0.7	0.6	-0.5	0.7	0.1	-0.9	-0.9	-1.0	-0.8	0.0	0.9	-0.1	-0.2	0.4	-0.5
Trunk fat mass	0.3	1.3	3.5	-0.6	-1.4	-1.3	-0.6	-1.1	-1.2	-0.3	-0.8	1.3	-1.5	-1.7	-0.7	-1.0	0.0	-1.0	-1.9	0.2	-1.5	1.4
Nervous feelings	0.3	0.5	1.9	-1.0	1.4	-0.3	0.9	0.9	0.9	-0.4	0.9	0.8	0.1	0.2	-0.2	-0.7	-0.9	0.8	-0.0	-0.1	0.1	0.4
Pain all over the body in last month	0.3	0.3	1.7	-0.2	-1.1	-0.4	-0.6	-0.5	-0.7	-0.1	-0.4	-1.3	-0.4	-0.5	-0.1	0.3	-0.2	-0.4	-0.2	-0.9	-0.7	-0.0
Diabetes (self-reported)	0.3	0.5	2.0	-0.6	-0.3	-0.3	-0.9	-0.8	-0.8	-0.5	-0.9	-0.6	-0.2	0.0	-0.1	0.2	-0.3	-0.8	-0.9	-1.0	-1.0	-1.4
Illnesses of siblings	0.3	0.4	1.2	-0.9	-0.6	-0.9	0.3	0.5	0.2	-0.4	0.4	0.7	-0.3	-0.4	-0.8	-0.7	-0.7	0.3	-0.2	-1.1	-1.1	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	2.5	1.6	-0.2	0.9	0.4	0.3	0.6	-0.8	0.3	-0.1	0.2	0.4	0.4	0.7	0.5	0.5	1.1	-0.7	0.5	-1.1
Medication: Cholesterol lowering	0.3	0.5	1.7	1.0	0.1	0.9	0.1	0.1	0.3	0.2	0.2	-1.3	0.6	0.6	0.5	0.9	1.1	0.2	0.1	1.3	0.1	0.3
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.9	-0.9	-0.1	0.1	-0.6	-0.2	0.1	-0.5	-0.1	-0.5	-0.5	-0.7	0.3	0.4	-0.4	-1.0	0.8	0.1	0.3
Headache pain in last month	0.3	0.4	2.9	1.7	-0.4	0.1	0.1	0.0	-0.1	0.8	-0.0	-0.7	-0.7	-0.9	-0.9	-0.6	-0.1	0.2	-0.7	0.9	-0.1	0.5
Glaucoma (self-reported)	0.3	0.3	1.8	-0.8	0.8	-0.1	-0.3	0.2	0.1	-1.0	0.0	-0.3	-0.1	0.1	0.4	-0.1	-0.7	-0.0	0.4	-0.8	-0.6	-1.3
Body fat percentage	0.3	1.2	5.3	1.4	-0.7	0.5	-0.2	-0.5	-0.5	-0.1	-0.3	1.4	0.9	0.9	1.2	1.4	2.0	-0.5	0.2	2.3	0.5	1.3
Number of children fathered	0.3	0.3	1.4	0.2	-0.9	-0.5	0.1	-0.4	-0.5	-0.4	0.3	-0.6	0.0	-0.2	-0.6	0.0	0.5	-0.2	-0.8	0.9	-0.7	1.2
Pulse wave peak to peak time	0.3	0.4	2.0	-1.4	-0.4	-0.3	-0.1	-0.3	0.1	-0.7	0.3	-0.7	0.7	0.8	0.6	0.8	0.1	-0.1	-0.1	-0.1	-1.2	0.1
Emphysema/chronic bronchitis	0.3	0.4	1.2	-0.0	-0.1	-0.0	0.8	0.7	0.8	-0.8	1.1	-0.5	-0.2	-0.2	-0.6	-0.1	-1.0	0.9	-0.1	-0.5	-0.7	-0.8
Migraine (self-reported)	0.3	0.3	2.4	1.6	-0.6	0.5	0.3	-0.3	-0.2	-0.7	-0.1	0.3	0.5	0.5	0.4	0.5	0.2	-0.3	0.4	0.6	0.9	-0.0
Medication: Allopurinol	0.3	0.4	2.1	0.3	-0.8	0.2	-0.6	-0.9	-0.4	-0.5	-0.1	0.3	0.6	0.5	0.4	1.1	0.8	-0.6	-0.6	1.5	-0.6	0.2
Overall health rating	0.3	0.6	1.8	1.0	-0.1	-0.1	0.8	1.1	0.3	-1.0	0.6	0.3	-1.1	-1.0	-0.9	-0.7	-0.6	0.9	0.2	-1.3	-0.1	-0.6
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.6	0.7	-0.9	-0.4	-0.4	-0.8	0.3	-0.5	-0.4	-0.6	-0.5	-0.3	-0.7	-0.3	-0.5	-0.6	-0.9	-0.6	0.3
Average weekly red wine intake	0.3	0.4	4.2	-0.9	0.3	-0.6	-0.0	0.1	-0.1	0.0	0.1	2.0	0.1	-0.0	-0.8	-0.2	-0.1	0.1	-0.9	0.4	0.1	0.9
Mood swings	0.3	0.5	4.0	2.0	0.4	0.6	0.6	0.2	0.3	0.1	0.3	-0.6	0.0	-0.0	0.6	-0.1	0.3	0.3	1.1	1.0	1.0	0.6
Long-standing illness, disability or infirmity	0.3	0.5	1.5	1.2	-0.3	0.9	1.2	0.9	0.7	0.4	0.6	-0.6	0.2	0.3	0.0	0.2	0.5	0.8	0.9	0.1	1.0	-0.0
Ever had bowel cancer screening	0.3	0.4	2.3	-0.5	-0.2	-0.3	0.2	0.5	0.4	-1.0	0.4	0.1	0.2	0.3	-0.6	0.0	-0.3	0.5	-0.5	0.1	-1.5	-1.4
Diabetes diagnosed by doctor	0.3	0.4	1.9	-0.4	0.3	-0.3	-0.1	-0.0	-0.3	-0.0	-0.2	-0.6	-0.6	-0.4	-0.8	-0.4	-0.5	-0.0	-0.9	-1.2	-1.2	-1.4
Breast cancer (self-reported)	0.3	0.3	1.0	0.0	-1.0	-0.1	-0.2	-0.7	-0.2	-0.8	-0.6	0.5	0.4	0.6	0.6	0.5	-0.1	-0.3	0.9	-0.6	0.6	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	0.4	-0.2	0.8	-0.8	0.1	-0.2	0.4	0.1	0.3	0.3	0.3	0.7	0.8	0.8	-0.5	0.1	1.0	0.6	1.0
Medication: Lisinopril	0.3	0.4	1.1	1.0	-0.0	1.0	-0.2	0.4	0.1	-0.5	-0.1	-0.3	0.6	0.6	0.8	0.9	1.1	0.0	0.4	0.6	0.0	-0.6
Alcohol drinker status: Never	0.3	0.3	1.2	0.9	-1.1	-0.5	-0.3	-0.3	-0.6	0.1	-0.6	-1.0	-0.3	-0.4	-0.7	-0.5	0.4	-0.5	-0.2	-0.1	-0.3	0.1
Unable to work because of sickness or disability	0.3	0.4	2.0	-0.9	0.2	-0.4	0.3	0.0	-0.4	1.0	0.3	-1.4	-0.2	-0.1	-0.1	-0.1	0.6	-0.0	-0.8	0.2	-0.6	1.1
Basal cell carcinoma (self-reported)	0.3	0.3	2.2	0.6	-0.8	-0.1	0.4	-0.1	-0.2	0.5	0.6	-0.7	-0.4	-0.7	-0.7	-0.4	0.3	0.4	-0.3	0.4	-0.1	1.5
Depressed Affect (Nagel 2018)	0.2	0.4	2.8	1.7	0.3	0.4	0.9	0.5	0.1	0.6	0.2	-0.4	-0.1	-0.2	0.4	-0.2	0.4	0.2	0.5	1.1	0.5	1.1
Neuroticism (Nagel 2018)	0.2	0.5	1.4	0.1	-0.1	-1.0	0.1	-0.4	-0.8	-0.7	-0.6	-0.7	-0.7	-0.8	-0.6	-1.2	-0.7	-0.7	-0.7	0.3	-0.2	1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	2.4	0.2	-0.5	0.1	-0.2	0.0	-0.1	0.6	-0.2	-0.2	0.2	-0.1	-0.6	-0.1	-0.1	-0.1	-0.5	0.8	0.5	1.5
LDL Cholesterol	0.2	0.3	1.5	0.8	-0.0	0.8	0.4	0.5	0.0	0.2	0.3	0.7	-0.1	-0.4	-1.0	0.5	0.3	0.0	-0.4	0.9	0.6	1.2
Primary Biliary Cirrhosis	0.2	0.4	1.4	0.4	-0.5	-0.0	-0.8	-0.4	-0.3	-1.2	-0.8	0.9	-0.5	-0.4	-0.4	-0.4	-0.5	-0.5	0.2	-0.6	0.7	-0.7
Triglycerides	0.2	0.3	0.8	0.9	-0.9	0.5	-0.6	-0.1	-0.0	-0.1	0.0	-0.3	0.4	0.3	-0.7	0.5	0.4	-0.1	-0.4	0.6	-0.4	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.4	0.5	-0.5	0.4	-0.1	-0.2	-0.1	-1.2	0.2	-0.6	-0.3	-0.0	0.2	0.4	-0.6	-0.2	0.4	-0.5	0.2	-1.0
Systolic Blood Pressure	0.2	1.0	5.3	2.3	0.2	0.9	-0.3	-0.3	-0.5	0.4	-1.0	-0.5	0.8	0.8	0.6	0.4	1.6	-0.3	0.8	1.6	1.2	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	3.5	-0.4	0.2	-0.1	0.0	-0.1	-0.1	-0.8	-0.3	0.0	-0.4	-0.1	-0.4	-0.1	-0.6	-0.0	-0.7	-1.1	-0.9	-1.9
Hair Pigment	0.2	6.2	15.7	0.8	3.0	1.2	3.7	4.0	4.0	2.6	3.5	2.4	-2.1	-1.9	-1.0	-2.2	-2.1	4.0	1.2	-1.2	0.8	0.1
Tanning	0.2	1.8	4.8	1.9	-1.7	0.7	-1.1	-1.4	-0.7	-0.0	-1.2	-1.8	1.1	1.1	1.9	1.8	2.2	-1.0	0.2	2.0	-0.0	-0.2
Medication for hormone replacement therapy	0.2	0.2	1.3	-0.5	-1.1	0.1	-0.2	-0.5	-0.4	-0.7	-0.1	-0.7	0.5	0.5	0.4	0.3	-0.1	-0.3	0.4	0.3	0.6	0.2
Trunk fat percentage	0.2	0.9	4.8	0.6	-0.9	-0.1	-0.5	-0.7	-0.8	-0.2	-0.7	1.2	0.4	0.3	0.8	0.8	1.5	-0.8	-0.4	2.2	-0.1	1.6
Stomach or abdominal pain in last month	0.2	0.3	1.2	-0.5	0.8	-0.6	-0.8	-0.8	-0.7	0.1	-0.7	-0.6	-0.3	-0.3	0.3	-0.3	-0.3	-1.1	-0.4	-0.0	0.3	0.4
Medication: Ramipril	0.2	0.2	0.9	0.0	0.2	0.0	-0.3	-1.0	-0.6	-0.2	-0.8	-0.2	0.1	0.1	0.2	0.1	0.4	-0.7	-0.8	0.9	-0.2	-0.1
Medication: Simvastatin	0.2	0.2	1.8	1.3	-0.5	0.4	0.1	-0.2	0.0	0.7	-0.2	-0.9	0.0	0.1	-0.0	0.4	0.7	-0.1	-0.0	-0.0	0.1	-0.4
Happiness	0.2	0.2	2.2	-1.5	0.8	-0.4	0.3	0.3	-0.5	0.3	-0.2	0.4	0.2	-0.0	-0.3	-0.6	-0.1	0.1	-0.0	0.1	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	3.0	-1.6	1.1	-0.9	0.1	0.1	0.4	0.7	-0.1	1.7	0.7	0.6	-0.1	-0.4	-0.8	0.0	-0.1	0.3	-0.2	-0.3
Arm fat mass (right)	0.2	0.8	2.6	-0.7	-1.2	-0.4	-0.8	-1.1	-1.2	-0.6	-0.8	1.2	-0.4	-0.1	0.7	0.4	0.3	-1.0	-0.5	-0.7	-1.6	-1.2
Health satisfaction	0.2	0.3	2.0	0.5	-0.4	-0.2	-0.2	-0.0	-0.4	-0.3	-0.0	0.9	-0.1	-0.2	-0.1	-0.4	0.5	-0.1	0.4	-0.1	1.1	1.4
Medication: Seretide 50 evohaler	0.2	0.2	1.1	0.0	0.2	0.1	0.3	-0.3	0.2	0.5	-0.0	-1.1	0.1	0.4	0.9	0.2	0.2	0.0	0.6	0.4	0.7	0.1
Whole body fat mass	0.2	0.8	2.0	-0.3	-1.1	-0.9	-0.5	-0.9	-1.0	-0.3	-0.6	1.4	-1.2	-1.2	-0.3	-0.5	0.2	-0.9	-1.2	-0.0	-1.2	0.8
Alcohol intake frequency.	0.2	0.5	1.7	0.7	-1.0	-1.0	-0.4	-0.3	-0.9	0.1	-0.9	-1.3	-0.7	-0.6	-0.8	-0.9	0.2	-0.7	-0.5	-0.1	-0.3	0.2
Loneliness, isolation	0.2	0.3	1.4	0.1	0.2	0.3	0.8	0.7	0.4	0.5	0.8	1.2	-0.4	-0.4	-0.1	-0.6	-0.3	0.7	0.1	0.4	0.2	-0.0
Commuting to job workplace: Walk	0.2	0.2	0.9	-1.0	0.2	-0.1	0.2	0.1	0.3	0.1	-0.0	-0.4	-0.8	-0.7	-0.2	-0.6	-0.6	0.3	-0.2	-0.6	-0.4	-0.8
Arm fat mass (left)	0.2	0.8	2.9	-0.7	-1.2	-0.5	-0.8	-1.2	-1.3	-0.8	-0.9	1.2	-0.4	-0.2	0.5	0.3	0.2	-1.1	-0.6	-0.9	-1.7	-1.3
Guilty feelings	0.2	0.4	2.5	0.1	-0.4	-0.5	-0.7	-0.7	-0.5	-0.9	-0.5	1.6	0.1	0.1	-0.3	-0.5	-0.1	-0.6	-0.0	-0.1	0.9	0.4
Wears glasses or contact lenses	0.2	0.3	1.4	-0.3	-0.2	-0.4	-0.6	-0.3	-0.4	-0.6	0.1	-0.8	0.8	0.7	0.3	0.3	-0.0	-0.4	-0.1	-0.2	-0.2	-1.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.3	0.2	1.1	1.1	0.3	0.3	0.4	0.2	0.0	-0.6	0.3	0.3	-0.4	0.7	0.3	0.4	0.3	-0.1	-0.1	-0.7
Medication: Blood pressure	0.2	0.3	2.9	1.7	-0.3	0.4	0.2	-0.3	0.0	-0.2	-0.2	-0.2	-0.1	-0.1	-0.2	0.2	0.7	0.2	-0.5	0.9	-0.6	-0.8
High cholesterol (Self-reported)	0.2	0.4	4.5	2.1	-0.2	0.3	0.6	-0.0	0.4	0.8	0.3	0.1	-0.4	-0.5	-0.7	-0.1	0.5	0.4	-0.3	0.3	0.5	0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.9	0.7	-0.5	0.3	0.9	0.7	0.6	0.5	0.6	0.3	0.1	0.0	-0.2	0.4	0.2	0.7	0.5	-0.0	-0.3	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	3.0	1.5	-1.7	0.8	0.3	-0.1	-0.1	-0.7	-0.2	-0.2	0.6	0.7	0.4	0.7	1.2	0.2	0.5	1.3	-0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.7	-1.5	0.4	-0.5	0.0	0.6	0.7	0.6	0.7	0.9	-0.1	-0.0	0.1	-0.3	-1.0	0.2	0.5	-1.6	0.3	-0.3
Pain experienced in last month	0.2	0.3	2.3	-1.5	0.4	-0.1	-0.5	0.3	0.2	-0.2	0.1	-0.8	0.3	0.5	0.1	0.6	-0.1	-0.1	-0.3	-0.5	-0.7	-1.2
Bipolar Disorder (2018)	0.1	0.2	1.7	1.3	0.3	0.2	-0.3	0.1	0.1	-0.8	-0.2	-0.3	-0.1	0.1	0.4	-0.1	0.4	-0.3	0.6	0.2	0.1	-0.9
Lung FVC	0.1	0.7	2.1	-0.7	0.3	-0.5	-1.4	-0.8	-0.7	-1.0	-0.4	-1.3	0.4	0.4	0.8	-0.1	-1.1	-0.9	0.2	-1.3	-0.8	-1.4
Supplements: Glucosamine	0.1	0.1	0.6	-0.5	-0.2	-0.8	-0.1	-0.3	-0.1	0.3	-0.2	-0.2	0.1	-0.0	-0.0	-0.5	-0.1	-0.4	-0.1	0.4	0.2	0.1
Mouth/teeth dental problems	0.1	0.2	0.8	-0.2	0.1	0.0	0.5	0.3	0.3	0.9	0.5	0.6	-0.0	-0.1	0.0	-0.3	0.3	0.3	-0.0	0.6	0.2	0.6
Neuroticism score	0.1	0.3	1.7	0.6	1.3	0.4	0.4	-0.1	-0.2	-0.0	0.0	-0.1	0.4	0.4	0.3	-0.1	0.4	0.0	0.4	0.6	0.6	1.1
Breastfed as a baby	0.1	0.2	0.6	-0.2	0.6	0.3	0.6	0.5	0.6	-0.8	0.6	-0.3	0.0	-0.1	-0.1	-0.3	-0.5	0.5	0.3	0.3	-0.1	-0.4
Shortness of breath walking on level ground	0.1	0.1	0.6	0.8	-0.3	0.1	0.2	0.8	0.0	-0.7	0.1	0.5	0.1	0.2	-0.4	0.2	0.3	0.3	0.2	-0.4	0.1	0.1
Leg fat mass (right)	0.1	0.5	2.8	0.2	-0.8	-0.2	-0.0	-0.5	-0.6	-0.1	-0.0	1.7	-0.9	-0.9	-0.1	0.0	0.6	-0.4	-0.9	0.0	-1.1	0.6
Suffer from ‘nerves’	0.1	0.2	0.9	-0.0	-0.3	-0.2	-0.3	-1.0	-0.5	-0.3	-0.5	-0.8	0.1	0.2	0.4	0.1	0.3	-0.4	-0.2	-0.6	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	-0.5	-0.4	-0.5	0.1	-0.0	0.1	0.0	0.3	0.6	0.6	0.3	0.2	-0.2	-0.7	0.3	0.4	0.8	0.1	0.8
Commuting to job workplace: Cycle	0.1	0.1	0.5	-0.0	-0.3	0.3	-0.1	0.0	0.2	0.3	0.0	-0.7	-0.0	-0.2	-0.0	-0.2	-0.5	0.2	-0.2	0.3	0.4	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.6	0.1	0.2	-0.1	-0.4	-0.1	-0.5	0.8	-0.3	-0.5	0.0	-0.0	0.1	0.1	-0.1	-0.3	0.3	-0.5	0.3	0.5
Leg fat mass (left)	0.1	0.4	2.5	0.4	-0.9	-0.1	0.1	-0.4	-0.4	-0.1	0.0	1.6	-0.7	-0.7	0.1	0.2	0.8	-0.3	-0.7	0.2	-0.9	0.7
Worry (Nagel 2018)	0.0	0.1	0.4	-0.1	0.6	-0.2	0.0	-0.1	-0.5	-0.1	-0.3	0.5	-0.1	-0.0	0.4	-0.3	-0.1	-0.3	0.1	-0.2	-0.3	0.3
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	-0.3	-0.0

Hub : Genes

FGFR4

Models

Trait associations