[Hub]/) : Traits : Leg predicted mass (right) : ← →

chr11:26,818,083-29,054,545

Best TWAS P=6.42e-21 · Best GWAS P=5.9e-26 conditioned to 4.37e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LIN7C 0.08 0.06 lasso 1 0.04 4.1e-04 8.8 8.8 1.1e-18 0.63 0.74 0.15 FALSE
2 GTEx Brain Putamen basal ganglia BDNF-AS 0.22 0.17 lasso 4 0.13 5.5e-04 -4.2 5.4 6.5e-08 0.33 0.23 0.05 FALSE
3 GTEx Cells Transformed fibroblasts LIN7C 0.26 0.22 lasso 6 0.25 1.4e-18 8.8 7.7 9.8e-15 0.62 1.00 0.00 FALSE
4 GTEx Esophagus Muscularis LIN7C 0.14 0.08 enet 11 0.07 5.4e-05 4.1 6.8 7.9e-12 0.60 0.68 0.18 FALSE
5 GTEx Liver METTL15 0.18 0.05 lasso 3 0.09 1.9e-03 -0.6 -6.3 3.2e-10 -0.68 0.02 0.82 FALSE
6 GTEx Nerve Tibial LIN7C 0.18 0.08 enet 27 0.12 4.2e-09 8.8 6.8 9.6e-12 0.56 0.60 0.37 FALSE
7 GTEx Thyroid LIN7C 0.08 0.04 lasso 4 0.04 6.0e-04 8.8 8.8 8.5e-19 0.69 0.50 0.38 FALSE
8 NTR Blood LIN7C 0.01 0.00 lasso 3 0.01 2.2e-03 9.6 -9.4 6.4e-21 -0.72 0.10 0.81 TRUE
9 The Cancer Genome Atlas Bladder Urothelial Carcinoma LIN7C 0.04 0.01 lasso 3 0.02 1.0e-02 -1.8 5.5 4.9e-08 0.46 0.02 0.85 FALSE
10 The Cancer Genome Atlas Colon Adenocarcinoma LIN7C 0.10 0.03 blup 32 0.08 2.8e-05 9.1 6.8 1.1e-11 0.57 0.01 0.95 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIN7C 0.05 0.02 lasso 3 0.03 2.9e-04 9.2 8.5 1.4e-17 0.63 0.00 0.98 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma LIN7C 0.09 0.12 lasso 2 0.12 2.6e-13 4.1 5.9 3.8e-09 0.52 0.93 0.07 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma LIN7C 0.09 0.10 enet 7 0.09 8.1e-09 4.1 5.2 2.6e-07 0.48 0.86 0.14 FALSE