Hub : Genes

METTL15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1100 0.0350 4.5e-08 0.079 0.074 0.060 0.082 0.093 8.0e-10 2.5e-09 7.9e-08 3.3e-10 2.2e-11
2 GTEx Adipose Subcutaneous 0.0770 0.0330 4.4e-04 0.005 NA 0.019 NA 0.013 1.2e-01 NA 1.0e-02 NA 2.8e-02
3 GTEx Brain Caudate basal ganglia 0.1040 0.0550 9.1e-03 0.095 NA 0.002 NA 0.091 1.1e-03 NA 2.7e-01 NA 1.4e-03
4 GTEx Brain Nucleus accumbens basal ganglia 0.1590 0.0680 2.0e-03 0.036 NA 0.039 NA 0.052 3.8e-02 NA 3.3e-02 NA 1.6e-02
5 GTEx Cells Transformed fibroblasts 0.1060 0.0440 4.8e-05 0.022 NA 0.031 NA 0.029 8.5e-03 NA 2.0e-03 NA 2.7e-03
6 GTEx Liver 0.1760 0.0730 3.7e-03 0.050 NA 0.061 NA 0.089 1.6e-02 NA 8.8e-03 NA 1.9e-03
7 GTEx Skin Sun Exposed Lower leg 0.0450 0.0230 5.5e-03 0.003 NA -0.002 NA -0.001 1.8e-01 NA 6.1e-01 NA 4.5e-01
8 GTEx Testis 0.1540 0.0580 5.8e-04 0.005 NA -0.006 NA 0.001 1.8e-01 NA 8.5e-01 NA 3.0e-01
9 METSIM Adipose 0.0430 0.0174 6.3e-05 0.055 0.024 0.044 0.044 0.059 1.1e-08 1.5e-04 2.7e-07 3.6e-07 3.7e-09
10 ROSMAP Brain Pre-frontal Cortex 0.0416 0.0194 8.4e-04 0.033 0.032 0.023 0.032 0.021 3.3e-05 4.6e-05 5.4e-04 5.1e-05 9.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.0 1.5 3.4 -1.4 -1.0 -1.2 -1.2 1.8 -1.5 -1.2 0.1 -1.5 0.2
Bipolar Disorder or Schizophrenia 1.7 4.1 9.2 -2.0 -1.1 -2.2 -1.9 3.0 -1.4 -2.2 1.0 -2.5 -2.1
Depressed Affect (Nagel 2018) 0.2 0.3 1.3 0.7 -0.4 -0.5 -0.2 0.7 -0.3 -0.5 0.5 1.1 -0.2
Depression (Nagel 2018) 3.1 4.6 12.0 -2.0 -1.7 -2.6 -2.9 3.5 -0.0 -2.9 0.5 -1.8 -0.4
Intelligence (Savage-Jansen 2018) 1.9 6.0 12.1 2.9 3.1 1.5 2.3 -3.5 -3.5 2.6 -0.4 1.5 0.7
Neuroticism (Nagel 2018) 0.7 1.8 7.1 -0.5 -0.5 -1.5 -1.3 2.7 1.5 -1.6 0.9 -0.1 -0.7
Schizophrenia (2018) 1.6 3.3 9.3 -1.4 -0.7 -1.8 -1.4 2.4 -0.6 -2.0 1.2 -2.1 -3.1
Schizophrenia vs Biploar Disorder 2.6 3.4 6.5 -2.6 -1.5 -1.9 -2.0 2.5 0.8 -2.4 -0.2 -1.9 -1.2
Worry (Nagel 2018) 1.8 3.8 10.2 -2.0 -0.7 -0.9 -2.3 2.9 3.2 -2.2 -0.9 -1.4 1.1
Alzheimer’s Disease (in mother) 2.5 2.9 6.9 2.4 1.3 1.4 1.8 -2.6 -0.6 2.2 -0.6 1.4 1.5
Alzheimer’s Disease (in father) 0.5 0.6 1.4 1.2 -0.1 0.8 0.7 -1.0 -1.1 0.5 -0.4 0.5 0.1
Alzheimer’s Disease (including proxy) 1.1 1.6 2.8 1.5 0.2 1.3 0.9 -1.7 -1.7 1.4 -0.9 0.5 1.6
Crohns Disease (2017) 0.3 0.6 1.8 0.8 0.8 0.6 0.4 -0.4 1.3 0.1 0.9 0.7 -0.4
Irritable Bowel Disease (IBD) 0.3 0.7 1.7 1.0 1.0 1.3 1.2 -0.8 0.1 0.5 0.4 0.9 -0.1
Ulcerative Colitis (UC) 0.5 0.9 2.3 1.0 1.1 1.4 1.5 -0.7 -0.6 0.8 0.3 0.7 -0.2
Major Depression (MDD) 3.0 3.7 7.7 -2.0 -1.4 -2.8 -2.5 2.4 0.6 -2.5 -0.5 -1.9 0.8
Reaction Time 4.5 8.6 17.5 -3.2 -3.1 -3.4 -3.6 4.2 -1.3 -3.5 0.2 -2.2 -2.3
Verbal and Numeric Reasoning (VNR) 1.7 4.0 12.1 2.0 2.0 1.5 1.6 -2.8 -3.5 1.9 -1.2 0.6 1.2
Breast Cancer 0.3 0.7 2.0 0.8 0.3 0.5 0.9 -0.8 -1.4 1.0 0.2 1.4 0.4
Ovarian Cancer 0.6 0.8 3.2 -0.6 -0.6 -0.8 -0.3 0.9 1.8 -1.0 0.5 -0.7 -0.9
Prostate Cancer 1.0 1.4 3.5 -0.9 -1.9 -1.4 -0.8 1.4 1.6 -1.2 -0.0 -0.9 0.2
Age at First Birth 4.6 6.7 17.0 2.6 2.1 3.2 3.2 -4.1 0.1 3.0 -0.1 2.8 1.2
Bipolar Disorder (2011) 0.8 0.7 3.5 0.2 0.2 -0.1 0.1 0.5 0.1 -0.3 1.9 0.6 -1.7
Body Mass Index (BMI) (2010) 2.3 3.2 12.5 -1.4 -1.1 -1.7 -1.4 1.5 -3.5 -1.4 -0.5 -0.9 -2.4
Coronary Artery Disease (CAD) 0.8 0.9 4.1 1.0 -0.1 0.0 0.9 -0.8 -2.0 0.4 0.6 0.2 -1.4
Crohns Disease (2012) 0.7 1.1 5.3 0.8 1.0 0.1 0.5 -0.1 -0.2 -0.1 1.7 1.0 -2.3
Mean Putamen Volume 0.5 0.6 1.5 -0.8 -0.5 -0.7 -1.2 0.6 1.2 -0.7 -0.4 -0.0 0.9
Fasting Glucose 0.7 0.9 1.8 -1.0 -0.5 -1.4 -0.9 0.7 -0.9 -0.6 -0.8 -1.4 0.8
HbA1C 1.5 1.7 5.4 1.4 0.5 2.3 1.2 -1.5 -0.5 0.9 0.3 1.7 -1.2
HDL Cholesterol 0.4 0.7 1.8 1.3 0.9 0.7 0.7 -0.7 0.7 1.2 -0.2 0.1 0.8
LDL Cholesterol 0.2 0.3 0.8 0.1 0.2 0.7 0.6 0.0 0.5 0.8 -0.0 0.9 -0.5
Lupus 0.1 0.2 0.6 0.4 -0.6 0.8 0.4 -0.1 -0.5 0.2 -0.4 -0.0 0.3
Neuroticism (2016) 0.5 0.8 5.6 -0.1 -0.4 -0.0 -0.3 0.6 2.4 -0.3 0.8 0.1 -0.9
Primary Biliary Cirrhosis 0.1 0.1 0.4 -0.1 -0.2 0.3 0.5 -0.3 -0.7 0.4 -0.3 -0.3 0.0
Rheumatoid Arthritis 1.0 1.3 3.4 -1.5 -1.2 -1.4 -0.9 1.3 -1.9 -1.1 -0.3 -0.5 0.1
Schizophrenia (2014) 3.9 8.6 18.9 -3.8 -2.3 -2.9 -3.1 4.3 -1.3 -3.5 0.4 -3.4 -1.9
Triglycerides 0.8 1.2 3.1 -1.0 -0.4 -0.6 -0.7 1.8 -1.8 -1.3 0.6 -0.2 -1.4
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.4 -0.6 -1.4 -0.6 -0.3 0.4 -1.9 -0.6 -1.4 -1.3 1.4
Ulcerative Colitis 0.9 1.3 4.4 0.7 0.5 0.3 1.2 -0.0 -1.9 0.2 1.5 0.7 -2.1
Blood Eosinophil Count 0.6 4.5 18.1 0.8 1.1 -0.6 -0.3 1.1 -4.1 -0.0 2.3 0.9 -4.2
Blood Platelet Count 0.2 2.7 9.4 -1.6 -1.6 -0.5 -1.2 1.1 -0.4 -1.2 -2.3 -1.7 3.1
Blood Red Count 0.1 1.2 3.0 0.9 0.8 1.4 0.7 -1.5 0.6 1.0 -0.2 1.0 1.7
Blood White Count 0.8 6.1 9.3 -3.0 -2.9 -1.8 -2.7 2.9 -0.7 -2.7 -2.0 -2.6 2.4
Heel T-Score 0.8 6.0 22.7 -1.8 -1.1 -3.4 -2.0 2.6 -4.8 -2.5 -0.4 -1.9 0.8
BMI 2.6 15.0 85.7 1.7 -0.6 -0.8 1.1 0.6 -9.3 -0.1 2.4 1.3 -7.2
Height 0.4 6.8 45.6 -0.0 0.1 -2.0 -0.5 1.8 -6.8 -0.4 1.1 0.0 -3.7
Waist Hip Ratio (WHR) 0.5 2.4 4.8 1.6 2.2 1.8 0.8 -1.8 -0.7 1.5 0.8 2.2 -0.8
Systolic Blood Pressure 1.1 5.7 21.3 0.4 -0.5 1.0 0.4 -1.6 3.8 0.4 -3.9 -1.2 4.6
Smoking Status 5.0 12.0 24.9 -2.5 -2.3 -3.6 -3.8 5.0 -4.4 -3.5 0.4 -3.7 -3.3
Allergy or Eczema 0.1 0.3 1.2 0.8 1.1 -0.1 -0.2 -0.4 -0.2 -0.2 0.6 -0.1 -0.8
Cardiovascular Disease 0.6 2.0 8.1 -1.1 -0.9 -0.8 -1.7 0.2 -0.2 -0.9 -2.8 -1.1 2.1
Hypothyroidism (self reported) 0.2 0.4 1.5 0.8 -0.2 -0.1 0.7 0.1 -0.0 0.2 1.0 0.2 -1.2
Respiratory disease 0.3 0.7 2.2 -0.2 -0.6 -1.3 -0.4 0.8 -0.9 -0.7 0.9 -0.6 -1.5
Type 2 Diabetes (T2D) (2018) 1.4 2.6 5.3 -1.4 -1.5 -1.6 -1.9 0.8 -2.3 -1.7 -1.6 -2.0 0.8
Lung FEV1/FVC ratio 0.8 4.0 13.1 0.8 1.4 0.7 1.4 -0.1 -3.3 1.0 3.1 0.8 -3.6
Lung FVC 1.2 6.0 11.7 -2.8 -1.8 -1.9 -3.0 3.2 3.4 -2.8 -0.3 -2.7 0.2
Neuroticism 0.8 2.0 6.6 -0.8 -0.8 -1.4 -1.6 2.6 1.8 -1.6 0.9 -0.4 -0.5
Chronotype (morning person) 0.6 1.3 3.6 -1.2 0.4 -1.2 -1.7 1.9 0.2 -1.3 1.1 -0.4 -0.1
Hair Pigment 0.0 0.5 2.1 0.7 -0.4 -0.8 -0.5 0.0 -1.4 -0.4 -1.2 -0.2 -0.4
Tanning 0.2 2.5 7.2 -1.9 -0.5 -1.7 -2.0 2.7 1.1 -1.4 0.8 -1.7 -0.5
Hand grip strength (left) 1.1 2.8 5.0 -1.9 -1.6 -2.0 -1.3 1.7 -2.0 -2.2 -1.2 -1.6 -0.3
Number of treatments/medications taken 0.4 0.7 1.7 -0.7 -0.8 -1.1 -0.7 1.1 -0.7 -0.6 -0.4 -1.3 -0.1
Average weekly spirits intake 5.9 7.3 19.5 -2.4 -2.6 -4.4 -2.8 3.3 1.3 -3.3 0.6 -2.8 -1.3
Sensitivity / hurt feelings 0.6 1.0 3.2 0.1 0.0 -0.7 -0.8 1.8 0.3 -0.8 1.4 -0.1 -1.7
Frequency of depressed mood in last 2 weeks 3.4 4.8 11.6 -2.5 -1.2 -2.3 -3.2 3.4 -1.0 -2.9 0.3 -1.9 -0.6
Hearing difficulty/problems: Yes 2.1 3.2 6.6 -1.3 -2.0 -2.1 -1.5 2.6 -0.6 -2.1 1.4 -1.2 -2.2
Relative age of first facial hair 1.2 2.6 14.5 -0.5 0.7 0.7 -0.5 -1.0 2.3 0.4 -1.7 -0.3 3.8
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.5 0.4 -0.6 -0.3 0.1 0.0 0.2 0.0 0.7 0.3 -0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.8 0.2 -0.7 -0.8 -0.1 0.6 0.6 -0.3 0.9 0.1 -0.8
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 -0.6 -0.1 -0.7 -0.3 0.8 0.4 -0.5 0.9 0.4 -0.8
Systolic blood pressure, automated reading 0.3 0.8 4.2 1.3 -0.3 0.6 0.9 -0.6 2.0 0.3 -0.6 0.1 0.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.2 -1.5 -1.1 -1.0 -1.0 0.7 -1.2 -1.0 -0.4 -0.8 0.2
Angina 0.1 0.1 0.3 -0.6 -0.0 -0.2 -0.2 0.0 -0.5 -0.0 0.5 0.0 -0.6
Medication for hormone replacement therapy 1.0 1.1 2.3 1.3 1.2 0.6 1.3 -1.2 0.8 1.5 0.3 1.0 0.1
Vitamin and mineral supplements 0.1 0.1 0.3 -0.6 -0.5 0.2 -0.2 -0.4 0.2 -0.4 -0.4 -0.1 0.3
Supplements: Zinc 1.3 1.4 3.6 1.8 1.9 0.6 0.9 -0.9 -0.6 1.3 0.8 1.4 -0.8
Medication: Co-codamol 2.3 2.7 5.7 -1.6 -1.0 -1.8 -2.3 2.4 -0.8 -1.6 -0.1 -1.8 -1.7
Medication: Metformin 0.8 1.1 5.4 -1.3 -2.3 0.2 -0.8 0.5 -0.2 -0.9 -1.2 -0.7 0.1
Diabetes (father) 1.6 1.9 4.5 -0.8 -0.8 -1.3 -1.3 0.6 -1.9 -1.2 -1.9 -2.1 1.1
Diabetes (mother) 0.6 0.8 2.5 -0.6 -1.2 -1.6 0.1 0.4 -1.2 -0.8 0.8 -0.6 -0.8
Severe depression (siblings) 1.2 1.3 3.0 -0.9 -0.7 -1.1 -1.2 1.1 -0.9 -0.6 -1.6 -1.2 1.7
Pack years adult smoking proportion 1.3 2.0 4.9 -1.8 -1.2 -1.0 -1.9 2.2 -1.6 -1.2 0.1 -1.0 -0.7
Impedance of leg (right) 1.7 8.3 28.3 1.4 2.5 2.9 1.6 -3.9 2.0 2.5 -2.6 1.8 5.3
Leg fat-free mass (left) 1.8 9.7 48.4 -0.5 -2.4 -2.5 -1.2 2.7 -7.0 -1.8 0.9 -1.1 -4.8
Trunk fat percentage 2.2 8.7 51.4 2.3 0.1 0.6 1.8 -0.8 -7.2 1.1 1.9 2.0 -4.2
Hand grip strength (right) 1.6 4.3 7.1 -2.3 -1.9 -2.6 -2.3 2.3 -1.1 -2.7 -1.8 -2.4 0.2
Townsend deprivation index at recruitment 1.2 1.7 8.8 0.5 0.4 -0.4 -0.3 0.4 -3.0 -0.2 1.1 0.9 -2.2
Current tobacco smoking 3.5 5.7 9.7 -2.4 -2.5 -2.1 -2.6 3.1 -2.7 -2.8 -0.5 -2.8 -1.2
Average weekly fortified wine intake 1.0 1.2 2.9 -1.2 -0.8 -1.3 -1.2 1.7 0.7 -1.4 0.4 -1.2 -0.3
Maternal smoking around birth 1.5 2.1 8.1 -0.1 0.5 -0.1 -0.2 1.1 -2.5 -0.3 2.1 1.1 -2.8
Fed-up feelings 0.6 1.1 4.2 1.5 -0.4 0.8 1.1 -0.8 1.0 0.8 0.3 2.0 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 3.3 0.0 -0.6 -0.4 0.0 1.0 -0.6 -0.5 1.8 0.6 -1.2
Relative age voice broke 2.5 3.8 16.8 0.1 1.3 1.9 0.5 -1.8 2.8 1.8 -1.1 0.3 4.1
Taking other prescription medications 0.5 0.8 3.2 -0.6 -1.0 -0.3 -0.6 1.1 -0.9 -0.7 -0.8 -1.8 0.0
Age when periods started (menarche) 6.2 14.8 26.1 3.6 3.3 4.1 4.2 -4.7 3.5 5.1 0.8 3.7 3.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 1.0 -0.3 -0.2 -0.3 -0.9 0.2 1.0 -0.7 -0.3 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 7.6 0.2 0.2 -1.2 0.3 0.4 -2.8 -0.2 -0.7 -0.0 0.4
Tinnitus: Yes, but not now, but have in the past 1.7 1.9 3.8 1.9 1.9 0.8 1.6 -1.5 0.1 1.9 1.2 0.7 0.0
Qualifications: CSEs or equivalent 4.5 6.0 13.2 2.4 3.6 2.7 2.0 -2.5 -0.6 2.8 1.6 3.3 -1.2
Serious illness, injury or assault to yourself 1.4 1.7 3.6 -1.2 -0.9 -1.5 -1.7 1.3 -1.1 -1.4 -0.9 -1.9 0.6
High blood pressure 0.4 1.2 4.4 0.3 -0.4 0.9 -0.0 -1.2 1.0 0.4 -2.1 0.6 1.8
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.6 0.4 1.3 -0.0 -0.8 -0.4 0.0 -0.5 -0.3 -0.1 -0.6
Multivitamins +/- minerals 0.2 0.3 0.8 0.9 0.2 0.1 0.6 -0.4 -0.1 0.6 -0.7 0.2 0.5
Stomach or abdominal pain in last month 0.6 0.7 2.3 1.5 1.3 0.4 0.0 -1.0 -0.1 0.6 -1.0 0.9 0.0
Supplements: Glucosamine 1.4 1.8 5.5 0.9 1.0 0.1 1.3 -0.7 -1.2 1.2 2.3 0.7 -2.3
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 5.1 -1.5 -0.9 -1.4 -1.4 1.6 2.2 -1.5 -0.4 -1.3 0.7
Medication: Atenolol 1.4 1.7 4.4 1.7 0.7 0.9 1.2 -1.7 2.1 1.5 -0.4 1.2 0.7
Medication: Levothyroxine sodium 0.9 1.5 3.1 1.4 0.3 1.5 1.8 -1.3 0.1 1.2 1.2 1.3 -1.1
Sitting height 0.5 3.7 17.2 -1.6 -1.8 -2.0 -1.5 1.4 -4.2 -1.6 -1.5 -1.3 0.0
Chronic bronchitis/emphysema (father) 1.4 1.6 6.7 -1.0 -0.5 -1.0 -1.0 1.4 -2.6 -1.5 0.6 -0.5 -1.3
High blood pressure (mother) 1.7 2.3 4.1 1.8 0.2 2.0 2.0 -1.9 1.1 2.0 -0.9 1.1 1.0
Body mass index (BMI) 2.1 8.9 44.9 1.1 -1.3 -0.7 0.4 1.3 -6.7 -0.4 2.0 0.8 -5.8
Impedance of leg (left) 2.3 11.0 30.5 2.0 2.9 3.6 2.4 -4.3 2.9 3.4 -2.2 2.3 5.5
Leg predicted mass (left) 1.8 9.5 47.8 -0.5 -2.4 -2.4 -1.2 2.7 -6.9 -1.8 0.8 -1.1 -4.8
Trunk fat mass 2.4 10.4 67.9 1.6 -0.8 -0.3 1.0 0.4 -8.2 0.3 1.9 1.3 -5.1
Waist circumference 2.3 8.5 48.8 1.5 -0.9 -0.3 0.4 0.8 -7.0 -0.2 1.8 1.2 -5.3
Number of incorrect matches in round 1.1 1.9 4.7 2.2 1.7 0.7 1.1 -1.0 1.4 1.5 1.5 1.1 -0.8
Past tobacco smoking 2.0 3.6 7.1 1.5 0.8 1.9 2.2 -2.7 2.6 2.2 0.1 1.6 1.9
Alcohol usually taken with meals 3.4 5.5 13.4 2.4 2.4 2.6 2.7 -3.7 -0.1 2.8 0.4 2.7 0.1
Nervous feelings 1.2 2.2 17.0 -0.1 1.0 1.3 -0.3 0.0 4.1 0.6 -0.6 -0.0 1.3
Frequency of tenseness / restlessness in last 2 weeks 4.7 7.3 14.5 -3.2 -2.7 -3.3 -3.7 3.8 1.1 -3.2 -0.5 -2.2 0.0
Hearing difficulty/problems with background noise 3.5 5.7 11.8 -1.4 -1.7 -2.7 -2.3 3.1 -2.5 -2.9 1.2 -1.6 -3.4
Hair/balding pattern: Pattern 2 0.7 0.9 5.7 -0.3 -0.3 0.6 -0.0 -0.6 0.1 0.5 -1.4 0.2 2.4
Had menopause 1.1 1.3 6.0 0.2 -0.9 0.6 0.5 0.6 1.6 -0.0 1.5 0.8 -2.5
Had other major operations 0.1 0.2 0.8 -0.1 -0.4 -0.1 -0.1 -0.1 -0.9 0.2 -0.5 -0.3 0.6
Forced vital capacity (FVC) 1.2 4.5 7.9 -2.8 -2.2 -2.2 -2.5 2.4 0.1 -2.4 -1.8 -2.5 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 6.1 0.5 0.4 -0.9 0.6 0.1 -2.5 0.0 -0.3 0.5 0.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 0.2 -0.1 -0.2 -0.4 -0.4 0.8 -0.3 -1.2 -0.1 1.1
Qualifications: None of the above 1.2 2.7 9.5 -1.0 -1.7 -0.4 -1.0 2.4 3.1 -1.3 1.0 -0.7 -1.7
Financial difficulties in last 2 years 0.1 0.1 0.5 0.1 -0.1 -0.2 -0.3 -0.3 -0.6 -0.1 -0.0 -0.0 0.7
Mouth/teeth dental problems 2.2 3.4 8.0 2.1 1.4 2.0 2.3 -2.8 1.0 2.6 -0.9 0.5 1.3
Heart attack 0.4 0.5 3.9 -0.5 0.1 0.2 0.3 -0.4 -0.1 0.3 -0.7 -0.6 2.0
Allergy 0.6 1.3 3.8 1.0 -0.3 1.4 1.9 -1.1 0.6 1.5 0.9 1.4 0.2
Pain all over the body in last month 1.2 1.3 6.4 1.0 0.1 -0.2 0.3 0.1 -0.7 0.4 2.1 0.6 -2.5
Diabetes (self-reported) 0.4 0.6 3.1 -0.2 -0.6 -0.3 -0.7 0.2 -1.8 -0.6 -1.0 -0.6 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.3 0.6 0.3 0.0 0.4 -0.2 -1.0 0.0 0.8 0.2 -1.1
Medication: Ramipril 2.0 2.5 5.3 -2.3 -0.6 -1.3 -2.2 2.0 -1.2 -2.0 -1.2 -1.6 -0.0
Medication: Simvastatin 0.5 0.7 1.5 0.7 0.7 0.6 1.2 -0.9 -0.5 1.0 0.6 1.2 -0.8
Fluid intelligence score 0.6 1.3 6.4 0.6 1.1 0.3 0.6 -1.5 -2.5 1.0 -0.7 -0.1 1.1
Illnesses of siblings 0.2 0.3 0.8 -0.1 0.9 0.5 0.2 -0.6 -0.7 0.6 0.3 0.8 -0.1
Neuroticism score 0.5 1.1 5.9 -0.3 -0.7 -0.7 -0.7 1.6 2.4 -0.8 0.8 0.1 -0.1
Weight 2.3 11.1 66.7 0.7 -1.6 -1.2 -0.0 1.7 -8.2 -0.7 1.6 0.4 -5.8
Impedance of arm (right) 0.8 3.9 9.5 1.1 2.7 1.5 1.5 -3.1 2.0 1.8 0.4 1.8 2.5
Arm fat percentage (right) 2.5 9.9 52.9 1.8 -0.4 -0.3 1.0 0.1 -7.3 0.1 2.5 1.8 -5.7
Trunk fat-free mass 1.9 10.8 35.3 -1.6 -3.3 -3.0 -2.2 3.8 -5.9 -2.8 0.1 -2.1 -4.3
Hip circumference 2.1 9.2 51.9 0.7 -1.6 -1.2 0.2 1.7 -7.2 -0.9 1.7 0.4 -5.3
Time employed in main current job 0.5 0.6 3.8 0.4 0.0 -0.5 0.3 0.7 -0.3 -0.2 0.9 0.1 -1.9
Alcohol intake versus 10 years previously 1.4 2.1 7.6 -1.0 -2.1 -0.2 -0.8 0.2 -0.1 -0.8 -2.8 -1.4 2.2
Father’s age at death 0.2 0.3 1.6 -0.2 -0.0 1.3 0.1 -0.1 0.8 0.3 0.5 0.6 0.2
Worrier / anxious feelings 1.6 3.1 14.8 -0.9 -1.0 -0.8 -1.5 1.5 3.8 -1.3 -1.8 -1.2 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 8.3 -0.6 -1.0 -0.7 -1.1 1.4 -2.9 -0.9 -0.2 -0.0 -0.8
Falls in the last year 6.1 8.2 15.1 -2.9 -2.6 -3.9 -3.4 3.4 -2.5 -3.4 -0.8 -2.6 -1.9
Hair/balding pattern: Pattern 3 0.9 1.3 4.7 0.5 1.4 0.2 0.3 0.1 -1.6 0.1 1.9 0.2 -2.2
Number of live births 3.0 4.3 8.2 -1.7 -2.2 -2.8 -2.1 2.9 -2.2 -2.3 -0.3 -1.8 -0.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 4.7 -2.2 -1.1 -1.4 -1.8 1.6 -0.2 -1.6 -1.3 -1.8 0.7
Pulse rate 1.1 1.9 7.3 -1.3 -1.2 0.4 -1.0 0.3 -0.3 -0.8 -2.7 -0.8 2.5
Happiness 0.5 0.6 1.0 0.7 0.4 0.7 0.6 -1.0 -0.9 0.6 -1.0 1.0 0.4
Noisy workplace 1.8 2.3 4.1 -2.0 -2.0 -1.5 -1.9 2.0 0.2 -1.8 -0.6 -1.0 0.3
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.4 1.0 1.0 -0.1 1.0 -1.5 -0.7 0.9 -1.4 -0.4 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 0.7 0.5 0.9 0.0 -0.5 -0.1 0.5 -0.4 -0.1 0.8
Mouth/teeth dental problems: Dentures 2.7 4.6 10.0 -2.8 -2.6 -2.0 -1.9 3.2 -1.7 -2.6 0.6 -0.8 -1.8
Asthma 0.7 1.4 3.2 -0.8 -1.0 -1.8 -1.1 1.7 -0.9 -1.2 0.3 -1.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.4 0.7 0.5 1.1 1.2 -0.5 -0.7 1.0 0.5 0.7 0.7
Medication: Cholesterol lowering 0.2 0.4 1.9 -0.5 0.5 0.3 0.1 -0.3 0.5 0.1 -0.9 0.1 1.4
Depression (self-reported) 0.9 1.1 4.6 1.0 2.2 1.2 0.1 -0.1 -0.5 1.1 0.7 0.6 1.0
Medication: Lansoprazole 0.3 0.3 1.1 -0.6 0.7 0.3 -0.6 0.1 0.8 0.3 -0.0 -0.3 1.1
Prospective memory result 1.0 1.3 3.4 -0.6 -0.6 -1.4 -0.9 1.8 0.4 -1.1 1.2 -0.9 -1.5
Lung cancer (father) 1.4 1.6 3.0 1.5 0.8 1.2 1.0 -0.8 0.8 1.0 1.7 1.7 -1.7
Illnesses of mother 0.3 0.4 1.5 -1.0 0.1 -0.5 -1.2 0.5 -0.0 -0.8 -0.0 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 4.3 -2.1 -1.1 -1.2 -1.7 1.9 0.8 -1.5 -0.9 -1.8 0.8
Pulse wave Arterial Stiffness index 0.2 0.3 1.9 -0.4 -0.0 -0.1 -0.3 0.1 1.4 -0.0 0.2 -0.0 0.7
Impedance of arm (left) 1.0 4.7 11.4 1.0 2.6 1.6 1.5 -3.3 2.5 1.9 -0.1 1.6 3.4
Arm fat mass (right) 2.5 10.1 58.5 1.3 -1.3 -0.7 0.5 1.0 -7.7 -0.3 1.9 1.1 -5.7
Trunk predicted mass 2.0 11.3 36.2 -1.7 -3.4 -3.1 -2.3 3.9 -6.0 -2.9 0.2 -2.2 -4.4
Standing height 0.2 2.4 17.5 -0.6 -0.9 -1.3 -0.7 1.0 -4.2 -0.7 -0.4 -0.7 -1.0
Length of working week for main job 1.7 1.9 4.3 0.9 1.8 1.0 0.4 -1.9 -0.6 2.0 -0.7 1.1 2.1
Exposure to tobacco smoke at home 0.4 0.5 1.5 0.2 1.1 -0.4 0.3 0.3 -1.2 0.3 0.7 -0.4 -0.9
Breastfed as a baby 0.9 1.1 7.6 0.9 0.5 -0.2 -0.1 0.5 -1.1 -0.2 1.1 0.0 -2.8
Tense / ‘highly strung’ 3.8 6.3 14.7 -2.8 -2.4 -2.7 -3.1 3.8 2.3 -3.1 0.3 -1.6 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 7.9 -1.6 -1.3 -1.2 -1.9 2.8 1.0 -1.8 -0.9 -2.1 1.2
Hair/balding pattern: Pattern 4 1.4 3.3 5.8 -2.2 -2.0 -2.3 -1.8 2.4 0.1 -2.1 0.1 -2.3 -0.7
Birth weight of first child 1.0 1.8 4.7 1.7 0.5 1.0 1.5 -1.1 -0.2 0.8 1.3 1.9 -2.2
Peak expiratory flow (PEF) 0.4 0.9 7.0 -0.8 0.1 0.1 -0.4 -0.1 -2.6 -0.3 -0.7 -0.7 0.3
Pulse wave reflection index 0.4 0.4 1.5 0.7 0.2 -0.0 0.2 -0.9 1.2 0.5 -0.4 0.1 1.0
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.4 -1.1 -1.0 -1.1 -1.2 0.8 0.2 -1.1 -0.5 -0.5 0.3
Loud music exposure frequency 0.3 0.4 1.3 0.3 0.3 0.3 1.1 -0.6 -0.5 1.1 0.4 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.3 -0.1 0.3 0.9 0.5 -1.3 -0.2 0.8 -2.0 -0.6 2.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 4.0 0.3 -0.8 -0.3 -0.1 0.1 2.0 -0.3 -0.7 0.0 1.2
Blood clot in the leg (DVT) 1.6 2.1 4.0 -1.4 -0.8 -1.9 -2.0 1.9 -1.4 -1.5 -0.0 -1.3 -1.0
Medication: Paracetamol 0.2 0.3 2.0 0.2 -0.8 0.0 -0.2 0.0 -1.4 0.3 -0.2 -0.2 0.5
Headache pain in last month 0.7 1.2 6.2 -0.1 0.7 1.0 -0.2 -0.8 -0.3 0.4 -1.9 -0.2 2.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 0.3 0.2 0.4 0.1 0.1 -0.8 0.3 1.0 0.0 -0.9
Glaucoma (self-reported) 2.2 2.6 4.9 1.5 1.3 1.9 1.7 -2.2 1.8 1.4 -0.2 2.2 0.8
Gout (self-reported) 1.7 2.3 8.1 -0.1 -0.3 -1.6 -0.3 1.3 -2.7 -0.8 1.6 -0.2 -2.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.5 0.6 -0.4 0.4 1.0 0.2 0.1 0.4 1.2 0.2 -1.2
Medication: Amlodipine 1.3 1.8 3.9 1.3 1.1 2.0 1.4 -1.7 0.5 1.8 0.4 1.7 0.2
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.6 -0.6 -0.3 -1.3 -1.4 1.6 -1.3 -1.0 -0.4 -1.5 -0.8
Birth weight 1.2 2.6 4.7 2.2 1.0 1.9 2.0 -2.0 -1.2 1.6 -0.2 1.7 -1.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 6.9 -0.6 -0.1 -0.9 -0.1 1.1 -2.6 -0.7 1.1 -0.7 -1.7
High blood pressure (siblings) 0.5 0.7 1.9 -0.7 -1.4 -0.4 -0.5 0.4 0.8 -0.7 -0.8 -0.9 1.0
Forced vital capacity (FVC), Best measure 1.2 4.5 6.9 -2.6 -2.2 -2.0 -2.4 2.4 1.2 -2.2 -1.6 -2.5 1.4
Body fat percentage 2.4 9.5 51.8 2.4 0.1 0.6 1.9 -0.7 -7.2 1.1 2.0 2.2 -4.7
Leg fat percentage (right) 2.7 9.6 50.6 2.1 -0.2 0.5 1.6 0.0 -7.1 0.5 2.2 2.2 -5.3
Arm fat-free mass (right) 1.4 7.4 34.0 -0.9 -2.9 -1.9 -1.3 2.8 -5.8 -1.6 -0.2 -1.4 -3.5
Exposure to tobacco smoke outside home 1.2 1.7 4.8 -1.1 -1.6 -2.2 -1.4 1.1 -0.9 -1.3 -0.7 -1.5 -0.4
Comparative body size at age 10 3.0 8.3 27.0 -1.8 -0.9 -2.2 -1.5 3.9 -3.8 -2.1 3.3 -0.1 -5.2
Number of full brothers 0.5 0.6 3.1 -0.1 -0.2 -0.7 -0.3 0.9 -0.7 -0.3 1.2 -0.1 -1.8
Worry too long after embarrassment 0.6 1.0 2.5 -0.1 -0.0 -1.6 -1.1 1.5 1.0 -0.9 0.7 -0.2 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.3 1.1 0.7 0.7 0.6 0.3 1.3 0.2 1.5 0.3 -1.2
Wheeze or whistling in the chest in last year 2.4 4.3 9.5 -1.0 -1.3 -2.3 -2.3 3.1 -2.7 -2.1 1.0 -1.2 -2.4
Number of children fathered 0.3 0.3 1.5 -0.2 -0.7 -0.0 0.5 -0.2 1.2 0.3 -0.1 0.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.5 -1.0 0.9 -1.2 -1.1 1.8 0.9 -1.2 0.7 -1.2 -1.9
Age at first live birth 2.3 4.2 9.7 2.5 2.1 2.3 2.4 -3.1 0.8 2.3 0.6 2.0 -0.4
Pulse wave peak to peak time 0.3 0.4 2.7 0.3 -0.2 -0.1 0.2 0.2 -1.6 -0.1 0.0 -0.1 -1.1
Health satisfaction 2.6 3.4 6.4 -1.6 -1.8 -2.5 -2.0 1.7 -0.7 -1.6 -2.1 -2.1 1.5
Shortness of breath walking on level ground 2.0 2.4 4.3 -1.8 0.1 -1.3 -2.1 1.3 -1.0 -1.1 -2.1 -2.0 1.3
Qualifications: College or University degree 1.2 3.8 10.7 2.3 2.6 1.1 1.9 -3.3 -0.5 2.1 -1.0 1.1 1.8
Eye problems/disorders: None of the above 1.3 1.5 3.1 1.2 0.5 1.2 0.9 -1.4 -0.9 1.4 -1.8 0.7 1.8
Mouth/teeth dental problems: Loose teeth 2.6 3.1 5.7 -2.0 -1.9 -2.1 -1.9 2.4 0.8 -1.9 1.3 -1.9 -0.7
Emphysema/chronic bronchitis 0.8 0.9 1.9 -1.0 -0.6 -0.9 -1.3 1.4 -0.6 -1.0 -0.5 -1.2 -0.2
Medication for pain relief, constipation, heartburn 0.5 0.9 3.9 1.0 1.0 0.6 0.7 -0.8 2.0 0.6 -0.0 0.9 -0.5
Neck or shoulder pain in last month 0.6 0.9 3.6 0.3 0.1 -0.5 0.2 0.4 -1.5 -0.0 1.2 0.7 -1.9
Medication: Blood pressure 0.6 1.0 3.7 -0.7 -1.0 -0.3 -0.4 -0.5 0.9 -0.5 -1.9 -0.2 1.8
Angina (self-reported) 0.1 0.1 0.4 -0.5 0.1 -0.0 -0.1 -0.1 -0.3 0.2 0.6 0.1 -0.4
Migraine (self-reported) 1.8 2.3 5.1 2.0 0.6 1.7 1.9 -1.4 2.3 1.7 -0.7 1.0 0.7
Medication: Ibuprofen 0.4 0.5 1.3 0.8 0.7 0.8 1.0 -0.5 -0.5 0.8 0.2 0.3 1.1
Medication: Allopurinol 0.7 1.0 4.9 0.3 -0.2 -0.8 0.3 0.5 -2.2 -0.2 1.0 -0.5 -1.5
Medication: Omeprazole 1.4 1.6 2.9 -1.5 -1.3 -1.3 -1.7 1.1 0.2 -1.6 -1.2 -1.6 0.4
Medication: Seretide 50 evohaler 0.6 0.7 3.7 0.6 0.1 -0.2 0.1 -0.1 -1.2 0.1 1.0 0.7 -1.9
Mean time to correctly identify matches 4.2 8.0 17.7 -2.6 -2.8 -2.8 -2.8 4.2 -1.3 -3.2 1.6 -1.5 -3.9
Heart disease (mother) 0.2 0.2 0.6 -0.0 -0.8 -0.2 -0.1 0.6 -0.1 -0.3 -0.5 -0.8 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.5 4.2 9.2 -3.0 -2.2 -1.4 -1.8 2.9 -1.1 -2.5 1.4 -1.5 -1.5
Whole body fat mass 2.6 10.7 67.6 1.8 -0.9 -0.2 1.1 0.3 -8.2 0.2 1.8 1.5 -5.4
Leg fat mass (right) 2.6 9.9 61.6 1.5 -1.0 -0.2 0.8 0.7 -7.8 -0.1 1.6 1.4 -5.3
Arm predicted mass (right) 1.3 6.6 31.4 -0.6 -2.6 -1.8 -1.2 2.6 -5.6 -1.5 -0.2 -1.3 -3.5
Pulse rate, automated reading 0.9 3.0 8.6 -2.0 -1.9 0.0 -0.8 0.8 -1.1 -1.2 -2.4 -2.0 2.9
Alcohol intake frequency. 0.4 0.9 3.1 0.8 -0.6 0.4 1.3 -1.2 -1.8 0.8 -0.2 0.7 0.6
Comparative height size at age 10 2.6 14.5 32.5 -3.0 -2.9 -3.6 -3.0 4.9 -5.1 -4.1 1.6 -2.0 -5.7
Number of full sisters 1.9 2.3 4.3 1.8 1.2 1.1 1.7 -1.0 -2.1 1.3 1.0 1.8 -1.9
Suffer from ‘nerves’ 0.5 0.7 4.6 -0.6 -0.5 0.1 -0.0 1.1 2.1 -0.3 0.8 0.6 -0.3
Overall health rating 0.6 1.2 7.5 -0.7 -0.5 -0.7 -0.9 0.9 -2.7 -0.4 -0.8 -0.5 0.5
Chest pain or discomfort 0.4 0.5 3.3 -0.4 -0.1 -0.7 -0.5 0.1 -1.8 -0.4 -0.8 -0.0 0.3
Had major operations 3.2 3.8 8.5 -2.0 -1.6 -2.9 -2.4 2.0 -0.2 -2.4 -0.2 -2.6 0.0
Age at last live birth 1.8 2.6 5.7 1.6 1.8 1.8 1.9 -2.4 -0.1 1.8 0.4 1.9 -0.5
Family relationship satisfaction 1.3 1.6 7.2 0.8 0.5 -0.3 0.2 0.1 -2.7 0.0 1.6 1.0 -1.9
Leg pain on walking 3.1 3.9 7.5 -2.5 -1.0 -2.7 -2.4 2.7 -0.0 -2.5 -0.4 -1.9 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.0 -0.0 0.2 -0.7 -0.3 0.2 1.0 0.1 0.7 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.5 -0.9 -1.3 -0.5 -0.8 0.2 -0.2 -0.8 -1.9 -0.4 1.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 0.3 0.1 -0.1 0.9 -0.1 1.3 0.4 1.4 1.0 -1.3
Medication: Aspirin 0.5 0.6 3.6 -0.9 0.2 -0.2 0.1 0.7 -0.9 0.1 1.9 0.1 -0.7
Supplements: Vitamin C 0.7 0.8 2.5 -0.2 -0.5 -1.6 -1.0 0.8 0.8 -0.8 -0.1 -1.3 -0.7
Knee pain experienced in last month 5.1 7.9 13.9 -2.7 -2.5 -3.3 -3.5 3.6 -0.4 -3.1 -1.8 -3.7 1.5
Hypertension (Self-reported) 0.5 1.4 5.7 0.0 -0.5 0.7 -0.2 -1.1 1.0 0.3 -2.4 0.4 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.5 0.3 -0.3 0.0 -0.7 -0.1 -0.2 -0.4 -0.2 -0.4 -0.0
Illnesses of father: Heart disease 1.3 1.8 4.7 1.5 1.3 0.8 1.6 -2.2 -0.2 1.5 0.4 2.0 -0.4
Illnesses of siblings: Diabetes 0.1 0.2 0.5 0.7 -0.4 -0.6 0.2 0.1 -0.2 -0.0 -0.4 0.4 -0.7
Smoking status: Previous 1.3 2.0 3.9 -1.1 -0.1 -1.4 -1.6 2.0 -1.7 -1.5 0.6 -0.9 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.1 7.5 -2.4 -2.6 -2.7 -2.3 2.6 -2.0 -2.5 -1.6 -2.5 0.5
Whole body fat-free mass 1.8 10.4 40.1 -1.2 -3.0 -2.9 -1.8 3.4 -6.3 -2.4 0.4 -1.8 -4.6
Leg fat-free mass (right) 1.6 8.7 39.8 -0.5 -2.2 -2.5 -1.1 2.7 -6.3 -1.6 1.1 -1.1 -4.7
Arm fat percentage (left) 2.1 8.6 47.5 1.7 -0.6 -0.3 1.0 0.1 -6.9 0.2 2.2 1.6 -5.2
Average weekly red wine intake 0.8 1.2 4.5 1.1 2.1 0.3 0.8 -1.2 -1.2 1.1 0.5 1.0 -0.6
Handedness (chirality/laterality): Left-handed 4.1 4.9 7.8 2.6 2.6 2.5 2.5 -2.7 -0.8 2.8 0.8 2.6 -0.1
Mood swings 0.5 1.0 2.4 -0.4 -1.4 -1.3 -0.8 1.2 1.6 -0.7 0.1 -0.1 1.0
Loneliness, isolation 0.3 0.3 1.1 -0.2 0.4 -0.7 -0.9 0.7 -1.0 -0.6 -0.3 0.1 0.3
Long-standing illness, disability or infirmity 0.3 0.5 2.0 0.1 -0.4 -0.2 0.1 0.5 -1.1 -0.1 1.1 -0.6 -1.4
Ever had bowel cancer screening 0.7 0.8 7.1 0.1 -0.1 0.3 0.1 0.4 2.7 0.1 0.9 -0.1 -0.1
Diabetes diagnosed by doctor 0.7 1.1 2.2 -1.0 -1.4 -0.7 -1.0 0.5 -1.5 -1.1 -1.4 -0.7 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 4.6 0.7 0.3 -0.8 -0.1 -0.6 -2.1 0.5 -0.1 0.1 -1.0
Friendships satisfaction 2.0 2.4 6.5 -0.8 -0.9 -2.1 -1.7 1.8 -2.5 -1.7 0.1 -1.0 -1.4
Qualifications: nursing, teaching 0.2 0.3 1.3 -0.2 0.1 -1.0 -0.2 -0.1 -0.0 -0.5 -0.5 -0.2 1.2
Commuting to job workplace: Walk 0.4 0.4 1.2 0.7 0.7 -0.1 0.2 0.1 -0.9 0.5 1.1 -0.7 -0.8
Eye problems/disorders: Cataract 3.3 3.9 8.5 -2.4 -0.9 -1.2 -2.2 2.9 1.6 -2.2 2.0 -1.6 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 -0.3 1.0 0.5 -0.7 0.3 0.4 -0.5 0.0 0.7 -0.7
Medication for cholesterol 0.8 1.2 3.3 -1.8 -1.0 -0.6 -0.9 1.2 0.8 -1.4 0.7 -1.2 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 4.7 -0.5 0.8 1.1 -0.1 0.0 -2.2 0.2 -0.3 -0.1 0.3
Back pain experienced in last month 0.2 0.4 0.9 0.7 0.4 0.9 0.3 -0.5 -0.9 0.8 -0.4 0.2 0.4
Mineral and other dietary supplements 1.3 1.7 6.4 -1.1 -1.0 0.7 -1.0 -0.3 0.5 -0.5 -2.5 -0.6 2.5
Breast cancer (self-reported) 0.7 0.9 2.5 0.6 0.7 0.7 0.7 -0.5 1.0 0.4 1.3 1.2 -1.6
Asthma (self-reported) 0.6 1.2 2.9 -0.8 -1.0 -1.7 -1.1 1.6 -0.5 -1.1 0.4 -1.1 -1.0
Osteoporosis (self-reported) 0.5 0.6 1.9 -1.2 -0.7 0.0 -0.8 0.9 1.4 -0.5 -0.1 -0.9 0.0
Osteoarthritis (self-reported) 1.5 1.9 5.2 -1.1 -1.1 -1.4 -1.6 2.3 -0.2 -1.4 0.7 -1.3 -1.5
Medication: Aspirin 0.4 0.5 1.9 -1.0 -0.1 -0.5 -0.1 0.6 -1.4 -0.1 1.1 -0.3 0.1
Medication: Gliclazide 0.3 0.4 1.5 -0.6 -0.7 0.1 -0.1 0.1 -1.2 -0.2 -0.5 -0.6 1.0
Illnesses of father: None of the above (group 1) 0.4 0.4 1.3 0.1 0.7 1.1 0.5 -0.2 0.9 1.1 0.1 0.2 0.6
Smoking status: Current 3.6 5.7 10.2 -2.4 -2.4 -2.2 -2.6 3.2 -2.6 -2.8 -0.3 -2.8 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.7 -1.9 0.3 -0.3 -1.5 1.6 1.2 -1.4 0.6 -1.1 -0.2
Whole body water mass 1.8 10.4 40.3 -1.3 -3.0 -2.9 -1.9 3.5 -6.3 -2.4 0.3 -1.8 -4.5
Leg predicted mass (right) 1.6 8.3 39.6 -0.4 -2.2 -2.4 -1.1 2.6 -6.3 -1.6 0.9 -1.1 -4.5
Arm fat mass (left) 2.4 10.0 60.7 1.4 -1.4 -0.6 0.6 0.9 -7.8 -0.2 1.7 1.1 -5.5
Number of self-reported non-cancer illnesses 0.2 0.4 1.8 0.2 -0.2 -0.6 -0.7 0.8 -0.3 -0.2 0.3 -0.7 -1.3
Average weekly champagne plus white wine intake 3.1 4.3 9.9 2.3 2.5 2.1 2.1 -3.1 -1.1 2.7 0.7 2.0 -0.5
Miserableness 0.3 0.5 1.4 -0.2 -1.2 -0.4 -0.8 0.7 -0.5 -1.0 -0.8 -0.3 0.6
Guilty feelings 1.2 1.8 6.8 0.9 0.7 -1.2 -0.1 1.1 -1.4 -0.4 2.1 0.7 -2.6
Wears glasses or contact lenses 1.0 1.2 4.2 0.5 -0.5 0.7 0.8 -0.2 1.2 0.0 2.0 0.9 -1.9
Ever taken oral contraceptive pill 1.8 2.0 10.1 -0.5 -0.1 -0.4 -0.9 -0.2 -0.6 0.1 -2.6 -1.3 3.2
Hearing aid user 0.4 0.5 3.1 -0.3 -0.2 -0.3 -0.1 1.1 -0.3 -0.2 1.8 -0.0 -0.6
Mother’s age at death 0.7 0.9 4.8 0.9 1.2 0.3 0.5 -0.7 2.2 0.8 0.6 0.1 -0.1
Financial situation satisfaction 0.9 1.1 2.2 1.3 1.1 0.7 0.8 -1.0 0.1 1.3 0.8 1.5 -1.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.2 -0.6 -0.7 -1.5 -1.1 0.5 -1.2 -1.0 -0.3 -0.2 -0.5
Commuting to job workplace: Public transport 0.3 0.4 1.4 0.8 -0.2 -0.2 0.8 -0.5 -1.2 0.3 -0.0 -0.5 0.6
Eye problems/disorders: Glaucoma 2.1 2.5 5.5 1.7 1.2 1.8 2.1 -2.3 1.4 1.6 0.1 1.7 0.7
Medication: Blood pressure 0.6 1.1 2.9 1.7 1.0 1.2 0.9 -1.3 0.1 1.3 0.1 1.2 -0.2
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 -0.2 -0.3 -0.9 -1.3 1.2 -0.0 -1.3 -0.1 -1.2 -0.8
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.8 0.7 0.1 -0.9 0.4 0.4 -0.2 -0.1 1.2 0.0 -1.4
High cholesterol (Self-reported) 0.5 0.9 1.6 -1.0 -1.2 -1.1 -1.0 1.1 -0.4 -1.3 0.1 -0.6 -1.1
Medication: Bendroflumethiazide 0.6 0.9 2.0 -0.8 -1.1 -0.8 -0.9 1.3 1.1 -1.4 0.2 -0.7 -0.8
Medication: Paracetamol 0.2 0.3 1.2 0.8 -0.5 0.1 0.1 -0.4 -1.1 0.7 -0.4 -0.2 0.6
Medication: Lisinopril 0.7 0.9 3.8 1.3 0.0 0.0 1.0 -1.9 0.1 1.1 -0.0 0.9 0.6
Medication: Atorvastatin 0.6 0.8 5.4 -0.3 0.1 0.6 0.2 -0.4 -2.3 0.2 -1.0 0.5 0.5
Illnesses of father: High blood pressure 0.3 0.4 1.9 0.5 -0.6 -0.7 0.3 -0.5 1.4 -0.1 -0.3 0.2 0.5
Alcohol drinker status: Never 0.3 0.4 1.4 -0.6 0.3 -0.1 0.6 0.0 -1.1 0.1 1.2 -0.3 0.1
Ever smoked 1.5 2.7 5.2 -1.3 -0.9 -1.6 -2.1 2.3 -2.0 -1.9 -0.5 -1.5 -1.4
Basal metabolic rate 1.8 10.2 50.0 -0.7 -2.7 -2.4 -1.4 3.0 -7.1 -1.9 0.4 -1.2 -4.7
Leg fat percentage (left) 2.7 9.9 45.2 2.6 -0.0 0.7 2.0 -0.2 -6.7 1.0 2.7 2.4 -5.4
Arm fat-free mass (left) 1.6 7.9 38.8 -0.4 -2.4 -1.6 -1.1 2.7 -6.2 -1.5 0.5 -1.1 -4.4
Number of operations (self-reported) 1.2 1.7 3.2 -1.8 -1.0 -1.6 -1.6 1.8 0.1 -1.7 0.3 -1.1 -0.6
Average weekly beer plus cider intake 4.9 7.1 13.1 -2.6 -1.7 -3.3 -3.5 3.5 -1.6 -2.9 -1.6 -3.6 -0.3
Irritability 1.5 2.5 8.8 -1.8 -1.5 -1.6 -1.4 1.7 3.0 -1.2 0.2 -1.2 0.7
Risk taking 1.3 1.9 6.8 -0.7 0.1 -2.1 -2.6 1.3 -0.8 -1.3 -0.3 -1.5 -0.8
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.6 -0.1 -0.3 -0.6 0.3 0.4 0.8 -0.4 0.2 0.1 -0.5
Fractured/broken bones in last 5 years 0.3 0.4 2.2 0.5 0.1 0.9 -0.6 0.0 1.5 0.5 -0.1 -0.4 -0.3
Age started oral contraceptive pill 0.9 1.2 3.1 1.6 0.1 0.3 1.2 -0.4 1.0 0.6 1.4 0.9 -1.8
Diastolic blood pressure, automated reading 0.2 0.5 3.1 -0.2 -1.0 -0.2 -0.4 0.4 1.8 -0.4 -0.4 -0.5 0.5
Ever depressed for a whole week 0.7 0.8 2.5 1.2 0.0 1.0 0.8 -1.2 1.6 0.6 -0.7 0.4 0.5
Unable to work because of sickness or disability 5.1 6.6 12.8 -2.8 -3.0 -2.4 -3.0 3.6 0.2 -3.3 -0.3 -3.1 -1.1
Commuting to job workplace: Cycle 0.3 0.4 1.0 -0.1 0.3 -0.7 -0.5 0.4 1.0 -0.3 0.9 -0.5 -0.7
Myopia 3.3 4.8 8.9 2.1 2.7 2.6 2.3 -3.0 -1.6 2.7 0.9 2.2 0.2
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.3 -0.5 -0.1 -1.3 -0.5 1.4 -1.3 -0.8 1.5 -1.0 -1.5
Cholesterol lowering medication 0.5 0.8 3.3 0.9 -0.3 0.0 0.7 -0.1 -1.4 0.2 0.7 0.9 -1.8
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 3.9 -1.6 -0.9 -1.2 -2.0 0.9 -0.1 -1.6 -1.6 -1.6 1.1
Pain experienced in last month 0.1 0.1 0.3 -0.2 -0.6 -0.1 0.6 -0.4 0.6 -0.2 0.0 0.2 0.4
Supplements: Calcium 0.6 0.7 2.3 0.1 -0.5 -1.4 -1.0 0.9 -0.2 -0.6 0.1 -0.5 -1.5
Basal cell carcinoma (self-reported) 1.8 2.1 5.8 2.0 0.8 1.2 1.1 -1.2 0.3 0.8 1.4 2.4 -1.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 3.2 -0.7 -0.2 0.1 0.2 -0.2 -0.3 0.1 -0.7 -0.8 1.8
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.6 -1.3 -0.5 -1.6 -1.9 1.8 -1.5 -1.4 0.1 -1.2 -1.0
Heart disease (siblings) 0.6 0.8 2.0 1.4 0.7 0.2 1.2 -0.8 -0.3 0.9 1.0 0.7 -0.9
Alcohol drinker status: Previous 1.8 2.1 5.0 -1.3 -0.6 -1.6 -2.2 1.4 -0.4 -1.6 -1.4 -2.0 0.6
Pack years of smoking 1.1 1.6 4.3 -1.7 -1.1 -0.8 -1.7 2.1 -1.4 -1.1 0.3 -0.8 -0.8
Impedance of whole body 1.7 8.7 23.3 1.6 3.1 2.7 2.0 -4.1 3.1 2.9 -1.2 2.1 4.8
Leg fat mass (left) 2.5 9.6 57.9 1.7 -1.0 -0.0 1.0 0.6 -7.6 0.2 1.7 1.5 -5.2
Arm predicted mass (left) 1.6 8.0 39.9 -0.6 -2.5 -1.8 -1.1 2.7 -6.3 -1.5 0.2 -1.2 -4.3