Hub : Genes

METTL15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1100	0.0350	4.5e-08	0.079	0.074	0.060	0.082	0.093	8.0e-10	2.5e-09	7.9e-08	3.3e-10	2.2e-11
2	GTEx	Adipose Subcutaneous	0.0770	0.0330	4.4e-04	0.005	NA	0.019	NA	0.013	1.2e-01	NA	1.0e-02	NA	2.8e-02
3	GTEx	Brain Caudate basal ganglia	0.1040	0.0550	9.1e-03	0.095	NA	0.002	NA	0.091	1.1e-03	NA	2.7e-01	NA	1.4e-03
4	GTEx	Brain Nucleus accumbens basal ganglia	0.1590	0.0680	2.0e-03	0.036	NA	0.039	NA	0.052	3.8e-02	NA	3.3e-02	NA	1.6e-02
5	GTEx	Cells Transformed fibroblasts	0.1060	0.0440	4.8e-05	0.022	NA	0.031	NA	0.029	8.5e-03	NA	2.0e-03	NA	2.7e-03
6	GTEx	Liver	0.1760	0.0730	3.7e-03	0.050	NA	0.061	NA	0.089	1.6e-02	NA	8.8e-03	NA	1.9e-03
7	GTEx	Skin Sun Exposed Lower leg	0.0450	0.0230	5.5e-03	0.003	NA	-0.002	NA	-0.001	1.8e-01	NA	6.1e-01	NA	4.5e-01
8	GTEx	Testis	0.1540	0.0580	5.8e-04	0.005	NA	-0.006	NA	0.001	1.8e-01	NA	8.5e-01	NA	3.0e-01
9	METSIM	Adipose	0.0430	0.0174	6.3e-05	0.055	0.024	0.044	0.044	0.059	1.1e-08	1.5e-04	2.7e-07	3.6e-07	3.7e-09
10	ROSMAP	Brain Pre-frontal Cortex	0.0416	0.0194	8.4e-04	0.033	0.032	0.023	0.032	0.021	3.3e-05	4.6e-05	5.4e-04	5.1e-05	9.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.0	1.5	3.4	-1.4	-1.0	-1.2	-1.2	1.8	-1.5	-1.2	0.1	-1.5	0.2
Bipolar Disorder or Schizophrenia	1.7	4.1	9.2	-2.0	-1.1	-2.2	-1.9	3.0	-1.4	-2.2	1.0	-2.5	-2.1
Depressed Affect (Nagel 2018)	0.2	0.3	1.3	0.7	-0.4	-0.5	-0.2	0.7	-0.3	-0.5	0.5	1.1	-0.2
Depression (Nagel 2018)	3.1	4.6	12.0	-2.0	-1.7	-2.6	-2.9	3.5	-0.0	-2.9	0.5	-1.8	-0.4
Intelligence (Savage-Jansen 2018)	1.9	6.0	12.1	2.9	3.1	1.5	2.3	-3.5	-3.5	2.6	-0.4	1.5	0.7
Neuroticism (Nagel 2018)	0.7	1.8	7.1	-0.5	-0.5	-1.5	-1.3	2.7	1.5	-1.6	0.9	-0.1	-0.7
Schizophrenia (2018)	1.6	3.3	9.3	-1.4	-0.7	-1.8	-1.4	2.4	-0.6	-2.0	1.2	-2.1	-3.1
Schizophrenia vs Biploar Disorder	2.6	3.4	6.5	-2.6	-1.5	-1.9	-2.0	2.5	0.8	-2.4	-0.2	-1.9	-1.2
Worry (Nagel 2018)	1.8	3.8	10.2	-2.0	-0.7	-0.9	-2.3	2.9	3.2	-2.2	-0.9	-1.4	1.1
Alzheimer’s Disease (in mother)	2.5	2.9	6.9	2.4	1.3	1.4	1.8	-2.6	-0.6	2.2	-0.6	1.4	1.5
Alzheimer’s Disease (in father)	0.5	0.6	1.4	1.2	-0.1	0.8	0.7	-1.0	-1.1	0.5	-0.4	0.5	0.1
Alzheimer’s Disease (including proxy)	1.1	1.6	2.8	1.5	0.2	1.3	0.9	-1.7	-1.7	1.4	-0.9	0.5	1.6
Crohns Disease (2017)	0.3	0.6	1.8	0.8	0.8	0.6	0.4	-0.4	1.3	0.1	0.9	0.7	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	1.7	1.0	1.0	1.3	1.2	-0.8	0.1	0.5	0.4	0.9	-0.1
Ulcerative Colitis (UC)	0.5	0.9	2.3	1.0	1.1	1.4	1.5	-0.7	-0.6	0.8	0.3	0.7	-0.2
Major Depression (MDD)	3.0	3.7	7.7	-2.0	-1.4	-2.8	-2.5	2.4	0.6	-2.5	-0.5	-1.9	0.8
Reaction Time	4.5	8.6	17.5	-3.2	-3.1	-3.4	-3.6	4.2	-1.3	-3.5	0.2	-2.2	-2.3
Verbal and Numeric Reasoning (VNR)	1.7	4.0	12.1	2.0	2.0	1.5	1.6	-2.8	-3.5	1.9	-1.2	0.6	1.2
Breast Cancer	0.3	0.7	2.0	0.8	0.3	0.5	0.9	-0.8	-1.4	1.0	0.2	1.4	0.4
Ovarian Cancer	0.6	0.8	3.2	-0.6	-0.6	-0.8	-0.3	0.9	1.8	-1.0	0.5	-0.7	-0.9
Prostate Cancer	1.0	1.4	3.5	-0.9	-1.9	-1.4	-0.8	1.4	1.6	-1.2	-0.0	-0.9	0.2
Age at First Birth	4.6	6.7	17.0	2.6	2.1	3.2	3.2	-4.1	0.1	3.0	-0.1	2.8	1.2
Bipolar Disorder (2011)	0.8	0.7	3.5	0.2	0.2	-0.1	0.1	0.5	0.1	-0.3	1.9	0.6	-1.7
Body Mass Index (BMI) (2010)	2.3	3.2	12.5	-1.4	-1.1	-1.7	-1.4	1.5	-3.5	-1.4	-0.5	-0.9	-2.4
Coronary Artery Disease (CAD)	0.8	0.9	4.1	1.0	-0.1	0.0	0.9	-0.8	-2.0	0.4	0.6	0.2	-1.4
Crohns Disease (2012)	0.7	1.1	5.3	0.8	1.0	0.1	0.5	-0.1	-0.2	-0.1	1.7	1.0	-2.3
Mean Putamen Volume	0.5	0.6	1.5	-0.8	-0.5	-0.7	-1.2	0.6	1.2	-0.7	-0.4	-0.0	0.9
Fasting Glucose	0.7	0.9	1.8	-1.0	-0.5	-1.4	-0.9	0.7	-0.9	-0.6	-0.8	-1.4	0.8
HbA1C	1.5	1.7	5.4	1.4	0.5	2.3	1.2	-1.5	-0.5	0.9	0.3	1.7	-1.2
HDL Cholesterol	0.4	0.7	1.8	1.3	0.9	0.7	0.7	-0.7	0.7	1.2	-0.2	0.1	0.8
LDL Cholesterol	0.2	0.3	0.8	0.1	0.2	0.7	0.6	0.0	0.5	0.8	-0.0	0.9	-0.5
Lupus	0.1	0.2	0.6	0.4	-0.6	0.8	0.4	-0.1	-0.5	0.2	-0.4	-0.0	0.3
Neuroticism (2016)	0.5	0.8	5.6	-0.1	-0.4	-0.0	-0.3	0.6	2.4	-0.3	0.8	0.1	-0.9
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.1	-0.2	0.3	0.5	-0.3	-0.7	0.4	-0.3	-0.3	0.0
Rheumatoid Arthritis	1.0	1.3	3.4	-1.5	-1.2	-1.4	-0.9	1.3	-1.9	-1.1	-0.3	-0.5	0.1
Schizophrenia (2014)	3.9	8.6	18.9	-3.8	-2.3	-2.9	-3.1	4.3	-1.3	-3.5	0.4	-3.4	-1.9
Triglycerides	0.8	1.2	3.1	-1.0	-0.4	-0.6	-0.7	1.8	-1.8	-1.3	0.6	-0.2	-1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	-0.6	-1.4	-0.6	-0.3	0.4	-1.9	-0.6	-1.4	-1.3	1.4
Ulcerative Colitis	0.9	1.3	4.4	0.7	0.5	0.3	1.2	-0.0	-1.9	0.2	1.5	0.7	-2.1
Blood Eosinophil Count	0.6	4.5	18.1	0.8	1.1	-0.6	-0.3	1.1	-4.1	-0.0	2.3	0.9	-4.2
Blood Platelet Count	0.2	2.7	9.4	-1.6	-1.6	-0.5	-1.2	1.1	-0.4	-1.2	-2.3	-1.7	3.1
Blood Red Count	0.1	1.2	3.0	0.9	0.8	1.4	0.7	-1.5	0.6	1.0	-0.2	1.0	1.7
Blood White Count	0.8	6.1	9.3	-3.0	-2.9	-1.8	-2.7	2.9	-0.7	-2.7	-2.0	-2.6	2.4
Heel T-Score	0.8	6.0	22.7	-1.8	-1.1	-3.4	-2.0	2.6	-4.8	-2.5	-0.4	-1.9	0.8
BMI	2.6	15.0	85.7	1.7	-0.6	-0.8	1.1	0.6	-9.3	-0.1	2.4	1.3	-7.2
Height	0.4	6.8	45.6	-0.0	0.1	-2.0	-0.5	1.8	-6.8	-0.4	1.1	0.0	-3.7
Waist Hip Ratio (WHR)	0.5	2.4	4.8	1.6	2.2	1.8	0.8	-1.8	-0.7	1.5	0.8	2.2	-0.8
Systolic Blood Pressure	1.1	5.7	21.3	0.4	-0.5	1.0	0.4	-1.6	3.8	0.4	-3.9	-1.2	4.6
Smoking Status	5.0	12.0	24.9	-2.5	-2.3	-3.6	-3.8	5.0	-4.4	-3.5	0.4	-3.7	-3.3
Allergy or Eczema	0.1	0.3	1.2	0.8	1.1	-0.1	-0.2	-0.4	-0.2	-0.2	0.6	-0.1	-0.8
Cardiovascular Disease	0.6	2.0	8.1	-1.1	-0.9	-0.8	-1.7	0.2	-0.2	-0.9	-2.8	-1.1	2.1
Hypothyroidism (self reported)	0.2	0.4	1.5	0.8	-0.2	-0.1	0.7	0.1	-0.0	0.2	1.0	0.2	-1.2
Respiratory disease	0.3	0.7	2.2	-0.2	-0.6	-1.3	-0.4	0.8	-0.9	-0.7	0.9	-0.6	-1.5
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.3	-1.4	-1.5	-1.6	-1.9	0.8	-2.3	-1.7	-1.6	-2.0	0.8
Lung FEV1/FVC ratio	0.8	4.0	13.1	0.8	1.4	0.7	1.4	-0.1	-3.3	1.0	3.1	0.8	-3.6
Lung FVC	1.2	6.0	11.7	-2.8	-1.8	-1.9	-3.0	3.2	3.4	-2.8	-0.3	-2.7	0.2
Neuroticism	0.8	2.0	6.6	-0.8	-0.8	-1.4	-1.6	2.6	1.8	-1.6	0.9	-0.4	-0.5
Chronotype (morning person)	0.6	1.3	3.6	-1.2	0.4	-1.2	-1.7	1.9	0.2	-1.3	1.1	-0.4	-0.1
Hair Pigment	0.0	0.5	2.1	0.7	-0.4	-0.8	-0.5	0.0	-1.4	-0.4	-1.2	-0.2	-0.4
Tanning	0.2	2.5	7.2	-1.9	-0.5	-1.7	-2.0	2.7	1.1	-1.4	0.8	-1.7	-0.5
Hand grip strength (left)	1.1	2.8	5.0	-1.9	-1.6	-2.0	-1.3	1.7	-2.0	-2.2	-1.2	-1.6	-0.3
Number of treatments/medications taken	0.4	0.7	1.7	-0.7	-0.8	-1.1	-0.7	1.1	-0.7	-0.6	-0.4	-1.3	-0.1
Average weekly spirits intake	5.9	7.3	19.5	-2.4	-2.6	-4.4	-2.8	3.3	1.3	-3.3	0.6	-2.8	-1.3
Sensitivity / hurt feelings	0.6	1.0	3.2	0.1	0.0	-0.7	-0.8	1.8	0.3	-0.8	1.4	-0.1	-1.7
Frequency of depressed mood in last 2 weeks	3.4	4.8	11.6	-2.5	-1.2	-2.3	-3.2	3.4	-1.0	-2.9	0.3	-1.9	-0.6
Hearing difficulty/problems: Yes	2.1	3.2	6.6	-1.3	-2.0	-2.1	-1.5	2.6	-0.6	-2.1	1.4	-1.2	-2.2
Relative age of first facial hair	1.2	2.6	14.5	-0.5	0.7	0.7	-0.5	-1.0	2.3	0.4	-1.7	-0.3	3.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	0.4	-0.6	-0.3	0.1	0.0	0.2	0.0	0.7	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	0.2	-0.7	-0.8	-0.1	0.6	0.6	-0.3	0.9	0.1	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.6	-0.1	-0.7	-0.3	0.8	0.4	-0.5	0.9	0.4	-0.8
Systolic blood pressure, automated reading	0.3	0.8	4.2	1.3	-0.3	0.6	0.9	-0.6	2.0	0.3	-0.6	0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	-1.5	-1.1	-1.0	-1.0	0.7	-1.2	-1.0	-0.4	-0.8	0.2
Angina	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.2	0.0	-0.5	-0.0	0.5	0.0	-0.6
Medication for hormone replacement therapy	1.0	1.1	2.3	1.3	1.2	0.6	1.3	-1.2	0.8	1.5	0.3	1.0	0.1
Vitamin and mineral supplements	0.1	0.1	0.3	-0.6	-0.5	0.2	-0.2	-0.4	0.2	-0.4	-0.4	-0.1	0.3
Supplements: Zinc	1.3	1.4	3.6	1.8	1.9	0.6	0.9	-0.9	-0.6	1.3	0.8	1.4	-0.8
Medication: Co-codamol	2.3	2.7	5.7	-1.6	-1.0	-1.8	-2.3	2.4	-0.8	-1.6	-0.1	-1.8	-1.7
Medication: Metformin	0.8	1.1	5.4	-1.3	-2.3	0.2	-0.8	0.5	-0.2	-0.9	-1.2	-0.7	0.1
Diabetes (father)	1.6	1.9	4.5	-0.8	-0.8	-1.3	-1.3	0.6	-1.9	-1.2	-1.9	-2.1	1.1
Diabetes (mother)	0.6	0.8	2.5	-0.6	-1.2	-1.6	0.1	0.4	-1.2	-0.8	0.8	-0.6	-0.8
Severe depression (siblings)	1.2	1.3	3.0	-0.9	-0.7	-1.1	-1.2	1.1	-0.9	-0.6	-1.6	-1.2	1.7
Pack years adult smoking proportion	1.3	2.0	4.9	-1.8	-1.2	-1.0	-1.9	2.2	-1.6	-1.2	0.1	-1.0	-0.7
Impedance of leg (right)	1.7	8.3	28.3	1.4	2.5	2.9	1.6	-3.9	2.0	2.5	-2.6	1.8	5.3
Leg fat-free mass (left)	1.8	9.7	48.4	-0.5	-2.4	-2.5	-1.2	2.7	-7.0	-1.8	0.9	-1.1	-4.8
Trunk fat percentage	2.2	8.7	51.4	2.3	0.1	0.6	1.8	-0.8	-7.2	1.1	1.9	2.0	-4.2
Hand grip strength (right)	1.6	4.3	7.1	-2.3	-1.9	-2.6	-2.3	2.3	-1.1	-2.7	-1.8	-2.4	0.2
Townsend deprivation index at recruitment	1.2	1.7	8.8	0.5	0.4	-0.4	-0.3	0.4	-3.0	-0.2	1.1	0.9	-2.2
Current tobacco smoking	3.5	5.7	9.7	-2.4	-2.5	-2.1	-2.6	3.1	-2.7	-2.8	-0.5	-2.8	-1.2
Average weekly fortified wine intake	1.0	1.2	2.9	-1.2	-0.8	-1.3	-1.2	1.7	0.7	-1.4	0.4	-1.2	-0.3
Maternal smoking around birth	1.5	2.1	8.1	-0.1	0.5	-0.1	-0.2	1.1	-2.5	-0.3	2.1	1.1	-2.8
Fed-up feelings	0.6	1.1	4.2	1.5	-0.4	0.8	1.1	-0.8	1.0	0.8	0.3	2.0	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	3.3	0.0	-0.6	-0.4	0.0	1.0	-0.6	-0.5	1.8	0.6	-1.2
Relative age voice broke	2.5	3.8	16.8	0.1	1.3	1.9	0.5	-1.8	2.8	1.8	-1.1	0.3	4.1
Taking other prescription medications	0.5	0.8	3.2	-0.6	-1.0	-0.3	-0.6	1.1	-0.9	-0.7	-0.8	-1.8	0.0
Age when periods started (menarche)	6.2	14.8	26.1	3.6	3.3	4.1	4.2	-4.7	3.5	5.1	0.8	3.7	3.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	-0.3	-0.2	-0.3	-0.9	0.2	1.0	-0.7	-0.3	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	7.6	0.2	0.2	-1.2	0.3	0.4	-2.8	-0.2	-0.7	-0.0	0.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	3.8	1.9	1.9	0.8	1.6	-1.5	0.1	1.9	1.2	0.7	0.0
Qualifications: CSEs or equivalent	4.5	6.0	13.2	2.4	3.6	2.7	2.0	-2.5	-0.6	2.8	1.6	3.3	-1.2
Serious illness, injury or assault to yourself	1.4	1.7	3.6	-1.2	-0.9	-1.5	-1.7	1.3	-1.1	-1.4	-0.9	-1.9	0.6
High blood pressure	0.4	1.2	4.4	0.3	-0.4	0.9	-0.0	-1.2	1.0	0.4	-2.1	0.6	1.8
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.6	0.4	1.3	-0.0	-0.8	-0.4	0.0	-0.5	-0.3	-0.1	-0.6
Multivitamins +/- minerals	0.2	0.3	0.8	0.9	0.2	0.1	0.6	-0.4	-0.1	0.6	-0.7	0.2	0.5
Stomach or abdominal pain in last month	0.6	0.7	2.3	1.5	1.3	0.4	0.0	-1.0	-0.1	0.6	-1.0	0.9	0.0
Supplements: Glucosamine	1.4	1.8	5.5	0.9	1.0	0.1	1.3	-0.7	-1.2	1.2	2.3	0.7	-2.3
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.1	-1.5	-0.9	-1.4	-1.4	1.6	2.2	-1.5	-0.4	-1.3	0.7
Medication: Atenolol	1.4	1.7	4.4	1.7	0.7	0.9	1.2	-1.7	2.1	1.5	-0.4	1.2	0.7
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.4	0.3	1.5	1.8	-1.3	0.1	1.2	1.2	1.3	-1.1
Sitting height	0.5	3.7	17.2	-1.6	-1.8	-2.0	-1.5	1.4	-4.2	-1.6	-1.5	-1.3	0.0
Chronic bronchitis/emphysema (father)	1.4	1.6	6.7	-1.0	-0.5	-1.0	-1.0	1.4	-2.6	-1.5	0.6	-0.5	-1.3
High blood pressure (mother)	1.7	2.3	4.1	1.8	0.2	2.0	2.0	-1.9	1.1	2.0	-0.9	1.1	1.0
Body mass index (BMI)	2.1	8.9	44.9	1.1	-1.3	-0.7	0.4	1.3	-6.7	-0.4	2.0	0.8	-5.8
Impedance of leg (left)	2.3	11.0	30.5	2.0	2.9	3.6	2.4	-4.3	2.9	3.4	-2.2	2.3	5.5
Leg predicted mass (left)	1.8	9.5	47.8	-0.5	-2.4	-2.4	-1.2	2.7	-6.9	-1.8	0.8	-1.1	-4.8
Trunk fat mass	2.4	10.4	67.9	1.6	-0.8	-0.3	1.0	0.4	-8.2	0.3	1.9	1.3	-5.1
Waist circumference	2.3	8.5	48.8	1.5	-0.9	-0.3	0.4	0.8	-7.0	-0.2	1.8	1.2	-5.3
Number of incorrect matches in round	1.1	1.9	4.7	2.2	1.7	0.7	1.1	-1.0	1.4	1.5	1.5	1.1	-0.8
Past tobacco smoking	2.0	3.6	7.1	1.5	0.8	1.9	2.2	-2.7	2.6	2.2	0.1	1.6	1.9
Alcohol usually taken with meals	3.4	5.5	13.4	2.4	2.4	2.6	2.7	-3.7	-0.1	2.8	0.4	2.7	0.1
Nervous feelings	1.2	2.2	17.0	-0.1	1.0	1.3	-0.3	0.0	4.1	0.6	-0.6	-0.0	1.3
Frequency of tenseness / restlessness in last 2 weeks	4.7	7.3	14.5	-3.2	-2.7	-3.3	-3.7	3.8	1.1	-3.2	-0.5	-2.2	0.0
Hearing difficulty/problems with background noise	3.5	5.7	11.8	-1.4	-1.7	-2.7	-2.3	3.1	-2.5	-2.9	1.2	-1.6	-3.4
Hair/balding pattern: Pattern 2	0.7	0.9	5.7	-0.3	-0.3	0.6	-0.0	-0.6	0.1	0.5	-1.4	0.2	2.4
Had menopause	1.1	1.3	6.0	0.2	-0.9	0.6	0.5	0.6	1.6	-0.0	1.5	0.8	-2.5
Had other major operations	0.1	0.2	0.8	-0.1	-0.4	-0.1	-0.1	-0.1	-0.9	0.2	-0.5	-0.3	0.6
Forced vital capacity (FVC)	1.2	4.5	7.9	-2.8	-2.2	-2.2	-2.5	2.4	0.1	-2.4	-1.8	-2.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	6.1	0.5	0.4	-0.9	0.6	0.1	-2.5	0.0	-0.3	0.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	0.2	-0.1	-0.2	-0.4	-0.4	0.8	-0.3	-1.2	-0.1	1.1
Qualifications: None of the above	1.2	2.7	9.5	-1.0	-1.7	-0.4	-1.0	2.4	3.1	-1.3	1.0	-0.7	-1.7
Financial difficulties in last 2 years	0.1	0.1	0.5	0.1	-0.1	-0.2	-0.3	-0.3	-0.6	-0.1	-0.0	-0.0	0.7
Mouth/teeth dental problems	2.2	3.4	8.0	2.1	1.4	2.0	2.3	-2.8	1.0	2.6	-0.9	0.5	1.3
Heart attack	0.4	0.5	3.9	-0.5	0.1	0.2	0.3	-0.4	-0.1	0.3	-0.7	-0.6	2.0
Allergy	0.6	1.3	3.8	1.0	-0.3	1.4	1.9	-1.1	0.6	1.5	0.9	1.4	0.2
Pain all over the body in last month	1.2	1.3	6.4	1.0	0.1	-0.2	0.3	0.1	-0.7	0.4	2.1	0.6	-2.5
Diabetes (self-reported)	0.4	0.6	3.1	-0.2	-0.6	-0.3	-0.7	0.2	-1.8	-0.6	-1.0	-0.6	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.6	0.3	0.0	0.4	-0.2	-1.0	0.0	0.8	0.2	-1.1
Medication: Ramipril	2.0	2.5	5.3	-2.3	-0.6	-1.3	-2.2	2.0	-1.2	-2.0	-1.2	-1.6	-0.0
Medication: Simvastatin	0.5	0.7	1.5	0.7	0.7	0.6	1.2	-0.9	-0.5	1.0	0.6	1.2	-0.8
Fluid intelligence score	0.6	1.3	6.4	0.6	1.1	0.3	0.6	-1.5	-2.5	1.0	-0.7	-0.1	1.1
Illnesses of siblings	0.2	0.3	0.8	-0.1	0.9	0.5	0.2	-0.6	-0.7	0.6	0.3	0.8	-0.1
Neuroticism score	0.5	1.1	5.9	-0.3	-0.7	-0.7	-0.7	1.6	2.4	-0.8	0.8	0.1	-0.1
Weight	2.3	11.1	66.7	0.7	-1.6	-1.2	-0.0	1.7	-8.2	-0.7	1.6	0.4	-5.8
Impedance of arm (right)	0.8	3.9	9.5	1.1	2.7	1.5	1.5	-3.1	2.0	1.8	0.4	1.8	2.5
Arm fat percentage (right)	2.5	9.9	52.9	1.8	-0.4	-0.3	1.0	0.1	-7.3	0.1	2.5	1.8	-5.7
Trunk fat-free mass	1.9	10.8	35.3	-1.6	-3.3	-3.0	-2.2	3.8	-5.9	-2.8	0.1	-2.1	-4.3
Hip circumference	2.1	9.2	51.9	0.7	-1.6	-1.2	0.2	1.7	-7.2	-0.9	1.7	0.4	-5.3
Time employed in main current job	0.5	0.6	3.8	0.4	0.0	-0.5	0.3	0.7	-0.3	-0.2	0.9	0.1	-1.9
Alcohol intake versus 10 years previously	1.4	2.1	7.6	-1.0	-2.1	-0.2	-0.8	0.2	-0.1	-0.8	-2.8	-1.4	2.2
Father’s age at death	0.2	0.3	1.6	-0.2	-0.0	1.3	0.1	-0.1	0.8	0.3	0.5	0.6	0.2
Worrier / anxious feelings	1.6	3.1	14.8	-0.9	-1.0	-0.8	-1.5	1.5	3.8	-1.3	-1.8	-1.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	8.3	-0.6	-1.0	-0.7	-1.1	1.4	-2.9	-0.9	-0.2	-0.0	-0.8
Falls in the last year	6.1	8.2	15.1	-2.9	-2.6	-3.9	-3.4	3.4	-2.5	-3.4	-0.8	-2.6	-1.9
Hair/balding pattern: Pattern 3	0.9	1.3	4.7	0.5	1.4	0.2	0.3	0.1	-1.6	0.1	1.9	0.2	-2.2
Number of live births	3.0	4.3	8.2	-1.7	-2.2	-2.8	-2.1	2.9	-2.2	-2.3	-0.3	-1.8	-0.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.7	-2.2	-1.1	-1.4	-1.8	1.6	-0.2	-1.6	-1.3	-1.8	0.7
Pulse rate	1.1	1.9	7.3	-1.3	-1.2	0.4	-1.0	0.3	-0.3	-0.8	-2.7	-0.8	2.5
Happiness	0.5	0.6	1.0	0.7	0.4	0.7	0.6	-1.0	-0.9	0.6	-1.0	1.0	0.4
Noisy workplace	1.8	2.3	4.1	-2.0	-2.0	-1.5	-1.9	2.0	0.2	-1.8	-0.6	-1.0	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.4	1.0	1.0	-0.1	1.0	-1.5	-0.7	0.9	-1.4	-0.4	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	0.7	0.5	0.9	0.0	-0.5	-0.1	0.5	-0.4	-0.1	0.8
Mouth/teeth dental problems: Dentures	2.7	4.6	10.0	-2.8	-2.6	-2.0	-1.9	3.2	-1.7	-2.6	0.6	-0.8	-1.8
Asthma	0.7	1.4	3.2	-0.8	-1.0	-1.8	-1.1	1.7	-0.9	-1.2	0.3	-1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	0.7	0.5	1.1	1.2	-0.5	-0.7	1.0	0.5	0.7	0.7
Medication: Cholesterol lowering	0.2	0.4	1.9	-0.5	0.5	0.3	0.1	-0.3	0.5	0.1	-0.9	0.1	1.4
Depression (self-reported)	0.9	1.1	4.6	1.0	2.2	1.2	0.1	-0.1	-0.5	1.1	0.7	0.6	1.0
Medication: Lansoprazole	0.3	0.3	1.1	-0.6	0.7	0.3	-0.6	0.1	0.8	0.3	-0.0	-0.3	1.1
Prospective memory result	1.0	1.3	3.4	-0.6	-0.6	-1.4	-0.9	1.8	0.4	-1.1	1.2	-0.9	-1.5
Lung cancer (father)	1.4	1.6	3.0	1.5	0.8	1.2	1.0	-0.8	0.8	1.0	1.7	1.7	-1.7
Illnesses of mother	0.3	0.4	1.5	-1.0	0.1	-0.5	-1.2	0.5	-0.0	-0.8	-0.0	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.3	-2.1	-1.1	-1.2	-1.7	1.9	0.8	-1.5	-0.9	-1.8	0.8
Pulse wave Arterial Stiffness index	0.2	0.3	1.9	-0.4	-0.0	-0.1	-0.3	0.1	1.4	-0.0	0.2	-0.0	0.7
Impedance of arm (left)	1.0	4.7	11.4	1.0	2.6	1.6	1.5	-3.3	2.5	1.9	-0.1	1.6	3.4
Arm fat mass (right)	2.5	10.1	58.5	1.3	-1.3	-0.7	0.5	1.0	-7.7	-0.3	1.9	1.1	-5.7
Trunk predicted mass	2.0	11.3	36.2	-1.7	-3.4	-3.1	-2.3	3.9	-6.0	-2.9	0.2	-2.2	-4.4
Standing height	0.2	2.4	17.5	-0.6	-0.9	-1.3	-0.7	1.0	-4.2	-0.7	-0.4	-0.7	-1.0
Length of working week for main job	1.7	1.9	4.3	0.9	1.8	1.0	0.4	-1.9	-0.6	2.0	-0.7	1.1	2.1
Exposure to tobacco smoke at home	0.4	0.5	1.5	0.2	1.1	-0.4	0.3	0.3	-1.2	0.3	0.7	-0.4	-0.9
Breastfed as a baby	0.9	1.1	7.6	0.9	0.5	-0.2	-0.1	0.5	-1.1	-0.2	1.1	0.0	-2.8
Tense / ‘highly strung’	3.8	6.3	14.7	-2.8	-2.4	-2.7	-3.1	3.8	2.3	-3.1	0.3	-1.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	7.9	-1.6	-1.3	-1.2	-1.9	2.8	1.0	-1.8	-0.9	-2.1	1.2
Hair/balding pattern: Pattern 4	1.4	3.3	5.8	-2.2	-2.0	-2.3	-1.8	2.4	0.1	-2.1	0.1	-2.3	-0.7
Birth weight of first child	1.0	1.8	4.7	1.7	0.5	1.0	1.5	-1.1	-0.2	0.8	1.3	1.9	-2.2
Peak expiratory flow (PEF)	0.4	0.9	7.0	-0.8	0.1	0.1	-0.4	-0.1	-2.6	-0.3	-0.7	-0.7	0.3
Pulse wave reflection index	0.4	0.4	1.5	0.7	0.2	-0.0	0.2	-0.9	1.2	0.5	-0.4	0.1	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	-1.1	-1.0	-1.1	-1.2	0.8	0.2	-1.1	-0.5	-0.5	0.3
Loud music exposure frequency	0.3	0.4	1.3	0.3	0.3	0.3	1.1	-0.6	-0.5	1.1	0.4	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.3	-0.1	0.3	0.9	0.5	-1.3	-0.2	0.8	-2.0	-0.6	2.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	4.0	0.3	-0.8	-0.3	-0.1	0.1	2.0	-0.3	-0.7	0.0	1.2
Blood clot in the leg (DVT)	1.6	2.1	4.0	-1.4	-0.8	-1.9	-2.0	1.9	-1.4	-1.5	-0.0	-1.3	-1.0
Medication: Paracetamol	0.2	0.3	2.0	0.2	-0.8	0.0	-0.2	0.0	-1.4	0.3	-0.2	-0.2	0.5
Headache pain in last month	0.7	1.2	6.2	-0.1	0.7	1.0	-0.2	-0.8	-0.3	0.4	-1.9	-0.2	2.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.3	0.2	0.4	0.1	0.1	-0.8	0.3	1.0	0.0	-0.9
Glaucoma (self-reported)	2.2	2.6	4.9	1.5	1.3	1.9	1.7	-2.2	1.8	1.4	-0.2	2.2	0.8
Gout (self-reported)	1.7	2.3	8.1	-0.1	-0.3	-1.6	-0.3	1.3	-2.7	-0.8	1.6	-0.2	-2.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	0.6	-0.4	0.4	1.0	0.2	0.1	0.4	1.2	0.2	-1.2
Medication: Amlodipine	1.3	1.8	3.9	1.3	1.1	2.0	1.4	-1.7	0.5	1.8	0.4	1.7	0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.6	-0.6	-0.3	-1.3	-1.4	1.6	-1.3	-1.0	-0.4	-1.5	-0.8
Birth weight	1.2	2.6	4.7	2.2	1.0	1.9	2.0	-2.0	-1.2	1.6	-0.2	1.7	-1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	6.9	-0.6	-0.1	-0.9	-0.1	1.1	-2.6	-0.7	1.1	-0.7	-1.7
High blood pressure (siblings)	0.5	0.7	1.9	-0.7	-1.4	-0.4	-0.5	0.4	0.8	-0.7	-0.8	-0.9	1.0
Forced vital capacity (FVC), Best measure	1.2	4.5	6.9	-2.6	-2.2	-2.0	-2.4	2.4	1.2	-2.2	-1.6	-2.5	1.4
Body fat percentage	2.4	9.5	51.8	2.4	0.1	0.6	1.9	-0.7	-7.2	1.1	2.0	2.2	-4.7
Leg fat percentage (right)	2.7	9.6	50.6	2.1	-0.2	0.5	1.6	0.0	-7.1	0.5	2.2	2.2	-5.3
Arm fat-free mass (right)	1.4	7.4	34.0	-0.9	-2.9	-1.9	-1.3	2.8	-5.8	-1.6	-0.2	-1.4	-3.5
Exposure to tobacco smoke outside home	1.2	1.7	4.8	-1.1	-1.6	-2.2	-1.4	1.1	-0.9	-1.3	-0.7	-1.5	-0.4
Comparative body size at age 10	3.0	8.3	27.0	-1.8	-0.9	-2.2	-1.5	3.9	-3.8	-2.1	3.3	-0.1	-5.2
Number of full brothers	0.5	0.6	3.1	-0.1	-0.2	-0.7	-0.3	0.9	-0.7	-0.3	1.2	-0.1	-1.8
Worry too long after embarrassment	0.6	1.0	2.5	-0.1	-0.0	-1.6	-1.1	1.5	1.0	-0.9	0.7	-0.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	1.1	0.7	0.7	0.6	0.3	1.3	0.2	1.5	0.3	-1.2
Wheeze or whistling in the chest in last year	2.4	4.3	9.5	-1.0	-1.3	-2.3	-2.3	3.1	-2.7	-2.1	1.0	-1.2	-2.4
Number of children fathered	0.3	0.3	1.5	-0.2	-0.7	-0.0	0.5	-0.2	1.2	0.3	-0.1	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.5	-1.0	0.9	-1.2	-1.1	1.8	0.9	-1.2	0.7	-1.2	-1.9
Age at first live birth	2.3	4.2	9.7	2.5	2.1	2.3	2.4	-3.1	0.8	2.3	0.6	2.0	-0.4
Pulse wave peak to peak time	0.3	0.4	2.7	0.3	-0.2	-0.1	0.2	0.2	-1.6	-0.1	0.0	-0.1	-1.1
Health satisfaction	2.6	3.4	6.4	-1.6	-1.8	-2.5	-2.0	1.7	-0.7	-1.6	-2.1	-2.1	1.5
Shortness of breath walking on level ground	2.0	2.4	4.3	-1.8	0.1	-1.3	-2.1	1.3	-1.0	-1.1	-2.1	-2.0	1.3
Qualifications: College or University degree	1.2	3.8	10.7	2.3	2.6	1.1	1.9	-3.3	-0.5	2.1	-1.0	1.1	1.8
Eye problems/disorders: None of the above	1.3	1.5	3.1	1.2	0.5	1.2	0.9	-1.4	-0.9	1.4	-1.8	0.7	1.8
Mouth/teeth dental problems: Loose teeth	2.6	3.1	5.7	-2.0	-1.9	-2.1	-1.9	2.4	0.8	-1.9	1.3	-1.9	-0.7
Emphysema/chronic bronchitis	0.8	0.9	1.9	-1.0	-0.6	-0.9	-1.3	1.4	-0.6	-1.0	-0.5	-1.2	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	3.9	1.0	1.0	0.6	0.7	-0.8	2.0	0.6	-0.0	0.9	-0.5
Neck or shoulder pain in last month	0.6	0.9	3.6	0.3	0.1	-0.5	0.2	0.4	-1.5	-0.0	1.2	0.7	-1.9
Medication: Blood pressure	0.6	1.0	3.7	-0.7	-1.0	-0.3	-0.4	-0.5	0.9	-0.5	-1.9	-0.2	1.8
Angina (self-reported)	0.1	0.1	0.4	-0.5	0.1	-0.0	-0.1	-0.1	-0.3	0.2	0.6	0.1	-0.4
Migraine (self-reported)	1.8	2.3	5.1	2.0	0.6	1.7	1.9	-1.4	2.3	1.7	-0.7	1.0	0.7
Medication: Ibuprofen	0.4	0.5	1.3	0.8	0.7	0.8	1.0	-0.5	-0.5	0.8	0.2	0.3	1.1
Medication: Allopurinol	0.7	1.0	4.9	0.3	-0.2	-0.8	0.3	0.5	-2.2	-0.2	1.0	-0.5	-1.5
Medication: Omeprazole	1.4	1.6	2.9	-1.5	-1.3	-1.3	-1.7	1.1	0.2	-1.6	-1.2	-1.6	0.4
Medication: Seretide 50 evohaler	0.6	0.7	3.7	0.6	0.1	-0.2	0.1	-0.1	-1.2	0.1	1.0	0.7	-1.9
Mean time to correctly identify matches	4.2	8.0	17.7	-2.6	-2.8	-2.8	-2.8	4.2	-1.3	-3.2	1.6	-1.5	-3.9
Heart disease (mother)	0.2	0.2	0.6	-0.0	-0.8	-0.2	-0.1	0.6	-0.1	-0.3	-0.5	-0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	9.2	-3.0	-2.2	-1.4	-1.8	2.9	-1.1	-2.5	1.4	-1.5	-1.5
Whole body fat mass	2.6	10.7	67.6	1.8	-0.9	-0.2	1.1	0.3	-8.2	0.2	1.8	1.5	-5.4
Leg fat mass (right)	2.6	9.9	61.6	1.5	-1.0	-0.2	0.8	0.7	-7.8	-0.1	1.6	1.4	-5.3
Arm predicted mass (right)	1.3	6.6	31.4	-0.6	-2.6	-1.8	-1.2	2.6	-5.6	-1.5	-0.2	-1.3	-3.5
Pulse rate, automated reading	0.9	3.0	8.6	-2.0	-1.9	0.0	-0.8	0.8	-1.1	-1.2	-2.4	-2.0	2.9
Alcohol intake frequency.	0.4	0.9	3.1	0.8	-0.6	0.4	1.3	-1.2	-1.8	0.8	-0.2	0.7	0.6
Comparative height size at age 10	2.6	14.5	32.5	-3.0	-2.9	-3.6	-3.0	4.9	-5.1	-4.1	1.6	-2.0	-5.7
Number of full sisters	1.9	2.3	4.3	1.8	1.2	1.1	1.7	-1.0	-2.1	1.3	1.0	1.8	-1.9
Suffer from ‘nerves’	0.5	0.7	4.6	-0.6	-0.5	0.1	-0.0	1.1	2.1	-0.3	0.8	0.6	-0.3
Overall health rating	0.6	1.2	7.5	-0.7	-0.5	-0.7	-0.9	0.9	-2.7	-0.4	-0.8	-0.5	0.5
Chest pain or discomfort	0.4	0.5	3.3	-0.4	-0.1	-0.7	-0.5	0.1	-1.8	-0.4	-0.8	-0.0	0.3
Had major operations	3.2	3.8	8.5	-2.0	-1.6	-2.9	-2.4	2.0	-0.2	-2.4	-0.2	-2.6	0.0
Age at last live birth	1.8	2.6	5.7	1.6	1.8	1.8	1.9	-2.4	-0.1	1.8	0.4	1.9	-0.5
Family relationship satisfaction	1.3	1.6	7.2	0.8	0.5	-0.3	0.2	0.1	-2.7	0.0	1.6	1.0	-1.9
Leg pain on walking	3.1	3.9	7.5	-2.5	-1.0	-2.7	-2.4	2.7	-0.0	-2.5	-0.4	-1.9	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	-0.0	0.2	-0.7	-0.3	0.2	1.0	0.1	0.7	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.5	-0.9	-1.3	-0.5	-0.8	0.2	-0.2	-0.8	-1.9	-0.4	1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	0.3	0.1	-0.1	0.9	-0.1	1.3	0.4	1.4	1.0	-1.3
Medication: Aspirin	0.5	0.6	3.6	-0.9	0.2	-0.2	0.1	0.7	-0.9	0.1	1.9	0.1	-0.7
Supplements: Vitamin C	0.7	0.8	2.5	-0.2	-0.5	-1.6	-1.0	0.8	0.8	-0.8	-0.1	-1.3	-0.7
Knee pain experienced in last month	5.1	7.9	13.9	-2.7	-2.5	-3.3	-3.5	3.6	-0.4	-3.1	-1.8	-3.7	1.5
Hypertension (Self-reported)	0.5	1.4	5.7	0.0	-0.5	0.7	-0.2	-1.1	1.0	0.3	-2.4	0.4	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.3	-0.3	0.0	-0.7	-0.1	-0.2	-0.4	-0.2	-0.4	-0.0
Illnesses of father: Heart disease	1.3	1.8	4.7	1.5	1.3	0.8	1.6	-2.2	-0.2	1.5	0.4	2.0	-0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.7	-0.4	-0.6	0.2	0.1	-0.2	-0.0	-0.4	0.4	-0.7
Smoking status: Previous	1.3	2.0	3.9	-1.1	-0.1	-1.4	-1.6	2.0	-1.7	-1.5	0.6	-0.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.1	7.5	-2.4	-2.6	-2.7	-2.3	2.6	-2.0	-2.5	-1.6	-2.5	0.5
Whole body fat-free mass	1.8	10.4	40.1	-1.2	-3.0	-2.9	-1.8	3.4	-6.3	-2.4	0.4	-1.8	-4.6
Leg fat-free mass (right)	1.6	8.7	39.8	-0.5	-2.2	-2.5	-1.1	2.7	-6.3	-1.6	1.1	-1.1	-4.7
Arm fat percentage (left)	2.1	8.6	47.5	1.7	-0.6	-0.3	1.0	0.1	-6.9	0.2	2.2	1.6	-5.2
Average weekly red wine intake	0.8	1.2	4.5	1.1	2.1	0.3	0.8	-1.2	-1.2	1.1	0.5	1.0	-0.6
Handedness (chirality/laterality): Left-handed	4.1	4.9	7.8	2.6	2.6	2.5	2.5	-2.7	-0.8	2.8	0.8	2.6	-0.1
Mood swings	0.5	1.0	2.4	-0.4	-1.4	-1.3	-0.8	1.2	1.6	-0.7	0.1	-0.1	1.0
Loneliness, isolation	0.3	0.3	1.1	-0.2	0.4	-0.7	-0.9	0.7	-1.0	-0.6	-0.3	0.1	0.3
Long-standing illness, disability or infirmity	0.3	0.5	2.0	0.1	-0.4	-0.2	0.1	0.5	-1.1	-0.1	1.1	-0.6	-1.4
Ever had bowel cancer screening	0.7	0.8	7.1	0.1	-0.1	0.3	0.1	0.4	2.7	0.1	0.9	-0.1	-0.1
Diabetes diagnosed by doctor	0.7	1.1	2.2	-1.0	-1.4	-0.7	-1.0	0.5	-1.5	-1.1	-1.4	-0.7	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	4.6	0.7	0.3	-0.8	-0.1	-0.6	-2.1	0.5	-0.1	0.1	-1.0
Friendships satisfaction	2.0	2.4	6.5	-0.8	-0.9	-2.1	-1.7	1.8	-2.5	-1.7	0.1	-1.0	-1.4
Qualifications: nursing, teaching	0.2	0.3	1.3	-0.2	0.1	-1.0	-0.2	-0.1	-0.0	-0.5	-0.5	-0.2	1.2
Commuting to job workplace: Walk	0.4	0.4	1.2	0.7	0.7	-0.1	0.2	0.1	-0.9	0.5	1.1	-0.7	-0.8
Eye problems/disorders: Cataract	3.3	3.9	8.5	-2.4	-0.9	-1.2	-2.2	2.9	1.6	-2.2	2.0	-1.6	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	-0.3	1.0	0.5	-0.7	0.3	0.4	-0.5	0.0	0.7	-0.7
Medication for cholesterol	0.8	1.2	3.3	-1.8	-1.0	-0.6	-0.9	1.2	0.8	-1.4	0.7	-1.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	4.7	-0.5	0.8	1.1	-0.1	0.0	-2.2	0.2	-0.3	-0.1	0.3
Back pain experienced in last month	0.2	0.4	0.9	0.7	0.4	0.9	0.3	-0.5	-0.9	0.8	-0.4	0.2	0.4
Mineral and other dietary supplements	1.3	1.7	6.4	-1.1	-1.0	0.7	-1.0	-0.3	0.5	-0.5	-2.5	-0.6	2.5
Breast cancer (self-reported)	0.7	0.9	2.5	0.6	0.7	0.7	0.7	-0.5	1.0	0.4	1.3	1.2	-1.6
Asthma (self-reported)	0.6	1.2	2.9	-0.8	-1.0	-1.7	-1.1	1.6	-0.5	-1.1	0.4	-1.1	-1.0
Osteoporosis (self-reported)	0.5	0.6	1.9	-1.2	-0.7	0.0	-0.8	0.9	1.4	-0.5	-0.1	-0.9	0.0
Osteoarthritis (self-reported)	1.5	1.9	5.2	-1.1	-1.1	-1.4	-1.6	2.3	-0.2	-1.4	0.7	-1.3	-1.5
Medication: Aspirin	0.4	0.5	1.9	-1.0	-0.1	-0.5	-0.1	0.6	-1.4	-0.1	1.1	-0.3	0.1
Medication: Gliclazide	0.3	0.4	1.5	-0.6	-0.7	0.1	-0.1	0.1	-1.2	-0.2	-0.5	-0.6	1.0
Illnesses of father: None of the above (group 1)	0.4	0.4	1.3	0.1	0.7	1.1	0.5	-0.2	0.9	1.1	0.1	0.2	0.6
Smoking status: Current	3.6	5.7	10.2	-2.4	-2.4	-2.2	-2.6	3.2	-2.6	-2.8	-0.3	-2.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.7	-1.9	0.3	-0.3	-1.5	1.6	1.2	-1.4	0.6	-1.1	-0.2
Whole body water mass	1.8	10.4	40.3	-1.3	-3.0	-2.9	-1.9	3.5	-6.3	-2.4	0.3	-1.8	-4.5
Leg predicted mass (right)	1.6	8.3	39.6	-0.4	-2.2	-2.4	-1.1	2.6	-6.3	-1.6	0.9	-1.1	-4.5
Arm fat mass (left)	2.4	10.0	60.7	1.4	-1.4	-0.6	0.6	0.9	-7.8	-0.2	1.7	1.1	-5.5
Number of self-reported non-cancer illnesses	0.2	0.4	1.8	0.2	-0.2	-0.6	-0.7	0.8	-0.3	-0.2	0.3	-0.7	-1.3
Average weekly champagne plus white wine intake	3.1	4.3	9.9	2.3	2.5	2.1	2.1	-3.1	-1.1	2.7	0.7	2.0	-0.5
Miserableness	0.3	0.5	1.4	-0.2	-1.2	-0.4	-0.8	0.7	-0.5	-1.0	-0.8	-0.3	0.6
Guilty feelings	1.2	1.8	6.8	0.9	0.7	-1.2	-0.1	1.1	-1.4	-0.4	2.1	0.7	-2.6
Wears glasses or contact lenses	1.0	1.2	4.2	0.5	-0.5	0.7	0.8	-0.2	1.2	0.0	2.0	0.9	-1.9
Ever taken oral contraceptive pill	1.8	2.0	10.1	-0.5	-0.1	-0.4	-0.9	-0.2	-0.6	0.1	-2.6	-1.3	3.2
Hearing aid user	0.4	0.5	3.1	-0.3	-0.2	-0.3	-0.1	1.1	-0.3	-0.2	1.8	-0.0	-0.6
Mother’s age at death	0.7	0.9	4.8	0.9	1.2	0.3	0.5	-0.7	2.2	0.8	0.6	0.1	-0.1
Financial situation satisfaction	0.9	1.1	2.2	1.3	1.1	0.7	0.8	-1.0	0.1	1.3	0.8	1.5	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	-0.6	-0.7	-1.5	-1.1	0.5	-1.2	-1.0	-0.3	-0.2	-0.5
Commuting to job workplace: Public transport	0.3	0.4	1.4	0.8	-0.2	-0.2	0.8	-0.5	-1.2	0.3	-0.0	-0.5	0.6
Eye problems/disorders: Glaucoma	2.1	2.5	5.5	1.7	1.2	1.8	2.1	-2.3	1.4	1.6	0.1	1.7	0.7
Medication: Blood pressure	0.6	1.1	2.9	1.7	1.0	1.2	0.9	-1.3	0.1	1.3	0.1	1.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.6	-0.2	-0.3	-0.9	-1.3	1.2	-0.0	-1.3	-0.1	-1.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.7	0.1	-0.9	0.4	0.4	-0.2	-0.1	1.2	0.0	-1.4
High cholesterol (Self-reported)	0.5	0.9	1.6	-1.0	-1.2	-1.1	-1.0	1.1	-0.4	-1.3	0.1	-0.6	-1.1
Medication: Bendroflumethiazide	0.6	0.9	2.0	-0.8	-1.1	-0.8	-0.9	1.3	1.1	-1.4	0.2	-0.7	-0.8
Medication: Paracetamol	0.2	0.3	1.2	0.8	-0.5	0.1	0.1	-0.4	-1.1	0.7	-0.4	-0.2	0.6
Medication: Lisinopril	0.7	0.9	3.8	1.3	0.0	0.0	1.0	-1.9	0.1	1.1	-0.0	0.9	0.6
Medication: Atorvastatin	0.6	0.8	5.4	-0.3	0.1	0.6	0.2	-0.4	-2.3	0.2	-1.0	0.5	0.5
Illnesses of father: High blood pressure	0.3	0.4	1.9	0.5	-0.6	-0.7	0.3	-0.5	1.4	-0.1	-0.3	0.2	0.5
Alcohol drinker status: Never	0.3	0.4	1.4	-0.6	0.3	-0.1	0.6	0.0	-1.1	0.1	1.2	-0.3	0.1
Ever smoked	1.5	2.7	5.2	-1.3	-0.9	-1.6	-2.1	2.3	-2.0	-1.9	-0.5	-1.5	-1.4
Basal metabolic rate	1.8	10.2	50.0	-0.7	-2.7	-2.4	-1.4	3.0	-7.1	-1.9	0.4	-1.2	-4.7
Leg fat percentage (left)	2.7	9.9	45.2	2.6	-0.0	0.7	2.0	-0.2	-6.7	1.0	2.7	2.4	-5.4
Arm fat-free mass (left)	1.6	7.9	38.8	-0.4	-2.4	-1.6	-1.1	2.7	-6.2	-1.5	0.5	-1.1	-4.4
Number of operations (self-reported)	1.2	1.7	3.2	-1.8	-1.0	-1.6	-1.6	1.8	0.1	-1.7	0.3	-1.1	-0.6
Average weekly beer plus cider intake	4.9	7.1	13.1	-2.6	-1.7	-3.3	-3.5	3.5	-1.6	-2.9	-1.6	-3.6	-0.3
Irritability	1.5	2.5	8.8	-1.8	-1.5	-1.6	-1.4	1.7	3.0	-1.2	0.2	-1.2	0.7
Risk taking	1.3	1.9	6.8	-0.7	0.1	-2.1	-2.6	1.3	-0.8	-1.3	-0.3	-1.5	-0.8
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.6	-0.1	-0.3	-0.6	0.3	0.4	0.8	-0.4	0.2	0.1	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	2.2	0.5	0.1	0.9	-0.6	0.0	1.5	0.5	-0.1	-0.4	-0.3
Age started oral contraceptive pill	0.9	1.2	3.1	1.6	0.1	0.3	1.2	-0.4	1.0	0.6	1.4	0.9	-1.8
Diastolic blood pressure, automated reading	0.2	0.5	3.1	-0.2	-1.0	-0.2	-0.4	0.4	1.8	-0.4	-0.4	-0.5	0.5
Ever depressed for a whole week	0.7	0.8	2.5	1.2	0.0	1.0	0.8	-1.2	1.6	0.6	-0.7	0.4	0.5
Unable to work because of sickness or disability	5.1	6.6	12.8	-2.8	-3.0	-2.4	-3.0	3.6	0.2	-3.3	-0.3	-3.1	-1.1
Commuting to job workplace: Cycle	0.3	0.4	1.0	-0.1	0.3	-0.7	-0.5	0.4	1.0	-0.3	0.9	-0.5	-0.7
Myopia	3.3	4.8	8.9	2.1	2.7	2.6	2.3	-3.0	-1.6	2.7	0.9	2.2	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.3	-0.5	-0.1	-1.3	-0.5	1.4	-1.3	-0.8	1.5	-1.0	-1.5
Cholesterol lowering medication	0.5	0.8	3.3	0.9	-0.3	0.0	0.7	-0.1	-1.4	0.2	0.7	0.9	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.9	-1.6	-0.9	-1.2	-2.0	0.9	-0.1	-1.6	-1.6	-1.6	1.1
Pain experienced in last month	0.1	0.1	0.3	-0.2	-0.6	-0.1	0.6	-0.4	0.6	-0.2	0.0	0.2	0.4
Supplements: Calcium	0.6	0.7	2.3	0.1	-0.5	-1.4	-1.0	0.9	-0.2	-0.6	0.1	-0.5	-1.5
Basal cell carcinoma (self-reported)	1.8	2.1	5.8	2.0	0.8	1.2	1.1	-1.2	0.3	0.8	1.4	2.4	-1.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.2	-0.7	-0.2	0.1	0.2	-0.2	-0.3	0.1	-0.7	-0.8	1.8
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.6	-1.3	-0.5	-1.6	-1.9	1.8	-1.5	-1.4	0.1	-1.2	-1.0
Heart disease (siblings)	0.6	0.8	2.0	1.4	0.7	0.2	1.2	-0.8	-0.3	0.9	1.0	0.7	-0.9
Alcohol drinker status: Previous	1.8	2.1	5.0	-1.3	-0.6	-1.6	-2.2	1.4	-0.4	-1.6	-1.4	-2.0	0.6
Pack years of smoking	1.1	1.6	4.3	-1.7	-1.1	-0.8	-1.7	2.1	-1.4	-1.1	0.3	-0.8	-0.8
Impedance of whole body	1.7	8.7	23.3	1.6	3.1	2.7	2.0	-4.1	3.1	2.9	-1.2	2.1	4.8
Leg fat mass (left)	2.5	9.6	57.9	1.7	-1.0	-0.0	1.0	0.6	-7.6	0.2	1.7	1.5	-5.2
Arm predicted mass (left)	1.6	8.0	39.9	-0.6	-2.5	-1.8	-1.1	2.7	-6.3	-1.5	0.2	-1.2	-4.3