Best TWAS P=7.77e-11 · Best GWAS P=8.62e-10 conditioned to 0.0526
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | MARK3 | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.5e-03 | 5.8 | 5.2 | 1.8e-07 | -0.12 | 0.09 | 0.61 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | CKB | 0.28 | 0.26 | lasso | 4 | 0.25 | 6.4e-14 | -6.1 | -6.1 | 9.4e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | CKB | 0.43 | 0.32 | enet | 16 | 0.34 | 5.9e-29 | -6.1 | -5.6 | 2.2e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Thyroid | TRMT61A | 0.11 | 0.03 | lasso | 4 | 0.02 | 1.2e-02 | 5.7 | -5.5 | 4.0e-08 | 0.34 | 0.03 | 0.94 | FALSE |
| 5 | YFS | Blood | MARK3 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.6e-12 | 5.6 | 5.7 | 1.2e-08 | -0.35 | 0.06 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CKB | 0.06 | 0.03 | lasso | 3 | 0.03 | 2.5e-06 | -6.1 | -6.2 | 4.6e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MARK3 | 0.07 | 0.06 | enet | 7 | 0.08 | 1.0e-08 | -6.1 | -5.4 | 6.0e-08 | 0.95 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -6.1 | -6.5 | 7.8e-11 | 0.74 | 0.01 | 0.66 | TRUE |