[Hub]/) : Traits : Leg predicted mass (right) :

chr17:15,149,905-17,037,222

Best TWAS P=5.18e-11 · Best GWAS P=1.57e-09 conditioned to 0.602

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADORA2B 0.06 0.07 blup 304 0.07 5.0e-09 -5.7 -6.1 1.1e-09 0.92 0.06 0.94 FALSE
2 GTEx Adipose Subcutaneous ADORA2B 0.16 0.23 lasso 4 0.26 1.7e-21 -5.0 -5.4 6.2e-08 0.98 0.10 0.90 FALSE
3 GTEx Adipose Visceral Omentum TTC19 0.11 0.12 lasso 4 0.11 3.0e-06 -5.8 5.7 9.4e-09 -0.92 0.10 0.90 FALSE
4 GTEx Adipose Visceral Omentum ADORA2B 0.13 0.16 lasso 3 0.16 1.8e-08 -5.5 -5.5 3.6e-08 0.98 0.06 0.94 FALSE
5 GTEx Adrenal Gland TTC19 0.07 0.09 enet 11 0.09 5.0e-04 -5.3 5.6 2.4e-08 -0.92 0.09 0.82 FALSE
6 GTEx Artery Aorta TTC19 0.06 0.00 lasso 3 0.00 7.1e-01 -5.7 6.6 5.5e-11 -0.86 0.07 0.40 FALSE
7 GTEx Artery Aorta PIGL 0.09 0.03 lasso 5 0.04 1.8e-03 -4.8 -5.9 3.4e-09 0.78 0.09 0.82 FALSE
8 GTEx Artery Aorta ADORA2B 0.24 0.08 lasso 5 0.05 8.3e-04 -5.0 -5.2 2.0e-07 0.92 0.09 0.86 FALSE
9 GTEx Artery Coronary TTC19 0.19 0.07 enet 2 0.03 3.9e-02 -5.8 5.8 5.8e-09 -0.93 0.07 0.66 FALSE
10 GTEx Artery Tibial TTC19 0.10 0.05 enet 17 0.04 9.0e-04 -5.8 5.2 2.4e-07 -0.74 0.09 0.90 FALSE
11 GTEx Artery Tibial ADORA2B 0.23 0.42 lasso 3 0.42 1.2e-35 -5.0 -5.3 1.4e-07 0.97 0.40 0.60 FALSE
12 GTEx Brain Cerebellar Hemisphere ADORA2B 0.16 0.00 lasso 9 -0.01 5.6e-01 -5.9 -5.5 3.4e-08 0.96 0.04 0.63 FALSE
13 GTEx Brain Cerebellar Hemisphere ZSWIM7 0.32 0.26 lasso 5 0.15 9.8e-05 -5.0 5.5 4.4e-08 -0.98 0.06 0.94 FALSE
14 GTEx Brain Cerebellum ZSWIM7 0.25 0.13 lasso 4 0.12 2.6e-04 -5.5 5.7 1.0e-08 -0.98 0.06 0.92 FALSE
15 GTEx Brain Cortex ZSWIM7 0.16 0.22 lasso 2 0.22 7.5e-07 -5.4 -5.4 7.2e-08 0.95 0.08 0.91 FALSE
16 GTEx Brain Frontal Cortex BA9 ZSWIM7 0.15 0.21 lasso 3 0.20 6.3e-06 -5.9 -5.8 7.7e-09 0.99 0.05 0.94 FALSE
17 GTEx Brain Hypothalamus ZSWIM7 0.13 0.18 lasso 2 0.14 3.8e-04 -6.0 -5.6 2.0e-08 0.99 0.05 0.84 FALSE
18 GTEx Breast Mammary Tissue TTC19 0.07 0.05 enet 6 0.05 2.0e-03 -5.7 5.7 1.3e-08 -0.97 0.09 0.87 FALSE
19 GTEx Breast Mammary Tissue ADORA2B 0.10 0.15 lasso 2 0.12 5.9e-07 -5.0 -5.1 2.9e-07 0.96 0.06 0.94 FALSE
20 GTEx Breast Mammary Tissue (Male) TTC19 0.13 0.08 lasso 3 0.01 1.6e-01 -5.9 5.6 2.3e-08 -0.99 0.05 0.70 FALSE
21 GTEx Cells EBV-transformed lymphocytes TTC19 0.15 0.05 lasso 4 0.08 1.6e-03 -6.0 5.7 1.2e-08 -0.99 0.04 0.92 FALSE
22 GTEx Cells Transformed fibroblasts TTC19 0.13 0.21 lasso 5 0.24 9.6e-18 -5.8 5.8 8.5e-09 -0.94 0.10 0.90 FALSE
23 GTEx Cells Transformed fibroblasts ADORA2B 0.18 0.11 enet 15 0.15 2.2e-11 -2.2 -5.1 2.8e-07 0.22 0.99 0.01 FALSE
24 GTEx Colon Transverse TTC19 0.09 0.10 lasso 5 0.11 5.4e-06 -5.7 5.5 3.1e-08 -0.91 0.12 0.88 FALSE
25 GTEx Esophagus Gastroesophageal Junction ADORA2B 0.39 0.44 lasso 4 0.41 3.3e-16 -5.0 -5.2 2.3e-07 0.97 0.12 0.88 FALSE
26 GTEx Esophagus Mucosa ADORA2B 0.07 0.04 enet 17 0.07 1.9e-05 -6.0 -5.9 3.3e-09 0.86 0.05 0.95 FALSE
27 GTEx Heart Atrial Appendage ADORA2B 0.19 0.14 lasso 10 0.13 2.4e-06 -6.0 -5.4 7.5e-08 0.98 0.04 0.96 FALSE
28 GTEx Heart Left Ventricle ADORA2B 0.14 0.11 lasso 7 0.10 6.0e-06 -6.0 -5.5 3.9e-08 0.96 0.04 0.95 FALSE
29 GTEx Heart Left Ventricle ZSWIM7 0.12 0.22 lasso 2 0.22 4.4e-12 -5.0 -5.2 2.0e-07 0.96 0.14 0.86 FALSE
30 GTEx Liver ADORA2B 0.15 0.15 lasso 6 0.10 8.2e-04 -5.0 -5.2 1.5e-07 0.97 0.06 0.83 FALSE
31 GTEx Lung TTC19 0.07 0.10 lasso 3 0.10 4.0e-08 -5.8 5.7 1.3e-08 -0.96 0.09 0.91 FALSE
32 GTEx Lung ADORA2B 0.19 0.09 lasso 4 0.07 3.2e-06 -5.0 -5.3 1.0e-07 0.96 0.06 0.94 FALSE
33 GTEx Muscle Skeletal TTC19 0.03 0.04 lasso 3 0.02 2.9e-03 -5.8 5.3 1.1e-07 -0.87 0.10 0.86 FALSE
34 GTEx Muscle Skeletal ADORA2B 0.27 0.44 lasso 3 0.45 5.3e-48 -5.0 -5.4 5.9e-08 0.98 0.70 0.30 FALSE
35 GTEx Muscle Skeletal ZSWIM7 0.22 0.42 enet 15 0.42 9.6e-45 -5.0 -5.5 4.0e-08 0.98 0.30 0.70 FALSE
36 GTEx Nerve Tibial TTC19 0.09 0.11 lasso 3 0.11 2.3e-08 -5.9 5.5 3.5e-08 -0.89 0.08 0.92 FALSE
37 GTEx Pancreas TTC19 0.12 0.09 enet 9 0.07 8.5e-04 -5.4 6.1 1.2e-09 -0.85 0.09 0.76 FALSE
38 GTEx Pancreas ADORA2B 0.12 0.16 enet 9 0.14 1.5e-06 -5.9 -5.8 6.4e-09 0.98 0.06 0.94 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic TTC19 0.21 0.18 lasso 5 0.18 6.3e-10 -5.8 5.5 3.8e-08 -0.92 0.10 0.90 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic ADORA2B 0.15 0.13 lasso 3 0.12 3.8e-07 -6.0 -6.0 1.6e-09 1.00 0.04 0.96 FALSE
41 GTEx Skin Not Sun Exposed Suprapubic ZSWIM7 0.17 0.17 lasso 4 0.19 1.1e-10 -5.5 5.6 2.1e-08 -0.98 0.06 0.94 FALSE
42 GTEx Skin Sun Exposed Lower leg TTC19 0.08 0.18 lasso 3 0.17 6.9e-14 -5.8 5.7 1.4e-08 -0.94 0.08 0.92 FALSE
43 GTEx Skin Sun Exposed Lower leg ADORA2B 0.12 0.17 lasso 4 0.17 3.1e-14 -5.9 -5.8 6.9e-09 0.99 0.04 0.96 FALSE
44 GTEx Skin Sun Exposed Lower leg ZSWIM7 0.12 0.08 enet 16 0.10 2.1e-08 -5.5 5.5 5.1e-08 -0.91 0.11 0.89 FALSE
45 GTEx Spleen TTC19 0.28 0.06 enet 12 0.03 7.0e-02 -5.8 5.8 6.2e-09 -0.88 0.07 0.77 FALSE
46 GTEx Spleen ADORA2B 0.23 0.27 enet 10 0.24 7.4e-07 -5.9 -6.2 5.8e-10 0.96 0.05 0.95 FALSE
47 GTEx Spleen ZSWIM7 0.37 0.39 lasso 7 0.40 2.8e-11 -5.7 5.6 2.3e-08 -0.98 0.11 0.89 FALSE
48 GTEx Stomach TTC19 0.14 0.12 enet 13 0.09 2.8e-05 -5.7 5.3 1.3e-07 -0.83 0.11 0.89 FALSE
49 GTEx Testis TRPV2 0.13 0.15 lasso 2 0.12 7.0e-06 -4.8 5.1 2.9e-07 -0.52 0.32 0.36 FALSE
50 GTEx Testis ZSWIM7 0.34 0.59 lasso 8 0.58 2.4e-31 -5.0 5.2 2.0e-07 -0.97 0.31 0.69 FALSE
51 GTEx Uterus TRPV2 0.28 0.09 lasso 4 0.06 2.4e-02 -4.8 5.1 3.0e-07 -0.65 0.05 0.29 FALSE
52 GTEx Whole Blood ADORA2B 0.08 0.00 lasso 5 0.00 2.5e-01 -4.9 -6.1 1.0e-09 0.84 0.04 0.65 FALSE
53 METSIM Adipose ADORA2B 0.10 0.20 lasso 3 0.20 4.2e-29 -5.6 -5.6 1.8e-08 0.98 0.07 0.93 FALSE
54 METSIM Adipose TTC19 0.09 0.21 lasso 4 0.21 4.1e-30 -5.8 5.8 6.3e-09 -0.92 0.09 0.91 FALSE
55 NTR Blood NCOR1 0.02 0.01 blup 321 0.01 7.2e-04 4.3 -5.4 7.8e-08 0.70 0.33 0.39 FALSE
56 NTR Blood ZSWIM7 0.02 0.03 lasso 5 0.03 9.3e-10 -5.3 5.2 1.8e-07 -0.96 0.05 0.95 FALSE
57 ROSMAP Brain Pre-frontal Cortex TTC19 0.14 0.24 lasso 10 0.27 1.2e-34 -5.9 -5.4 7.9e-08 0.95 0.03 0.97 FALSE
58 ROSMAP Brain Pre-frontal Cortex ADORA2B 0.09 0.11 lasso 5 0.10 5.7e-13 -5.7 -5.6 2.6e-08 0.98 0.05 0.95 FALSE
59 YFS Blood ADORA2B 0.17 0.04 enet 38 0.07 7.7e-21 -5.8 -5.3 1.1e-07 0.64 0.10 0.90 FALSE
60 YFS Blood NCOR1 0.02 0.04 lasso 5 0.04 2.6e-13 -5.7 -5.3 9.6e-08 0.91 0.10 0.90 FALSE
61 YFS Blood PIGL 0.02 0.02 blup 279 0.02 1.5e-06 -4.0 -6.6 5.2e-11 0.88 0.20 0.80 TRUE
62 The Cancer Genome Atlas Breast Invasive Carcinoma PIGL 0.02 0.01 blup 71 0.02 3.5e-04 -4.7 -5.3 1.0e-07 0.90 0.08 0.84 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma ZSWIM7 0.06 0.10 lasso 2 0.09 1.4e-17 -5.6 -5.6 1.9e-08 0.98 0.04 0.96 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma ZSWIM7 0.04 0.02 blup 44 0.03 5.0e-03 -5.9 -5.6 2.1e-08 0.99 0.02 0.77 FALSE
65 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TTC19 0.03 0.04 enet 11 0.04 1.0e-05 -5.0 5.5 4.7e-08 -0.90 0.03 0.96 FALSE
66 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TTC19 0.04 0.06 lasso 2 0.06 7.7e-07 -5.3 5.4 8.1e-08 -0.91 0.04 0.96 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZSWIM7 0.14 0.25 lasso 7 0.24 3.3e-27 -5.0 -5.2 2.3e-07 0.97 0.09 0.91 FALSE
68 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ADORA2B 0.28 0.24 enet 14 0.27 7.3e-16 -5.0 -5.7 1.0e-08 0.94 0.04 0.96 FALSE
69 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TTC19 0.07 0.08 lasso 2 0.07 5.2e-05 -5.4 5.4 6.2e-08 -0.91 0.05 0.91 FALSE
70 The Cancer Genome Atlas Brain Lower Grade Glioma NCOR1 0.03 0.04 blup 97 0.04 8.1e-06 -5.7 -5.6 1.9e-08 0.99 0.05 0.95 FALSE
71 The Cancer Genome Atlas Brain Lower Grade Glioma ZSWIM7 0.19 0.32 lasso 4 0.32 5.9e-37 -5.0 -5.2 1.5e-07 0.97 0.10 0.90 FALSE
72 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ADORA2B 0.13 0.17 blup 37 0.16 8.2e-08 -5.5 -5.9 3.2e-09 0.95 0.02 0.98 FALSE
73 The Cancer Genome Atlas Lung Adenocarcinoma ZSWIM7 0.05 0.05 blup 48 0.05 3.3e-06 -5.0 -5.8 9.1e-09 0.98 0.03 0.97 FALSE
74 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TTC19 0.03 0.03 enet 8 0.03 2.0e-04 -5.6 5.6 2.4e-08 -0.96 0.04 0.95 FALSE
75 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADORA2B 0.10 0.07 enet 9 0.08 5.0e-06 -5.8 -5.8 5.0e-09 0.94 0.01 0.98 FALSE
76 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ZSWIM7 0.10 0.04 lasso 5 0.04 1.6e-03 -4.9 -5.2 2.0e-07 0.95 0.03 0.95 FALSE
77 The Cancer Genome Atlas Pancreatic Adenocarcinoma TTC19 0.10 0.11 lasso 1 0.09 9.6e-05 -5.6 5.6 2.5e-08 -0.98 0.04 0.95 FALSE
78 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ADORA2B 0.15 0.16 enet 12 0.18 1.6e-07 -5.0 -5.1 2.7e-07 0.93 0.02 0.97 FALSE
79 The Cancer Genome Atlas Prostate Adenocarcinoma ADORA2B 0.14 0.19 lasso 3 0.20 8.0e-21 -5.0 -5.3 1.2e-07 0.96 0.05 0.95 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma ZSWIM7 0.15 0.25 enet 13 0.26 2.0e-27 -5.5 -5.7 1.6e-08 0.99 0.02 0.98 FALSE
81 The Cancer Genome Atlas Skin Cutaneous Melanoma ZSWIM7 0.27 0.26 blup 44 0.30 1.2e-08 -5.6 -5.2 2.2e-07 0.96 0.03 0.97 FALSE
82 The Cancer Genome Atlas Stomach Adenocarcinoma ZSWIM7 0.14 0.15 lasso 3 0.15 4.1e-11 -5.0 -5.2 2.1e-07 0.96 0.05 0.95 FALSE
83 The Cancer Genome Atlas Thyroid Carcinoma ADORA2B 0.12 0.23 lasso 7 0.24 1.5e-23 -5.0 -5.3 1.1e-07 0.97 0.03 0.97 FALSE
84 The Cancer Genome Atlas Thyroid Carcinoma TTC19 0.16 0.21 lasso 5 0.20 1.4e-19 -5.8 5.8 6.5e-09 -0.92 0.03 0.97 FALSE
85 The Cancer Genome Atlas Thyroid Carcinoma ZSWIM7 0.28 0.45 lasso 7 0.46 2.5e-50 -5.0 -5.2 2.4e-07 0.97 0.14 0.86 FALSE