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chr19:1,127,720-5,153,606

Best TWAS P=3.05e-14 · Best GWAS P=7.28e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	REXO1	0.07	0.01	bslmm	391	0.01	1.7e-02	-2.78	6.7	1.9e-11	0.16	0.28	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	UBXN6	0.27	0.25	enet	28	0.29	4.6e-36	5.03	-6.1	8.7e-10	0.11	0.05	0.95	FALSE
3	GTEx	Adipose Subcutaneous	AMH	0.18	0.05	lasso	8	0.06	1.9e-05	-4.10	5.2	2.4e-07	0.46	0.91	0.02	FALSE
4	GTEx	Adipose Subcutaneous	NFIC	0.14	0.00	enet	11	0.00	2.7e-01	-1.96	-5.4	8.0e-08	0.03	0.02	0.67	FALSE
5	GTEx	Adipose Subcutaneous	CTB-50L17.9	0.29	0.30	lasso	2	0.30	2.3e-24	5.38	-5.4	7.5e-08	0.09	0.05	0.95	FALSE
6	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	6.08	-6.4	2.1e-10	-0.04	0.07	0.19	FALSE
7	GTEx	Adipose Visceral Omentum	CHAF1A	0.24	0.26	lasso	3	0.26	6.2e-14	5.52	-5.4	7.8e-08	0.09	0.01	0.99	FALSE
8	GTEx	Adipose Visceral Omentum	CTB-50L17.9	0.30	0.23	lasso	4	0.22	2.1e-11	5.38	-5.4	5.5e-08	0.10	0.04	0.96	FALSE
9	GTEx	Adrenal Gland	CHAF1A	0.22	0.18	lasso	3	0.17	1.1e-06	5.03	-5.3	1.1e-07	0.10	0.02	0.98	FALSE
10	GTEx	Adrenal Gland	CTB-50L17.9	0.38	0.35	lasso	3	0.34	5.8e-13	5.38	-5.4	7.3e-08	0.09	0.05	0.95	FALSE
11	GTEx	Artery Aorta	CHAF1A	0.29	0.33	lasso	3	0.34	2.4e-19	5.52	-5.2	2.3e-07	0.09	0.01	0.99	FALSE
12	GTEx	Artery Aorta	UBXN6	0.13	0.02	lasso	5	0.03	5.7e-03	-5.28	-6.5	8.8e-11	0.09	0.02	0.95	FALSE
13	GTEx	Artery Aorta	CTB-50L17.5	0.16	0.15	lasso	7	0.15	1.0e-08	5.90	-5.8	5.4e-09	0.09	0.00	1.00	FALSE
14	GTEx	Artery Aorta	CTB-50L17.9	0.32	0.31	lasso	4	0.30	2.9e-17	5.38	-5.5	4.3e-08	0.09	0.06	0.94	FALSE
15	GTEx	Artery Coronary	CTB-50L17.9	0.43	0.14	lasso	6	0.12	6.5e-05	5.38	-5.5	4.0e-08	0.07	0.03	0.87	FALSE
16	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	6.29	5.7	9.4e-09	0.78	0.26	0.67	TRUE
17	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	6.08	-6.4	1.5e-10	-0.02	0.28	0.72	TRUE
18	GTEx	Artery Tibial	UBXN6	0.18	0.07	lasso	3	0.14	6.3e-11	5.83	-6.5	7.0e-11	0.11	0.01	0.99	FALSE
19	GTEx	Artery Tibial	AC005306.3	0.25	0.12	enet	59	0.11	3.9e-09	-3.57	-5.4	8.2e-08	-0.11	1.00	0.00	TRUE
20	GTEx	Artery Tibial	CTB-50L17.9	0.27	0.31	lasso	3	0.31	2.2e-24	5.38	-5.4	5.4e-08	0.09	0.06	0.94	FALSE
21	GTEx	Brain Caudate basal ganglia	CTB-50L17.9	0.27	0.25	lasso	2	0.24	1.8e-07	5.90	-5.9	3.7e-09	0.09	0.00	0.99	FALSE
22	GTEx	Brain Cerebellar Hemisphere	CHAF1A	0.62	0.40	lasso	8	0.36	3.5e-10	5.90	-5.8	7.4e-09	0.09	0.00	0.99	FALSE
23	GTEx	Brain Cerebellar Hemisphere	CTB-50L17.9	0.61	0.45	lasso	2	0.50	1.2e-14	5.38	-5.4	5.3e-08	0.09	0.01	0.99	FALSE
24	GTEx	Brain Cerebellum	CHAF1A	0.51	0.35	lasso	4	0.34	9.7e-11	5.90	-5.7	1.0e-08	0.09	0.01	0.99	FALSE
25	GTEx	Brain Cerebellum	CTB-50L17.5	0.33	0.22	lasso	4	0.20	1.8e-06	5.38	-5.4	8.5e-08	0.09	0.02	0.98	FALSE
26	GTEx	Brain Cerebellum	CTB-50L17.9	0.53	0.41	lasso	2	0.50	3.6e-17	5.38	-6.0	2.3e-09	0.10	0.01	0.99	FALSE
27	GTEx	Brain Cortex	CTB-50L17.9	0.28	0.25	lasso	2	0.25	1.7e-07	5.38	-5.4	5.9e-08	0.09	0.02	0.97	FALSE
28	GTEx	Brain Frontal Cortex BA9	UBXN6	0.31	0.06	enet	5	0.12	3.5e-04	5.38	-5.5	3.7e-08	0.11	0.01	0.92	FALSE
29	GTEx	Brain Frontal Cortex BA9	CTB-50L17.9	0.27	0.21	lasso	3	0.19	7.9e-06	5.38	-5.9	4.2e-09	0.10	0.01	0.97	FALSE
30	GTEx	Brain Frontal Cortex BA9	AC007292.6	0.35	0.01	lasso	6	0.12	3.6e-04	-0.35	-5.2	1.5e-07	0.07	0.04	0.48	FALSE
31	GTEx	Brain Hypothalamus	CTB-50L17.9	0.44	0.26	lasso	4	0.24	2.8e-06	5.38	-5.3	1.2e-07	0.09	0.02	0.89	FALSE
32	GTEx	Brain Nucleus accumbens basal ganglia	CHAF1A	0.31	0.28	lasso	2	0.24	4.0e-07	5.52	-5.5	3.7e-08	0.09	0.01	0.98	FALSE
33	GTEx	Brain Nucleus accumbens basal ganglia	CTB-50L17.9	0.45	0.25	lasso	8	0.23	8.6e-07	5.90	-6.9	6.6e-12	0.09	0.01	0.98	FALSE
34	GTEx	Brain Putamen basal ganglia	CHAF1A	0.40	0.34	lasso	4	0.37	1.2e-09	5.90	-5.5	4.9e-08	0.09	0.00	0.99	FALSE
35	GTEx	Brain Putamen basal ganglia	CTB-50L17.9	0.33	0.32	lasso	1	0.33	1.2e-08	5.38	-5.4	7.2e-08	0.09	0.01	0.98	FALSE
36	GTEx	Breast Mammary Tissue	CTB-50L17.9	0.42	0.33	lasso	9	0.32	3.0e-17	5.38	-5.5	4.6e-08	0.09	0.05	0.95	FALSE
37	GTEx	Breast Mammary Tissue (Male)	CHAF1A	0.20	-0.01	lasso	12	0.00	4.2e-01	5.03	-5.1	2.8e-07	0.09	0.03	0.60	FALSE
38	GTEx	Breast Mammary Tissue (Male)	CTB-50L17.9	0.30	0.18	lasso	4	0.10	2.3e-03	5.38	-5.3	9.3e-08	0.10	0.03	0.63	FALSE
39	GTEx	Breast Mammary Tissue (Female)	CHAF1A	0.33	0.14	lasso	6	0.09	1.6e-03	5.52	-5.3	1.4e-07	0.09	0.02	0.95	FALSE
40	GTEx	Breast Mammary Tissue (Female)	CTB-50L17.9	0.45	0.25	lasso	7	0.26	1.6e-08	5.41	-5.3	9.6e-08	0.07	0.02	0.97	FALSE
41	GTEx	Cells EBV-transformed lymphocytes	CTB-50L17.9	0.31	0.27	lasso	1	0.23	3.6e-08	5.38	-5.4	7.2e-08	0.09	0.05	0.95	FALSE
42	GTEx	Cells Transformed fibroblasts	AMH	0.30	0.18	enet	18	0.18	1.1e-13	-4.10	5.2	1.7e-07	0.33	1.00	0.00	TRUE
43	GTEx	Cells Transformed fibroblasts	UBXN6	0.09	0.10	lasso	1	0.08	1.5e-06	-5.28	-5.3	1.3e-07	0.05	0.08	0.91	FALSE
44	GTEx	Cells Transformed fibroblasts	CTB-50L17.9	0.17	0.16	lasso	4	0.16	7.4e-12	5.38	-5.1	2.8e-07	0.09	0.06	0.94	FALSE
45	GTEx	Colon Sigmoid	CHAF1A	0.33	0.08	lasso	5	0.12	7.5e-05	5.52	-5.4	7.1e-08	0.08	0.01	0.98	FALSE
46	GTEx	Colon Sigmoid	UBXN6	0.34	0.15	lasso	6	0.14	1.7e-05	5.38	-5.9	4.4e-09	0.09	0.02	0.97	FALSE
47	GTEx	Colon Sigmoid	CTB-50L17.9	0.42	0.38	lasso	5	0.37	4.4e-14	5.38	-5.4	5.8e-08	0.09	0.02	0.98	FALSE
48	GTEx	Colon Transverse	AC007292.6	0.32	0.05	lasso	6	0.20	1.2e-09	5.03	-5.4	8.1e-08	0.05	0.02	0.98	FALSE
49	GTEx	Esophagus Gastroesophageal Junction	CTB-50L17.9	0.22	0.18	lasso	2	0.19	1.7e-07	5.38	-5.4	5.9e-08	0.09	0.03	0.97	FALSE
50	GTEx	Esophagus Mucosa	CTB-50L17.9	0.20	0.23	lasso	4	0.22	8.2e-15	5.38	-5.4	7.0e-08	0.09	0.06	0.94	FALSE
51	GTEx	Esophagus Muscularis	UBXN6	0.35	0.24	enet	20	0.29	3.7e-18	5.38	-5.5	3.6e-08	0.09	0.01	0.99	FALSE
52	GTEx	Esophagus Muscularis	CTB-50L17.5	0.28	0.17	lasso	3	0.19	6.7e-12	5.83	-5.1	2.9e-07	0.10	0.00	1.00	FALSE
53	GTEx	Esophagus Muscularis	CTB-50L17.9	0.37	0.36	lasso	5	0.35	3.8e-22	5.38	-5.4	7.2e-08	0.09	0.05	0.95	FALSE
54	GTEx	Esophagus Muscularis	AC007292.6	0.13	0.08	lasso	2	0.05	4.9e-04	5.03	-5.1	2.9e-07	0.10	0.06	0.91	FALSE
55	GTEx	Heart Atrial Appendage	UBXN6	0.34	0.12	lasso	6	0.21	6.5e-10	5.90	-6.4	2.0e-10	0.09	0.01	0.99	FALSE
56	GTEx	Heart Atrial Appendage	CTB-50L17.9	0.32	0.34	lasso	3	0.34	3.8e-16	5.38	-5.6	2.5e-08	0.09	0.05	0.95	FALSE
57	GTEx	Heart Left Ventricle	CHAF1A	0.17	0.12	lasso	2	0.11	1.9e-06	5.90	-5.9	3.3e-09	0.09	0.00	1.00	FALSE
58	GTEx	Heart Left Ventricle	UBXN6	0.21	0.14	lasso	6	0.16	5.6e-09	-5.34	-6.2	5.3e-10	0.08	0.04	0.96	FALSE
59	GTEx	Lung	CTB-50L17.9	0.23	0.32	lasso	2	0.32	2.4e-25	5.41	-5.4	5.7e-08	0.09	0.05	0.95	FALSE
60	GTEx	Muscle Skeletal	CHAF1A	0.18	0.21	lasso	2	0.20	9.7e-20	5.90	-5.8	6.0e-09	0.09	0.00	1.00	FALSE
61	GTEx	Muscle Skeletal	UBXN6	0.19	0.14	lasso	5	0.18	4.1e-17	-5.35	-6.6	5.6e-11	0.08	0.07	0.93	FALSE
62	GTEx	Muscle Skeletal	CTB-50L17.9	0.23	0.23	lasso	5	0.21	2.0e-20	5.38	-5.5	4.8e-08	0.09	0.05	0.95	FALSE
63	GTEx	Nerve Tibial	UBXN6	0.17	0.08	enet	20	0.09	4.4e-07	5.41	-5.9	3.0e-09	0.13	0.02	0.98	FALSE
64	GTEx	Nerve Tibial	CTB-50L17.5	0.11	0.08	enet	4	0.08	1.6e-06	5.52	-5.7	1.2e-08	0.09	0.01	0.99	FALSE
65	GTEx	Nerve Tibial	CTB-50L17.9	0.35	0.41	lasso	1	0.40	2.1e-30	5.38	-5.4	7.2e-08	0.09	0.06	0.94	FALSE
66	GTEx	Ovary	CTB-50L17.9	0.29	0.24	lasso	2	0.21	6.5e-06	5.41	-5.4	6.0e-08	0.09	0.03	0.94	FALSE
67	GTEx	Pancreas	CHAF1A	0.23	0.10	enet	14	0.10	6.6e-05	5.83	-5.4	8.7e-08	0.09	0.01	0.98	FALSE
68	GTEx	Pancreas	CTB-50L17.9	0.24	0.15	lasso	4	0.07	1.0e-03	5.38	-5.3	9.6e-08	0.09	0.04	0.94	FALSE
69	GTEx	Skin Not Sun Exposed Suprapubic	CTB-50L17.9	0.43	0.52	lasso	2	0.51	3.3e-32	5.38	-5.4	6.6e-08	0.09	0.05	0.95	FALSE
70	GTEx	Skin Not Sun Exposed Suprapubic	AC007292.6	0.11	0.08	lasso	6	0.07	7.8e-05	5.83	-5.6	2.7e-08	0.10	0.02	0.96	FALSE
71	GTEx	Skin Sun Exposed Lower leg	CHAF1A	0.19	0.18	lasso	1	0.17	5.1e-14	5.52	-5.5	3.3e-08	0.09	0.01	0.99	FALSE
72	GTEx	Skin Sun Exposed Lower leg	CTB-50L17.9	0.39	0.48	lasso	3	0.47	7.7e-44	5.38	-5.4	6.3e-08	0.09	0.06	0.94	FALSE
73	GTEx	Small Intestine Terminal Ileum	CTB-50L17.9	0.46	0.34	lasso	4	0.36	7.2e-09	5.38	-5.2	1.6e-07	0.09	0.02	0.97	FALSE
74	GTEx	Stomach	CTB-50L17.9	0.28	0.31	lasso	1	0.31	3.6e-15	5.38	-5.4	7.2e-08	0.09	0.06	0.94	FALSE
75	GTEx	Stomach	AC007292.4	0.27	0.09	lasso	5	0.04	4.0e-03	-5.66	5.9	4.8e-09	-0.05	0.02	0.89	FALSE
76	GTEx	Testis	CHAF1A	0.18	0.09	lasso	2	0.07	4.0e-04	5.90	-5.5	3.4e-08	0.08	0.01	0.95	FALSE
77	GTEx	Testis	UBXN6	0.20	0.10	lasso	3	0.10	2.9e-05	5.38	-5.5	4.3e-08	0.09	0.02	0.97	FALSE
78	GTEx	Testis	CTB-50L17.9	0.39	0.30	enet	36	0.34	9.4e-16	5.38	-6.0	1.6e-09	0.08	0.04	0.96	FALSE
79	GTEx	Thyroid	UBXN6	0.25	0.19	lasso	5	0.23	8.8e-18	5.83	-5.9	4.6e-09	0.11	0.01	0.99	FALSE
80	GTEx	Thyroid	CTB-50L17.9	0.35	0.42	lasso	2	0.42	2.2e-34	5.38	-5.4	7.2e-08	0.09	0.06	0.94	FALSE
81	GTEx	Vagina	CTB-50L17.9	0.38	0.26	lasso	5	0.23	5.7e-06	5.90	-5.8	7.8e-09	0.11	0.01	0.97	FALSE
82	GTEx	Whole Blood	CTB-50L17.9	0.21	0.17	lasso	3	0.18	9.6e-17	5.38	-5.2	1.7e-07	0.09	0.02	0.98	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	KLF16	0.12	0.08	bslmm	372	0.08	1.0e-10	-5.35	-5.6	1.9e-08	-0.01	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBXN6	0.03	0.03	lasso	3	0.03	2.3e-06	-5.28	-5.6	2.5e-08	0.06	0.03	0.96	FALSE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBXN6	0.05	0.01	blup	57	0.04	6.6e-05	5.90	-7.6	3.1e-14	0.10	0.01	0.98	TRUE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHAF1A	0.12	0.11	lasso	3	0.12	7.9e-13	5.52	-5.9	4.9e-09	0.10	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	6.29	6.6	3.8e-11	0.84	0.14	0.86	TRUE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPND	0.05	0.03	lasso	3	0.02	5.3e-03	5.59	5.5	4.0e-08	-0.09	0.01	0.87	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBXN6	0.18	0.17	enet	18	0.18	9.9e-20	5.90	-5.6	2.3e-08	0.09	0.00	1.00	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHAF1A	0.15	0.12	lasso	2	0.12	3.2e-07	5.52	-5.6	2.1e-08	0.09	0.03	0.97	FALSE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FZR1	0.21	0.07	lasso	3	0.07	5.6e-05	-4.38	-5.3	1.1e-07	-0.03	0.00	0.31	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBXN6	0.15	0.10	lasso	1	0.10	2.8e-06	5.38	-5.4	7.2e-08	0.09	0.02	0.97	FALSE
93	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	-5.32	6.1	1.3e-09	0.68	0.22	0.52	TRUE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	CHAF1A	0.05	0.04	lasso	4	0.03	2.3e-04	5.90	-5.5	3.1e-08	0.09	0.01	0.98	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JSRP1	0.03	0.00	blup	33	0.02	2.1e-03	-3.88	-5.9	4.7e-09	-0.52	0.01	0.25	FALSE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBXN6	0.04	0.03	lasso	2	0.02	1.6e-03	5.38	-5.8	7.3e-09	0.09	0.01	0.91	FALSE
97	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHAF1A	0.20	0.11	lasso	2	0.11	5.6e-05	5.83	-6.0	1.5e-09	0.11	0.01	0.98	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UBXN6	0.23	0.11	lasso	5	0.12	2.5e-05	5.38	-6.4	2.0e-10	0.12	0.02	0.77	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHAF1A	0.13	0.09	lasso	6	0.10	3.5e-10	5.90	-5.1	3.0e-07	0.09	0.00	1.00	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBXN6	0.13	0.10	lasso	2	0.10	1.3e-10	5.90	-6.3	3.9e-10	0.09	0.00	1.00	FALSE
101	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	-4.25	5.7	1.3e-08	0.50	0.01	0.16	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	UBXN6	0.16	0.12	lasso	2	0.12	5.4e-12	5.90	-6.1	9.6e-10	0.09	0.00	1.00	FALSE