TWAS hub - DOT1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0230	1.9e-02	0.000	0.012	0.000	0.011	-0.001	3.3e-01	1.1e-02	3.5e-01	1.5e-02	4.3e-01
2	GTEx	Artery Tibial	0.0912	0.0335	2.6e-03	0.064	NA	0.027	NA	0.051	8.8e-06	NA	3.1e-03	NA	7.3e-05
3	GTEx	Esophagus Muscularis	0.1180	0.0460	3.6e-03	0.027	NA	0.034	NA	0.049	8.4e-03	NA	3.8e-03	NA	6.3e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0820	0.0251	2.8e-04	0.056	0.009	0.063	0.054	0.066	1.1e-07	2.0e-02	1.7e-08	1.4e-07	8.0e-09
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0787	0.0299	1.5e-10	0.119	0.083	0.100	NA	0.070	3.0e-13	1.4e-09	2.5e-11	NA	2.6e-08
6	TCGA	Liver Hepatocellular Carcinoma	0.0900	0.0400	2.5e-04	0.080	0.068	0.050	NA	0.063	1.3e-04	4.1e-04	2.2e-03	NA	6.5e-04
7	TCGA	Testicular Germ Cell Tumors	0.3970	0.1670	4.8e-03	-0.008	0.005	0.028	NA	0.002	8.7e-01	2.0e-01	3.6e-02	NA	2.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	10.9	104.9	207.4	-0.7	12.9	10.4	4.7	14.4	12.9	8.0
Comparative height size at age 10	10.9	59.9	116.6	-2.1	9.6	7.0	3.0	10.8	9.3	7.9
Standing height	9.2	91.7	198.8	-1.8	12.2	8.3	2.9	14.1	11.5	9.0
Height	9.1	174.6	376.4	-1.7	16.5	12.1	4.8	19.4	16.1	11.9
Lupus	8.2	12.4	26.5	0.7	3.4	5.1	4.5	3.3	3.9	1.0
Trunk fat-free mass	7.2	41.6	84.8	0.8	8.3	4.9	1.8	9.2	8.4	6.2
Trunk predicted mass	7.2	41.2	84.1	0.9	8.3	5.0	1.9	9.2	8.3	6.2
Hand grip strength (right)	7.0	18.9	35.8	-0.6	5.8	4.3	2.7	6.0	5.5	2.6
Waist Hip Ratio (WHR)	6.7	29.9	52.1	1.8	-7.0	-6.6	-4.0	-7.2	-6.5	-1.3
Unable to work because of sickness or disability	6.6	8.5	20.1	4.5	3.1	1.8	1.1	2.9	3.3	2.5
Whole body fat-free mass	6.1	34.6	69.7	1.5	7.5	4.2	1.2	8.3	7.6	6.1
Forced expiratory volume in 1-second (FEV1), predicted	6.0	12.4	29.7	-0.9	4.5	2.7	0.8	5.4	4.3	3.1
Whole body water mass	6.0	34.3	69.3	1.6	7.4	4.2	1.1	8.3	7.6	6.0
Sitting height	5.9	42.2	94.7	0.1	8.6	4.8	1.0	9.7	7.9	6.4
Arm fat-free mass (right)	5.7	29.2	59.4	1.6	6.8	3.7	0.8	7.7	7.3	5.4
Arm predicted mass (right)	5.6	28.7	58.9	1.9	6.7	3.7	0.8	7.7	7.2	5.3
Arm fat-free mass (left)	5.6	28.5	55.9	1.7	6.7	3.7	1.1	7.5	7.2	5.3
Basal metabolic rate	5.5	30.3	59.7	1.9	6.9	3.8	1.0	7.7	7.2	5.8
Heel T-Score	5.4	43.1	96.0	-1.9	-8.1	-5.6	-0.8	-9.8	-8.7	-5.3
Hand grip strength (left)	5.3	14.0	26.4	0.1	5.0	3.6	2.7	5.1	4.8	1.8
Arm predicted mass (left)	5.2	26.7	53.3	1.6	6.6	3.6	1.0	7.3	7.0	5.0
Number of incorrect matches in round	4.8	8.0	14.2	1.6	3.5	3.2	1.8	3.6	3.8	-0.9
Leg fat-free mass (left)	4.7	24.6	48.0	2.4	6.0	3.1	0.4	6.9	6.3	5.7
Leg predicted mass (left)	4.7	24.8	48.3	2.3	6.1	3.1	0.4	7.0	6.3	5.7
Comparative body size at age 10	4.6	12.8	27.9	-0.1	-5.3	-3.7	-2.2	-4.8	-4.0	-2.1
Systolic Blood Pressure	4.4	21.9	60.2	4.0	2.9	6.5	7.8	3.0	4.1	0.5
Hip circumference	4.4	19.1	33.8	3.0	5.4	3.6	1.6	5.5	5.8	4.0
Leg fat-free mass (right)	4.3	23.1	44.5	2.3	5.8	2.9	0.1	6.7	6.1	5.7
Leg predicted mass (right)	4.3	22.7	43.7	2.3	5.7	2.8	0.0	6.6	6.1	5.7
Systolic blood pressure, automated reading	4.1	11.8	30.9	2.1	2.3	4.6	5.6	2.4	3.9	0.1
Schizophrenia (2018)	4.0	8.3	14.7	-1.9	3.1	3.8	3.8	2.5	3.1	0.2
Schizophrenia (2014)	4.0	8.9	16.1	-2.4	3.3	3.9	4.0	2.5	2.8	-0.0
Pulse wave Arterial Stiffness index	3.9	4.6	9.9	-1.8	2.8	1.1	0.1	2.9	3.1	1.3
Lung FVC	3.7	19.0	32.5	-1.6	-5.2	-4.2	-1.9	-5.7	-5.7	-4.0
Ever had stillbirth, spontaneous miscarriage or termination	3.7	4.0	8.7	0.6	3.0	2.5	1.5	2.4	1.6	1.4
Chronotype (morning person)	3.6	8.4	13.5	-3.0	3.4	1.7	0.7	3.6	3.7	3.0
Hypertension (Self-reported)	3.4	9.5	17.9	3.6	2.2	3.8	4.2	2.3	3.1	0.8
Back pain experienced in last month	3.4	4.9	10.9	3.3	2.6	1.4	0.7	2.8	2.2	1.2
Bipolar Disorder or Schizophrenia	3.3	8.0	15.8	-2.3	2.9	3.6	4.0	2.2	3.0	-0.1
Weight	3.3	16.1	28.8	3.2	4.7	2.6	0.7	5.2	5.4	4.2
High blood pressure	3.2	8.8	18.0	3.5	2.1	3.8	4.2	2.1	2.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.0	3.5	6.7	1.0	2.0	2.6	1.9	2.2	2.0	0.8
Medication: Blood pressure	3.0	5.7	8.1	2.8	2.1	2.8	2.8	1.9	2.5	1.1
Overall health rating	2.9	6.2	24.1	4.9	2.1	0.5	0.4	1.9	2.6	2.0
High blood pressure (mother)	2.8	4.0	10.1	1.8	1.4	2.6	3.2	1.3	1.8	1.0
Medication for hormone replacement therapy	2.7	3.0	5.6	0.0	-2.3	-2.1	-1.1	-2.4	-2.0	-1.0
Severe depression (siblings)	2.7	3.0	5.9	1.6	1.5	1.9	2.0	1.8	2.4	0.2
Relative age voice broke	2.7	4.1	6.6	-0.8	-2.2	-2.5	-2.6	-2.2	-2.4	-0.7
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	6.7	1.0	2.1	2.0	1.1	1.9	2.6	0.7
Birth weight of first child	2.7	4.9	6.8	2.0	-2.6	-2.6	-1.8	-2.4	-2.5	1.0
Wheeze or whistling in the chest in last year	2.7	4.8	22.9	4.8	1.6	0.8	0.9	1.7	1.9	0.3
Financial difficulties in last 2 years	2.6	3.5	10.0	1.5	1.6	0.7	-0.9	1.9	2.1	3.2
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	5.7	0.3	-2.0	-1.6	-0.3	-2.4	-2.1	-2.3
Pain experienced in last month	2.6	4.3	7.9	-2.8	-2.1	-0.6	-0.2	-2.3	-2.1	-2.8
Medication: Paracetamol	2.5	4.1	11.6	3.4	-0.3	-2.5	-2.8	-0.9	-1.0	1.0
Qualifications: nursing, teaching	2.5	3.9	7.9	-2.8	-2.3	-0.5	-0.4	-2.2	-1.8	-2.3
Medication: Paracetamol	2.5	3.8	12.8	3.6	-0.1	-2.2	-2.4	-0.7	-0.9	1.5
Vascular/heart problems diagnosed by doctor	2.5	6.9	16.3	-4.0	-1.5	-3.0	-3.5	-1.6	-2.2	-0.8
Breast Cancer	2.4	5.7	12.0	0.9	-2.8	-1.4	-0.7	-3.1	-3.5	-2.7
Tense / ‘highly strung’	2.4	4.0	6.5	1.0	2.5	2.3	1.4	2.5	2.0	1.7
Family relationship satisfaction	2.4	2.9	5.0	0.7	2.2	1.6	1.7	2.0	2.2	0.7
Average weekly beer plus cider intake	2.3	3.3	5.1	2.1	2.3	2.0	1.4	1.9	2.0	-0.3
Supplements: Calcium	2.3	2.5	4.5	-0.7	-1.6	-2.1	-2.1	-1.4	-1.4	-1.3
Cardiovascular Disease	2.2	7.2	16.3	4.0	1.6	2.9	3.0	1.6	2.6	2.2
Exposure to tobacco smoke outside home	2.2	2.9	5.0	2.2	1.5	1.7	1.7	1.2	1.6	1.8
Emphysema/chronic bronchitis	2.2	2.5	4.7	0.9	1.5	2.2	1.4	1.8	2.1	0.6
Heart attack	2.1	2.7	10.1	3.2	-1.7	-1.3	-1.5	-1.1	-0.8	0.3
Headache pain in last month	2.1	3.7	8.8	1.4	-1.4	-3.0	-2.4	-1.3	-1.8	-1.6
Birth weight	2.1	4.7	9.4	1.3	-2.3	-2.8	-1.8	-1.9	-3.1	-1.2
Supplements: Vitamin C	2.1	2.5	6.4	2.2	-1.2	-1.7	-2.5	-0.7	-1.0	-0.6
Diastolic blood pressure, automated reading	2.1	6.4	14.0	0.6	3.2	1.2	0.8	3.2	3.7	2.8
Hair/balding pattern: Pattern 3	2.0	3.0	6.7	-0.9	1.5	2.6	2.1	2.0	1.5	0.9
Medication: Ventolin 100micrograms inhaler	2.0	2.6	8.6	-0.2	1.2	0.5	-0.6	1.9	2.0	2.9
Pulse wave peak to peak time	2.0	2.3	5.7	1.6	-1.9	-0.5	0.2	-1.9	-2.4	-0.6
Lung cancer (father)	1.9	2.2	4.8	0.8	1.1	2.1	2.2	1.1	1.7	-0.8
Qualifications: College or University degree	1.9	5.9	28.5	-5.3	-1.6	-1.5	-1.8	-1.4	-1.6	-0.0
Breast cancer (self-reported)	1.9	2.2	5.6	0.1	-1.2	-1.4	-0.4	-1.6	-1.9	-2.4
Pain type(s) experienced in last month: Hip pain	1.9	2.4	6.2	2.0	1.5	-0.0	-0.7	1.4	1.4	2.5
Crohns Disease (2017)	1.8	3.9	6.6	0.6	-2.2	-1.8	-1.2	-2.3	-2.6	-2.3
Primary Biliary Cirrhosis	1.8	2.6	4.9	1.8	1.4	1.6	1.4	1.4	2.2	1.1
Relative age of first facial hair	1.8	3.7	6.2	-0.2	-2.2	-2.5	-2.3	-2.1	-2.3	0.2
Diabetes (mother)	1.8	2.3	9.1	0.3	0.9	0.4	-0.4	1.7	1.7	3.0
Noisy workplace	1.8	2.2	6.3	1.3	-0.8	-2.5	-2.0	-1.2	-1.0	-0.5
Neck or shoulder pain in last month	1.8	2.6	4.8	1.7	2.2	0.9	0.6	2.2	2.0	0.8
Osteoarthritis (self-reported)	1.8	2.3	4.8	1.2	1.5	1.0	1.2	1.1	2.0	2.2
Mother’s age at death	1.8	2.3	3.6	-1.5	1.8	1.6	0.3	1.9	1.9	-0.9
Heart attack/myocardial infarction (self-reported)	1.8	2.3	8.8	3.0	-1.4	-1.3	-1.6	-0.8	-0.5	0.4
Supplements: Zinc	1.7	1.8	4.1	0.6	-1.4	-1.5	-1.3	-1.3	-0.7	-2.0
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.8	1.7	-1.3	-1.6	-2.0	-1.5	-1.1	-0.2
Intelligence (Savage-Jansen 2018)	1.6	5.0	23.6	-4.9	-1.3	-1.2	-0.6	-1.5	-2.4	-0.4
Prostate Cancer	1.6	2.2	4.9	-1.6	1.1	2.0	2.2	0.9	0.6	-1.2
Mean Putamen Volume	1.6	1.9	3.5	-0.8	-1.1	-1.7	-1.9	-1.1	-1.0	-1.7
Medication: Atenolol	1.6	2.0	6.6	2.6	0.9	1.6	1.9	0.6	0.2	0.6
Time employed in main current job	1.6	1.8	3.1	-0.6	-1.4	-1.8	-1.7	-1.5	-1.5	0.4
Average weekly fortified wine intake	1.5	1.8	3.5	-0.3	-1.6	-1.3	-1.3	-1.4	-1.9	-1.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	4.0	2.0	-1.9	-1.1	-0.6	-1.5	-0.6	0.5
Length of working week for main job	1.5	1.6	3.5	-0.3	1.6	1.0	1.0	1.6	1.9	0.8
Shortness of breath walking on level ground	1.5	1.8	6.6	2.6	1.6	0.8	-0.4	1.4	1.0	0.4
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.3	-2.1	1.6	1.0	0.9	1.3	1.3	0.6
Chest pain or discomfort	1.5	2.2	5.8	1.3	-0.5	-2.4	-2.2	-0.6	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.2	0.1	-2.0	-1.6	-0.9	-2.3	-2.3	-1.9
Multivitamins +/- minerals	1.4	1.8	4.2	2.0	0.9	1.3	1.5	1.1	1.2	-1.1
Supplements: Glucosamine	1.4	1.9	4.6	-2.1	-1.1	-1.5	-1.6	-0.6	-1.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.6	0.0	1.1	1.2	0.4	1.5	2.1	1.8
Number of children fathered	1.4	1.6	2.7	-1.0	1.5	0.5	0.1	1.4	1.6	1.6
Age at first live birth	1.4	2.5	3.8	-0.8	-1.7	-1.8	-1.9	-1.9	-2.0	-0.1
Medication for pain relief, constipation, heartburn	1.4	2.4	6.4	-2.5	-0.7	1.4	1.6	-0.4	-0.2	-2.3
Average weekly red wine intake	1.4	2.1	3.9	-1.5	-2.0	-1.3	-0.8	-1.6	-1.5	-1.0
Commuting to job workplace: Walk	1.4	1.5	3.4	-1.9	0.7	0.7	0.5	1.0	1.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.4	1.6	-1.6	-1.3	-1.4	-1.1	-1.2	-0.3
Hair/balding pattern: Pattern 2	1.3	1.6	5.9	-0.9	-0.2	-1.8	-2.4	-0.5	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	4.7	0.2	1.3	-0.9	-1.8	1.0	0.2	2.2
Alcohol intake frequency.	1.3	2.9	4.0	2.0	1.9	1.3	0.6	1.9	2.0	1.9
Osteoporosis (self-reported)	1.3	1.6	2.7	-0.0	-1.5	-1.2	-0.3	-1.6	-1.5	-1.6
Medication: Bendroflumethiazide	1.3	1.9	6.2	0.1	0.8	2.0	2.5	0.8	1.0	1.0
Ever depressed for a whole week	1.3	1.6	11.0	-3.3	-0.5	-0.3	-0.2	-0.3	-0.1	0.0
Worry (Nagel 2018)	1.2	2.5	4.3	0.6	2.0	1.3	0.8	2.1	1.7	1.9
LDL Cholesterol	1.2	1.9	4.5	0.0	0.0	0.0	0.0	-2.1	-2.1	-2.1
Angina	1.2	1.6	5.8	2.4	-0.6	-1.0	-1.3	-0.8	-0.6	1.2
Townsend deprivation index at recruitment	1.2	1.7	4.2	2.1	1.1	1.0	0.3	1.2	1.6	1.2
Trunk fat mass	1.2	5.1	13.1	3.6	2.0	0.9	0.3	2.1	2.6	2.5
Had other major operations	1.2	1.4	2.3	0.8	-1.5	-1.0	-0.7	-1.4	-1.5	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.7	-0.0	-1.9	-1.4	0.2	-2.6	-2.4	-0.8
Angina (self-reported)	1.2	1.6	6.8	2.6	-0.4	-0.7	-1.0	-0.6	-0.4	1.5
Long-standing illness, disability or infirmity	1.2	1.9	5.2	2.3	1.3	0.6	1.0	1.0	1.6	1.1
Eye problems/disorders: Cataract	1.2	1.4	3.1	1.7	-0.0	0.9	1.7	-0.4	-0.2	-1.8
Hearing aid user	1.2	1.3	2.6	1.0	-1.6	-1.2	-1.1	-1.5	-1.0	0.1
Depression (Nagel 2018)	1.1	1.7	4.7	0.6	2.2	0.9	1.1	1.4	1.6	-0.3
HbA1C	1.1	1.3	4.2	-0.7	-1.1	-0.3	0.3	-1.5	-0.4	-2.1
Hearing difficulty/problems: Yes	1.1	1.6	5.4	2.3	0.1	-1.2	-2.1	0.1	0.3	-0.4
Fed-up feelings	1.1	1.9	5.2	1.9	-0.7	-2.3	-1.9	-0.9	-0.3	-0.0
Forced vital capacity (FVC)	1.1	4.3	8.2	-2.2	2.4	2.1	1.0	2.9	1.9	1.4
Pain all over the body in last month	1.1	1.2	7.5	2.7	0.3	0.4	0.4	0.2	0.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.1	0.4	1.4	1.3	0.8	1.8	1.6	1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	7.3	-0.6	-1.7	0.2	0.2	-0.8	-0.8	-2.7
Health satisfaction	1.1	1.4	5.2	1.8	0.4	-0.0	-0.4	0.6	1.0	2.3
Medication: Blood pressure	1.1	2.0	7.5	2.7	-0.5	1.2	2.0	-0.4	0.3	0.7
Number of full sisters	1.1	1.3	6.9	2.6	0.5	0.8	1.0	0.4	0.2	0.6
Ever taken oral contraceptive pill	1.1	1.2	2.9	-1.1	1.6	0.7	-0.3	1.7	1.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.0	0.7	1.7	0.9	0.9	1.3	1.6	-0.3
Nervous feelings	1.0	1.8	2.6	0.4	1.6	1.6	1.3	1.6	1.6	0.9
Qualifications: A levels/AS levels or equivalent	1.0	2.1	12.0	-3.5	-0.9	0.6	0.4	-0.1	-0.3	-1.2
Arm fat mass (right)	1.0	3.9	15.8	4.0	1.4	0.4	0.2	1.4	2.2	1.7
Number of full brothers	1.0	1.3	3.2	-0.1	1.5	0.2	-0.1	1.8	1.4	1.3
Whole body fat mass	1.0	4.3	12.2	3.5	1.7	0.7	0.1	1.9	2.6	2.1
Leg fat mass (right)	1.0	3.8	10.6	3.3	1.6	0.6	0.4	1.6	2.5	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.3	1.5	0.4	1.3	1.1	0.7	1.3	-0.9
Smoking status: Current	1.0	1.5	6.4	2.5	1.3	-0.3	-0.5	1.0	0.6	0.9
Arm fat mass (left)	1.0	4.0	15.4	3.9	1.5	0.4	0.0	1.6	2.3	1.7
Number of self-reported non-cancer illnesses	1.0	1.8	5.4	1.4	0.7	0.7	1.2	0.7	1.5	2.3
Illnesses of father: High blood pressure	1.0	1.2	3.2	-0.6	-0.1	1.4	1.6	0.2	0.5	-1.8
Alcohol drinker status: Never	1.0	1.1	5.2	0.9	0.6	0.4	0.4	0.6	1.0	2.3
Fractured/broken bones in last 5 years	1.0	1.3	5.2	0.7	-0.1	-1.6	-2.3	-0.1	-0.9	-0.2
Alcohol drinker status: Previous	1.0	1.2	2.0	0.2	1.2	1.0	1.0	1.0	1.3	1.4
Leg fat mass (left)	1.0	3.9	10.6	3.3	1.6	0.6	0.2	1.6	2.6	2.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	5.9	-2.4	-1.3	-0.9	-0.5	-1.4	-2.1	0.6
Rheumatoid Arthritis	0.9	1.2	1.9	1.3	-0.9	-1.4	-1.3	-1.0	-1.1	0.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	5.3	0.9	0.3	-0.2	-0.5	0.3	0.7	2.3
Current tobacco smoking	0.9	1.5	5.0	2.2	1.6	0.1	-0.1	1.2	0.9	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.2	-0.2	-1.6	-1.0	0.4	-2.3	-2.2	-0.4
Qualifications: CSEs or equivalent	0.9	1.1	1.9	1.2	-1.2	-1.2	-1.4	-1.1	-0.6	-0.5
Waist circumference	0.9	3.1	15.1	3.9	0.5	-0.8	-0.8	0.4	1.3	1.8
Falls in the last year	0.9	1.2	2.5	1.1	1.1	1.3	0.8	1.1	1.6	-0.1
Illnesses of mother	0.9	1.2	2.3	-0.4	-0.8	-1.0	-1.3	-0.9	-1.2	-1.5
Worry too long after embarrassment	0.9	1.4	5.2	-2.3	-0.1	-1.3	-1.6	-0.2	-0.5	0.4
Smoking status: Previous	0.9	1.4	8.9	-3.0	-0.2	-0.1	0.1	-0.0	-0.4	-0.8
Mineral and other dietary supplements	0.9	1.2	1.7	1.0	1.3	1.1	1.1	0.9	1.1	1.2
Average weekly champagne plus white wine intake	0.9	1.2	2.5	-0.7	-1.6	-1.0	-0.2	-1.5	-1.4	-0.2
Financial situation satisfaction	0.9	1.1	3.0	0.6	1.5	0.7	-0.2	0.9	0.8	1.7
BMI	0.8	4.7	21.9	4.7	-1.2	-1.7	-2.1	-1.3	0.3	0.6
Vitamin and mineral supplements	0.8	1.1	4.5	-2.1	-0.2	-0.1	-0.3	-0.6	-0.6	1.5
Pack years adult smoking proportion	0.8	1.3	2.8	1.6	1.2	0.3	-0.1	0.7	1.2	1.7
Maternal smoking around birth	0.8	1.2	2.9	1.7	0.6	1.4	0.6	1.1	1.0	-0.7
Body mass index (BMI)	0.8	3.2	18.4	4.3	-0.7	-1.2	-0.7	-1.1	0.3	0.3
Alcohol usually taken with meals	0.8	1.3	6.6	-2.6	0.2	0.1	-0.3	0.4	0.3	1.4
Arm fat percentage (right)	0.8	3.1	16.8	4.1	-1.1	-1.1	-0.1	-1.5	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	8.7	3.0	0.4	-0.4	0.2	-0.2	0.5	0.2
Breastfed as a baby	0.8	1.1	1.7	-0.4	1.1	1.3	1.3	0.9	1.3	-0.3
Pulse wave reflection index	0.8	1.0	2.0	-0.5	1.4	0.2	-1.1	1.4	1.1	0.7
Gout (self-reported)	0.8	1.0	3.1	0.2	-0.7	0.8	1.8	-1.1	-0.3	-1.2
Forced vital capacity (FVC), Best measure	0.8	2.8	5.7	-2.0	1.7	1.7	0.8	2.4	1.5	0.8
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	1.8	0.8	1.2	0.6	0.7	0.7	-0.1
Arm fat percentage (left)	0.8	3.0	17.2	4.2	-1.0	-1.0	-0.3	-1.3	-0.1	0.1
Friendships satisfaction	0.8	1.0	1.6	-0.4	1.1	0.9	1.0	0.7	1.2	1.3
Medication: Gliclazide	0.8	0.9	5.9	2.4	-0.0	0.2	0.5	-0.1	0.2	0.1
Guilty feelings	0.8	1.2	2.4	-1.3	-0.5	-1.6	-0.9	-1.0	-1.1	-0.9
Age started oral contraceptive pill	0.8	1.1	7.0	-2.7	0.1	0.1	0.1	-0.2	-0.6	-0.1
Commuting to job workplace: Cycle	0.8	0.9	4.0	-1.1	-0.6	-0.5	-0.6	-0.5	-0.2	2.0
Ovarian Cancer	0.7	1.0	1.5	1.0	1.2	0.6	1.1	1.2	1.0	0.6
Respiratory disease	0.7	1.5	3.8	0.1	1.4	0.9	-0.1	1.8	1.9	1.0
Qualifications: None of the above	0.7	1.5	6.2	2.5	1.4	-0.3	0.2	0.6	0.7	1.3
Diabetes (self-reported)	0.7	1.1	2.8	1.7	0.7	1.0	0.9	0.3	0.6	1.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	0.2	-1.6	-1.0	-0.3	-1.2	-0.8	-0.8
Happiness	0.7	0.8	1.3	0.0	1.1	0.8	1.0	0.5	1.1	1.1
Depression (self-reported)	0.7	0.8	3.0	-0.7	0.6	0.9	0.7	0.4	0.6	1.7
Medication: Lansoprazole	0.7	0.8	2.5	1.6	-0.7	-0.3	-0.1	-0.9	-0.3	1.3
Loud music exposure frequency	0.7	0.7	3.1	0.5	-0.1	-0.6	-0.1	-0.4	-1.1	-1.8
Medication: Amlodipine	0.7	1.0	3.2	1.8	0.0	1.0	1.6	-0.1	0.4	0.2
Medication: Ibuprofen	0.7	0.8	2.4	0.7	0.9	-0.8	-1.6	0.7	-0.2	1.1
Medication: Seretide 50 evohaler	0.7	0.9	1.8	-0.4	-1.1	-1.3	-0.9	-0.9	-1.1	-0.2
Mean time to correctly identify matches	0.7	1.3	2.3	0.0	1.4	1.5	1.2	1.2	1.2	0.6
Had major operations	0.7	0.8	1.7	-0.8	0.9	0.5	0.6	0.9	1.0	1.3
Illnesses of father: Heart disease	0.7	0.9	3.1	-0.0	0.3	-0.9	-1.8	0.2	0.4	1.5
Medication for cholesterol	0.7	1.1	6.1	-2.5	0.7	-0.3	-0.8	0.5	0.1	0.0
Medication: Aspirin	0.7	0.9	3.9	2.0	0.4	0.9	0.9	0.6	0.8	0.1
Wears glasses or contact lenses	0.7	0.8	1.7	-1.0	-0.6	-1.1	-0.5	-1.0	-1.3	-0.6
Commuting to job workplace: Public transport	0.7	0.8	1.7	-1.3	0.9	0.7	1.1	0.5	1.2	0.0
Heart disease (siblings)	0.7	0.9	2.8	0.6	-0.1	-1.6	-1.7	-0.3	0.2	0.8
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.4	0.7	0.8	1.1	0.6	0.5	1.2
Alzheimer’s Disease (in father)	0.6	0.6	1.4	0.8	0.6	1.2	1.0	0.5	0.7	0.2
Reaction Time	0.6	1.2	1.8	-0.6	1.3	1.4	1.2	1.1	0.9	0.9
Blood Platelet Count	0.6	6.4	15.8	1.2	-3.2	-1.2	0.4	-4.0	-2.6	-3.1
Blood White Count	0.6	4.6	10.7	3.0	-1.5	-1.4	0.8	-3.3	-2.3	-1.6
Smoking Status	0.6	1.5	4.6	-0.0	2.1	0.5	0.1	2.0	1.2	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	4.1	2.0	-0.5	-0.3	0.1	-1.2	-0.7	1.0
Medication: Co-codamol	0.6	0.7	4.2	2.1	0.0	-0.6	-0.4	-0.1	0.3	0.2
Diabetes (father)	0.6	0.7	2.4	-0.4	0.3	0.9	1.5	0.6	0.4	-1.0
Had menopause	0.6	0.8	3.4	-0.2	-0.8	-0.5	-0.5	-0.5	-0.8	-1.8
Medication: Ramipril	0.6	0.7	2.0	0.8	0.3	1.0	1.4	-0.1	0.8	0.8
Fluid intelligence score	0.6	1.2	4.3	-0.9	-1.0	-0.6	-0.0	-1.2	-2.1	-0.2
Worrier / anxious feelings	0.6	1.2	1.8	-0.9	0.7	0.8	1.2	1.1	1.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.7	-1.5	1.7	1.1	0.3	1.9	1.2	1.3
Exposure to tobacco smoke at home	0.6	0.7	1.5	1.2	0.8	0.8	0.1	0.8	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.5	-1.3	0.3	1.2	2.1	0.5	0.4	0.2
Body fat percentage	0.6	2.3	14.0	3.7	-0.5	-0.8	-0.3	-0.8	0.2	0.6
Medication: Allopurinol	0.6	0.8	1.7	0.0	-1.3	0.4	1.0	-1.2	-0.4	-1.0
Diabetes diagnosed by doctor	0.6	0.9	3.8	1.9	0.4	0.6	0.3	0.2	0.4	1.4
Medication: Atorvastatin	0.6	0.7	4.4	2.1	0.6	0.2	0.5	0.1	0.1	0.2
Ever smoked	0.6	1.1	3.0	-1.7	-0.2	-0.9	-1.1	-0.5	-0.9	-1.2
Pack years of smoking	0.6	0.9	2.2	1.5	0.9	0.0	-0.3	0.4	0.9	1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	0.3	0.8	1.1	1.2	0.7	0.8	0.8
Irritable Bowel Disease (IBD)	0.5	1.2	2.7	0.3	-1.6	-0.7	-0.3	-1.3	-1.5	-1.1
Neuroticism (2016)	0.5	0.7	2.5	1.0	-0.1	-1.1	-1.6	0.2	-0.0	0.2
Lung FEV1/FVC ratio	0.5	2.5	5.1	-0.4	-1.6	-2.2	-1.7	-1.6	-2.0	-0.4
Trunk fat percentage	0.5	2.2	13.7	3.7	-0.4	-0.5	-0.3	-0.5	0.3	0.8
Taking other prescription medications	0.5	0.7	2.4	0.3	-0.0	-0.7	-1.0	0.3	1.0	1.5
Past tobacco smoking	0.5	0.9	5.2	2.3	-0.3	0.4	0.6	-0.3	0.3	0.7
Mouth/teeth dental problems	0.5	0.8	1.8	-0.7	-1.0	-0.7	-0.9	-1.0	-1.3	-0.1
Father’s age at death	0.5	0.7	2.0	-1.0	0.3	1.1	1.4	0.4	0.4	0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	3.1	1.8	-0.5	-0.6	-0.5	-0.6	-0.5	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.6	0.6	0.6	0.1	0.6	0.7	1.1	-1.3
Medication: Aspirin	0.5	0.6	2.9	1.7	0.2	0.5	0.4	0.4	0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	0.8	-0.6	-0.7	-0.2	-0.9	0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.6	-1.6	-0.7	-0.7	-0.4	-0.9	-1.0	-0.1
High cholesterol (Self-reported)	0.5	0.9	4.0	1.4	0.5	-0.1	-0.3	0.2	0.6	2.0
Leg fat percentage (left)	0.5	2.0	10.4	3.2	-0.8	-0.9	-0.0	-1.3	0.3	0.4
Basal cell carcinoma (self-reported)	0.5	0.7	2.2	-0.1	-0.7	-0.5	0.0	-1.1	-0.6	-1.5
Depressed Affect (Nagel 2018)	0.4	0.7	2.0	1.4	0.8	-0.1	0.0	0.7	1.4	0.1
Neuroticism (Nagel 2018)	0.4	1.0	2.3	0.2	1.3	0.3	-0.1	1.3	1.5	1.0
Fasting Glucose	0.4	0.5	1.0	-0.8	0.8	-0.7	-1.0	0.5	0.5	-0.5
Number of treatments/medications taken	0.4	0.8	2.6	1.6	-0.3	-1.0	-1.0	-0.2	0.1	0.9
Average weekly spirits intake	0.4	0.5	2.3	1.5	0.6	0.4	0.1	0.6	-0.1	-0.3
Sensitivity / hurt feelings	0.4	0.6	3.1	1.8	-0.2	-0.5	-0.8	0.1	0.3	0.4
Impedance of leg (right)	0.4	2.0	9.2	-3.0	-0.1	0.9	1.5	-0.2	-0.7	-1.2
Medication: Levothyroxine sodium	0.4	0.7	3.4	0.2	0.4	1.1	1.8	0.6	-0.1	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.8	0.0	0.0	0.7	0.6	0.3	-0.0	-1.4
Impedance of leg (left)	0.4	2.1	9.0	-3.0	-0.7	0.3	1.0	-0.9	-1.1	-1.4
Allergy	0.4	0.9	2.1	1.1	-0.9	-0.5	0.1	-1.4	-1.1	-0.6
Medication: Simvastatin	0.4	0.6	3.1	0.4	0.1	-0.2	-0.5	0.3	0.9	1.8
Neuroticism score	0.4	0.8	2.1	0.7	0.7	-0.5	-0.8	0.8	0.8	1.4
Number of live births	0.4	0.6	3.3	1.8	-0.5	-0.2	0.0	-0.7	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.0	-1.4	0.2	-0.3	-0.7	0.2	-0.7	-1.3
Leg fat percentage (right)	0.4	1.6	9.3	3.0	-0.5	-0.7	0.2	-1.0	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	-0.7	-0.9	-0.6	-0.5	-0.6	-0.7	-0.7
Medication: Omeprazole	0.4	0.4	1.1	0.4	-0.3	-1.1	-0.7	-0.7	0.3	0.8
Leg pain on walking	0.4	0.5	2.2	1.5	0.3	-0.4	0.2	-0.1	0.3	0.7
Knee pain experienced in last month	0.4	0.7	3.0	0.1	0.9	0.3	0.5	0.6	0.5	1.7
Mood swings	0.4	0.7	3.9	2.0	0.2	-0.5	-0.0	0.3	0.6	-0.1
Medication: Lisinopril	0.4	0.6	1.6	0.4	0.7	0.5	-0.2	0.6	1.1	1.3
Impedance of whole body	0.4	1.8	6.2	-2.5	-0.8	0.6	1.0	-0.7	-1.6	-1.2
Age at First Birth	0.3	0.4	1.2	-0.7	-0.5	-0.5	-0.3	-0.7	-1.1	-0.3
Crohns Disease (2012)	0.3	0.4	1.5	0.0	0.0	0.0	0.0	-1.2	-1.0	-0.6
Triglycerides	0.3	0.5	1.9	0.0	0.0	0.0	0.0	-1.4	-1.2	-0.3
Hypothyroidism (self reported)	0.3	0.6	3.4	-0.4	-0.1	0.9	1.8	-0.3	-0.0	0.3
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	0.9	0.3	0.1	-0.4	0.5	0.8	0.8
Medication: Metformin	0.3	0.4	0.8	0.7	0.8	0.3	0.3	0.6	0.6	0.9
Age when periods started (menarche)	0.3	0.6	1.5	0.8	-1.0	-0.5	0.3	-0.9	-0.3	-1.2
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.2	0.5	0.6	0.5	0.9	0.9	0.5
Stomach or abdominal pain in last month	0.3	0.3	1.4	1.2	-0.1	-0.7	-0.6	-0.2	0.1	-0.0
Impedance of arm (right)	0.3	1.5	4.1	-2.0	-0.8	0.5	0.9	-0.7	-1.8	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.8	0.9	-0.3	-0.7	0.6	0.6	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.4	0.6	-0.1	-0.6	-0.5	-0.2	0.9	1.2
Impedance of arm (left)	0.3	1.2	3.2	-1.8	-0.7	0.5	0.5	-0.4	-1.7	-1.1
Glaucoma (self-reported)	0.3	0.3	0.7	-0.6	-0.7	0.1	0.8	-0.4	-0.4	-0.7
High blood pressure (siblings)	0.3	0.4	0.7	-0.8	0.3	0.3	0.8	0.6	0.8	-0.4
Eye problems/disorders: None of the above	0.3	0.4	1.0	-0.4	0.1	-0.6	-1.0	0.3	0.5	0.9
Suffer from ‘nerves’	0.3	0.4	2.3	1.5	0.2	-0.1	-0.4	0.2	0.0	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.4	-0.1	0.4	0.2	0.2	1.0	1.2	-0.0
Loneliness, isolation	0.3	0.5	2.5	1.6	-0.1	-0.5	-0.4	-0.2	0.1	-0.5
Asthma (self-reported)	0.3	0.6	1.5	0.3	0.7	0.6	0.2	1.2	1.0	0.7
Miserableness	0.3	0.5	1.8	1.4	0.1	-0.7	-1.0	-0.2	0.4	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	-1.1	0.7	0.1	0.5	0.6	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.8	-0.0	-0.7	-0.2	-0.5	0.2	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	1.5	0.0	0.0	0.0	0.0	0.6	1.2	0.4
Neuroticism	0.2	0.5	1.0	0.6	0.8	-0.3	-0.6	0.9	0.7	1.0
Hair Pigment	0.2	4.4	6.4	1.8	-1.9	-2.4	-2.2	-2.2	-2.5	-1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.4	0.9	-0.6	-0.8	0.4	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.4	-0.3	-0.2	0.5	-0.5	0.0	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	-0.0	0.0	0.3	0.8	0.2	-0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.7	0.7	-0.0	0.5	0.2	0.5	-0.6
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.1	0.9	0.6	0.1	0.8	0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-1.0	0.2	0.3	0.6	0.0	0.3	0.5
Illnesses of siblings	0.2	0.2	0.6	0.7	-0.6	-0.1	-0.2	-0.3	-0.8	-0.0
Asthma	0.2	0.5	1.2	0.2	0.6	0.5	0.2	1.1	0.9	0.8
Prospective memory result	0.2	0.2	0.5	0.7	-0.2	-0.3	-0.7	0.1	0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	-1.2	0.7	0.7	0.1	1.1	0.4	0.7
Peak expiratory flow (PEF)	0.2	0.5	1.7	-1.3	0.4	-0.2	-0.8	0.7	0.3	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	0.2	-0.2	-0.9	-0.5	-0.3	0.0	0.1
Migraine (self-reported)	0.2	0.3	1.1	0.3	-0.0	-0.5	-0.4	-0.6	-1.1	0.2
Pulse rate, automated reading	0.2	0.6	1.5	0.6	0.7	0.5	0.4	0.8	1.2	0.8
Ever had bowel cancer screening	0.2	0.3	0.9	-1.0	0.1	-0.5	-0.7	0.1	-0.2	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.7	-0.5	0.1	0.5	-0.5	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.4	-0.7	-0.2	-0.5	-0.6	-0.6	-0.7
Cholesterol lowering medication	0.2	0.4	1.5	1.2	0.4	0.3	-0.3	0.4	0.2	0.6
Bipolar Disorder (2018)	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.4	0.7	-0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.5	-0.6	0.4	0.5	-0.2	-0.0	-0.0
HDL Cholesterol	0.1	0.2	0.8	0.0	0.0	0.0	0.0	-0.9	-0.9	-0.1
Blood Eosinophil Count	0.1	0.5	1.5	1.2	0.8	0.8	0.3	-0.0	-0.4	-0.0
Allergy or Eczema	0.1	0.4	1.0	-0.5	0.2	-0.2	-1.0	0.4	0.5	0.9
Tanning	0.1	0.7	0.9	-0.9	1.0	1.0	0.8	0.7	0.2	0.9
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-1.0	0.0	-0.1	-0.3	0.3	0.1	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.5	0.6	0.3	0.1	0.6	-0.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.6	-0.8	0.2	-0.1	-0.1	0.0	-0.0	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.5	-0.0	0.3	0.7	-0.1	0.4	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.4	0.0	-0.6	-0.3
Heart disease (mother)	0.1	0.1	0.5	0.7	-0.0	-0.0	0.2	0.1	-0.3	-0.2
Age at last live birth	0.1	0.2	0.6	0.3	-0.2	-0.3	-0.3	-0.8	-0.6	0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.5	0.2	-0.3	0.3	-0.1	-0.3	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.0	0.5	0.1	0.2	0.4	0.2	0.4
Number of operations (self-reported)	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.1	-0.1	0.2	0.4
Irritability	0.1	0.3	0.4	-0.5	0.4	-0.2	-0.6	0.3	0.6	0.7
Risk taking	0.1	0.1	0.3	0.6	0.1	-0.2	-0.3	0.2	0.6	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	-0.5	0.6	0.4	0.4	0.3	0.1	-0.2
Myopia	0.1	0.1	0.3	0.6	-0.3	0.1	-0.1	-0.3	-0.6	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.2	0.3	-0.1	-0.5	0.1	-0.5	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.1	0.4	0.0	0.0	0.0	0.0	-0.1	0.2	0.6
Pulse rate	0.0	0.1	0.2	0.3	-0.2	-0.1	0.5	-0.2	0.3	0.1

Hub : Genes

DOT1L

Models

Trait associations