Best TWAS P=2.24e-20 · Best GWAS P=6.91e-20 conditioned to 0.0221
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | AP3B1 | 0.07 | 0.01 | blup | 556 | 0.02 | 2.4e-04 | 4.5 | -6.4 | 1.9e-10 | 0.53 | 0.11 | 0.77 | FALSE |
| 2 | YFS | Blood | AP3B1 | 0.25 | 0.22 | lasso | 9 | 0.23 | 2.6e-74 | 5.9 | -6.0 | 1.6e-09 | 0.31 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -9.1 | -9.2 | 2.2e-20 | 0.86 | 0.02 | 0.89 | TRUE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 6.5 | -6.7 | 1.6e-11 | 0.53 | 0.04 | 0.54 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -8.7 | -6.5 | 8.2e-11 | 0.58 | 0.02 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | AP3B1 | 0.05 | 0.03 | lasso | 3 | 0.04 | 4.4e-05 | 6.5 | -6.0 | 1.4e-09 | 0.36 | 0.43 | 0.25 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 6.8 | -8.8 | 1.2e-18 | 0.80 | 0.02 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | AP3B1 | 0.11 | 0.06 | lasso | 2 | 0.05 | 1.3e-05 | 5.9 | -5.5 | 4.9e-08 | 0.20 | 0.59 | 0.06 | FALSE |