[Hub]/) : Traits : Leg predicted mass (right) :

chr5:175,756,956-177,591,495

Best TWAS P=1.16e-10 · Best GWAS P=9.29e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MXD3 0.16 0.05 enet 13 0.06 1.7e-05 6.0 5.5 3.8e-08 0.77 0.01 0.99 FALSE
2 GTEx Adipose Visceral Omentum MXD3 0.33 0.06 lasso 6 0.05 9.1e-04 6.0 5.5 4.6e-08 0.84 0.02 0.95 FALSE
3 GTEx Artery Tibial MXD3 0.12 0.13 enet 5 0.12 7.0e-10 6.0 6.1 1.3e-09 0.89 0.02 0.98 FALSE
4 GTEx Brain Cerebellum MXD3 0.28 0.31 lasso 2 0.30 1.6e-09 6.0 6.0 2.0e-09 0.87 0.02 0.98 FALSE
5 GTEx Brain Cortex MXD3 0.47 0.20 lasso 10 0.22 7.7e-07 6.0 5.2 2.0e-07 0.78 0.02 0.83 FALSE
6 GTEx Brain Nucleus accumbens basal ganglia MXD3 0.24 0.14 enet 10 0.25 2.9e-07 6.0 5.5 3.5e-08 0.83 0.02 0.93 FALSE
7 GTEx Breast Mammary Tissue MXD3 0.26 0.08 lasso 5 0.10 1.3e-05 6.0 5.7 1.5e-08 0.86 0.00 0.99 FALSE
8 GTEx Breast Mammary Tissue (Female) MXD3 0.23 0.08 lasso 3 0.09 1.1e-03 6.5 5.1 2.7e-07 0.82 0.01 0.91 FALSE
9 GTEx Colon Sigmoid MXD3 0.35 0.27 lasso 9 0.29 6.3e-11 6.0 6.1 1.4e-09 0.90 0.02 0.98 FALSE
10 GTEx Colon Transverse PRELID1 0.31 0.28 lasso 4 0.26 1.1e-12 6.0 -6.1 9.2e-10 -0.90 0.01 0.99 FALSE
11 GTEx Esophagus Gastroesophageal Junction MXD3 0.17 0.12 lasso 3 0.08 9.5e-04 6.0 5.5 4.8e-08 0.78 0.02 0.76 FALSE
12 GTEx Esophagus Mucosa MXD3 0.16 0.14 lasso 8 0.15 1.7e-10 6.0 5.6 2.2e-08 0.85 0.02 0.98 FALSE
13 GTEx Esophagus Muscularis MXD3 0.27 0.20 enet 10 0.24 1.6e-14 6.0 6.1 1.0e-09 0.91 0.02 0.98 FALSE
14 GTEx Heart Atrial Appendage MXD3 0.33 0.15 enet 24 0.16 1.5e-07 6.0 5.3 9.0e-08 0.76 0.00 1.00 FALSE
15 GTEx Heart Left Ventricle MXD3 0.17 0.03 lasso 3 0.03 1.5e-02 6.0 5.8 5.0e-09 0.86 0.02 0.84 FALSE
16 GTEx Liver PRELID1 0.22 0.25 lasso 3 0.24 2.4e-07 6.5 -6.4 1.2e-10 -0.98 0.00 1.00 TRUE
17 GTEx Lung MXD3 0.20 0.12 lasso 10 0.12 1.8e-09 6.0 6.1 1.1e-09 0.85 0.02 0.98 FALSE
18 GTEx Nerve Tibial MXD3 0.26 0.17 lasso 7 0.28 6.9e-20 6.0 6.2 5.8e-10 0.87 0.02 0.98 FALSE
19 GTEx Pituitary MXD3 0.25 0.20 lasso 6 0.16 7.5e-05 5.7 6.2 7.2e-10 0.74 0.03 0.92 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic MXD3 0.22 0.18 lasso 3 0.17 1.8e-09 6.0 6.3 2.6e-10 0.94 0.01 0.99 FALSE
21 GTEx Skin Sun Exposed Lower leg PRELID1 0.06 0.02 enet 5 0.03 3.4e-03 6.0 -6.2 6.0e-10 -0.92 0.01 0.99 FALSE
22 GTEx Skin Sun Exposed Lower leg MXD3 0.19 0.14 lasso 6 0.12 4.2e-10 6.5 5.9 3.7e-09 0.91 0.00 1.00 FALSE
23 GTEx Small Intestine Terminal Ileum PRELID1 0.47 0.16 enet 10 0.13 7.6e-04 6.5 -6.4 1.5e-10 -0.94 0.00 0.96 FALSE
24 GTEx Testis DBN1 0.10 0.00 lasso 6 0.00 4.6e-01 5.6 -5.3 1.0e-07 -0.66 0.03 0.53 FALSE
25 GTEx Thyroid MXD3 0.31 0.17 lasso 8 0.24 1.1e-18 6.0 6.1 1.3e-09 0.91 0.00 1.00 FALSE
26 METSIM Adipose MXD3 0.18 0.18 lasso 3 0.21 1.3e-30 6.0 5.8 8.9e-09 0.86 0.03 0.97 FALSE
27 METSIM Adipose ZNF346 0.04 0.00 blup 373 0.03 9.6e-05 5.3 5.3 9.2e-08 0.38 0.29 0.58 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FGFR4 0.08 0.06 blup 46 0.07 2.5e-08 5.0 -6.0 1.6e-09 -0.39 0.12 0.88 FALSE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PRELID1 0.24 0.11 lasso 5 0.10 1.2e-11 6.3 -6.2 6.5e-10 -0.88 0.00 1.00 FALSE
30 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PRELID1 0.33 0.08 enet 4 0.08 2.7e-05 6.0 -6.2 7.4e-10 -0.90 0.01 0.98 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma FGFR4 0.06 0.02 enet 7 0.05 1.2e-06 -2.8 -5.6 1.8e-08 -0.27 0.26 0.34 TRUE
32 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PRELID1 0.08 0.10 lasso 4 0.07 2.9e-04 5.4 -5.7 1.2e-08 -0.83 0.01 0.94 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma MXD3 0.04 0.02 blup 41 0.02 5.6e-04 4.8 5.7 1.2e-08 0.79 0.10 0.63 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma MXD3 0.04 0.02 blup 40 0.03 2.8e-04 6.0 6.1 1.4e-09 0.84 0.04 0.92 FALSE