Best TWAS P=1.62e-11 · Best GWAS P=4.28e-11 conditioned to 3.63e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SNF8 | 0.08 | 0.07 | lasso | 5 | 0.08 | 9.3e-10 | -4.3 | 5.4 | 5.7e-08 | 0.07 | 0.37 | 0.63 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-6N17.9 | 0.45 | -0.01 | enet | 28 | 0.16 | 3.3e-05 | -1.0 | -5.6 | 1.7e-08 | -0.48 | 0.06 | 0.13 | FALSE |
| 3 | GTEx | Esophagus Mucosa | NFE2L1 | 0.07 | 0.02 | lasso | 4 | 0.01 | 8.6e-02 | -5.6 | -5.5 | 3.2e-08 | -0.11 | 0.26 | 0.22 | FALSE |
| 4 | GTEx | Esophagus Muscularis | COPZ2 | 0.14 | 0.04 | lasso | 5 | 0.06 | 1.3e-04 | 3.0 | 5.7 | 9.5e-09 | -0.04 | 0.17 | 0.08 | FALSE |
| 5 | GTEx | Heart Left Ventricle | ATP5G1 | 0.24 | 0.22 | lasso | 4 | 0.22 | 9.3e-12 | -4.6 | 5.1 | 2.7e-07 | 0.12 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Muscle Skeletal | AC003665.1 | 0.05 | 0.03 | enet | 8 | 0.03 | 1.4e-03 | 4.5 | 5.1 | 2.9e-07 | 0.63 | 0.12 | 0.72 | FALSE |
| 7 | GTEx | Ovary | ATP5G1 | 0.15 | 0.08 | enet | 13 | 0.09 | 2.8e-03 | -3.8 | 5.3 | 1.1e-07 | 0.07 | 0.05 | 0.78 | FALSE |
| 8 | GTEx | Pancreas | CDK5RAP3 | 0.11 | -0.01 | lasso | 4 | 0.02 | 5.1e-02 | 4.2 | -5.1 | 3.0e-07 | -0.48 | 0.09 | 0.18 | FALSE |
| 9 | GTEx | Stomach | RP11-6N17.9 | 0.13 | 0.02 | lasso | 6 | 0.04 | 8.0e-03 | 4.7 | -5.7 | 1.4e-08 | -0.70 | 0.12 | 0.69 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SNX11 | 0.06 | 0.06 | lasso | 3 | 0.05 | 2.8e-06 | -5.6 | 5.4 | 7.5e-08 | 0.10 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBX1 | 0.03 | 0.04 | lasso | 4 | 0.04 | 3.7e-05 | 5.2 | -5.2 | 2.2e-07 | -0.84 | 0.04 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK5RAP3 | 0.06 | 0.00 | blup | 62 | 0.03 | 1.0e-03 | -5.0 | -6.7 | 1.6e-11 | -0.35 | 0.02 | 0.46 | TRUE |