Best TWAS P=5.77e-14 · Best GWAS P=6.08e-18 conditioned to 0.000503
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -6.9 | -7.5 | 5.8e-14 | 0.64 | 0.02 | 0.84 | TRUE |
| 2 | GTEx | Heart Left Ventricle | AC007292.4 | 0.18 | 0.00 | enet | 32 | 0.03 | 7.0e-03 | -1.3 | 5.5 | 3.1e-08 | -0.35 | 0.05 | 0.40 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -6.7 | -6.7 | 2.3e-11 | 0.58 | 1.00 | 0.00 | FALSE |
| 4 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | 3.0 | 6.0 | 2.6e-09 | -0.51 | 0.09 | 0.46 | FALSE |
| 5 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | -6.7 | -7.4 | 1.3e-13 | 0.60 | 0.03 | 0.97 | TRUE |