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chr19:17,512,412-20,313,262

Best TWAS P=5.94e-17 · Best GWAS P=7.38e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.31	-8.4	5.9e-17	-0.95	0.01	0.94	TRUE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.77	7.1	1.4e-12	0.22	0.04	0.08	TRUE
4	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	6.61	-6.4	1.3e-10	-0.02	0.02	0.72	TRUE
5	GTEx	Colon Transverse	SSBP4	0.18	0.01	enet	21	0.00	3.6e-01	5.55	-6.4	2.0e-10	-0.25	0.04	0.43	TRUE
8	GTEx	Esophagus Muscularis	MEF2BNB	0.12	0.00	lasso	4	0.00	7.5e-01	6.05	-6.3	3.0e-10	-0.03	0.05	0.20	TRUE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-3.59	-6.0	2.6e-09	0.04	0.04	0.52	TRUE
12	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.67	-5.8	7.4e-09	-0.41	1.00	0.00	TRUE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	YJEFN3	0.03	0.03	blup	32	0.02	3.0e-03	-4.28	5.4	7.5e-08	0.02	0.09	0.16	TRUE
21	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	8.71	-8.3	7.9e-17	-0.56	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.31	-8.3	1.1e-16	-0.95	0.02	0.86	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	6.81	7.9	3.8e-15	0.25	0.01	0.59	FALSE
13	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	4.61	7.7	1.6e-14	0.23	0.22	0.78	FALSE
15	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	8.23	7.0	2.8e-12	0.31	0.18	0.81	FALSE
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	2.09	-6.9	5.1e-12	-0.62	0.01	0.62	FALSE
14	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	6.81	-6.8	9.4e-12	-0.20	0.04	0.15	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	6.81	6.8	9.6e-12	0.20	0.14	0.13	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	6.81	6.7	1.7e-11	0.19	0.19	0.04	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.11	-6.7	2.7e-11	-0.57	0.87	0.11	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	8.71	-6.5	1.1e-10	-0.53	0.01	0.54	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	TSSK6	0.07	0.02	blup	32	0.04	2.9e-03	-4.28	-6.1	8.2e-10	-0.02	0.04	0.20	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	6.81	6.1	9.2e-10	0.13	1.00	0.00	FALSE
7	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	6.40	6.0	1.7e-09	0.00	0.02	0.88	FALSE
10	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	8.71	-6.0	1.9e-09	-0.29	0.02	0.69	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MAU2	0.09	0.08	blup	369	0.10	1.0e-12	1.67	-6.0	2.0e-09	-0.03	0.11	0.89	FALSE
20	YFS	Blood	IFI30	0.08	0.04	bslmm	405	0.08	1.1e-23	-2.03	5.9	3.5e-09	0.12	0.95	0.05	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	6.19	5.8	5.4e-09	0.02	0.00	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-2.85	-5.8	6.6e-09	-0.22	0.88	0.12	FALSE
6	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-3.66	5.8	6.8e-09	0.15	0.33	0.16	FALSE
11	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.67	-5.7	1.5e-08	-0.39	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-3.44	5.6	1.9e-08	0.13	0.93	0.07	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	6.19	5.5	3.4e-08	0.00	0.01	0.99	FALSE
9	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	6.81	5.5	4.5e-08	0.08	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL12RB1	0.10	0.08	blup	58	0.09	6.9e-10	5.55	-5.5	4.6e-08	-0.35	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	SUGP1	0.03	0.00	blup	364	0.01	4.3e-02	6.61	5.4	7.5e-08	0.00	0.01	0.90	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	5.23	-5.4	7.7e-08	-0.43	0.14	0.08	FALSE
3	GTEx	Adipose Subcutaneous	AC005253.4	0.11	0.06	enet	23	0.04	1.6e-04	0.34	5.4	7.8e-08	0.22	0.29	0.24	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	MAU2	0.17	0.05	bslmm	362	0.06	8.0e-08	5.41	-5.1	2.7e-07	-0.06	0.52	0.39	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.78	-5.1	3.1e-07	-0.44	0.49	0.39	FALSE