[Hub]/) : Traits : Leg fat percentage (left) :

chr19:17,512,412-20,313,262

Best TWAS P=5.94e-17 · Best GWAS P=7.38e-19 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KIAA1683 0.09 0.06 enet 14 0.10 6.6e-12 -3.44 5.6 1.9e-08 0.13 0.93 0.07 FALSE
2 CommonMind Brain Pre-frontal Cortex MAU2 0.09 0.08 blup 369 0.10 1.0e-12 1.67 -6.0 2.0e-09 -0.03 0.11 0.89 FALSE
3 GTEx Adipose Subcutaneous AC005253.4 0.11 0.06 enet 23 0.04 1.6e-04 0.34 5.4 7.8e-08 0.22 0.29 0.24 FALSE
4 GTEx Brain Hippocampus DDX49 0.23 -0.01 lasso 4 -0.01 6.6e-01 6.61 -6.4 1.3e-10 -0.02 0.02 0.72 TRUE
5 GTEx Colon Transverse SSBP4 0.18 0.01 enet 21 0.00 3.6e-01 5.55 -6.4 2.0e-10 -0.25 0.04 0.43 TRUE
6 GTEx Colon Transverse KIAA1683 0.15 0.02 lasso 3 0.02 3.3e-02 -3.66 5.8 6.8e-09 0.15 0.33 0.16 FALSE
7 GTEx Esophagus Mucosa GATAD2A 0.11 0.02 lasso 3 0.02 2.3e-02 6.40 6.0 1.7e-09 0.00 0.02 0.88 FALSE
8 GTEx Esophagus Muscularis MEF2BNB 0.12 0.00 lasso 4 0.00 7.5e-01 6.05 -6.3 3.0e-10 -0.03 0.05 0.20 TRUE
9 GTEx Nerve Tibial KIAA1683 0.25 0.22 lasso 9 0.28 5.2e-20 6.81 5.5 4.5e-08 0.08 1.00 0.00 FALSE
10 GTEx Pancreas AC007192.6 0.19 0.00 enet 28 0.01 1.3e-01 8.71 -6.0 1.9e-09 -0.29 0.02 0.69 FALSE
11 GTEx Testis PDE4C 0.39 0.44 lasso 2 0.43 5.8e-21 -5.67 -5.7 1.5e-08 -0.39 1.00 0.00 FALSE
12 GTEx Testis AC068499.10 0.38 0.41 lasso 3 0.40 6.8e-19 -5.67 -5.8 7.4e-09 -0.41 1.00 0.00 TRUE
13 GTEx Thyroid KIAA1683 0.11 0.07 enet 14 0.12 2.1e-09 4.61 7.7 1.6e-14 0.23 0.22 0.78 FALSE
14 GTEx Vagina LRRC25 0.63 0.02 enet 2 0.04 5.3e-02 6.81 -6.8 9.4e-12 -0.20 0.04 0.15 FALSE
15 NTR Blood IFI30 0.03 0.02 lasso 6 0.02 8.8e-08 8.23 7.0 2.8e-12 0.31 0.18 0.81 FALSE
16 ROSMAP Brain Pre-frontal Cortex PDE4C 0.18 0.12 enet 17 0.19 3.3e-24 -2.85 -5.8 6.6e-09 -0.22 0.88 0.12 FALSE
17 ROSMAP Brain Pre-frontal Cortex SUGP1 0.03 0.00 blup 364 0.01 4.3e-02 6.61 5.4 7.5e-08 0.00 0.01 0.90 FALSE
18 ROSMAP Brain Pre-frontal Cortex MAU2 0.17 0.05 bslmm 362 0.06 8.0e-08 5.41 -5.1 2.7e-07 -0.06 0.52 0.39 FALSE
19 ROSMAP Brain Pre-frontal Cortex JUND 0.17 0.17 lasso 5 0.20 2.7e-25 6.81 6.1 9.2e-10 0.13 1.00 0.00 FALSE
20 YFS Blood IFI30 0.08 0.04 bslmm 405 0.08 1.1e-23 -2.03 5.9 3.5e-09 0.12 0.95 0.05 FALSE
21 YFS Blood MAST3 0.06 0.04 lasso 5 0.04 4.2e-12 8.71 -8.3 7.9e-17 -0.56 0.01 0.99 FALSE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma IL12RB1 0.07 0.02 lasso 3 0.01 6.4e-02 5.23 -5.4 7.7e-08 -0.43 0.14 0.08 FALSE
23 The Cancer Genome Atlas Colon Adenocarcinoma TSSK6 0.07 0.02 blup 32 0.04 2.9e-03 -4.28 -6.1 8.2e-10 -0.02 0.04 0.20 FALSE
24 The Cancer Genome Atlas Glioblastoma Multiforme JUND 0.17 0.00 blup 57 0.03 5.4e-02 6.81 7.9 3.8e-15 0.25 0.01 0.59 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IL12RB1 0.05 0.03 enet 11 0.05 2.3e-06 -2.78 -5.1 3.1e-07 -0.44 0.49 0.39 FALSE
26 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL12RB1 0.10 0.08 blup 58 0.09 6.9e-10 5.55 -5.5 4.6e-08 -0.35 1.00 0.00 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma JUND 0.05 0.04 lasso 1 0.04 4.3e-05 6.81 6.8 9.6e-12 0.20 0.14 0.13 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MAST3 0.04 0.02 blup 65 0.01 7.3e-02 8.71 -6.5 1.1e-10 -0.53 0.01 0.54 FALSE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TM6SF2 0.04 0.03 blup 35 0.03 2.5e-04 6.19 5.8 5.4e-09 0.02 0.00 0.99 FALSE
30 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma JUND 0.11 0.03 blup 58 0.04 1.4e-03 -3.77 7.1 1.4e-12 0.22 0.04 0.08 TRUE
31 The Cancer Genome Atlas Brain Lower Grade Glioma JUND 0.04 0.03 lasso 2 0.02 7.9e-04 6.81 6.7 1.7e-11 0.19 0.19 0.04 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma MAST3 0.02 0.02 lasso 3 0.01 1.5e-02 8.31 -8.4 5.9e-17 -0.95 0.01 0.94 TRUE
33 The Cancer Genome Atlas Lung Adenocarcinoma YJEFN3 0.03 0.03 blup 32 0.02 3.0e-03 -4.28 5.4 7.5e-08 0.02 0.09 0.16 TRUE
34 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IL12RB1 0.07 0.04 blup 58 0.06 4.9e-07 5.11 -6.7 2.7e-11 -0.57 0.87 0.11 FALSE
35 The Cancer Genome Atlas Testicular Germ Cell Tumors CRTC1 0.33 0.08 lasso 5 0.12 3.6e-05 -3.59 -6.0 2.6e-09 0.04 0.04 0.52 TRUE
36 The Cancer Genome Atlas Testicular Germ Cell Tumors IL12RB1 0.10 0.01 enet 10 0.06 2.6e-03 2.09 -6.9 5.1e-12 -0.62 0.01 0.62 FALSE
37 The Cancer Genome Atlas Thyroid Carcinoma MAST3 0.04 0.02 lasso 2 0.00 3.4e-01 8.31 -8.3 1.1e-16 -0.95 0.02 0.86 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma TM6SF2 0.05 0.04 blup 34 0.05 2.8e-05 6.19 5.5 3.4e-08 0.00 0.01 0.99 FALSE