Best TWAS P=2.09e-07 · Best GWAS P=5.35e-09 conditioned to 0.00147
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM165 | 0.09 | 0.01 | lasso | 3 | 0.03 | 1.6e-03 | 4.8 | -5.1 | 2.8e-07 | -0.76 | 0.47 | 0.48 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | TMEM165 | 0.09 | 0.07 | blup | 404 | 0.08 | 4.9e-11 | 4.5 | -5.2 | 2.1e-07 | -0.67 | 0.74 | 0.25 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM165 | 0.02 | 0.04 | lasso | 3 | 0.03 | 1.0e-07 | 4.8 | -5.1 | 3.0e-07 | -0.77 | 0.17 | 0.83 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SRD5A3 | 0.03 | 0.03 | enet | 4 | 0.05 | 3.1e-06 | -5.3 | 5.1 | 2.9e-07 | 0.80 | 0.02 | 0.96 | FALSE |