Best TWAS P=9.01e-12 · Best GWAS P=5.39e-13 conditioned to 0.000561
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | 5.3 | -6.2 | 5.7e-10 | -0.69 | 0.16 | 0.32 | FALSE |
2 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | -4.6 | -5.4 | 5.8e-08 | -0.45 | 0.20 | 0.52 | FALSE |
3 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | 5.9 | -6.8 | 9.0e-12 | -0.69 | 0.04 | 0.56 | TRUE |
4 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | -4.6 | -5.3 | 9.2e-08 | -0.32 | 0.16 | 0.28 | FALSE |
5 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | -4.5 | -6.6 | 3.1e-11 | -0.66 | 0.08 | 0.30 | FALSE |
6 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | -4.5 | -6.1 | 1.3e-09 | -0.53 | 0.31 | 0.46 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | 5.8 | -5.5 | 4.3e-08 | -0.79 | 0.03 | 0.90 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | 5.8 | 5.6 | 1.7e-08 | 0.73 | 0.88 | 0.12 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | -4.5 | -6.4 | 1.7e-10 | -0.55 | 0.23 | 0.42 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | 5.6 | 5.6 | 2.4e-08 | 0.75 | 0.03 | 0.53 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | -4.5 | -6.4 | 1.9e-10 | -0.60 | 0.21 | 0.41 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | 6.3 | 5.9 | 3.5e-09 | 0.86 | 0.01 | 0.86 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | -4.7 | -6.2 | 7.2e-10 | -0.55 | 0.44 | 0.33 | FALSE |