TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
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chr6:125,970,401-127,355,237
Best TWAS P=1.88e-10 · Best GWAS P=1.87e-11 conditioned to 0.0146
126M
126.2M
126.4M
126.6M
126.8M
127M
127.2M
127.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
CENPW
0.04
0.06
lasso
10
0.06
2.4e-07
-6.2
6.4
1.9e-10
0.86
0.11
0.89
TRUE
2
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
CENPW
0.04
0.05
lasso
5
0.05
2.6e-06
-5.9
5.4
5.9e-08
0.81
0.02
0.98
FALSE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
CENPW
0.04
0.06
blup
35
0.05
9.2e-07
-6.0
5.4
6.0e-08
0.83
0.02
0.98
FALSE