Best TWAS P=1.1e-09 · Best GWAS P=6.51e-09 conditioned to 0.0765
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZDHHC4 | 0.29 | 0.09 | enet | 19 | 0.13 | 7.5e-08 | 4.0 | -5.8 | 8.1e-09 | -0.19 | 0.86 | 0.08 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PMS2CL | 0.20 | -0.01 | lasso | 4 | -0.01 | 6.7e-01 | 5.4 | -5.6 | 2.8e-08 | -0.64 | 0.02 | 0.37 | FALSE |
| 3 | GTEx | Colon Sigmoid | PMS2CL | 0.21 | 0.07 | lasso | 4 | 0.07 | 1.6e-03 | 5.4 | -5.3 | 1.1e-07 | -0.88 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Nerve Tibial | ZNF12 | 0.16 | 0.10 | enet | 7 | 0.15 | 5.3e-11 | 5.4 | -6.1 | 1.2e-09 | -0.86 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Thyroid | PMS2CL | 0.10 | 0.07 | lasso | 3 | 0.07 | 6.5e-06 | 5.8 | -5.5 | 4.0e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Whole Blood | RP11-611L7.1 | 0.08 | 0.03 | lasso | 4 | 0.02 | 6.7e-03 | 5.1 | -6.1 | 1.1e-09 | -0.81 | 0.07 | 0.84 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF12 | 0.05 | 0.02 | blup | 32 | 0.02 | 7.1e-04 | 5.8 | -5.2 | 2.3e-07 | -0.90 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PMS2CL | 0.14 | 0.10 | lasso | 2 | 0.07 | 1.5e-03 | 5.4 | -5.6 | 2.6e-08 | -0.90 | 0.01 | 0.84 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | PMS2CL | 0.08 | 0.12 | lasso | 5 | 0.11 | 1.0e-10 | 5.4 | -5.4 | 5.6e-08 | -0.90 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF12 | 0.07 | 0.02 | blup | 32 | 0.05 | 2.8e-05 | -3.8 | -5.5 | 4.6e-08 | -0.79 | 0.01 | 0.97 | FALSE |