Best TWAS P=5.53e-14 · Best GWAS P=5.39e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-165J3.6 | 0.31 | 0.11 | lasso | 6 | 0.16 | 5.4e-05 | -3.3 | -5.6 | 1.9e-08 | -0.27 | 0.18 | 0.11 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PHF2 | 0.07 | 0.06 | lasso | 5 | 0.04 | 5.5e-04 | 7.2 | 7.5 | 5.5e-14 | 0.96 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Colon Sigmoid | RP11-165J3.6 | 0.31 | 0.12 | enet | 17 | 0.16 | 1.8e-06 | -3.1 | -5.1 | 2.9e-07 | -0.27 | 0.72 | 0.02 | TRUE |
| 4 | GTEx | Stomach | RP11-165J3.6 | 0.57 | 0.23 | enet | 35 | 0.27 | 1.9e-13 | -2.9 | -5.3 | 8.9e-08 | -0.17 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Whole Blood | RP11-165J3.6 | 0.10 | 0.07 | lasso | 4 | 0.05 | 1.1e-05 | -5.4 | -6.2 | 4.3e-10 | -0.61 | 0.54 | 0.40 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHF2 | 0.02 | 0.01 | blup | 104 | 0.01 | 4.6e-03 | 7.1 | 7.3 | 2.6e-13 | 0.91 | 0.00 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | PHF2 | 0.29 | 0.14 | blup | 103 | 0.16 | 1.0e-05 | 6.6 | 5.7 | 1.2e-08 | 0.85 | 0.02 | 0.96 | FALSE |