Best TWAS P=1.62e-31 · Best GWAS P=1.53e-27 conditioned to 0.195
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CCDC171 | 0.18 | 0.05 | lasso | 5 | 0.08 | 2.2e-05 | -3.2 | -5.2 | 2.0e-07 | 0.31 | 0.34 | 0.06 | FALSE |
2 | GTEx | Artery Tibial | CCDC171 | 0.10 | 0.09 | enet | 9 | 0.12 | 7.2e-10 | 5.6 | -6.4 | 1.5e-10 | 0.60 | 0.90 | 0.09 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | 9.3 | -10.4 | 1.9e-25 | 0.95 | 0.06 | 0.94 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | -10.9 | -11.7 | 1.6e-31 | 0.91 | 0.05 | 0.94 | TRUE |
5 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | -10.5 | -11.0 | 3.3e-28 | 0.97 | 0.03 | 0.97 | FALSE |
6 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | -8.9 | -9.8 | 1.2e-22 | 0.92 | 0.08 | 0.88 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | 9.6 | -9.2 | 2.9e-20 | 0.83 | 0.07 | 0.87 | FALSE |
8 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | -10.9 | -9.2 | 4.7e-20 | 0.91 | 0.04 | 0.85 | FALSE |
9 | GTEx | Breast Mammary Tissue | CCDC171 | 0.21 | 0.01 | lasso | 5 | 0.03 | 1.5e-02 | 8.8 | -5.6 | 1.8e-08 | 0.55 | 0.37 | 0.20 | FALSE |
10 | GTEx | Lung | CCDC171 | 0.13 | 0.03 | enet | 9 | 0.01 | 5.0e-02 | 6.5 | -8.2 | 2.1e-16 | 0.72 | 0.42 | 0.33 | FALSE |
11 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | -10.5 | -10.4 | 1.7e-25 | 0.96 | 0.11 | 0.89 | FALSE |
12 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | 9.0 | 8.7 | 4.3e-18 | -0.85 | 0.16 | 0.51 | TRUE |
13 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | 9.3 | -9.9 | 3.7e-23 | 0.90 | 0.21 | 0.73 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC171 | 0.20 | 0.04 | enet | 45 | 0.06 | 4.9e-04 | 9.5 | -5.2 | 2.0e-07 | 0.40 | 0.67 | 0.22 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | CCDC171 | 0.14 | 0.09 | enet | 13 | 0.12 | 1.9e-10 | 9.0 | -6.8 | 1.5e-11 | 0.63 | 0.99 | 0.01 | FALSE |
16 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | 9.6 | -8.8 | 2.1e-18 | 0.79 | 0.19 | 0.60 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | 9.4 | -9.5 | 1.6e-21 | 0.81 | 0.87 | 0.13 | FALSE |
18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf93 | 0.06 | 0.05 | lasso | 3 | 0.03 | 5.3e-03 | 8.8 | -7.4 | 1.3e-13 | 0.70 | 0.13 | 0.28 | FALSE |