[Hub]/) : Traits : Leg fat percentage (left) :

chr11:42,881,882-44,607,471

Best TWAS P=2.12e-15 · Best GWAS P=1.62e-16 conditioned to 0.00429

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD17B12 0.44 0.51 lasso 11 0.53 6.0e-76 6.9 -6.9 4.7e-12 -0.82 0.98 0.02 FALSE
2 GTEx Adipose Subcutaneous HSD17B12 0.31 0.35 lasso 5 0.37 2.8e-31 7.3 -7.2 7.6e-13 -0.83 0.88 0.12 FALSE
3 GTEx Adipose Subcutaneous RP11-613D13.5 0.10 0.11 lasso 2 0.10 8.1e-09 6.9 -7.1 1.1e-12 -0.82 0.47 0.53 FALSE
4 GTEx Adipose Visceral Omentum HSD17B12 0.28 0.25 enet 17 0.21 2.6e-11 6.9 -7.2 8.6e-13 -0.84 0.60 0.40 FALSE
5 GTEx Adipose Visceral Omentum SEC14L1P1 0.12 0.00 enet 6 0.00 3.5e-01 3.2 5.5 3.7e-08 0.50 0.05 0.49 FALSE
6 GTEx Adipose Visceral Omentum RP11-613D13.5 0.18 0.01 lasso 3 0.05 8.9e-04 6.9 -5.8 7.0e-09 -0.67 0.10 0.89 FALSE
7 GTEx Adrenal Gland HSD17B12 0.20 0.19 lasso 7 0.18 5.2e-07 6.9 -7.0 3.6e-12 -0.81 0.71 0.23 FALSE
8 GTEx Artery Aorta HSD17B12 0.61 0.55 lasso 9 0.59 3.4e-39 6.9 -6.7 1.7e-11 -0.81 0.90 0.10 FALSE
9 GTEx Artery Aorta RP11-613D13.5 0.31 0.27 lasso 3 0.27 3.0e-15 6.9 -7.0 3.2e-12 -0.83 0.89 0.11 FALSE
10 GTEx Artery Coronary HSD17B12 0.61 0.41 lasso 19 0.43 4.5e-16 6.9 -7.2 8.6e-13 -0.81 0.86 0.14 FALSE
11 GTEx Artery Tibial HSD17B12 0.47 0.54 lasso 5 0.59 8.9e-57 6.9 -7.0 2.2e-12 -0.83 0.94 0.06 FALSE
12 GTEx Artery Tibial RP11-613D13.5 0.17 0.18 lasso 6 0.18 2.4e-14 6.9 -7.2 7.3e-13 -0.84 0.81 0.19 FALSE
13 GTEx Brain Caudate basal ganglia HSD17B12 0.68 0.43 lasso 18 0.49 6.0e-16 7.3 -7.0 2.3e-12 -0.81 0.76 0.24 FALSE
14 GTEx Brain Caudate basal ganglia RP11-613D13.5 0.32 0.14 enet 24 0.13 1.6e-04 7.4 -5.8 5.0e-09 -0.84 0.06 0.89 FALSE
15 GTEx Brain Cerebellar Hemisphere HSD17B12 0.50 0.41 enet 33 0.29 3.0e-08 7.3 -6.4 1.3e-10 -0.82 0.61 0.38 FALSE
16 GTEx Brain Cerebellum HSD17B12 0.52 0.39 lasso 16 0.36 2.4e-11 7.3 -7.3 2.7e-13 -0.84 0.80 0.20 FALSE
17 GTEx Brain Cortex HSD17B12 0.52 0.37 lasso 9 0.40 5.4e-12 7.3 -7.4 1.2e-13 -0.83 0.54 0.46 FALSE
18 GTEx Brain Frontal Cortex BA9 HSD17B12 0.45 0.38 lasso 7 0.36 2.8e-10 6.9 -7.2 6.8e-13 -0.83 0.36 0.64 FALSE
19 GTEx Brain Hippocampus HSD17B12 0.49 0.43 lasso 6 0.41 8.9e-11 6.9 -7.1 9.6e-13 -0.83 0.23 0.77 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia HSD17B12 0.41 0.27 lasso 16 0.20 4.5e-06 7.3 -6.5 9.6e-11 -0.73 0.35 0.62 FALSE
21 GTEx Brain Putamen basal ganglia HSD17B12 0.51 0.30 enet 28 0.33 1.3e-08 7.3 -7.0 3.5e-12 -0.79 0.12 0.86 FALSE
22 GTEx Breast Mammary Tissue HSD17B12 0.21 0.17 lasso 1 0.12 6.0e-07 6.9 -6.9 4.4e-12 -0.81 0.56 0.44 FALSE
23 GTEx Breast Mammary Tissue RP11-613D13.5 0.18 0.11 lasso 5 0.15 6.3e-08 6.9 -6.5 9.8e-11 -0.78 0.22 0.75 FALSE
24 GTEx Breast Mammary Tissue (Male) HSD17B12 0.48 0.34 lasso 14 0.34 1.1e-08 7.4 -7.3 3.7e-13 -0.84 0.30 0.67 FALSE
25 GTEx Cells Transformed fibroblasts HSD17B12 0.60 0.69 lasso 10 0.69 2.0e-71 6.9 -7.2 7.6e-13 -0.83 0.90 0.10 FALSE
26 GTEx Cells Transformed fibroblasts RP11-613D13.5 0.34 0.42 lasso 9 0.42 4.5e-34 7.3 -7.2 5.2e-13 -0.84 0.87 0.13 FALSE
27 GTEx Colon Sigmoid HSD17B12 0.44 0.38 lasso 8 0.37 6.7e-14 6.9 -7.2 7.4e-13 -0.83 0.79 0.21 FALSE
28 GTEx Colon Transverse HSD17B12 0.48 0.49 lasso 4 0.50 1.3e-26 6.9 -7.1 1.2e-12 -0.83 0.89 0.11 FALSE
29 GTEx Colon Transverse RP11-613D13.5 0.21 0.24 lasso 3 0.23 3.4e-11 6.9 -7.0 2.2e-12 -0.82 0.86 0.14 FALSE
30 GTEx Esophagus Gastroesophageal Junction HSD17B12 0.51 0.35 lasso 7 0.37 3.1e-14 6.9 -7.9 2.1e-15 -0.85 0.65 0.35 TRUE
31 GTEx Esophagus Mucosa HSD17B12 0.54 0.58 lasso 12 0.58 1.3e-47 6.9 -7.2 5.0e-13 -0.84 0.89 0.11 FALSE
32 GTEx Esophagus Mucosa RP11-613D13.5 0.17 0.19 lasso 6 0.18 2.5e-12 7.4 -7.5 5.2e-14 -0.86 0.45 0.55 FALSE
33 GTEx Esophagus Muscularis HSD17B12 0.57 0.56 lasso 8 0.58 1.1e-42 6.9 -6.9 4.0e-12 -0.81 0.89 0.11 FALSE
34 GTEx Esophagus Muscularis RP11-613D13.5 0.21 0.20 lasso 2 0.19 9.6e-12 6.9 -7.0 3.5e-12 -0.83 0.87 0.13 FALSE
35 GTEx Heart Atrial Appendage HSD17B12 0.52 0.46 lasso 6 0.44 1.2e-21 6.9 -6.7 2.6e-11 -0.82 0.90 0.10 FALSE
36 GTEx Heart Atrial Appendage RP11-613D13.5 0.18 0.02 enet 11 0.07 5.3e-04 6.9 -6.0 1.6e-09 -0.78 0.08 0.89 FALSE
37 GTEx Heart Left Ventricle HSD17B12 0.25 0.28 lasso 4 0.25 8.2e-14 6.9 -7.0 2.0e-12 -0.81 0.88 0.12 FALSE
38 GTEx Liver HSD17B12 0.46 0.38 enet 24 0.28 1.3e-08 7.2 -6.9 4.2e-12 -0.83 0.16 0.83 FALSE
39 GTEx Liver RP11-613D13.5 0.30 0.24 lasso 3 0.23 4.6e-07 8.2 -7.7 1.2e-14 -0.97 0.01 0.99 FALSE
40 GTEx Lung HSD17B12 0.54 0.59 enet 32 0.61 8.3e-59 6.9 -6.8 8.3e-12 -0.81 0.93 0.07 FALSE
41 GTEx Lung RP11-613D13.5 0.18 0.20 lasso 2 0.17 6.0e-13 6.9 -7.0 2.9e-12 -0.82 0.92 0.08 FALSE
42 GTEx Muscle Skeletal HSD17B12 0.35 0.38 enet 24 0.37 3.4e-38 6.9 -7.0 3.2e-12 -0.83 0.94 0.06 FALSE
43 GTEx Nerve Tibial HSD17B12 0.58 0.52 enet 56 0.56 3.5e-47 7.3 -6.2 6.8e-10 -0.80 0.87 0.13 FALSE
44 GTEx Nerve Tibial RP11-613D13.5 0.14 0.19 lasso 2 0.18 1.1e-12 7.4 -7.4 1.5e-13 -0.85 0.72 0.28 FALSE
45 GTEx Ovary HSD17B12 0.45 0.36 lasso 17 0.33 5.4e-09 6.9 -7.3 2.3e-13 -0.82 0.43 0.56 FALSE
46 GTEx Pancreas HSD17B12 0.43 0.40 lasso 2 0.40 7.6e-18 6.9 -7.0 2.2e-12 -0.81 0.90 0.10 FALSE
47 GTEx Prostate HSD17B12 0.65 0.51 enet 34 0.53 8.8e-16 7.3 -6.6 3.9e-11 -0.81 0.71 0.29 FALSE
48 GTEx Prostate RP11-613D13.5 0.29 0.07 enet 27 0.16 8.2e-05 7.3 -5.7 1.3e-08 -0.68 0.25 0.36 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic HSD17B12 0.45 0.59 lasso 1 0.59 1.9e-39 6.9 -6.9 4.4e-12 -0.81 0.99 0.01 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic RP11-613D13.5 0.17 0.12 enet 19 0.15 2.2e-08 7.4 -7.8 8.6e-15 -0.93 0.03 0.97 FALSE
51 GTEx Skin Sun Exposed Lower leg HSD17B12 0.46 0.60 lasso 7 0.61 9.2e-63 6.9 -7.2 4.9e-13 -0.84 0.93 0.07 FALSE
52 GTEx Skin Sun Exposed Lower leg RP11-613D13.5 0.17 0.22 lasso 3 0.21 2.2e-17 6.9 -7.0 2.3e-12 -0.83 0.74 0.26 FALSE
53 GTEx Spleen HSD17B12 0.55 0.48 enet 48 0.47 9.6e-14 6.9 -5.7 9.8e-09 -0.73 0.38 0.62 FALSE
54 GTEx Stomach HSD17B12 0.37 0.51 lasso 2 0.51 9.5e-28 6.9 -6.9 4.8e-12 -0.80 0.91 0.09 FALSE
55 GTEx Stomach RP11-613D13.5 0.18 0.21 lasso 3 0.21 1.6e-10 6.9 -6.9 4.5e-12 -0.81 0.84 0.16 FALSE
56 GTEx Testis HSD17B12 0.67 0.58 lasso 10 0.60 8.5e-33 7.4 -7.4 1.0e-13 -0.86 0.85 0.15 FALSE
57 GTEx Thyroid HSD17B12 0.52 0.59 lasso 4 0.59 1.1e-55 6.9 -7.0 2.1e-12 -0.82 0.97 0.03 FALSE
58 GTEx Thyroid RP11-613D13.5 0.24 0.18 lasso 2 0.15 7.3e-12 6.9 -7.1 1.0e-12 -0.83 0.79 0.21 FALSE
59 GTEx Uterus HSD17B12 0.60 0.48 enet 20 0.52 2.1e-12 7.2 -7.0 1.9e-12 -0.82 0.62 0.37 FALSE
60 GTEx Uterus RP11-613D13.5 0.61 0.22 lasso 12 0.26 3.9e-06 5.9 -7.7 1.9e-14 -0.62 0.28 0.42 FALSE
61 GTEx Vagina HSD17B12 0.55 0.31 lasso 19 0.34 1.3e-08 6.9 -6.8 1.5e-11 -0.76 0.39 0.55 FALSE
62 GTEx Whole Blood HSD17B12 0.29 0.36 lasso 3 0.36 4.5e-34 6.9 -7.1 1.6e-12 -0.82 0.93 0.07 FALSE
63 GTEx Whole Blood RP11-613D13.5 0.06 0.01 lasso 4 0.00 1.2e-01 -4.7 -5.9 3.6e-09 -0.71 0.06 0.32 FALSE
64 METSIM Adipose HSD17B12 0.19 0.29 bslmm 660 0.29 4.7e-43 7.4 -7.2 8.5e-13 -0.82 0.80 0.20 FALSE
65 ROSMAP Brain Pre-frontal Cortex HSD17B12 0.45 0.37 enet 72 0.47 1.1e-68 6.9 -5.7 1.4e-08 -0.72 0.99 0.01 FALSE
66 YFS Blood HSD17B12 0.37 0.44 enet 31 0.47 1.2e-176 7.4 -7.0 2.7e-12 -0.78 0.79 0.21 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma HSD17B12 0.19 0.27 enet 10 0.27 6.1e-23 6.9 -7.3 3.6e-13 -0.83 0.86 0.14 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma HSD17B12 0.10 0.20 lasso 4 0.20 7.5e-39 6.9 -7.0 2.0e-12 -0.81 0.98 0.02 FALSE
69 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma HSD17B12 0.18 0.22 lasso 2 0.20 2.2e-10 6.9 -7.2 7.0e-13 -0.79 0.76 0.24 FALSE
70 The Cancer Genome Atlas Colon Adenocarcinoma HSD17B12 0.33 0.36 enet 17 0.39 7.5e-24 7.4 -7.2 4.1e-13 -0.83 0.83 0.17 FALSE
71 The Cancer Genome Atlas Esophageal Carcinoma HSD17B12 0.27 0.31 enet 17 0.31 1.2e-10 7.2 -7.1 1.6e-12 -0.81 0.78 0.22 FALSE
72 The Cancer Genome Atlas Glioblastoma Multiforme HSD17B12 0.43 0.43 lasso 6 0.45 3.4e-15 7.3 -7.2 5.6e-13 -0.83 0.84 0.16 FALSE
73 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HSD17B12 0.19 0.27 lasso 3 0.27 9.8e-31 6.9 -7.2 6.0e-13 -0.82 0.86 0.14 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HSD17B12 0.35 0.52 lasso 4 0.54 4.7e-71 7.3 -7.2 4.8e-13 -0.84 0.86 0.14 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma HSD17B12 0.19 0.24 lasso 6 0.24 4.7e-14 6.9 -7.2 5.8e-13 -0.84 0.85 0.15 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma HSD17B12 0.32 0.48 lasso 4 0.47 1.5e-60 6.9 -7.0 2.8e-12 -0.82 0.98 0.02 FALSE
77 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HSD17B12 0.22 0.25 lasso 1 0.24 9.8e-12 6.9 -6.9 4.4e-12 -0.81 0.90 0.10 FALSE
78 The Cancer Genome Atlas Lung Adenocarcinoma HSD17B12 0.22 0.33 enet 18 0.33 1.1e-39 6.9 -7.4 1.7e-13 -0.82 0.90 0.10 FALSE
79 The Cancer Genome Atlas Lung Squamous Cell Carcinoma HSD17B12 0.20 0.26 lasso 2 0.26 1.3e-29 6.9 -7.1 1.6e-12 -0.82 0.94 0.06 FALSE
80 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HSD17B12 0.18 0.23 lasso 4 0.23 6.6e-16 7.2 -7.1 1.2e-12 -0.84 0.81 0.19 FALSE
81 The Cancer Genome Atlas Pancreatic Adenocarcinoma HSD17B12 0.28 0.30 lasso 4 0.29 8.1e-13 6.9 -6.9 3.8e-12 -0.81 0.86 0.14 FALSE
82 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HSD17B12 0.21 0.24 lasso 8 0.23 1.9e-09 6.9 -7.0 3.5e-12 -0.83 0.12 0.88 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma HSD17B12 0.36 0.52 lasso 6 0.52 3.8e-63 6.9 -7.1 1.0e-12 -0.83 0.95 0.05 FALSE
84 The Cancer Genome Atlas Rectum Adenocarcinoma HSD17B12 0.39 0.25 lasso 4 0.26 7.2e-07 7.2 -7.2 4.9e-13 -0.85 0.24 0.73 FALSE
85 The Cancer Genome Atlas Soft Tissue Sarcoma HSD17B12 0.13 0.20 lasso 3 0.18 3.9e-11 6.9 -7.0 2.9e-12 -0.82 0.92 0.08 FALSE
86 The Cancer Genome Atlas Skin Cutaneous Melanoma HSD17B12 0.15 0.08 enet 17 0.08 3.0e-03 7.3 -7.7 1.2e-14 -0.92 0.03 0.77 FALSE
87 The Cancer Genome Atlas Stomach Adenocarcinoma HSD17B12 0.17 0.27 lasso 1 0.26 6.0e-19 6.9 -6.9 4.4e-12 -0.81 0.97 0.03 FALSE
88 The Cancer Genome Atlas Testicular Germ Cell Tumors HSD17B12 0.34 0.26 blup 115 0.26 1.6e-09 6.9 -6.0 2.7e-09 -0.62 0.84 0.15 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma HSD17B12 0.60 0.66 lasso 2 0.65 4.5e-84 6.9 -7.0 2.5e-12 -0.81 0.99 0.01 FALSE
90 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma HSD17B12 0.21 0.20 lasso 1 0.16 4.3e-05 6.9 -6.9 4.4e-12 -0.81 0.20 0.62 FALSE