Best TWAS P=2.73e-19 · Best GWAS P=1.11e-23 conditioned to 9.32e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 8.98 | 9.0 | 2.7e-19 | 0.65 | 0.66 | 0.23 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | -6.48 | 7.6 | 3.1e-14 | 0.33 | 0.23 | 0.05 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | METTL15 | 0.04 | 0.03 | blup | 364 | 0.03 | 4.6e-05 | -3.43 | -5.4 | 8.1e-08 | -0.19 | 0.72 | 0.01 | TRUE |
| 7 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 8.74 | -8.5 | 1.9e-17 | -0.74 | 0.11 | 0.79 | FALSE |
| 6 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 8.98 | 8.4 | 5.4e-17 | 0.71 | 0.38 | 0.54 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 9.29 | 8.1 | 6.0e-16 | 0.65 | 0.00 | 0.99 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 8.98 | 7.2 | 8.8e-13 | 0.64 | 0.97 | 0.03 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 9.21 | 6.8 | 8.4e-12 | 0.56 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | 0.18 | -6.7 | 1.8e-11 | -0.69 | 0.02 | 0.84 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 2.18 | 5.9 | 3.4e-09 | 0.62 | 0.66 | 0.19 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LIN7C | 0.04 | 0.01 | lasso | 3 | 0.02 | 1.0e-02 | -1.24 | 5.1 | 3.0e-07 | 0.48 | 0.02 | 0.83 | FALSE |