Best TWAS P=7.34e-09 · Best GWAS P=3.31e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | ARPC3 | 0.13 | 0.09 | lasso | 4 | 0.04 | 2.0e-02 | 5.5 | -5.5 | 3.8e-08 | -0.97 | 0.02 | 0.87 | FALSE |
| 2 | GTEx | Muscle Skeletal | ARPC3 | 0.14 | 0.11 | enet | 23 | 0.10 | 2.2e-10 | 5.4 | -5.2 | 2.0e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Muscle Skeletal | IFT81 | 0.08 | 0.08 | lasso | 5 | 0.07 | 1.7e-07 | 5.5 | 5.8 | 7.3e-09 | 0.98 | 0.02 | 0.98 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | VPS29 | 0.06 | 0.01 | lasso | 3 | 0.01 | 6.9e-02 | 5.5 | 5.2 | 2.2e-07 | 0.90 | 0.03 | 0.75 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ARPC3 | 0.13 | 0.15 | lasso | 3 | 0.15 | 1.9e-12 | 5.3 | -5.3 | 9.6e-08 | -0.97 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Spleen | VPS29 | 0.24 | 0.01 | enet | 14 | 0.04 | 2.9e-02 | 4.1 | 5.5 | 3.3e-08 | 0.88 | 0.02 | 0.73 | FALSE |
| 7 | GTEx | Testis | ARPC3 | 0.16 | 0.16 | lasso | 3 | 0.14 | 7.5e-07 | 5.3 | -5.3 | 1.1e-07 | -0.97 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAD9B | 0.04 | 0.03 | lasso | 5 | 0.01 | 7.0e-03 | 5.3 | 5.4 | 8.0e-08 | 0.95 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | RAD9B | 0.10 | 0.06 | enet | 5 | 0.06 | 1.2e-06 | 5.3 | 5.4 | 7.8e-08 | 0.97 | 0.01 | 0.99 | FALSE |