TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
:
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chr12:107,433,672-108,852,590
Best TWAS P=3.38e-09 · Best GWAS P=1.2e-17 conditioned to 1.32e-16
107.4M
107.6M
107.8M
108M
108.2M
108.4M
108.6M
108.8M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Whole Blood
PRDM4
0.10
0.08
lasso
5
0.05
1.8e-05
6
-5.9
3.4e-09
0.05
0.99
0.00
TRUE
1
CommonMind
Brain Pre-frontal Cortex
PRDM4
0.07
0.08
lasso
2
0.07
5.0e-09
6
5.8
8.7e-09
-0.03
1.00
0.00
FALSE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
ASCL4
0.03
0.03
blup
49
0.03
2.9e-04
6
5.5
2.8e-08
-0.05
0.01
0.94
FALSE