[Hub]/) : Traits : Leg fat mass (left) :

chr10:125,455,780-127,174,440

Best TWAS P=6.43e-09 · Best GWAS P=1.6e-08 conditioned to 0.136

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex METTL10 0.20 0.26 lasso 9 0.26 4.5e-31 -5.5 -5.5 3.4e-08 0.98 0.01 0.99 FALSE
2 GTEx Brain Cerebellum LHPP 0.41 0.03 enet 34 0.11 4.1e-04 3.8 5.8 8.5e-09 -0.37 0.19 0.16 TRUE
3 GTEx Lung METTL10 0.11 0.06 enet 6 0.05 1.7e-04 -5.5 -5.7 1.2e-08 0.96 0.02 0.98 FALSE
4 GTEx Testis METTL10 0.26 0.14 lasso 9 0.08 2.3e-04 -5.7 -5.4 5.4e-08 0.96 0.01 0.99 FALSE
5 GTEx Thyroid METTL10 0.19 0.09 enet 33 0.10 3.0e-08 -5.5 -5.5 3.2e-08 0.84 0.01 0.99 FALSE
6 METSIM Adipose METTL10 0.12 0.15 enet 27 0.15 1.1e-21 -5.5 -5.3 9.6e-08 0.95 0.01 0.99 FALSE
7 ROSMAP Brain Pre-frontal Cortex METTL10 0.14 0.16 lasso 7 0.18 5.5e-22 -4.3 -5.2 2.4e-07 0.93 0.03 0.97 FALSE
8 The Cancer Genome Atlas Bladder Urothelial Carcinoma METTL10 0.09 0.08 blup 43 0.11 1.2e-09 -5.6 -5.7 1.4e-08 0.96 0.01 0.99 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma METTL10 0.06 0.13 lasso 7 0.13 1.1e-25 -5.6 -5.6 2.1e-08 0.99 0.01 0.99 FALSE
10 The Cancer Genome Atlas Colon Adenocarcinoma METTL10 0.09 0.14 lasso 9 0.12 3.1e-07 -5.3 -5.5 3.8e-08 0.99 0.01 0.99 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma METTL10 0.10 0.14 blup 43 0.14 7.4e-16 -5.7 -5.7 1.4e-08 0.98 0.01 0.99 FALSE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma METTL10 0.10 0.16 lasso 7 0.17 1.0e-18 -5.6 -5.5 3.6e-08 0.97 0.01 0.99 FALSE
13 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma METTL10 0.11 0.12 lasso 5 0.13 8.4e-08 -5.5 -5.4 7.5e-08 0.98 0.01 0.99 FALSE
14 The Cancer Genome Atlas Liver Hepatocellular Carcinoma METTL10 0.11 0.08 blup 43 0.12 4.8e-06 -5.5 -5.7 1.6e-08 0.96 0.01 0.99 FALSE
15 The Cancer Genome Atlas Lung Adenocarcinoma METTL10 0.11 0.19 lasso 6 0.19 7.3e-22 -5.5 -5.6 2.1e-08 1.00 0.01 0.99 FALSE
16 The Cancer Genome Atlas Lung Squamous Cell Carcinoma METTL10 0.05 0.06 blup 43 0.07 4.6e-08 -5.4 -5.4 7.6e-08 0.96 0.01 0.99 FALSE
17 The Cancer Genome Atlas Prostate Adenocarcinoma METTL10 0.10 0.17 blup 43 0.18 1.9e-18 -5.6 -5.4 7.1e-08 0.94 0.01 0.99 FALSE
18 The Cancer Genome Atlas Rectum Adenocarcinoma METTL10 0.25 0.11 lasso 4 0.23 3.8e-06 -5.6 -5.8 6.4e-09 0.88 0.02 0.90 TRUE
19 The Cancer Genome Atlas Soft Tissue Sarcoma METTL10 0.05 0.05 blup 43 0.05 4.4e-04 -5.6 -5.2 2.2e-07 0.94 0.01 0.95 FALSE
20 The Cancer Genome Atlas Stomach Adenocarcinoma METTL10 0.07 0.07 lasso 4 0.07 6.2e-06 -4.3 -5.2 2.3e-07 0.92 0.02 0.98 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma METTL10 0.25 0.35 lasso 5 0.36 5.9e-36 -5.5 -5.3 9.8e-08 0.98 0.01 0.99 FALSE
22 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma METTL10 0.13 0.08 blup 43 0.12 2.4e-04 -5.5 -5.4 5.4e-08 0.96 0.01 0.94 FALSE