TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat mass (left)
:
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→
chr14:21,718,739-22,221,211
Best TWAS P=1.23e-08 · Best GWAS P=2.12e-08 conditioned to 0.37
21.7M
21.8M
21.9M
22M
22.1M
22.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Testicular Germ Cell Tumors
METTL3
0.17
0.03
lasso
2
0.04
1.5e-02
-5.5
-5.7
1.2e-08
0.92
0.01
0.84
TRUE
1
The Cancer Genome Atlas
Breast Invasive Carcinoma
METTL3
0.03
0.04
lasso
1
0.04
3.1e-08
-5.5
-5.5
3.4e-08
0.96
0.01
0.99
FALSE
2
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
METTL3
0.04
0.04
lasso
2
0.04
2.5e-05
-5.5
-5.5
4.9e-08
0.96
0.00
0.99
FALSE