TWAS
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Models
Genes
Traits
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Traits
:
Leg fat mass (left)
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chr19:1,127,720-2,551,470
Best TWAS P=9.96e-11 · Best GWAS P=3.84e-09 conditioned to 0.0028
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
REXO1
0.07
0.01
bslmm
391
0.01
0.01660
-3.4
6.5
1.0e-10
-0.51
0.04
0.85
TRUE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
ATP8B3
0.04
0.01
blup
49
0.02
0.00220
-5.9
-5.6
2.0e-08
0.84
0.00
0.71
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
ATP8B3
0.06
0.00
blup
49
0.03
0.00027
-1.8
-5.5
3.2e-08
0.54
0.04
0.46
FALSE
2
GTEx
Esophagus Muscularis
CTB-31O20.6
0.16
0.07
lasso
5
0.05
0.00078
-5.4
-5.4
5.2e-08
0.50
0.03
0.95
FALSE