Best TWAS P=9.96e-11 · Best GWAS P=3.84e-09 conditioned to 0.0028
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 0.01660 | -3.4 | 6.5 | 1.0e-10 | -0.51 | 0.04 | 0.85 | TRUE |
| 2 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 0.00078 | -5.4 | -5.4 | 5.2e-08 | 0.50 | 0.03 | 0.95 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 0.00027 | -1.8 | -5.5 | 3.2e-08 | 0.54 | 0.04 | 0.46 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 0.00220 | -5.9 | -5.6 | 2.0e-08 | 0.84 | 0.00 | 0.71 | FALSE |