TWAS
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Models
Genes
Traits
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Traits
:
Leg fat mass (left)
:
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chr2:216,578,979-218,224,510
Best TWAS P=9.85e-08 · Best GWAS P=1.96e-07 conditioned to 1
216.6M
216.8M
217M
217.2M
217.4M
217.6M
217.8M
218M
218.2M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
GTEx
Skin Not Sun Exposed Suprapubic
SMARCAL1
0.13
0.13
lasso
2
0.11
1.3e-06
5.2
-5.3
9.9e-08
-0.99
0.00
1.00
TRUE
3
GTEx
Esophagus Mucosa
SMARCAL1
0.19
0.11
lasso
3
0.09
9.4e-07
5.2
-5.3
1.4e-07
-0.98
0.00
1.00
FALSE
1
CommonMind
Brain Pre-frontal Cortex
IGFBP2
0.09
0.04
enet
14
0.05
4.8e-07
5.2
5.2
1.6e-07
0.91
0.00
0.99
FALSE
5
GTEx
Stomach
SMARCAL1
0.16
0.06
lasso
4
0.06
1.1e-03
5.2
-5.2
1.9e-07
-0.96
0.01
0.94
FALSE
2
GTEx
Cells Transformed fibroblasts
SMARCAL1
0.10
0.04
lasso
5
0.04
5.6e-04
5.2
-5.1
2.8e-07
-0.92
0.01
0.99
FALSE