TWAS hub - IGFBP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0260	2.9e-06	0.041	0.033	0.053	0.039	0.037	7.7e-06	6.0e-05	4.8e-07	1.5e-05	2.1e-05
2	GTEx	Adrenal Gland	0.5411	0.0974	7.5e-06	0.300	NA	0.272	NA	0.309	2.3e-11	NA	2.7e-10	NA	1.0e-11
3	GTEx	Nerve Tibial	0.1415	0.0469	7.6e-04	0.082	NA	0.085	NA	0.076	2.1e-06	NA	1.3e-06	NA	4.9e-06
4	GTEx	Whole Blood	0.1040	0.0410	6.5e-03	0.217	NA	0.201	NA	0.217	8.9e-20	NA	2.6e-18	NA	9.9e-20
5	ROSMAP	Brain Pre-frontal Cortex	0.0994	0.0262	9.3e-06	0.045	0.049	0.057	0.045	0.028	1.7e-06	5.7e-07	7.2e-08	1.6e-06	1.2e-04
6	YFS	Blood	0.0204	0.0107	1.4e-02	0.001	0.005	0.002	0.007	0.002	1.8e-01	7.5e-03	8.2e-02	1.3e-03	6.7e-02
7	TCGA	Glioblastoma Multiforme	0.1890	0.0800	3.1e-03	0.022	0.027	0.043	NA	0.011	7.0e-02	5.3e-02	2.0e-02	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Relative age of first facial hair	5.0	10.3	18.2	-4.3	4.3	-2.3	1.9	-3.8	3.3	1.1
Schizophrenia vs Biploar Disorder	4.8	6.3	16.1	4.0	-2.9	1.8	0.0	3.7	0.3	-1.6
Diabetes (self-reported)	4.3	6.6	10.9	3.3	-3.1	1.6	-1.9	3.3	-2.1	-2.0
Supplements: Vitamin C	4.1	4.8	11.4	3.4	-2.2	1.3	-0.8	3.3	-1.6	-1.3
Ever taken oral contraceptive pill	3.9	4.4	8.2	2.5	-2.5	1.4	-1.0	2.9	-0.0	-2.6
Reaction Time	3.7	7.1	13.8	3.0	-3.7	0.4	-0.7	3.5	-3.5	-1.6
Illnesses of father: None of the above (group 1)	3.7	4.6	10.8	-2.9	3.3	-1.5	1.9	-2.2	1.6	-0.6
Vitamin and mineral supplements	3.6	4.8	11.6	-3.4	2.0	-2.1	-0.0	-2.9	1.6	1.6
Depression (Nagel 2018)	3.5	5.3	8.3	2.9	-2.4	2.6	1.6	2.5	-2.0	-1.7
Diabetes diagnosed by doctor	3.2	5.3	9.0	2.9	-2.7	1.3	-1.7	3.0	-1.8	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	7.3	2.7	-2.4	1.0	-0.4	2.6	-2.2	-1.8
Leg fat mass (left)	2.9	11.4	27.5	5.2	-4.0	2.5	-0.9	4.7	-2.1	-1.6
Mean time to correctly identify matches	2.8	5.4	12.0	2.6	-3.5	-0.6	-0.1	3.3	-2.3	-1.4
Leg fat mass (right)	2.8	10.7	26.2	5.1	-4.0	2.3	-0.8	4.7	-1.9	-1.5
Illnesses of father: Heart disease	2.8	3.9	8.2	2.8	-2.6	2.9	-0.9	1.1	-1.5	-0.5
Medication: Gliclazide	2.8	3.2	6.9	1.2	-2.6	0.4	-2.3	1.1	-2.2	-1.5
Supplements: Calcium	2.8	3.1	5.8	2.2	-2.3	2.4	0.4	1.8	-0.8	-1.2
Hip circumference	2.7	11.7	26.3	5.1	-4.5	1.9	-1.0	4.4	-3.3	-0.6
Pain type(s) experienced in last month: Hip pain	2.7	3.4	8.1	2.9	-2.3	1.9	0.2	2.5	-0.4	-0.9
Waist circumference	2.6	9.6	24.0	4.9	-3.8	1.7	-0.6	4.5	-2.2	-0.5
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	7.5	2.6	-2.6	0.9	0.8	2.7	-0.7	-0.9
Leg fat percentage (left)	2.6	9.3	19.4	4.4	-3.3	2.8	0.2	3.9	-2.0	-2.7
Headache pain in last month	2.5	4.3	11.3	2.0	-2.3	1.1	0.6	2.1	-3.4	-2.0
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.9	2.0	-2.1	0.9	-0.4	2.0	-2.2	-0.2
Multivitamins +/- minerals	2.4	3.0	5.5	2.4	-1.9	1.8	-0.3	2.0	-2.1	-0.5
Arm fat percentage (right)	2.4	9.5	23.0	4.7	-3.5	0.8	1.0	4.8	-2.5	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.9	4.9	-1.9	2.2	-1.8	1.7	-1.7	1.5	-0.0
Falls in the last year	2.3	3.1	5.2	2.0	-0.9	2.3	-0.9	1.9	-1.7	-2.1
Whole body fat mass	2.3	9.6	23.0	4.8	-3.8	1.7	-0.5	4.4	-2.6	-1.1
Medication: Co-codamol	2.2	2.5	8.2	2.3	-1.5	0.1	-0.1	2.9	0.6	-1.1
Arm fat mass (right)	2.2	9.1	22.0	4.7	-3.6	0.8	-0.5	4.6	-2.5	-0.7
Peak expiratory flow (PEF)	2.2	5.0	23.8	-1.6	-0.1	-0.1	2.1	-2.1	0.3	4.9
Body fat percentage	2.2	8.8	19.7	4.4	-3.5	1.4	0.8	4.2	-2.4	-1.8
Leg fat percentage (right)	2.2	8.0	17.9	4.2	-3.1	2.1	0.3	4.0	-1.6	-2.3
Trunk fat mass	2.1	9.2	21.8	4.7	-3.8	1.4	-0.1	4.2	-2.8	-0.6
Medication: Paracetamol	2.1	3.4	6.2	2.5	-2.2	1.4	-0.7	2.2	-1.7	-1.8
Glaucoma (self-reported)	2.1	2.5	6.1	2.0	-1.5	1.4	-0.2	1.6	1.0	-2.5
Arm fat percentage (left)	2.1	8.2	20.9	4.3	-3.3	0.3	0.9	4.6	-2.1	-1.3
Type 2 Diabetes (T2D) (2018)	2.0	3.7	6.1	2.4	-2.5	1.8	-1.3	2.1	-1.1	-1.9
Trunk fat percentage	2.0	8.0	17.5	4.2	-3.4	1.0	1.1	3.9	-2.8	-1.1
Shortness of breath walking on level ground	2.0	2.4	4.5	1.8	-2.0	1.4	1.2	2.1	1.1	-0.8
Arm fat mass (left)	2.0	8.4	20.8	4.6	-3.4	0.7	-0.5	4.4	-2.3	-0.8
Breast Cancer	1.9	4.7	9.4	3.1	-2.1	2.8	1.8	2.4	-1.5	-0.1
BMI	1.9	10.8	25.0	5.0	-4.0	2.4	-0.9	4.9	-1.6	-1.3
Pack years adult smoking proportion	1.9	2.9	4.2	2.1	-1.9	1.6	-1.9	1.5	-1.6	-1.4
Body mass index (BMI)	1.9	8.3	21.1	4.6	-3.5	1.3	-0.4	4.4	-0.9	-1.6
Neck or shoulder pain in last month	1.9	2.8	6.8	2.6	-1.3	0.8	-1.3	2.6	-0.5	-1.3
Smoking status: Previous	1.9	2.9	9.7	-1.6	1.5	-0.7	-0.8	-1.4	3.1	-1.5
Weight	1.8	9.1	23.1	4.8	-3.8	1.5	-1.6	4.1	-2.0	0.2
Time employed in main current job	1.8	2.1	4.4	1.6	-1.1	1.9	-0.8	1.3	-2.1	-0.8
Eye problems/disorders: None of the above	1.8	2.1	5.0	-1.7	1.5	-0.9	-2.2	-1.3	0.2	1.5
Commuting to job workplace: Cycle	1.8	2.1	7.0	-0.6	0.6	-1.9	-0.0	-0.1	1.9	2.6
Pack years of smoking	1.8	2.6	3.6	1.9	-1.8	1.7	-1.7	1.4	-1.1	-1.4
Alzheimer’s Disease (in father)	1.7	1.8	3.6	1.3	-1.0	-0.1	-0.5	1.6	-1.9	-1.9
Lung FVC	1.7	8.5	18.7	-4.3	2.4	-2.8	1.9	-3.4	2.4	2.6
Townsend deprivation index at recruitment	1.7	2.3	6.5	1.7	-1.3	0.7	-1.9	2.5	-1.2	-0.0
Supplements: Glucosamine	1.7	2.2	6.9	1.8	-2.6	1.8	1.0	0.7	-0.2	-0.4
Medication: Simvastatin	1.7	2.5	6.7	2.2	-1.8	0.8	1.1	2.6	0.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.2	1.9	-0.9	0.2	-1.8	2.1	0.5	-1.8
Osteoporosis (self-reported)	1.7	2.1	4.1	1.4	-1.7	0.3	-2.0	1.8	0.0	-1.6
Chronotype (morning person)	1.6	3.8	10.4	-2.0	1.8	-2.1	-0.2	-2.0	3.2	-0.7
Relative age voice broke	1.6	2.4	6.2	-1.6	2.0	-1.1	0.9	-1.3	2.5	0.6
Past tobacco smoking	1.6	3.0	5.1	2.0	-1.8	1.2	0.5	1.8	-2.2	2.0
Financial difficulties in last 2 years	1.6	2.1	6.2	0.9	0.2	-0.8	0.2	1.3	-2.5	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	16.4	0.4	0.5	0.1	0.1	0.3	-0.3	-4.0
Birth weight	1.6	3.5	5.9	1.8	-1.7	1.5	-2.3	1.8	-1.4	2.4
Exposure to tobacco smoke outside home	1.6	2.1	4.4	1.5	-2.0	-0.6	-1.8	2.1	-0.8	0.5
Worry (Nagel 2018)	1.5	3.3	7.9	2.8	-2.5	2.2	-0.2	1.8	-0.7	-0.5
Primary Biliary Cirrhosis	1.5	2.2	6.6	1.6	-1.9	0.1	-0.3	1.5	-2.6	0.0
Frequency of depressed mood in last 2 weeks	1.5	2.0	3.7	1.9	-1.3	1.1	0.2	1.8	-1.7	-1.3
Medication: Metformin	1.5	2.2	5.3	1.7	-1.6	0.6	-2.3	1.4	-1.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.2	1.8	-1.3	0.9	1.2	1.7	-1.2	1.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.8	-2.1	1.9	-2.0	0.2	-2.2	-0.5	-0.8
Migraine (self-reported)	1.5	1.8	3.4	1.2	-1.0	1.7	-1.4	0.9	-1.9	-1.0
Heart disease (mother)	1.5	1.8	5.8	-0.0	0.6	-1.9	-0.8	0.4	1.5	2.4
Alcohol intake frequency.	1.5	3.5	7.1	1.6	-1.5	1.8	0.7	1.5	-2.7	-2.7
Average weekly red wine intake	1.5	2.2	4.0	-1.3	0.7	-2.0	1.9	-1.1	0.8	1.8
Mood swings	1.5	2.6	4.8	1.6	-0.9	2.1	-0.6	1.0	-2.1	-2.2
Ever depressed for a whole week	1.5	1.8	3.5	1.9	-1.2	1.5	0.8	1.7	-1.3	-0.8
Schizophrenia (2014)	1.4	3.0	11.9	1.8	-1.4	0.7	0.0	1.7	-3.5	-0.8
Father’s age at death	1.4	1.9	2.9	1.5	-1.3	1.1	-1.2	1.3	-1.5	1.7
Noisy workplace	1.4	1.7	3.4	-1.5	1.6	0.3	0.5	-1.8	1.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	5.8	-1.1	0.5	-1.5	-2.4	-0.7	1.2	0.4
Medication: Ibuprofen	1.4	1.7	4.3	1.4	-0.8	0.9	1.4	1.4	-0.1	2.1
Medication: Paracetamol	1.4	2.2	5.1	2.3	-2.1	1.0	0.2	2.0	-0.8	-0.6
Age started oral contraceptive pill	1.4	1.7	5.4	-0.7	0.3	-1.4	0.7	-0.8	1.7	2.3
Severe depression (siblings)	1.3	1.5	3.8	1.1	0.1	-0.9	-0.6	1.9	-1.4	-1.6
Leg fat-free mass (left)	1.3	6.7	16.4	4.0	-2.8	0.9	-2.2	3.5	-1.4	1.7
Leg predicted mass (left)	1.3	6.7	16.5	4.1	-2.8	0.9	-2.2	3.5	-1.4	1.6
Tense / ‘highly strung’	1.3	2.2	5.4	1.8	-1.2	2.3	-1.4	1.2	-0.5	-1.3
Medication: Allopurinol	1.3	1.8	4.1	-1.3	1.3	2.0	-0.9	-1.6	0.0	-1.2
Comparative height size at age 10	1.3	7.2	17.0	2.7	-3.0	1.7	-4.1	1.6	-3.2	1.2
Leg fat-free mass (right)	1.3	6.8	16.2	4.0	-3.0	1.4	-2.2	3.2	-1.6	1.6
Loneliness, isolation	1.3	1.8	4.2	2.0	-1.8	0.7	-0.3	1.6	-1.3	-0.3
Mineral and other dietary supplements	1.3	1.7	3.6	-1.6	1.9	-1.4	0.5	-1.2	1.0	1.2
Leg predicted mass (right)	1.3	6.9	16.4	4.0	-2.9	1.4	-2.3	3.3	-1.6	1.6
Commuting to job workplace: Public transport	1.3	1.6	3.2	1.2	-1.7	1.8	-0.6	1.0	-1.2	-0.8
Medication: Atorvastatin	1.3	1.7	8.5	0.1	0.4	1.1	-2.9	-1.1	-0.8	-0.2
Basal metabolic rate	1.3	7.2	16.6	4.1	-3.0	1.6	-2.8	3.3	-1.4	1.4
Arm fat-free mass (left)	1.3	6.7	14.9	3.9	-2.7	1.5	-3.3	3.1	-0.9	1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.7	-0.4	-0.9	-1.5	1.5	0.1	1.7	1.4
Arm predicted mass (left)	1.3	6.4	13.2	3.6	-2.8	1.6	-3.3	2.8	-1.1	1.2
Schizophrenia (2018)	1.2	2.5	11.8	1.3	-0.9	0.4	0.0	1.5	-3.4	-0.6
Alzheimer’s Disease (including proxy)	1.2	1.7	5.1	1.4	-0.6	0.1	-0.1	1.4	-1.7	-2.3
Coronary Artery Disease (CAD)	1.2	1.4	2.5	-1.5	1.4	-0.5	0.0	-1.4	-1.0	-1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	5.2	-1.0	0.5	-0.7	2.3	-1.1	1.2	0.8
Medication: Cholesterol lowering	1.2	1.8	4.7	2.0	-1.5	0.8	-0.1	2.2	0.5	1.0
Birth weight of first child	1.2	2.2	8.4	-0.3	0.3	-1.4	-1.8	0.3	-1.3	2.9
Medication for pain relief, constipation, heartburn	1.2	2.0	4.5	-2.1	1.7	-0.9	-0.7	-2.0	0.9	0.4
Eye problems/disorders: Glaucoma	1.2	1.4	3.1	1.0	-0.9	0.8	1.2	0.5	1.7	-1.8
Prostate Cancer	1.1	1.5	4.6	-1.1	0.8	-1.3	-2.1	-1.4	0.1	-0.5
Fed-up feelings	1.1	1.9	6.2	1.3	-0.7	0.2	-0.1	1.2	-1.9	-2.5
Qualifications: CSEs or equivalent	1.1	1.4	2.6	1.6	-0.4	1.1	-0.1	1.6	-1.3	-1.4
High blood pressure	1.1	3.1	6.0	2.5	-2.4	1.5	1.0	2.4	-0.7	-0.4
Sitting height	1.1	8.1	13.5	3.0	-3.0	2.7	-3.7	1.7	-2.4	3.0
Chronic bronchitis/emphysema (father)	1.1	1.3	6.4	-1.0	0.5	-1.0	-0.2	-0.6	-2.5	0.3
Hearing difficulty/problems with background noise	1.1	1.7	3.2	1.6	-1.8	1.8	0.8	1.0	0.0	1.2
Qualifications: None of the above	1.1	2.3	5.2	1.1	-1.7	0.8	1.7	1.3	-1.1	-2.3
Neuroticism score	1.1	2.4	4.5	2.1	-1.4	0.9	-0.9	1.7	-1.4	-1.9
Gout (self-reported)	1.1	1.5	6.2	0.3	0.2	2.5	-1.6	-0.2	-0.0	-1.2
Arm predicted mass (right)	1.1	5.4	10.8	3.3	-2.6	1.4	-3.2	2.5	-0.3	1.2
Medication: Aspirin	1.1	1.4	3.3	1.8	-1.3	0.6	-0.1	1.5	-0.6	-1.4
Whole body fat-free mass	1.1	6.2	13.0	3.6	-2.6	1.4	-3.1	2.8	-0.9	1.9
Commuting to job workplace: Walk	1.1	1.2	3.2	1.4	-1.4	1.8	-0.6	0.9	0.5	-0.1
Eye problems/disorders: Cataract	1.1	1.3	4.0	1.2	-1.0	1.0	2.0	0.8	0.4	-0.9
Whole body water mass	1.1	6.3	13.0	3.6	-2.6	1.3	-3.2	2.9	-0.9	1.8
Hand grip strength (left)	1.0	2.6	6.2	-1.1	2.4	-0.8	0.2	-1.1	1.7	2.5
Sensitivity / hurt feelings	1.0	1.7	5.1	2.2	-1.1	0.5	-0.3	2.0	-0.5	-0.9
Nervous feelings	1.0	1.8	4.6	1.9	-2.1	0.9	-0.7	1.1	-1.4	-0.6
Pulse rate	1.0	1.7	5.6	-1.8	2.4	-0.8	-0.2	-1.6	-0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.8	-1.0	1.0	-1.3	-0.0	-1.3	-0.9	1.3
Exposure to tobacco smoke at home	1.0	1.1	3.1	1.4	-1.2	-0.2	-0.9	1.8	0.2	-0.4
Arm fat-free mass (right)	1.0	5.1	10.1	3.2	-2.3	1.5	-3.2	2.5	-0.4	1.3
Pulse wave peak to peak time	1.0	1.1	2.7	1.6	-1.4	0.2	-0.5	1.6	-0.4	0.6
Overall health rating	1.0	2.2	4.1	1.6	-2.0	1.4	0.8	1.0	1.0	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	5.0	1.0	-0.5	0.2	1.0	0.7	-2.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.8	-2.2	0.5	-0.4	1.6	-1.9	1.5	0.7
Average weekly beer plus cider intake	1.0	1.5	4.2	0.5	-0.5	0.8	1.1	0.2	-1.9	-2.0
Risk taking	1.0	1.5	4.4	-0.2	1.6	0.6	-1.3	-0.4	1.2	-2.1
Fractured/broken bones in last 5 years	1.0	1.3	3.0	-0.7	1.2	1.0	0.5	-1.4	1.0	-1.7
Bipolar Disorder (2018)	0.9	1.4	3.8	-1.9	1.5	0.1	0.0	-1.5	-0.9	0.9
Neuroticism (Nagel 2018)	0.9	2.1	4.8	2.2	-1.7	1.6	1.2	1.3	-0.9	-0.6
Major Depression (MDD)	0.9	1.1	2.5	1.5	-0.6	-0.1	-1.4	1.6	-0.8	-0.3
Neuroticism	0.9	2.2	4.2	2.0	-1.8	1.8	1.2	1.2	-0.5	-1.1
Average weekly spirits intake	0.9	1.1	2.2	0.1	0.7	-1.5	-1.3	0.8	1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.9	1.2	-1.0	0.8	1.7	1.3	-0.0	-0.7
Diabetes (father)	0.9	1.2	2.9	0.6	-1.0	-1.5	-1.7	1.3	0.0	0.2
Diabetes (mother)	0.9	1.2	2.6	1.3	-1.0	1.6	-0.5	0.9	-1.3	0.4
Current tobacco smoking	0.9	1.5	3.8	0.6	0.5	1.5	-1.1	0.3	-2.0	-1.7
Taking other prescription medications	0.9	1.4	3.7	-1.5	1.9	-0.1	0.8	-1.5	0.2	-1.0
Age when periods started (menarche)	0.9	2.1	5.0	-1.6	2.2	-2.2	0.8	-0.7	1.0	-0.0
Number of incorrect matches in round	0.9	1.4	7.8	-0.7	1.1	-0.7	-2.8	-0.1	0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.6	1.1	0.1	1.1	1.6	1.3	-0.8	-0.9
Trunk fat-free mass	0.9	5.0	11.0	2.8	-2.2	1.4	-3.3	2.1	-0.3	2.2
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	13.8	-1.7	0.3	-0.8	0.4	-1.8	-0.1	3.7
Medication: Lansoprazole	0.9	1.0	3.5	-0.7	1.2	-1.9	0.8	-0.5	0.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	14.1	-1.5	-0.4	-0.1	-0.4	-1.6	-0.9	3.8
Trunk predicted mass	0.9	5.2	11.5	2.9	-2.3	1.3	-3.4	2.1	-0.4	2.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.8	0.9	-1.1	1.2	-0.8	0.1	-0.5	-1.7
Angina (self-reported)	0.9	1.2	2.8	1.6	-0.9	0.1	-0.4	1.3	-1.7	-0.2
Age at last live birth	0.9	1.3	2.3	1.3	-1.1	1.2	0.7	1.1	0.6	1.5
Family relationship satisfaction	0.9	1.1	2.7	1.6	-0.2	1.0	-0.2	1.6	-0.3	-1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.4	-0.7	1.6	-1.3	0.6	-0.5	0.6	-1.3
Hypertension (Self-reported)	0.9	2.6	4.7	2.2	-2.0	1.7	1.2	2.1	-0.5	-0.6
Breast cancer (self-reported)	0.9	1.0	3.2	-1.0	-0.0	-1.8	-0.6	-0.6	1.0	-1.1
Average weekly champagne plus white wine intake	0.9	1.2	2.8	-1.1	1.6	-0.3	-1.1	-1.7	0.7	-0.5
Miserableness	0.9	1.6	4.6	1.0	-0.2	0.5	1.2	0.7	-1.8	-2.1
Hearing aid user	0.9	1.0	5.3	0.7	0.2	0.2	-0.0	0.9	-2.3	0.4
Financial situation satisfaction	0.9	1.1	2.7	0.9	0.4	0.3	1.0	1.7	-1.4	-1.1
Medication: Bendroflumethiazide	0.9	1.3	3.6	0.6	-1.9	-1.2	1.1	1.0	1.1	-0.4
Ever smoked	0.9	1.6	5.9	-1.1	1.1	-1.2	-0.8	-0.9	0.5	-2.4
Unable to work because of sickness or disability	0.9	1.1	3.2	0.8	-0.1	1.5	-1.8	1.1	0.4	0.5
Vascular/heart problems diagnosed by doctor	0.9	2.6	5.8	-2.3	2.2	-0.9	-0.6	-2.4	0.5	0.2
Alzheimer’s Disease (in mother)	0.8	0.9	2.2	1.1	-0.4	-0.2	0.8	1.2	-1.0	-1.5
Verbal and Numeric Reasoning (VNR)	0.8	2.0	7.2	-0.9	-0.5	-0.4	2.7	-1.5	-0.2	1.8
Bipolar Disorder (2011)	0.8	0.7	4.0	-0.5	0.6	0.4	0.0	-0.6	-2.0	0.0
Stomach or abdominal pain in last month	0.8	1.0	1.8	1.3	-0.6	0.9	1.0	1.4	-0.2	-1.3
Forced vital capacity (FVC)	0.8	3.3	13.7	-2.0	0.4	-1.0	-0.4	-1.9	-0.1	3.7
Impedance of arm (right)	0.8	3.7	10.0	-1.5	1.0	-1.6	3.2	-1.3	-2.8	0.6
Alcohol intake versus 10 years previously	0.8	1.2	2.6	1.6	-1.2	0.3	0.2	1.5	-0.7	-1.4
Number of live births	0.8	1.1	2.7	1.6	-0.5	-0.1	-0.1	1.5	-0.1	-1.6
Illnesses of mother	0.8	0.9	2.3	-1.5	1.0	-0.1	0.0	-1.5	-0.2	-1.0
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	-1.5	1.3	-0.4	0.2	-1.4	0.2	-0.2
Impedance of arm (left)	0.8	3.7	8.2	-2.0	1.1	-2.2	2.9	-1.7	-2.1	0.5
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.4	1.3	-1.5	1.0	-0.1	1.3	-0.4	-0.1
Forced vital capacity (FVC), Best measure	0.8	3.0	13.7	-1.7	-0.2	-0.1	-1.0	-1.8	-0.4	3.7
Comparative body size at age 10	0.8	2.2	4.3	2.0	-2.0	1.0	0.1	2.1	0.8	-1.1
Worry too long after embarrassment	0.8	1.4	3.7	1.7	-1.9	-0.1	0.0	1.5	-0.8	0.2
Emphysema/chronic bronchitis	0.8	1.0	2.6	0.7	-0.8	-1.6	0.3	1.6	-0.3	-0.3
Medication: Omeprazole	0.8	0.9	5.4	-0.1	0.6	0.0	2.3	0.2	0.6	0.7
Smoking status: Current	0.8	1.3	3.7	0.2	0.7	1.4	-0.7	-0.1	-1.9	-1.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.0	1.4	-0.5	0.4	-1.1	1.2	-0.9	-1.3
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	1.2	-0.8	1.2	1.7	0.6	-1.0	-1.5
Intelligence (Savage-Jansen 2018)	0.7	2.3	5.2	-1.6	1.0	-0.2	1.6	-1.9	1.1	2.3
Ovarian Cancer	0.7	0.9	5.0	0.1	-0.7	2.2	0.2	-0.8	0.2	0.1
Mean Putamen Volume	0.7	0.8	4.1	-0.5	0.9	-0.6	0.4	-0.1	0.2	2.0
Cardiovascular Disease	0.7	2.4	4.8	2.1	-2.0	2.2	0.5	1.6	-0.3	-0.6
Angina	0.7	1.0	2.7	1.4	-0.8	-0.1	-0.5	1.1	-1.6	-0.3
Maternal smoking around birth	0.7	1.0	4.8	0.4	-0.2	1.2	-0.6	0.1	-0.4	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	6.1	-0.3	0.8	0.2	0.1	-0.9	-0.5	-2.5
Heart attack	0.7	0.9	1.8	1.3	-0.5	0.5	-1.0	1.0	-0.9	-1.1
Pain all over the body in last month	0.7	0.8	3.0	0.3	0.1	-0.7	0.7	0.5	-1.1	-1.7
Medication: Ramipril	0.7	0.9	3.8	0.7	-0.2	-0.9	1.0	0.7	1.9	0.3
Hair/balding pattern: Pattern 3	0.7	1.1	6.4	-0.1	0.9	-0.3	-2.5	0.4	0.6	0.2
Number of children fathered	0.7	0.8	2.1	-0.9	1.2	0.3	1.4	-0.7	-0.4	-0.6
Medication: Blood pressure	0.7	1.3	2.5	1.4	-1.2	1.6	-0.7	1.6	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.1	-0.1	-0.4	-1.3	0.4	0.1	1.8	-1.1
Back pain experienced in last month	0.7	1.0	2.2	1.0	-0.9	-0.7	-0.4	1.5	1.4	0.7
Medication: Aspirin	0.7	0.9	2.2	1.5	-0.8	0.3	-0.1	1.4	-0.5	-1.0
Wears glasses or contact lenses	0.7	0.8	3.5	-0.1	0.2	-0.8	1.9	0.3	1.1	-0.6
Mother’s age at death	0.7	0.8	1.6	-1.1	0.5	-1.0	1.3	-0.4	0.6	1.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.9	1.1	-1.4	1.3	-0.1	0.9	-0.1	-0.9
Illnesses of father: High blood pressure	0.7	0.8	2.4	1.3	-0.5	1.6	-0.1	0.7	-0.2	1.0
Diastolic blood pressure, automated reading	0.7	2.1	4.6	2.1	-1.5	0.8	-1.5	1.9	-1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	-0.6	1.1	-1.2	1.3	0.1	0.8	0.6
Bipolar Disorder or Schizophrenia	0.6	1.6	10.6	-0.2	0.2	0.4	0.0	0.2	-3.3	-0.1
Age at First Birth	0.6	0.9	2.9	-1.0	-0.4	-1.2	-0.6	-0.7	1.7	0.1
Fasting Glucose	0.6	0.7	2.5	0.2	-0.2	-1.6	-1.1	0.4	-0.2	1.0
LDL Cholesterol	0.6	0.9	3.9	-0.1	1.1	0.4	1.1	0.1	2.0	-0.3
Neuroticism (2016)	0.6	0.9	4.2	0.8	-0.2	-0.4	2.1	0.8	-0.5	0.4
Lung FEV1/FVC ratio	0.6	3.0	5.4	2.1	-2.3	1.5	1.8	1.3	-1.7	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	-1.0	1.3	-0.7	0.3	-1.4	0.2	-0.4
Serious illness, injury or assault to yourself	0.6	0.8	1.7	1.2	-1.1	0.8	-0.0	1.3	-0.4	0.5
High blood pressure (mother)	0.6	0.9	3.9	-0.9	2.0	0.0	0.3	-0.7	0.8	-0.2
Impedance of leg (left)	0.6	2.7	5.3	-1.7	1.0	1.6	1.3	-2.3	-1.5	-1.8
Mouth/teeth dental problems	0.6	0.9	4.2	-0.5	0.4	-1.0	-2.1	0.4	0.3	0.9
Happiness	0.6	0.7	1.4	-0.5	1.1	0.4	-0.4	-0.8	-1.0	-1.2
Depression (self-reported)	0.6	0.7	2.7	1.0	-0.2	1.1	0.2	0.4	0.1	-1.6
Pulse wave reflection index	0.6	0.8	2.9	0.8	-0.8	1.7	0.6	0.3	-0.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-0.1	0.6	-1.4	-1.1	0.0	-1.4	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	0.4	-0.0	-0.3	-0.9	1.1	1.1	1.3
Number of full brothers	0.6	0.7	1.7	0.5	-0.5	-0.7	1.2	0.5	-0.9	-1.3
Age at first live birth	0.6	1.1	3.2	0.1	-0.5	0.6	1.6	0.3	1.1	1.8
Health satisfaction	0.6	0.7	1.4	0.5	-1.2	0.7	-0.8	0.3	1.1	-1.1
Chest pain or discomfort	0.6	0.9	2.9	1.4	0.1	0.3	-0.5	0.9	-0.3	-1.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.0	-0.2	-0.0	-0.2	0.7	-0.6	1.7	1.0
Medication for cholesterol	0.6	1.0	2.0	-1.4	1.4	0.6	-0.2	-1.3	0.4	0.8
Guilty feelings	0.6	0.9	2.4	-0.0	-0.2	-1.5	-1.3	0.0	0.0	-1.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.8	1.3	0.8	0.7	-1.0	0.4	-0.7
Medication: Lisinopril	0.6	0.8	2.9	0.1	0.9	0.4	1.1	0.2	-1.7	-0.7
Myopia	0.6	0.8	2.4	-1.1	0.8	0.5	-1.6	-1.0	0.1	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	0.2	0.1	1.1	-0.6	-0.6	-1.2	-1.2
Impedance of whole body	0.6	2.8	5.3	-2.0	1.2	-0.7	2.3	-2.0	-2.1	-0.2
Height	0.5	9.2	34.3	1.9	-0.8	1.0	-5.9	0.9	-3.3	3.7
Respiratory disease	0.5	1.2	3.2	-1.0	1.2	-1.0	-0.7	-0.9	1.8	0.8
Number of treatments/medications taken	0.5	0.8	1.8	1.0	-1.2	0.2	1.3	0.7	-0.8	-0.8
Hearing difficulty/problems: Yes	0.5	0.7	2.0	-0.7	1.4	-0.4	-0.1	0.1	-0.7	1.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-1.2	1.1	0.1	0.0	-1.2	-0.0	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.0	0.9	-0.5	0.9	-0.1	0.8	0.6	1.0
Impedance of leg (right)	0.5	2.4	5.4	-2.2	1.6	0.3	1.2	-2.3	-0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	-1.0	1.1	0.1	-1.1	-1.8	0.6	-0.8
Alcohol usually taken with meals	0.5	0.8	4.2	0.9	-2.0	-0.1	-0.6	0.6	0.3	-0.2
Had other major operations	0.5	0.6	2.7	-0.1	0.8	0.2	-1.6	0.8	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.0	1.1	-0.4	-0.6	0.4	1.4	-0.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.6	-0.1	0.8	-1.3	-0.5	-0.4	-1.5	1.6
Asthma	0.5	1.0	3.4	-0.8	1.1	0.1	-0.2	-1.1	1.9	0.6
Standing height	0.5	4.9	16.6	1.1	-1.3	0.6	-2.7	-0.1	-2.6	4.1
Length of working week for main job	0.5	0.5	2.2	-0.2	0.7	-0.1	1.5	-0.4	-0.3	0.7
Hair/balding pattern: Pattern 4	0.5	1.1	4.9	0.6	-1.5	0.2	0.6	0.3	2.2	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	-0.5	0.8	-0.9	-0.6	-0.2	-0.4	-1.4
Qualifications: College or University degree	0.5	1.5	4.7	-0.8	0.7	-0.5	-2.2	-0.8	1.5	1.1
Medication: Seretide 50 evohaler	0.5	0.5	1.7	0.2	-0.2	-0.8	-0.1	1.3	1.2	-0.0
Leg pain on walking	0.5	0.6	3.1	-0.5	0.2	0.8	1.8	-0.5	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.0	0.2	-0.4	0.4	-2.0	-0.3	-0.5	1.6
Medication: Blood pressure	0.5	1.0	1.6	1.2	-1.1	-0.6	1.3	1.1	-0.1	-0.9
Alcohol drinker status: Never	0.5	0.5	1.3	-1.0	0.1	-0.7	0.9	-1.1	0.2	0.4
Number of operations (self-reported)	0.5	0.8	3.6	-0.1	0.8	-0.6	-1.9	0.4	0.3	-0.6
Cholesterol lowering medication	0.5	0.7	3.4	0.7	-0.3	-0.8	-0.1	0.4	-0.4	-1.9
Ulcerative Colitis (UC)	0.4	0.7	2.2	-0.0	-1.5	-1.1	1.1	0.2	0.2	0.5
HDL Cholesterol	0.4	0.6	2.5	0.7	-0.7	-0.4	1.6	0.8	0.5	0.2
Lupus	0.4	0.7	1.6	0.1	-0.5	-0.0	-1.3	1.2	-1.0	0.6
Rheumatoid Arthritis	0.4	0.6	2.3	0.5	-0.8	0.9	0.0	0.2	-0.0	-1.5
Triglycerides	0.4	0.6	1.6	0.5	-0.2	-0.5	0.3	1.1	0.9	1.3
Ulcerative Colitis	0.4	0.6	2.8	0.4	-1.7	-0.2	0.0	0.3	-1.0	-0.4
Supplements: Zinc	0.4	0.4	1.4	0.8	-0.2	-0.7	0.1	1.2	-0.4	0.0
Hand grip strength (right)	0.4	1.1	3.3	-0.5	1.7	-0.3	-0.0	-0.7	0.7	1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.8	-1.0	1.2	-0.5	0.5	-0.0	0.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.2	0.2	0.2	1.3	1.5	-1.2	0.1	0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.6	0.7	-0.3	0.8	-0.8	-1.2	-0.3
Had menopause	0.4	0.5	3.0	-0.2	-0.5	-1.7	0.1	-0.1	-0.6	0.3
Allergy	0.4	0.9	2.0	-0.1	-0.4	-1.4	-1.1	1.1	-1.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.2	0.6	-0.1	0.8	1.5	-0.6	-0.2	0.0
Worrier / anxious feelings	0.4	0.8	1.9	1.0	-0.7	-0.2	-1.4	0.9	-0.9	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	2.4	-0.9	0.4	0.7	0.8	-1.6	0.2	-0.7
Lung cancer (father)	0.4	0.5	1.5	0.5	0.0	-0.4	1.0	1.2	0.8	-0.3
Blood clot in the leg (DVT)	0.4	0.5	1.8	0.4	0.4	0.5	-1.3	0.6	0.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.8	0.9	-0.2	-0.5	-0.7	-1.2	0.3
Suffer from ‘nerves’	0.4	0.6	2.1	1.0	-1.4	0.1	0.8	0.1	0.0	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-0.6	0.1	0.0	1.1	-0.7	-0.5	1.0
Long-standing illness, disability or infirmity	0.4	0.6	1.4	1.2	-0.7	0.9	-0.2	0.8	-0.2	-1.0
Ever had bowel cancer screening	0.4	0.4	1.8	-0.5	0.4	0.1	0.4	-0.5	1.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	-0.6	1.0	0.1	1.1	-0.6	0.1	-0.2
Asthma (self-reported)	0.4	0.9	2.6	-0.9	1.0	-0.0	-0.3	-1.1	1.6	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.4	-1.0	0.9	0.8	-0.3	-0.0	0.9
Number of self-reported non-cancer illnesses	0.4	0.6	1.6	0.9	-0.8	1.0	0.3	0.6	-0.1	-1.3
Pain experienced in last month	0.4	0.7	2.0	-1.4	0.7	-0.4	0.5	-1.3	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.3	0.5	0.3	-1.1	0.6	0.9	0.7
Alcohol drinker status: Previous	0.4	0.4	2.1	0.0	0.1	0.6	-0.2	0.0	-0.7	-1.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.8	0.1	-1.3	-0.0	1.7	0.0	-0.3	0.2
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.6	-0.6	-0.5	-0.9	0.9	-0.2	-0.2
Blood Red Count	0.3	2.9	7.5	2.0	-1.3	0.5	-2.7	2.1	1.2	-1.1
Blood White Count	0.3	2.1	4.8	1.7	-1.3	2.2	-0.8	1.5	0.3	-1.6
Smoking Status	0.3	0.8	2.4	-0.4	1.6	0.7	-1.1	-0.5	-0.2	-1.0
Tanning	0.3	3.2	8.1	2.4	-1.7	2.8	-1.0	2.0	-0.6	-0.8
Average weekly fortified wine intake	0.3	0.4	1.7	0.4	0.5	0.4	0.5	0.1	0.5	-1.3
Fluid intelligence score	0.3	0.7	2.2	0.5	-1.5	-0.2	0.5	-0.2	-0.7	1.1
Prospective memory result	0.3	0.3	0.8	-0.1	-0.0	0.7	0.7	-0.6	0.9	0.4
Breastfed as a baby	0.3	0.3	1.0	0.9	-1.0	0.1	-0.1	0.7	0.1	0.1
Loud music exposure frequency	0.3	0.3	1.0	0.5	-0.4	-0.2	1.0	0.3	0.2	0.9
Wheeze or whistling in the chest in last year	0.3	0.6	1.8	0.2	-0.2	-1.1	-0.5	0.8	1.3	0.4
Pulse rate, automated reading	0.3	0.8	3.0	-1.3	1.7	-0.4	-0.1	-1.0	-0.4	-0.0
Knee pain experienced in last month	0.3	0.5	1.9	0.9	-1.4	0.7	-0.1	0.1	-0.2	-0.5
Friendships satisfaction	0.3	0.4	2.2	0.6	-0.3	0.6	1.5	0.1	0.2	0.0
Qualifications: nursing, teaching	0.3	0.5	2.8	0.4	-0.4	-0.4	-1.7	0.6	0.3	0.1
Irritability	0.3	0.5	1.3	-0.6	1.1	-0.9	0.1	-0.5	1.0	-0.2
Crohns Disease (2017)	0.2	0.4	1.3	-0.3	-0.0	0.8	1.1	-0.7	-0.2	0.7
HbA1C	0.2	0.2	0.7	0.3	-0.5	0.4	0.3	0.4	-0.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.3	0.7	0.4	0.0	0.0	-0.3	-0.7
Blood Eosinophil Count	0.2	1.8	5.0	0.3	0.4	1.0	-2.0	-0.3	-2.2	-1.5
Blood Platelet Count	0.2	1.8	10.6	-0.5	0.9	-0.3	-0.0	-0.5	-3.2	-0.8
Heel T-Score	0.2	1.7	9.3	-0.9	0.7	-0.1	-0.2	-1.0	0.2	-3.0
Hypothyroidism (self reported)	0.2	0.4	0.9	0.4	-0.9	0.5	-0.5	-0.2	-0.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.1	-0.2	0.8	0.6	-0.4	-0.1	0.3
Medication: Atenolol	0.2	0.3	0.7	0.2	-0.4	0.9	-0.4	0.3	0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-0.3	0.3	-0.0	-0.5	-1.3	0.7	-0.3
Medication: Amlodipine	0.2	0.3	0.9	0.9	-0.8	0.2	-0.1	0.9	0.1	-0.1
Number of full sisters	0.2	0.3	0.7	-0.2	0.2	-0.7	0.8	-0.3	0.5	0.4
Had major operations	0.2	0.3	1.0	-0.4	0.3	-0.5	-1.0	-0.3	0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.2	-0.3	-0.8	0.6	0.2	0.2	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.9	-0.4	-0.1	0.5	-0.1	-0.8	1.4	-0.1
Heart disease (siblings)	0.2	0.2	0.7	0.1	0.1	0.1	0.6	0.7	0.1	-0.9
Waist Hip Ratio (WHR)	0.1	0.4	1.4	0.1	0.6	-0.7	-0.5	0.5	0.1	1.2
Systolic Blood Pressure	0.1	0.3	0.8	0.0	-0.1	0.5	-0.5	-0.1	0.8	-0.9
Systolic blood pressure, automated reading	0.1	0.3	1.0	0.0	0.2	0.5	0.5	-0.2	0.8	-1.0
Medication: Levothyroxine sodium	0.1	0.1	0.6	-0.2	0.1	0.1	-0.8	-0.4	-0.2	0.3
Illnesses of siblings	0.1	0.2	0.5	-0.4	0.1	-0.3	-0.3	-0.7	0.5	-0.2
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	0.4	-0.6	0.1	-0.0	0.7	0.3
Crohns Disease (2012)	0.0	0.0	0.2	-0.3	-0.1	-0.0	0.0	-0.4	0.1	0.2
Allergy or Eczema	0.0	0.1	0.2	0.4	0.0	0.1	0.3	-0.4	0.1	0.3
Hair Pigment	0.0	0.6	2.8	-0.1	1.1	0.1	0.1	-0.0	1.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	-0.4	0.0	-0.2	-0.1	-0.6	-0.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.3	0.6	0.1	0.1	0.0	-0.2	-0.1	-0.2

Hub : Genes

IGFBP2

Models

Trait associations