Hub : Genes

IGFBP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0940 0.0260 2.9e-06 0.041 0.033 0.053 0.039 0.037 7.7e-06 6.0e-05 4.8e-07 1.5e-05 2.1e-05
2 GTEx Adrenal Gland 0.5411 0.0974 7.5e-06 0.300 NA 0.272 NA 0.309 2.3e-11 NA 2.7e-10 NA 1.0e-11
3 GTEx Nerve Tibial 0.1415 0.0469 7.6e-04 0.082 NA 0.085 NA 0.076 2.1e-06 NA 1.3e-06 NA 4.9e-06
4 GTEx Whole Blood 0.1040 0.0410 6.5e-03 0.217 NA 0.201 NA 0.217 8.9e-20 NA 2.6e-18 NA 9.9e-20
5 ROSMAP Brain Pre-frontal Cortex 0.0994 0.0262 9.3e-06 0.045 0.049 0.057 0.045 0.028 1.7e-06 5.7e-07 7.2e-08 1.6e-06 1.2e-04
6 YFS Blood 0.0204 0.0107 1.4e-02 0.001 0.005 0.002 0.007 0.002 1.8e-01 7.5e-03 8.2e-02 1.3e-03 6.7e-02
7 TCGA Glioblastoma Multiforme 0.1890 0.0800 3.1e-03 0.022 0.027 0.043 NA 0.011 7.0e-02 5.3e-02 2.0e-02 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.9 1.4 3.8 -1.9 1.5 0.1 0.0 -1.5 -0.9 0.9
Bipolar Disorder or Schizophrenia 0.6 1.6 10.6 -0.2 0.2 0.4 0.0 0.2 -3.3 -0.1
Depressed Affect (Nagel 2018) 0.7 1.4 3.0 1.2 -0.8 1.2 1.7 0.6 -1.0 -1.5
Depression (Nagel 2018) 3.5 5.3 8.3 2.9 -2.4 2.6 1.6 2.5 -2.0 -1.7
Intelligence (Savage-Jansen 2018) 0.7 2.3 5.2 -1.6 1.0 -0.2 1.6 -1.9 1.1 2.3
Neuroticism (Nagel 2018) 0.9 2.1 4.8 2.2 -1.7 1.6 1.2 1.3 -0.9 -0.6
Schizophrenia (2018) 1.2 2.5 11.8 1.3 -0.9 0.4 0.0 1.5 -3.4 -0.6
Schizophrenia vs Biploar Disorder 4.8 6.3 16.1 4.0 -2.9 1.8 0.0 3.7 0.3 -1.6
Worry (Nagel 2018) 1.5 3.3 7.9 2.8 -2.5 2.2 -0.2 1.8 -0.7 -0.5
Alzheimer’s Disease (in mother) 0.8 0.9 2.2 1.1 -0.4 -0.2 0.8 1.2 -1.0 -1.5
Alzheimer’s Disease (in father) 1.7 1.8 3.6 1.3 -1.0 -0.1 -0.5 1.6 -1.9 -1.9
Alzheimer’s Disease (including proxy) 1.2 1.7 5.1 1.4 -0.6 0.1 -0.1 1.4 -1.7 -2.3
Crohns Disease (2017) 0.2 0.4 1.3 -0.3 -0.0 0.8 1.1 -0.7 -0.2 0.7
Irritable Bowel Disease (IBD) 0.3 0.7 2.8 0.1 -1.3 -0.0 1.7 0.0 -0.3 0.2
Ulcerative Colitis (UC) 0.4 0.7 2.2 -0.0 -1.5 -1.1 1.1 0.2 0.2 0.5
Major Depression (MDD) 0.9 1.1 2.5 1.5 -0.6 -0.1 -1.4 1.6 -0.8 -0.3
Reaction Time 3.7 7.1 13.8 3.0 -3.7 0.4 -0.7 3.5 -3.5 -1.6
Verbal and Numeric Reasoning (VNR) 0.8 2.0 7.2 -0.9 -0.5 -0.4 2.7 -1.5 -0.2 1.8
Breast Cancer 1.9 4.7 9.4 3.1 -2.1 2.8 1.8 2.4 -1.5 -0.1
Ovarian Cancer 0.7 0.9 5.0 0.1 -0.7 2.2 0.2 -0.8 0.2 0.1
Prostate Cancer 1.1 1.5 4.6 -1.1 0.8 -1.3 -2.1 -1.4 0.1 -0.5
Age at First Birth 0.6 0.9 2.9 -1.0 -0.4 -1.2 -0.6 -0.7 1.7 0.1
Bipolar Disorder (2011) 0.8 0.7 4.0 -0.5 0.6 0.4 0.0 -0.6 -2.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 0.6 -0.6 -0.5 -0.9 0.9 -0.2 -0.2
Coronary Artery Disease (CAD) 1.2 1.4 2.5 -1.5 1.4 -0.5 0.0 -1.4 -1.0 -1.6
Crohns Disease (2012) 0.0 0.0 0.2 -0.3 -0.1 -0.0 0.0 -0.4 0.1 0.2
Mean Putamen Volume 0.7 0.8 4.1 -0.5 0.9 -0.6 0.4 -0.1 0.2 2.0
Fasting Glucose 0.6 0.7 2.5 0.2 -0.2 -1.6 -1.1 0.4 -0.2 1.0
HbA1C 0.2 0.2 0.7 0.3 -0.5 0.4 0.3 0.4 -0.8 -0.4
HDL Cholesterol 0.4 0.6 2.5 0.7 -0.7 -0.4 1.6 0.8 0.5 0.2
LDL Cholesterol 0.6 0.9 3.9 -0.1 1.1 0.4 1.1 0.1 2.0 -0.3
Lupus 0.4 0.7 1.6 0.1 -0.5 -0.0 -1.3 1.2 -1.0 0.6
Neuroticism (2016) 0.6 0.9 4.2 0.8 -0.2 -0.4 2.1 0.8 -0.5 0.4
Primary Biliary Cirrhosis 1.5 2.2 6.6 1.6 -1.9 0.1 -0.3 1.5 -2.6 0.0
Rheumatoid Arthritis 0.4 0.6 2.3 0.5 -0.8 0.9 0.0 0.2 -0.0 -1.5
Schizophrenia (2014) 1.4 3.0 11.9 1.8 -1.4 0.7 0.0 1.7 -3.5 -0.8
Triglycerides 0.4 0.6 1.6 0.5 -0.2 -0.5 0.3 1.1 0.9 1.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.5 0.3 0.7 0.4 0.0 0.0 -0.3 -0.7
Ulcerative Colitis 0.4 0.6 2.8 0.4 -1.7 -0.2 0.0 0.3 -1.0 -0.4
Blood Eosinophil Count 0.2 1.8 5.0 0.3 0.4 1.0 -2.0 -0.3 -2.2 -1.5
Blood Platelet Count 0.2 1.8 10.6 -0.5 0.9 -0.3 -0.0 -0.5 -3.2 -0.8
Blood Red Count 0.3 2.9 7.5 2.0 -1.3 0.5 -2.7 2.1 1.2 -1.1
Blood White Count 0.3 2.1 4.8 1.7 -1.3 2.2 -0.8 1.5 0.3 -1.6
Heel T-Score 0.2 1.7 9.3 -0.9 0.7 -0.1 -0.2 -1.0 0.2 -3.0
BMI 1.9 10.8 25.0 5.0 -4.0 2.4 -0.9 4.9 -1.6 -1.3
Height 0.5 9.2 34.3 1.9 -0.8 1.0 -5.9 0.9 -3.3 3.7
Waist Hip Ratio (WHR) 0.1 0.4 1.4 0.1 0.6 -0.7 -0.5 0.5 0.1 1.2
Systolic Blood Pressure 0.1 0.3 0.8 0.0 -0.1 0.5 -0.5 -0.1 0.8 -0.9
Smoking Status 0.3 0.8 2.4 -0.4 1.6 0.7 -1.1 -0.5 -0.2 -1.0
Allergy or Eczema 0.0 0.1 0.2 0.4 0.0 0.1 0.3 -0.4 0.1 0.3
Cardiovascular Disease 0.7 2.4 4.8 2.1 -2.0 2.2 0.5 1.6 -0.3 -0.6
Hypothyroidism (self reported) 0.2 0.4 0.9 0.4 -0.9 0.5 -0.5 -0.2 -0.9 -0.5
Respiratory disease 0.5 1.2 3.2 -1.0 1.2 -1.0 -0.7 -0.9 1.8 0.8
Type 2 Diabetes (T2D) (2018) 2.0 3.7 6.1 2.4 -2.5 1.8 -1.3 2.1 -1.1 -1.9
Lung FEV1/FVC ratio 0.6 3.0 5.4 2.1 -2.3 1.5 1.8 1.3 -1.7 1.1
Lung FVC 1.7 8.5 18.7 -4.3 2.4 -2.8 1.9 -3.4 2.4 2.6
Neuroticism 0.9 2.2 4.2 2.0 -1.8 1.8 1.2 1.2 -0.5 -1.1
Chronotype (morning person) 1.6 3.8 10.4 -2.0 1.8 -2.1 -0.2 -2.0 3.2 -0.7
Hair Pigment 0.0 0.6 2.8 -0.1 1.1 0.1 0.1 -0.0 1.7 -0.1
Tanning 0.3 3.2 8.1 2.4 -1.7 2.8 -1.0 2.0 -0.6 -0.8
Hand grip strength (left) 1.0 2.6 6.2 -1.1 2.4 -0.8 0.2 -1.1 1.7 2.5
Number of treatments/medications taken 0.5 0.8 1.8 1.0 -1.2 0.2 1.3 0.7 -0.8 -0.8
Average weekly spirits intake 0.9 1.1 2.2 0.1 0.7 -1.5 -1.3 0.8 1.5 -0.7
Sensitivity / hurt feelings 1.0 1.7 5.1 2.2 -1.1 0.5 -0.3 2.0 -0.5 -0.9
Frequency of depressed mood in last 2 weeks 1.5 2.0 3.7 1.9 -1.3 1.1 0.2 1.8 -1.7 -1.3
Hearing difficulty/problems: Yes 0.5 0.7 2.0 -0.7 1.4 -0.4 -0.1 0.1 -0.7 1.4
Relative age of first facial hair 5.0 10.3 18.2 -4.3 4.3 -2.3 1.9 -3.8 3.3 1.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.0 -1.0 1.3 -0.7 0.3 -1.4 0.2 -0.4
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.9 1.2 -1.0 0.8 1.7 1.3 -0.0 -0.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 -1.2 1.1 0.1 0.0 -1.2 -0.0 -0.2
Systolic blood pressure, automated reading 0.1 0.3 1.0 0.0 0.2 0.5 0.5 -0.2 0.8 -1.0
Eye problems/disorders: Diabetes related eye disease 2.4 2.6 4.9 2.0 -2.1 0.9 -0.4 2.0 -2.2 -0.2
Angina 0.7 1.0 2.7 1.4 -0.8 -0.1 -0.5 1.1 -1.6 -0.3
Medication for hormone replacement therapy 0.5 0.6 1.0 0.9 -0.5 0.9 -0.1 0.8 0.6 1.0
Vitamin and mineral supplements 3.6 4.8 11.6 -3.4 2.0 -2.1 -0.0 -2.9 1.6 1.6
Supplements: Zinc 0.4 0.4 1.4 0.8 -0.2 -0.7 0.1 1.2 -0.4 0.0
Medication: Co-codamol 2.2 2.5 8.2 2.3 -1.5 0.1 -0.1 2.9 0.6 -1.1
Medication: Metformin 1.5 2.2 5.3 1.7 -1.6 0.6 -2.3 1.4 -1.0 -1.1
Diabetes (father) 0.9 1.2 2.9 0.6 -1.0 -1.5 -1.7 1.3 0.0 0.2
Diabetes (mother) 0.9 1.2 2.6 1.3 -1.0 1.6 -0.5 0.9 -1.3 0.4
Severe depression (siblings) 1.3 1.5 3.8 1.1 0.1 -0.9 -0.6 1.9 -1.4 -1.6
Pack years adult smoking proportion 1.9 2.9 4.2 2.1 -1.9 1.6 -1.9 1.5 -1.6 -1.4
Impedance of leg (right) 0.5 2.4 5.4 -2.2 1.6 0.3 1.2 -2.3 -0.9 -1.3
Leg fat-free mass (left) 1.3 6.7 16.4 4.0 -2.8 0.9 -2.2 3.5 -1.4 1.7
Trunk fat percentage 2.0 8.0 17.5 4.2 -3.4 1.0 1.1 3.9 -2.8 -1.1
Hand grip strength (right) 0.4 1.1 3.3 -0.5 1.7 -0.3 -0.0 -0.7 0.7 1.8
Townsend deprivation index at recruitment 1.7 2.3 6.5 1.7 -1.3 0.7 -1.9 2.5 -1.2 -0.0
Current tobacco smoking 0.9 1.5 3.8 0.6 0.5 1.5 -1.1 0.3 -2.0 -1.7
Average weekly fortified wine intake 0.3 0.4 1.7 0.4 0.5 0.4 0.5 0.1 0.5 -1.3
Maternal smoking around birth 0.7 1.0 4.8 0.4 -0.2 1.2 -0.6 0.1 -0.4 -2.2
Fed-up feelings 1.1 1.9 6.2 1.3 -0.7 0.2 -0.1 1.2 -1.9 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 7.3 2.7 -2.4 1.0 -0.4 2.6 -2.2 -1.8
Relative age voice broke 1.6 2.4 6.2 -1.6 2.0 -1.1 0.9 -1.3 2.5 0.6
Taking other prescription medications 0.9 1.4 3.7 -1.5 1.9 -0.1 0.8 -1.5 0.2 -1.0
Age when periods started (menarche) 0.9 2.1 5.0 -1.6 2.2 -2.2 0.8 -0.7 1.0 -0.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 0.8 -1.0 1.2 -0.5 0.5 -0.0 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.1 -1.0 1.1 0.1 -1.1 -1.8 0.6 -0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 -0.1 -0.2 0.8 0.6 -0.4 -0.1 0.3
Qualifications: CSEs or equivalent 1.1 1.4 2.6 1.6 -0.4 1.1 -0.1 1.6 -1.3 -1.4
Serious illness, injury or assault to yourself 0.6 0.8 1.7 1.2 -1.1 0.8 -0.0 1.3 -0.4 0.5
High blood pressure 1.1 3.1 6.0 2.5 -2.4 1.5 1.0 2.4 -0.7 -0.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.2 0.2 0.2 1.3 1.5 -1.2 0.1 0.5
Multivitamins +/- minerals 2.4 3.0 5.5 2.4 -1.9 1.8 -0.3 2.0 -2.1 -0.5
Stomach or abdominal pain in last month 0.8 1.0 1.8 1.3 -0.6 0.9 1.0 1.4 -0.2 -1.3
Supplements: Glucosamine 1.7 2.2 6.9 1.8 -2.6 1.8 1.0 0.7 -0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 5.2 -1.0 0.5 -0.7 2.3 -1.1 1.2 0.8
Medication: Atenolol 0.2 0.3 0.7 0.2 -0.4 0.9 -0.4 0.3 0.1 -0.8
Medication: Levothyroxine sodium 0.1 0.1 0.6 -0.2 0.1 0.1 -0.8 -0.4 -0.2 0.3
Sitting height 1.1 8.1 13.5 3.0 -3.0 2.7 -3.7 1.7 -2.4 3.0
Chronic bronchitis/emphysema (father) 1.1 1.3 6.4 -1.0 0.5 -1.0 -0.2 -0.6 -2.5 0.3
High blood pressure (mother) 0.6 0.9 3.9 -0.9 2.0 0.0 0.3 -0.7 0.8 -0.2
Body mass index (BMI) 1.9 8.3 21.1 4.6 -3.5 1.3 -0.4 4.4 -0.9 -1.6
Impedance of leg (left) 0.6 2.7 5.3 -1.7 1.0 1.6 1.3 -2.3 -1.5 -1.8
Leg predicted mass (left) 1.3 6.7 16.5 4.1 -2.8 0.9 -2.2 3.5 -1.4 1.6
Trunk fat mass 2.1 9.2 21.8 4.7 -3.8 1.4 -0.1 4.2 -2.8 -0.6
Waist circumference 2.6 9.6 24.0 4.9 -3.8 1.7 -0.6 4.5 -2.2 -0.5
Number of incorrect matches in round 0.9 1.4 7.8 -0.7 1.1 -0.7 -2.8 -0.1 0.2 -0.2
Past tobacco smoking 1.6 3.0 5.1 2.0 -1.8 1.2 0.5 1.8 -2.2 2.0
Alcohol usually taken with meals 0.5 0.8 4.2 0.9 -2.0 -0.1 -0.6 0.6 0.3 -0.2
Nervous feelings 1.0 1.8 4.6 1.9 -2.1 0.9 -0.7 1.1 -1.4 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 6.1 -0.3 0.8 0.2 0.1 -0.9 -0.5 -2.5
Hearing difficulty/problems with background noise 1.1 1.7 3.2 1.6 -1.8 1.8 0.8 1.0 0.0 1.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.4 -0.6 0.7 -0.3 0.8 -0.8 -1.2 -0.3
Had menopause 0.4 0.5 3.0 -0.2 -0.5 -1.7 0.1 -0.1 -0.6 0.3
Had other major operations 0.5 0.6 2.7 -0.1 0.8 0.2 -1.6 0.8 -0.1 -0.3
Forced vital capacity (FVC) 0.8 3.3 13.7 -2.0 0.4 -1.0 -0.4 -1.9 -0.1 3.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.6 -0.3 0.3 -0.0 -0.5 -1.3 0.7 -0.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.6 1.1 0.1 1.1 1.6 1.3 -0.8 -0.9
Qualifications: None of the above 1.1 2.3 5.2 1.1 -1.7 0.8 1.7 1.3 -1.1 -2.3
Financial difficulties in last 2 years 1.6 2.1 6.2 0.9 0.2 -0.8 0.2 1.3 -2.5 -2.3
Mouth/teeth dental problems 0.6 0.9 4.2 -0.5 0.4 -1.0 -2.1 0.4 0.3 0.9
Heart attack 0.7 0.9 1.8 1.3 -0.5 0.5 -1.0 1.0 -0.9 -1.1
Allergy 0.4 0.9 2.0 -0.1 -0.4 -1.4 -1.1 1.1 -1.2 -0.2
Pain all over the body in last month 0.7 0.8 3.0 0.3 0.1 -0.7 0.7 0.5 -1.1 -1.7
Diabetes (self-reported) 4.3 6.6 10.9 3.3 -3.1 1.6 -1.9 3.3 -2.1 -2.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.2 0.6 -0.1 0.8 1.5 -0.6 -0.2 0.0
Medication: Ramipril 0.7 0.9 3.8 0.7 -0.2 -0.9 1.0 0.7 1.9 0.3
Medication: Simvastatin 1.7 2.5 6.7 2.2 -1.8 0.8 1.1 2.6 0.0 -0.9
Fluid intelligence score 0.3 0.7 2.2 0.5 -1.5 -0.2 0.5 -0.2 -0.7 1.1
Illnesses of siblings 0.1 0.2 0.5 -0.4 0.1 -0.3 -0.3 -0.7 0.5 -0.2
Neuroticism score 1.1 2.4 4.5 2.1 -1.4 0.9 -0.9 1.7 -1.4 -1.9
Weight 1.8 9.1 23.1 4.8 -3.8 1.5 -1.6 4.1 -2.0 0.2
Impedance of arm (right) 0.8 3.7 10.0 -1.5 1.0 -1.6 3.2 -1.3 -2.8 0.6
Arm fat percentage (right) 2.4 9.5 23.0 4.7 -3.5 0.8 1.0 4.8 -2.5 -1.1
Trunk fat-free mass 0.9 5.0 11.0 2.8 -2.2 1.4 -3.3 2.1 -0.3 2.2
Hip circumference 2.7 11.7 26.3 5.1 -4.5 1.9 -1.0 4.4 -3.3 -0.6
Time employed in main current job 1.8 2.1 4.4 1.6 -1.1 1.9 -0.8 1.3 -2.1 -0.8
Alcohol intake versus 10 years previously 0.8 1.2 2.6 1.6 -1.2 0.3 0.2 1.5 -0.7 -1.4
Father’s age at death 1.4 1.9 2.9 1.5 -1.3 1.1 -1.2 1.3 -1.5 1.7
Worrier / anxious feelings 0.4 0.8 1.9 1.0 -0.7 -0.2 -1.4 0.9 -0.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.0 1.1 -0.4 -0.6 0.4 1.4 -0.9 -1.1
Falls in the last year 2.3 3.1 5.2 2.0 -0.9 2.3 -0.9 1.9 -1.7 -2.1
Hair/balding pattern: Pattern 3 0.7 1.1 6.4 -0.1 0.9 -0.3 -2.5 0.4 0.6 0.2
Number of live births 0.8 1.1 2.7 1.6 -0.5 -0.1 -0.1 1.5 -0.1 -1.6
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 13.8 -1.7 0.3 -0.8 0.4 -1.8 -0.1 3.7
Pulse rate 1.0 1.7 5.6 -1.8 2.4 -0.8 -0.2 -1.6 -0.1 0.1
Happiness 0.6 0.7 1.4 -0.5 1.1 0.4 -0.4 -0.8 -1.0 -1.2
Noisy workplace 1.4 1.7 3.4 -1.5 1.6 0.3 0.5 -1.8 1.7 -0.7
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.6 -0.1 0.8 -1.3 -0.5 -0.4 -1.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.8 -1.0 1.0 -1.3 -0.0 -1.3 -0.9 1.3
Mouth/teeth dental problems: Dentures 0.4 0.7 2.4 -0.9 0.4 0.7 0.8 -1.6 0.2 -0.7
Asthma 0.5 1.0 3.4 -0.8 1.1 0.1 -0.2 -1.1 1.9 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.2 1.8 -1.3 0.9 1.2 1.7 -1.2 1.1
Medication: Cholesterol lowering 1.2 1.8 4.7 2.0 -1.5 0.8 -0.1 2.2 0.5 1.0
Depression (self-reported) 0.6 0.7 2.7 1.0 -0.2 1.1 0.2 0.4 0.1 -1.6
Medication: Lansoprazole 0.9 1.0 3.5 -0.7 1.2 -1.9 0.8 -0.5 0.8 0.1
Prospective memory result 0.3 0.3 0.8 -0.1 -0.0 0.7 0.7 -0.6 0.9 0.4
Lung cancer (father) 0.4 0.5 1.5 0.5 0.0 -0.4 1.0 1.2 0.8 -0.3
Illnesses of mother 0.8 0.9 2.3 -1.5 1.0 -0.1 0.0 -1.5 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 14.1 -1.5 -0.4 -0.1 -0.4 -1.6 -0.9 3.8
Pulse wave Arterial Stiffness index 0.8 0.9 2.4 -1.5 1.3 -0.4 0.2 -1.4 0.2 -0.2
Impedance of arm (left) 0.8 3.7 8.2 -2.0 1.1 -2.2 2.9 -1.7 -2.1 0.5
Arm fat mass (right) 2.2 9.1 22.0 4.7 -3.6 0.8 -0.5 4.6 -2.5 -0.7
Trunk predicted mass 0.9 5.2 11.5 2.9 -2.3 1.3 -3.4 2.1 -0.4 2.2
Standing height 0.5 4.9 16.6 1.1 -1.3 0.6 -2.7 -0.1 -2.6 4.1
Length of working week for main job 0.5 0.5 2.2 -0.2 0.7 -0.1 1.5 -0.4 -0.3 0.7
Exposure to tobacco smoke at home 1.0 1.1 3.1 1.4 -1.2 -0.2 -0.9 1.8 0.2 -0.4
Breastfed as a baby 0.3 0.3 1.0 0.9 -1.0 0.1 -0.1 0.7 0.1 0.1
Tense / ‘highly strung’ 1.3 2.2 5.4 1.8 -1.2 2.3 -1.4 1.2 -0.5 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 16.4 0.4 0.5 0.1 0.1 0.3 -0.3 -4.0
Hair/balding pattern: Pattern 4 0.5 1.1 4.9 0.6 -1.5 0.2 0.6 0.3 2.2 -0.3
Birth weight of first child 1.2 2.2 8.4 -0.3 0.3 -1.4 -1.8 0.3 -1.3 2.9
Peak expiratory flow (PEF) 2.2 5.0 23.8 -1.6 -0.1 -0.1 2.1 -2.1 0.3 4.9
Pulse wave reflection index 0.6 0.8 2.9 0.8 -0.8 1.7 0.6 0.3 -0.1 -0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.8 -0.5 0.8 -0.9 -0.6 -0.2 -0.4 -1.4
Loud music exposure frequency 0.3 0.3 1.0 0.5 -0.4 -0.2 1.0 0.3 0.2 0.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.0 -0.1 0.6 -1.4 -1.1 0.0 -1.4 1.1
Mouth/teeth dental problems: Bleeding gums 2.6 3.4 7.5 2.6 -2.6 0.9 0.8 2.7 -0.7 -0.9
Blood clot in the leg (DVT) 0.4 0.5 1.8 0.4 0.4 0.5 -1.3 0.6 0.5 0.6
Medication: Paracetamol 2.1 3.4 6.2 2.5 -2.2 1.4 -0.7 2.2 -1.7 -1.8
Headache pain in last month 2.5 4.3 11.3 2.0 -2.3 1.1 0.6 2.1 -3.4 -2.0
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 4.8 -2.1 1.9 -2.0 0.2 -2.2 -0.5 -0.8
Glaucoma (self-reported) 2.1 2.5 6.1 2.0 -1.5 1.4 -0.2 1.6 1.0 -2.5
Gout (self-reported) 1.1 1.5 6.2 0.3 0.2 2.5 -1.6 -0.2 -0.0 -1.2
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.3 -0.4 0.0 -0.2 -0.1 -0.6 -0.3 -0.0
Medication: Amlodipine 0.2 0.3 0.9 0.9 -0.8 0.2 -0.1 0.9 0.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.7 0.4 -0.0 -0.3 -0.9 1.1 1.1 1.3
Birth weight 1.6 3.5 5.9 1.8 -1.7 1.5 -2.3 1.8 -1.4 2.4
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.4 1.3 -1.5 1.0 -0.1 1.3 -0.4 -0.1
High blood pressure (siblings) 0.1 0.2 0.5 -0.3 0.4 -0.6 0.1 -0.0 0.7 0.3
Forced vital capacity (FVC), Best measure 0.8 3.0 13.7 -1.7 -0.2 -0.1 -1.0 -1.8 -0.4 3.7
Body fat percentage 2.2 8.8 19.7 4.4 -3.5 1.4 0.8 4.2 -2.4 -1.8
Leg fat percentage (right) 2.2 8.0 17.9 4.2 -3.1 2.1 0.3 4.0 -1.6 -2.3
Arm fat-free mass (right) 1.0 5.1 10.1 3.2 -2.3 1.5 -3.2 2.5 -0.4 1.3
Exposure to tobacco smoke outside home 1.6 2.1 4.4 1.5 -2.0 -0.6 -1.8 2.1 -0.8 0.5
Comparative body size at age 10 0.8 2.2 4.3 2.0 -2.0 1.0 0.1 2.1 0.8 -1.1
Number of full brothers 0.6 0.7 1.7 0.5 -0.5 -0.7 1.2 0.5 -0.9 -1.3
Worry too long after embarrassment 0.8 1.4 3.7 1.7 -1.9 -0.1 0.0 1.5 -0.8 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.2 1.9 -0.9 0.2 -1.8 2.1 0.5 -1.8
Wheeze or whistling in the chest in last year 0.3 0.6 1.8 0.2 -0.2 -1.1 -0.5 0.8 1.3 0.4
Number of children fathered 0.7 0.8 2.1 -0.9 1.2 0.3 1.4 -0.7 -0.4 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 5.8 -1.1 0.5 -1.5 -2.4 -0.7 1.2 0.4
Age at first live birth 0.6 1.1 3.2 0.1 -0.5 0.6 1.6 0.3 1.1 1.8
Pulse wave peak to peak time 1.0 1.1 2.7 1.6 -1.4 0.2 -0.5 1.6 -0.4 0.6
Health satisfaction 0.6 0.7 1.4 0.5 -1.2 0.7 -0.8 0.3 1.1 -1.1
Shortness of breath walking on level ground 2.0 2.4 4.5 1.8 -2.0 1.4 1.2 2.1 1.1 -0.8
Qualifications: College or University degree 0.5 1.5 4.7 -0.8 0.7 -0.5 -2.2 -0.8 1.5 1.1
Eye problems/disorders: None of the above 1.8 2.1 5.0 -1.7 1.5 -0.9 -2.2 -1.3 0.2 1.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.8 0.9 -1.1 1.2 -0.8 0.1 -0.5 -1.7
Emphysema/chronic bronchitis 0.8 1.0 2.6 0.7 -0.8 -1.6 0.3 1.6 -0.3 -0.3
Medication for pain relief, constipation, heartburn 1.2 2.0 4.5 -2.1 1.7 -0.9 -0.7 -2.0 0.9 0.4
Neck or shoulder pain in last month 1.9 2.8 6.8 2.6 -1.3 0.8 -1.3 2.6 -0.5 -1.3
Medication: Blood pressure 0.7 1.3 2.5 1.4 -1.2 1.6 -0.7 1.6 0.2 -0.2
Angina (self-reported) 0.9 1.2 2.8 1.6 -0.9 0.1 -0.4 1.3 -1.7 -0.2
Migraine (self-reported) 1.5 1.8 3.4 1.2 -1.0 1.7 -1.4 0.9 -1.9 -1.0
Medication: Ibuprofen 1.4 1.7 4.3 1.4 -0.8 0.9 1.4 1.4 -0.1 2.1
Medication: Allopurinol 1.3 1.8 4.1 -1.3 1.3 2.0 -0.9 -1.6 0.0 -1.2
Medication: Omeprazole 0.8 0.9 5.4 -0.1 0.6 0.0 2.3 0.2 0.6 0.7
Medication: Seretide 50 evohaler 0.5 0.5 1.7 0.2 -0.2 -0.8 -0.1 1.3 1.2 -0.0
Mean time to correctly identify matches 2.8 5.4 12.0 2.6 -3.5 -0.6 -0.1 3.3 -2.3 -1.4
Heart disease (mother) 1.5 1.8 5.8 -0.0 0.6 -1.9 -0.8 0.4 1.5 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.4 -0.8 0.9 -0.2 -0.5 -0.7 -1.2 0.3
Whole body fat mass 2.3 9.6 23.0 4.8 -3.8 1.7 -0.5 4.4 -2.6 -1.1
Leg fat mass (right) 2.8 10.7 26.2 5.1 -4.0 2.3 -0.8 4.7 -1.9 -1.5
Arm predicted mass (right) 1.1 5.4 10.8 3.3 -2.6 1.4 -3.2 2.5 -0.3 1.2
Pulse rate, automated reading 0.3 0.8 3.0 -1.3 1.7 -0.4 -0.1 -1.0 -0.4 -0.0
Alcohol intake frequency. 1.5 3.5 7.1 1.6 -1.5 1.8 0.7 1.5 -2.7 -2.7
Comparative height size at age 10 1.3 7.2 17.0 2.7 -3.0 1.7 -4.1 1.6 -3.2 1.2
Number of full sisters 0.2 0.3 0.7 -0.2 0.2 -0.7 0.8 -0.3 0.5 0.4
Suffer from ‘nerves’ 0.4 0.6 2.1 1.0 -1.4 0.1 0.8 0.1 0.0 -0.7
Overall health rating 1.0 2.2 4.1 1.6 -2.0 1.4 0.8 1.0 1.0 -1.9
Chest pain or discomfort 0.6 0.9 2.9 1.4 0.1 0.3 -0.5 0.9 -0.3 -1.7
Had major operations 0.2 0.3 1.0 -0.4 0.3 -0.5 -1.0 -0.3 0.2 -0.3
Age at last live birth 0.9 1.3 2.3 1.3 -1.1 1.2 0.7 1.1 0.6 1.5
Family relationship satisfaction 0.9 1.1 2.7 1.6 -0.2 1.0 -0.2 1.6 -0.3 -1.2
Leg pain on walking 0.5 0.6 3.1 -0.5 0.2 0.8 1.8 -0.5 0.0 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 5.0 1.0 -0.5 0.2 1.0 0.7 -2.2 0.9
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.4 -0.7 1.6 -1.3 0.6 -0.5 0.6 -1.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 3.0 -0.2 -0.0 -0.2 0.7 -0.6 1.7 1.0
Medication: Aspirin 1.1 1.4 3.3 1.8 -1.3 0.6 -0.1 1.5 -0.6 -1.4
Supplements: Vitamin C 4.1 4.8 11.4 3.4 -2.2 1.3 -0.8 3.3 -1.6 -1.3
Knee pain experienced in last month 0.3 0.5 1.9 0.9 -1.4 0.7 -0.1 0.1 -0.2 -0.5
Hypertension (Self-reported) 0.9 2.6 4.7 2.2 -2.0 1.7 1.2 2.1 -0.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.9 4.9 -1.9 2.2 -1.8 1.7 -1.7 1.5 -0.0
Illnesses of father: Heart disease 2.8 3.9 8.2 2.8 -2.6 2.9 -0.9 1.1 -1.5 -0.5
Illnesses of siblings: Diabetes 0.4 0.5 1.2 -0.6 0.1 0.0 1.1 -0.7 -0.5 1.0
Smoking status: Previous 1.9 2.9 9.7 -1.6 1.5 -0.7 -0.8 -1.4 3.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.0 0.2 -0.4 0.4 -2.0 -0.3 -0.5 1.6
Whole body fat-free mass 1.1 6.2 13.0 3.6 -2.6 1.4 -3.1 2.8 -0.9 1.9
Leg fat-free mass (right) 1.3 6.8 16.2 4.0 -3.0 1.4 -2.2 3.2 -1.6 1.6
Arm fat percentage (left) 2.1 8.2 20.9 4.3 -3.3 0.3 0.9 4.6 -2.1 -1.3
Average weekly red wine intake 1.5 2.2 4.0 -1.3 0.7 -2.0 1.9 -1.1 0.8 1.8
Handedness (chirality/laterality): Left-handed 0.7 0.9 3.1 -0.1 -0.4 -1.3 0.4 0.1 1.8 -1.1
Mood swings 1.5 2.6 4.8 1.6 -0.9 2.1 -0.6 1.0 -2.1 -2.2
Loneliness, isolation 1.3 1.8 4.2 2.0 -1.8 0.7 -0.3 1.6 -1.3 -0.3
Long-standing illness, disability or infirmity 0.4 0.6 1.4 1.2 -0.7 0.9 -0.2 0.8 -0.2 -1.0
Ever had bowel cancer screening 0.4 0.4 1.8 -0.5 0.4 0.1 0.4 -0.5 1.3 0.7
Diabetes diagnosed by doctor 3.2 5.3 9.0 2.9 -2.7 1.3 -1.7 3.0 -1.8 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 0.2 -0.3 -0.8 0.6 0.2 0.2 -0.6
Friendships satisfaction 0.3 0.4 2.2 0.6 -0.3 0.6 1.5 0.1 0.2 0.0
Qualifications: nursing, teaching 0.3 0.5 2.8 0.4 -0.4 -0.4 -1.7 0.6 0.3 0.1
Commuting to job workplace: Walk 1.1 1.2 3.2 1.4 -1.4 1.8 -0.6 0.9 0.5 -0.1
Eye problems/disorders: Cataract 1.1 1.3 4.0 1.2 -1.0 1.0 2.0 0.8 0.4 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.3 0.6 0.1 0.1 0.0 -0.2 -0.1 -0.2
Medication for cholesterol 0.6 1.0 2.0 -1.4 1.4 0.6 -0.2 -1.3 0.4 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.1 -0.6 1.0 0.1 1.1 -0.6 0.1 -0.2
Back pain experienced in last month 0.7 1.0 2.2 1.0 -0.9 -0.7 -0.4 1.5 1.4 0.7
Mineral and other dietary supplements 1.3 1.7 3.6 -1.6 1.9 -1.4 0.5 -1.2 1.0 1.2
Breast cancer (self-reported) 0.9 1.0 3.2 -1.0 -0.0 -1.8 -0.6 -0.6 1.0 -1.1
Asthma (self-reported) 0.4 0.9 2.6 -0.9 1.0 -0.0 -0.3 -1.1 1.6 0.7
Osteoporosis (self-reported) 1.7 2.1 4.1 1.4 -1.7 0.3 -2.0 1.8 0.0 -1.6
Osteoarthritis (self-reported) 0.4 0.5 1.1 0.4 -1.0 0.9 0.8 -0.3 -0.0 0.9
Medication: Aspirin 0.7 0.9 2.2 1.5 -0.8 0.3 -0.1 1.4 -0.5 -1.0
Medication: Gliclazide 2.8 3.2 6.9 1.2 -2.6 0.4 -2.3 1.1 -2.2 -1.5
Illnesses of father: None of the above (group 1) 3.7 4.6 10.8 -2.9 3.3 -1.5 1.9 -2.2 1.6 -0.6
Smoking status: Current 0.8 1.3 3.7 0.2 0.7 1.4 -0.7 -0.1 -1.9 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.0 4.8 -2.2 0.5 -0.4 1.6 -1.9 1.5 0.7
Whole body water mass 1.1 6.3 13.0 3.6 -2.6 1.3 -3.2 2.9 -0.9 1.8
Leg predicted mass (right) 1.3 6.9 16.4 4.0 -2.9 1.4 -2.3 3.3 -1.6 1.6
Arm fat mass (left) 2.0 8.4 20.8 4.6 -3.4 0.7 -0.5 4.4 -2.3 -0.8
Number of self-reported non-cancer illnesses 0.4 0.6 1.6 0.9 -0.8 1.0 0.3 0.6 -0.1 -1.3
Average weekly champagne plus white wine intake 0.9 1.2 2.8 -1.1 1.6 -0.3 -1.1 -1.7 0.7 -0.5
Miserableness 0.9 1.6 4.6 1.0 -0.2 0.5 1.2 0.7 -1.8 -2.1
Guilty feelings 0.6 0.9 2.4 -0.0 -0.2 -1.5 -1.3 0.0 0.0 -1.5
Wears glasses or contact lenses 0.7 0.8 3.5 -0.1 0.2 -0.8 1.9 0.3 1.1 -0.6
Ever taken oral contraceptive pill 3.9 4.4 8.2 2.5 -2.5 1.4 -1.0 2.9 -0.0 -2.6
Hearing aid user 0.9 1.0 5.3 0.7 0.2 0.2 -0.0 0.9 -2.3 0.4
Mother’s age at death 0.7 0.8 1.6 -1.1 0.5 -1.0 1.3 -0.4 0.6 1.1
Financial situation satisfaction 0.9 1.1 2.7 0.9 0.4 0.3 1.0 1.7 -1.4 -1.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.6 -0.8 1.3 0.8 0.7 -1.0 0.4 -0.7
Commuting to job workplace: Public transport 1.3 1.6 3.2 1.2 -1.7 1.8 -0.6 1.0 -1.2 -0.8
Eye problems/disorders: Glaucoma 1.2 1.4 3.1 1.0 -0.9 0.8 1.2 0.5 1.7 -1.8
Medication: Blood pressure 0.5 1.0 1.6 1.2 -1.1 -0.6 1.3 1.1 -0.1 -0.9
Pain type(s) experienced in last month: Hip pain 2.7 3.4 8.1 2.9 -2.3 1.9 0.2 2.5 -0.4 -0.9
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.9 1.1 -1.4 1.3 -0.1 0.9 -0.1 -0.9
High cholesterol (Self-reported) 0.2 0.4 1.9 -0.4 -0.1 0.5 -0.1 -0.8 1.4 -0.1
Medication: Bendroflumethiazide 0.9 1.3 3.6 0.6 -1.9 -1.2 1.1 1.0 1.1 -0.4
Medication: Paracetamol 1.4 2.2 5.1 2.3 -2.1 1.0 0.2 2.0 -0.8 -0.6
Medication: Lisinopril 0.6 0.8 2.9 0.1 0.9 0.4 1.1 0.2 -1.7 -0.7
Medication: Atorvastatin 1.3 1.7 8.5 0.1 0.4 1.1 -2.9 -1.1 -0.8 -0.2
Illnesses of father: High blood pressure 0.7 0.8 2.4 1.3 -0.5 1.6 -0.1 0.7 -0.2 1.0
Alcohol drinker status: Never 0.5 0.5 1.3 -1.0 0.1 -0.7 0.9 -1.1 0.2 0.4
Ever smoked 0.9 1.6 5.9 -1.1 1.1 -1.2 -0.8 -0.9 0.5 -2.4
Basal metabolic rate 1.3 7.2 16.6 4.1 -3.0 1.6 -2.8 3.3 -1.4 1.4
Leg fat percentage (left) 2.6 9.3 19.4 4.4 -3.3 2.8 0.2 3.9 -2.0 -2.7
Arm fat-free mass (left) 1.3 6.7 14.9 3.9 -2.7 1.5 -3.3 3.1 -0.9 1.1
Number of operations (self-reported) 0.5 0.8 3.6 -0.1 0.8 -0.6 -1.9 0.4 0.3 -0.6
Average weekly beer plus cider intake 1.0 1.5 4.2 0.5 -0.5 0.8 1.1 0.2 -1.9 -2.0
Irritability 0.3 0.5 1.3 -0.6 1.1 -0.9 0.1 -0.5 1.0 -0.2
Risk taking 1.0 1.5 4.4 -0.2 1.6 0.6 -1.3 -0.4 1.2 -2.1
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.7 -0.4 -0.9 -1.5 1.5 0.1 1.7 1.4
Fractured/broken bones in last 5 years 1.0 1.3 3.0 -0.7 1.2 1.0 0.5 -1.4 1.0 -1.7
Age started oral contraceptive pill 1.4 1.7 5.4 -0.7 0.3 -1.4 0.7 -0.8 1.7 2.3
Diastolic blood pressure, automated reading 0.7 2.1 4.6 2.1 -1.5 0.8 -1.5 1.9 -1.0 -0.1
Ever depressed for a whole week 1.5 1.8 3.5 1.9 -1.2 1.5 0.8 1.7 -1.3 -0.8
Unable to work because of sickness or disability 0.9 1.1 3.2 0.8 -0.1 1.5 -1.8 1.1 0.4 0.5
Commuting to job workplace: Cycle 1.8 2.1 7.0 -0.6 0.6 -1.9 -0.0 -0.1 1.9 2.6
Myopia 0.6 0.8 2.4 -1.1 0.8 0.5 -1.6 -1.0 0.1 0.6
Vascular/heart problems diagnosed by doctor 0.9 2.6 5.8 -2.3 2.2 -0.9 -0.6 -2.4 0.5 0.2
Cholesterol lowering medication 0.5 0.7 3.4 0.7 -0.3 -0.8 -0.1 0.4 -0.4 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.8 -0.6 1.1 -1.2 1.3 0.1 0.8 0.6
Pain experienced in last month 0.4 0.7 2.0 -1.4 0.7 -0.4 0.5 -1.3 0.4 0.3
Supplements: Calcium 2.8 3.1 5.8 2.2 -2.3 2.4 0.4 1.8 -0.8 -1.2
Basal cell carcinoma (self-reported) 0.6 0.7 1.5 0.2 0.1 1.1 -0.6 -0.6 -1.2 -1.2
Heart attack/myocardial infarction (self-reported) 0.8 1.1 2.0 1.4 -0.5 0.4 -1.1 1.2 -0.9 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.3 0.3 0.5 0.3 -1.1 0.6 0.9 0.7
Heart disease (siblings) 0.2 0.2 0.7 0.1 0.1 0.1 0.6 0.7 0.1 -0.9
Alcohol drinker status: Previous 0.4 0.4 2.1 0.0 0.1 0.6 -0.2 0.0 -0.7 -1.5
Pack years of smoking 1.8 2.6 3.6 1.9 -1.8 1.7 -1.7 1.4 -1.1 -1.4
Impedance of whole body 0.6 2.8 5.3 -2.0 1.2 -0.7 2.3 -2.0 -2.1 -0.2
Leg fat mass (left) 2.9 11.4 27.5 5.2 -4.0 2.5 -0.9 4.7 -2.1 -1.6
Arm predicted mass (left) 1.3 6.4 13.2 3.6 -2.8 1.6 -3.3 2.8 -1.1 1.2