TWAS
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Models
Genes
Traits
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Traits
:
Leg fat mass (left)
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chr1:61,448,835-63,322,743
Best TWAS P=7.34e-09 · Best GWAS P=2.99e-11 conditioned to 3.41e-05
61.5M
62M
62.5M
63M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Muscularis
TM2D1
0.12
0.03
lasso
3
0.04
0.00319
4.3
5.8
7.3e-09
-0.55
0.02
0.86
TRUE
1
GTEx
Cells Transformed fibroblasts
INADL
0.15
0.06
lasso
5
0.05
0.00017
5.1
-5.2
1.6e-07
0.81
0.07
0.42
FALSE