TWAS
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Models
Genes
Traits
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Traits
:
Leg fat mass (left)
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chr8:86,841,229-88,211,679
Best TWAS P=1.67e-08 · Best GWAS P=2.36e-08 conditioned to 0.151
86.8M
87M
87.2M
87.4M
87.6M
87.8M
88M
88.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Soft Tissue Sarcoma
FAM82B
0.07
0.00
blup
45
0.01
1.1e-01
-5.6
5.6
1.7e-08
-0.86
0.01
0.60
TRUE
2
GTEx
Stomach
RMDN1
0.15
0.05
lasso
6
0.06
1.2e-03
-5.6
5.5
3.5e-08
-0.88
0.01
0.95
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
WWP1
0.03
0.01
blup
63
0.02
1.8e-03
-5.1
-5.3
1.4e-07
0.92
0.02
0.94
FALSE
1
GTEx
Artery Tibial
RMDN1
0.18
0.08
lasso
9
0.10
1.8e-08
-5.5
5.2
2.2e-07
-0.95
0.01
0.99
FALSE