TWAS
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Models
Genes
Traits
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Traits
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Leg fat mass (left)
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chr8:29,996,824-31,433,801
Best TWAS P=1.14e-10 · Best GWAS P=5.85e-13 conditioned to 0.000173
30M
30.2M
30.4M
30.6M
30.8M
31M
31.2M
31.4M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
TEX15
0.05
0.03
enet
9
0.02
6.8e-04
5.4
6.4
1.1e-10
0.70
0.09
0.88
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
TEX15
0.05
0.04
lasso
4
0.04
2.7e-06
5.6
5.3
1.4e-07
0.66
0.56
0.43
FALSE