TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat-free mass (left)
:
←
→
chr7:5,753,101-7,186,554
Best TWAS P=3.82e-09 · Best GWAS P=5.83e-10 conditioned to 1
5.8M
6M
6.2M
6.4M
6.6M
6.8M
7M
7.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
DAGLB
0.09
0.06
lasso
5
0.06
4.8e-08
6.0
-5.9
3.8e-09
-0.98
0.01
0.99
TRUE
2
The Cancer Genome Atlas
Thyroid Carcinoma
DAGLB
0.06
0.02
blup
71
0.03
7.4e-04
3.9
-5.3
1.3e-07
-0.72
0.02
0.70
FALSE