[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr7:2,032,803-3,581,391

Best TWAS P=1.09e-42 · Best GWAS P=3.17e-42 conditioned to 0.0107

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-13.6	13.7	1.1e-42	-0.92	0.01	0.99	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-13.5	-13.5	2.6e-41	0.95	0.01	0.99	FALSE
17	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-13.3	-13.3	2.8e-40	0.95	0.02	0.92	FALSE
10	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-13.6	-13.2	1.1e-39	0.96	0.01	0.99	FALSE
9	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-13.3	-12.3	7.8e-35	0.88	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	8.4	-11.8	3.4e-32	0.74	0.01	0.70	FALSE
3	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-13.6	-11.6	2.3e-31	0.86	0.02	0.98	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-8.6	-11.5	2.1e-30	0.84	0.04	0.94	FALSE
5	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-13.5	-11.3	8.2e-30	0.88	0.02	0.98	FALSE
6	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-8.4	-11.3	1.7e-29	0.83	0.04	0.87	FALSE
11	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-13.3	-11.2	3.5e-29	0.77	0.03	0.97	FALSE
14	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-8.5	-11.2	5.9e-29	0.88	0.16	0.84	FALSE
12	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-8.6	-11.1	8.2e-29	0.84	0.89	0.11	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	5.5	-10.8	2.5e-27	0.78	0.06	0.75	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	8.4	9.7	2.3e-22	-0.63	0.03	0.91	FALSE
19	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-9.7	-9.5	1.4e-21	0.61	0.94	0.06	FALSE
2	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-8.6	-9.5	3.1e-21	0.73	0.31	0.69	FALSE
15	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-8.7	-9.3	1.7e-20	0.74	0.09	0.72	FALSE
18	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-8.7	-8.8	1.9e-18	0.75	0.20	0.80	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-8.6	-8.6	7.9e-18	0.69	0.10	0.71	FALSE
16	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-8.4	-8.5	1.7e-17	0.67	0.54	0.45	FALSE
21	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	5.9	-8.5	2.5e-17	0.51	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	6.4	7.9	2.1e-15	-0.45	1.00	0.00	FALSE
7	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	6.6	-7.8	9.4e-15	0.62	0.32	0.66	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	6.6	-7.4	1.9e-13	0.51	0.43	0.55	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-8.6	6.3	2.4e-10	-0.64	0.05	0.76	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-9.7	5.9	2.8e-09	-0.56	0.18	0.82	FALSE