[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr8:56,269,387-57,683,880

Best TWAS P=4.18e-22 · Best GWAS P=1.87e-41 conditioned to 6.84e-22

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial RP11-446E9.1 0.07 0.00 lasso 6 0.00 6.6e-01 -6.2 7.4 1.1e-13 -0.71 0.04 0.49 FALSE
2 GTEx Brain Cerebellum RPS20 0.26 0.07 enet 17 0.10 5.4e-04 -8.8 -7.4 1.8e-13 0.64 0.10 0.75 FALSE
3 GTEx Brain Cerebellum RP11-446E9.1 0.15 0.05 lasso 3 0.03 3.7e-02 -5.3 5.1 2.7e-07 -0.54 0.06 0.42 FALSE
4 GTEx Brain Nucleus accumbens basal ganglia RPS20 0.41 0.05 lasso 8 0.13 3.1e-04 -6.1 -5.5 3.2e-08 0.54 0.04 0.47 FALSE
5 GTEx Esophagus Muscularis RPS20 0.12 0.04 lasso 6 0.05 7.2e-04 -8.9 -8.6 7.2e-18 0.81 0.19 0.69 FALSE
6 GTEx Muscle Skeletal RPS20 0.07 0.09 lasso 1 0.07 1.5e-07 -5.2 -5.2 2.4e-07 0.52 0.89 0.11 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic RPS20 0.18 0.03 enet 12 0.07 1.5e-04 -8.5 -9.7 4.2e-22 0.80 0.19 0.34 TRUE
8 ROSMAP Brain Pre-frontal Cortex RPS20 0.24 0.20 lasso 6 0.23 3.4e-29 -6.6 -5.7 1.0e-08 0.55 1.00 0.00 FALSE
9 ROSMAP Brain Pre-frontal Cortex RP11-446E9.1 0.23 0.32 lasso 7 0.34 2.0e-45 -5.2 6.0 2.2e-09 -0.56 1.00 0.00 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS20 0.04 0.02 blup 29 0.03 4.8e-04 -6.4 -5.9 3.4e-09 0.51 0.03 0.03 FALSE
11 The Cancer Genome Atlas Brain Lower Grade Glioma RPS20 0.33 0.07 enet 8 0.07 1.7e-08 -6.6 -7.7 1.9e-14 0.52 0.96 0.03 FALSE
12 The Cancer Genome Atlas Prostate Adenocarcinoma RPS20 0.04 0.03 lasso 3 0.04 1.3e-04 -6.6 -6.7 1.8e-11 0.60 0.15 0.05 FALSE