TWAS hub - RPS20

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2580	0.1030	9.5e-04	0.074	NA	0.105	NA	0.090	3.2e-03	NA	5.4e-04	NA	1.2e-03
2	GTEx	Brain Nucleus accumbens basal ganglia	0.4060	0.1100	6.4e-04	0.054	NA	0.079	NA	0.126	1.5e-02	NA	3.9e-03	NA	3.1e-04
3	GTEx	Esophagus Muscularis	0.1170	0.0460	8.2e-04	0.041	NA	0.038	NA	0.048	1.6e-03	NA	2.2e-03	NA	7.2e-04
4	GTEx	Muscle Skeletal	0.0675	0.0244	3.5e-05	0.086	NA	0.046	NA	0.072	9.1e-09	NA	2.6e-05	NA	1.5e-07
5	GTEx	Nerve Tibial	0.0838	0.0381	4.3e-03	0.041	NA	0.030	NA	0.035	6.3e-04	NA	3.3e-03	NA	1.6e-03
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1820	0.0640	7.4e-04	0.025	NA	0.067	NA	0.049	1.5e-02	NA	1.5e-04	NA	1.1e-03
7	GTEx	Skin Sun Exposed Lower leg	0.0730	0.0360	4.5e-03	0.005	NA	0.019	NA	0.010	1.1e-01	NA	8.8e-03	NA	4.9e-02
8	NTR	Blood	0.0272	0.0103	1.7e-04	0.021	0.012	0.013	0.014	0.015	1.3e-07	5.4e-05	3.8e-05	1.5e-05	7.9e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.2366	0.0524	0.0e+00	0.196	0.155	0.227	0.180	0.230	1.1e-24	1.8e-19	1.1e-28	1.5e-22	3.4e-29
10	YFS	Blood	0.1371	0.0272	0.0e+00	0.071	0.078	0.085	0.087	0.092	4.3e-22	3.3e-24	1.5e-26	4.0e-27	1.8e-28
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0364	0.0227	3.6e-03	0.018	0.027	0.025	NA	0.025	3.4e-03	4.8e-04	7.8e-04	NA	6.9e-04
12	TCGA	Brain Lower Grade Glioma	0.3271	0.1137	2.3e-08	0.067	0.066	0.071	NA	0.058	4.4e-08	5.4e-08	1.7e-08	NA	3.8e-07
13	TCGA	Prostate Adenocarcinoma	0.0376	0.0262	1.5e-03	0.035	0.027	0.034	NA	0.035	1.4e-04	7.0e-04	1.7e-04	NA	1.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Trunk predicted mass	11.4	65.2	156.6	-9.7	-7.5	-10.7	-7.5	-4.4	-12.5	-2.1	2.1	-8.4	-2.0	-8.3	-10.6	-9.3
Trunk fat-free mass	11.2	64.2	153.8	-9.7	-7.5	-10.6	-7.5	-4.3	-12.4	-2.1	2.0	-8.3	-1.9	-8.2	-10.5	-9.2
Whole body water mass	9.4	53.4	132.2	-8.8	-6.8	-9.9	-6.6	-3.6	-11.5	-1.9	1.9	-7.4	-1.8	-7.4	-9.6	-8.4
Whole body fat-free mass	9.3	53.2	132.2	-8.8	-6.8	-9.9	-6.6	-3.6	-11.5	-1.9	2.0	-7.3	-1.8	-7.4	-9.5	-8.3
Arm fat-free mass (right)	8.3	42.4	99.2	-7.7	-6.1	-8.6	-6.1	-3.6	-10.0	-1.7	1.5	-6.8	-1.5	-6.6	-8.8	-7.5
Comparative height size at age 10	8.2	45.0	114.5	-8.5	-6.2	-8.8	-5.9	-4.0	-10.7	-0.8	2.0	-6.9	-1.9	-6.4	-9.1	-7.2
Arm fat-free mass (left)	8.0	40.8	96.8	-7.7	-5.9	-8.4	-5.8	-3.4	-9.8	-1.6	1.8	-6.6	-1.8	-6.7	-8.5	-7.3
Arm predicted mass (right)	7.9	40.4	96.3	-7.6	-6.1	-8.4	-6.1	-3.6	-9.8	-1.5	1.2	-6.7	-1.3	-6.2	-8.5	-7.3
Basal metabolic rate	7.8	43.4	108.2	-8.1	-6.2	-9.0	-5.9	-3.3	-10.4	-1.8	1.8	-6.6	-1.7	-6.7	-8.6	-7.4
Arm predicted mass (left)	7.7	39.3	93.3	-7.5	-5.8	-8.3	-5.8	-3.6	-9.7	-1.7	1.4	-6.6	-1.6	-6.3	-8.3	-7.2
Leg predicted mass (left)	6.9	36.7	95.8	-7.4	-5.6	-8.7	-5.3	-2.7	-9.8	-1.7	1.5	-5.8	-1.4	-6.0	-7.7	-6.8
Leg fat-free mass (left)	6.7	35.7	93.4	-7.4	-5.5	-8.6	-5.2	-2.7	-9.7	-1.6	1.5	-5.7	-1.4	-5.9	-7.7	-6.7
Leg fat-free mass (right)	6.7	35.6	91.1	-7.3	-5.4	-8.5	-5.2	-2.6	-9.5	-1.4	1.7	-5.8	-1.5	-6.0	-7.8	-6.7
Leg predicted mass (right)	6.6	35.5	91.4	-7.3	-5.4	-8.5	-5.2	-2.6	-9.6	-1.4	1.7	-5.7	-1.5	-6.0	-7.7	-6.7
Height	6.5	125.9	380.2	-14.6	-10.0	-15.5	-9.4	-4.6	-19.5	1.6	3.8	-10.4	-2.5	-10.4	-14.5	-11.9
Standing height	6.1	60.2	180.2	-9.5	-6.0	-10.5	-6.4	-3.7	-13.4	0.1	3.1	-7.5	-2.7	-7.6	-10.7	-8.2
Forced vital capacity (FVC), Best measure	5.5	20.0	59.4	-5.8	-3.4	-6.9	-4.0	-1.6	-7.7	-0.2	1.0	-4.0	-0.6	-4.1	-5.4	-5.0
Impedance of whole body	5.0	25.6	44.9	5.9	5.1	6.7	5.7	2.6	6.4	2.6	0.0	5.6	-0.2	5.2	6.3	6.6
Hair/balding pattern: Pattern 2	4.6	5.9	14.7	2.1	1.4	3.8	2.6	1.3	3.8	0.7	-0.4	2.7	-0.0	2.4	3.2	3.0
Forced vital capacity (FVC)	4.6	17.8	53.9	-5.3	-3.1	-6.4	-3.6	-1.7	-7.3	-0.0	1.2	-3.7	-1.0	-4.1	-5.3	-4.7
Sitting height	4.5	32.0	96.4	-6.8	-4.0	-7.7	-5.0	-2.2	-9.8	1.4	1.9	-5.4	-1.4	-5.2	-8.4	-6.0
Alzheimer’s Disease (in mother)	4.3	5.1	9.3	1.7	0.8	1.7	1.1	2.3	2.6	2.0	-2.4	2.6	2.7	3.0	2.9	2.3
Loud music exposure frequency	4.3	4.7	8.3	-1.8	-1.9	-2.4	-2.4	-2.4	-2.2	-1.4	1.1	-2.9	-1.0	-2.4	-2.6	-2.6
Impedance of leg (left)	4.2	20.3	47.5	5.2	4.5	6.9	4.9	1.5	6.3	2.3	0.4	4.4	-0.8	4.2	5.3	5.8
Impedance of arm (left)	4.0	18.6	32.7	4.7	4.5	4.7	4.9	3.3	4.8	2.4	-0.3	5.3	0.7	4.7	5.7	5.7
Medication: Paracetamol	4.0	6.7	13.1	1.3	3.6	1.6	3.4	2.8	1.7	2.0	-0.8	3.6	0.4	2.7	3.3	3.4
Lupus	3.9	6.0	10.7	-2.9	-1.9	-2.5	-3.1	-1.8	-2.3	-0.4	0.9	-3.1	-0.7	-3.0	-3.1	-3.3
Lung FVC	3.7	19.0	54.5	-5.6	-4.0	-7.4	-4.4	-2.0	-6.9	-1.4	-0.3	-4.1	0.5	-3.6	-3.9	-5.1
Impedance of leg (right)	3.7	17.9	39.9	4.9	4.1	6.3	4.5	1.4	5.8	2.0	-0.3	4.1	-0.3	4.3	5.2	5.4
Weight	3.7	18.0	49.3	-5.5	-4.3	-6.0	-3.4	-2.2	-7.0	-1.4	1.3	-4.0	-1.4	-4.1	-5.1	-4.4
Ever highly irritable/argumentative for 2 days	3.7	4.4	8.4	-2.2	-2.7	-2.0	-1.8	-2.7	-1.3	-2.9	0.2	-2.5	-1.0	-2.0	-1.8	-2.4
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	7.0	-2.0	-2.6	-2.4	-2.3	-1.5	-1.7	-2.2	0.3	-2.4	-0.1	-2.1	-1.6	-2.6
Illnesses of mother	3.5	4.3	8.6	-2.6	-2.1	-2.5	-2.9	-1.1	-2.2	-1.1	-1.2	-2.3	1.0	-1.4	-2.6	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.9	17.2	3.6	2.6	3.4	1.3	1.1	4.2	0.6	-2.8	2.3	2.2	3.6	3.0	3.2
Alzheimer’s Disease (including proxy)	3.3	4.8	9.3	1.6	1.6	1.5	2.2	2.2	1.7	1.4	-1.4	2.8	1.6	2.9	3.0	3.1
Impedance of arm (right)	3.2	15.1	26.3	4.1	4.2	4.8	4.6	2.5	4.6	1.8	0.3	4.5	-0.3	3.8	5.0	5.1
HbA1C	3.1	3.5	11.6	-1.5	-1.4	-0.5	-3.4	-0.7	-0.0	-1.0	-2.3	-2.1	2.2	-0.5	-2.2	-2.7
Medication: Co-codamol	3.1	3.6	9.7	-1.2	-3.1	-0.4	-1.3	-2.0	-1.2	-2.0	0.8	-2.3	-1.6	-2.4	-2.5	-2.1
Heart disease (siblings)	3.1	3.8	8.2	2.1	1.9	2.6	1.3	2.1	2.9	1.0	-1.0	2.0	1.5	1.8	2.2	1.9
Leg pain on walking	3.0	3.7	8.4	-2.4	-1.4	-1.2	-0.2	-2.0	-1.8	-2.9	1.7	-1.5	-2.7	-2.1	-2.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	2.9	4.6	13.1	1.8	1.5	1.9	0.9	1.0	2.2	-0.3	-3.3	2.0	2.8	3.6	1.9	2.3
Ever had prostate specific antigen (PSA) test	2.7	3.1	8.8	-2.5	-3.0	-2.4	-1.9	-0.7	-1.8	-0.3	0.4	-1.5	0.2	-1.4	-1.5	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.0	25.5	-3.8	-1.6	-4.2	-2.7	-1.1	-5.1	0.7	0.2	-2.5	-0.1	-2.3	-3.6	-3.2
Guilty feelings	2.5	3.8	7.4	-2.3	-1.9	-2.4	-2.7	-2.3	-1.4	-1.0	-0.8	-2.6	0.3	-1.4	-1.9	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.7	-1.9	-2.2	-2.6	-2.4	-0.5	-2.0	-0.6	-1.0	-1.8	1.5	-1.1	-1.3	-2.5
Number of live births	2.4	3.4	6.1	-2.5	-1.2	-1.6	-2.4	-1.8	-0.9	-2.0	-1.3	-2.4	0.9	-1.1	-2.3	-2.4
Ever taken oral contraceptive pill	2.4	2.7	5.0	-1.0	-2.1	-1.3	-1.6	-2.1	-1.2	-0.7	0.6	-2.2	-0.7	-1.9	-2.2	-2.1
Depression (Nagel 2018)	2.3	3.5	7.6	-1.9	-2.3	-2.1	-2.2	-1.0	-1.8	-0.5	0.8	-2.2	0.2	-2.1	-2.3	-2.8
Illnesses of siblings	2.3	3.2	6.6	-2.6	-1.7	-1.7	-1.1	-1.7	-1.7	0.4	1.6	-1.9	-1.3	-2.4	-2.1	-2.0
Medication: Paracetamol	2.3	3.5	11.8	0.8	3.4	0.8	2.1	1.6	0.5	1.2	-1.2	2.4	0.5	2.2	2.3	2.5
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	11.7	2.5	1.8	2.9	1.2	0.5	3.4	0.4	-2.6	1.9	1.6	2.9	2.7	2.5
Handedness (chirality/laterality): Left-handed	2.2	2.7	6.6	-1.7	-1.1	-1.9	-0.2	-0.6	-2.2	-0.4	2.6	-1.1	-2.0	-2.3	-1.6	-1.3
Heel T-Score	2.1	16.6	46.2	5.2	3.7	5.6	1.9	-0.5	6.8	-0.6	-3.9	2.7	2.3	5.2	4.7	4.1
Hair/balding pattern: Pattern 3	2.1	3.1	6.4	-1.1	-0.8	-2.2	-1.5	-2.1	-2.3	-1.8	0.5	-2.2	-1.0	-1.7	-2.5	-1.7
High blood pressure (mother)	2.0	2.8	6.7	2.1	2.0	2.1	2.6	0.8	1.7	0.2	1.6	1.5	-1.6	0.7	1.5	1.9
Number of incorrect matches in round	2.0	3.3	11.4	-2.4	-1.7	-3.2	-1.6	-0.1	-3.4	-1.3	-0.4	-1.1	0.3	-1.2	-1.4	-1.8
Medication: Aspirin	2.0	2.6	4.8	-2.1	-1.5	-1.9	-2.1	-1.2	-1.7	-1.0	-0.5	-1.9	0.4	-1.7	-1.4	-2.2
Medication: Gliclazide	2.0	2.3	4.1	-1.8	-1.8	-2.0	-1.6	-1.0	-1.8	-1.8	0.0	-1.5	-0.4	-1.6	-0.8	-1.9
Bipolar Disorder (2018)	1.9	3.0	6.2	-1.3	0.2	-2.3	-2.3	-0.9	-2.1	-1.7	-0.5	-1.9	0.3	-1.7	-2.5	-2.3
Systolic Blood Pressure	1.9	9.7	19.5	4.4	3.4	4.0	3.3	2.1	3.9	1.2	-0.4	3.5	0.5	3.2	3.0	4.0
Lung FEV1/FVC ratio	1.9	9.6	25.8	4.0	3.7	5.0	1.3	0.9	5.1	2.1	-2.4	2.3	1.7	3.4	1.8	2.9
Had other major operations	1.9	2.4	4.6	2.2	1.5	1.7	1.6	1.4	1.5	0.6	-1.3	2.0	0.9	1.7	1.3	1.7
Medication: Omeprazole	1.9	2.3	8.9	0.8	0.9	0.9	-0.5	1.1	1.9	-1.2	-3.0	0.9	2.7	2.0	0.3	0.6
Medication: Blood pressure	1.9	3.5	7.2	1.8	2.2	2.2	1.7	0.6	2.2	-0.2	-1.4	2.0	0.7	2.7	2.1	2.6
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	19.6	-3.1	-1.1	-3.6	-2.5	-1.3	-4.4	0.5	-0.1	-2.3	-0.2	-2.0	-3.5	-2.7
Rheumatoid Arthritis	1.7	2.3	4.6	-1.4	-1.2	-1.3	-1.0	-1.4	-1.7	-1.3	1.4	-1.8	-1.6	-2.2	-1.4	-1.6
Hearing difficulty/problems with background noise	1.7	2.7	11.5	-1.1	-2.2	0.1	-1.2	-2.5	0.5	-3.4	-0.6	-1.8	-0.6	-0.5	-1.9	-1.1
Comparative body size at age 10	1.7	4.6	9.7	-3.1	-3.0	-2.7	-1.1	-2.3	-2.8	-1.0	0.9	-2.2	-1.5	-1.9	-1.6	-1.9
Mean time to correctly identify matches	1.7	3.3	6.2	-2.3	-1.1	-1.8	-2.4	-2.0	-1.7	-1.7	0.2	-2.5	-0.4	-1.9	-1.6	-2.3
Cardiovascular Disease	1.6	5.1	10.9	2.9	3.3	2.7	1.9	1.8	3.0	0.4	-0.9	2.4	0.7	2.4	2.1	2.7
Maternal smoking around birth	1.6	2.4	6.3	-1.5	-2.0	-2.5	-2.0	-0.2	-1.9	0.0	-0.0	-1.3	0.8	-1.5	-1.3	-2.1
Taking other prescription medications	1.6	2.5	7.4	-1.6	-0.3	-2.1	-2.7	-0.5	-1.4	-1.2	-1.3	-1.8	1.5	-1.0	-1.3	-2.3
Pain all over the body in last month	1.6	1.7	8.2	-1.1	-0.9	-1.3	-1.0	-2.1	-1.2	-2.9	-0.8	-1.4	-0.6	-0.1	-0.7	-0.8
Hip circumference	1.6	6.8	21.6	-3.4	-2.5	-3.7	-1.5	-1.2	-4.7	-1.0	1.1	-2.2	-1.4	-2.7	-3.0	-2.5
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.4	0.9	0.8	1.4	1.5	1.2	1.2	1.2	-0.7	1.8	0.8	1.8	1.5	1.7
Smoking status: Previous	1.6	2.4	7.8	-1.8	-2.8	-2.0	-1.2	-0.9	-2.1	-0.5	0.1	-1.4	-0.0	-1.4	-1.4	-1.9
Eye problems/disorders: Cataract	1.6	1.9	7.8	0.7	1.0	1.4	-0.7	-0.6	1.8	0.1	-2.8	-0.1	2.0	2.0	0.6	0.6
Medication: Aspirin	1.6	2.0	3.8	-1.9	-1.2	-1.5	-1.8	-1.0	-1.4	-1.2	-0.3	-1.7	0.2	-1.6	-1.5	-1.9
Sensitivity / hurt feelings	1.5	2.5	6.2	1.6	1.4	1.7	0.9	0.9	2.5	-0.8	-1.7	1.6	1.2	2.2	1.3	1.6
Supplements: Glucosamine	1.5	2.0	7.8	-1.7	-0.5	-2.1	-0.5	-1.2	-2.8	0.0	0.7	-1.1	-1.4	-1.5	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	1.5	2.0	4.2	1.1	0.6	0.2	-2.0	-1.8	1.5	-1.9	-2.0	-1.7	0.9	0.3	-1.2	-1.3
Illnesses of siblings: Diabetes	1.5	1.8	3.6	1.9	1.3	1.6	1.9	1.7	1.2	0.3	1.1	1.6	-0.8	0.6	0.8	1.7
Asthma (self-reported)	1.5	2.9	7.5	-0.7	-0.6	-1.4	-2.4	-2.0	-1.2	-2.7	-0.8	-2.5	-0.1	-1.4	-1.7	-2.3
Age at First Birth	1.4	2.0	6.0	-0.9	-1.3	-1.4	-2.2	-1.1	-0.5	-0.2	-2.5	-1.5	2.2	0.2	-0.1	-1.5
Average weekly fortified wine intake	1.4	1.6	3.8	1.5	1.9	1.2	1.9	0.6	1.0	0.9	0.3	1.5	-0.7	0.8	1.1	1.7
Illnesses of father: High blood pressure	1.4	1.7	5.1	-0.6	-0.3	-0.1	-1.1	-1.6	-0.3	-2.3	0.3	-1.7	-1.2	-1.6	-2.1	-1.3
Diabetes (mother)	1.3	1.7	5.2	1.8	1.6	2.3	1.4	0.2	1.9	-0.4	0.1	1.0	-0.6	0.7	0.9	1.4
Asthma	1.3	2.5	5.9	-0.7	-0.4	-1.6	-2.4	-1.5	-1.3	-2.2	-1.2	-2.3	0.5	-1.1	-1.3	-2.2
Birth weight	1.3	2.8	12.2	-2.5	0.0	-2.5	-0.6	0.0	-3.5	0.1	1.1	-1.0	-1.0	-1.8	-1.8	-1.4
Medication: Seretide 50 evohaler	1.3	1.5	4.7	-0.8	-1.2	-0.6	-1.5	-2.2	-0.7	-1.8	-0.4	-1.8	-0.3	-0.5	-1.1	-1.0
Financial situation satisfaction	1.3	1.7	3.8	1.6	1.0	1.5	1.9	0.1	1.3	0.5	1.3	1.1	-1.5	0.5	1.3	1.8
Blood Eosinophil Count	1.2	9.4	15.4	-3.7	-3.4	-3.9	-3.5	-2.6	-3.6	-1.6	-0.9	-3.5	0.4	-2.3	-3.9	-3.7
Respiratory disease	1.2	2.6	8.6	-0.5	-0.6	-1.1	-2.3	-2.1	-0.8	-2.9	-1.1	-2.4	0.1	-0.9	-1.4	-2.0
Medication: Metformin	1.2	1.7	2.9	-1.0	-1.6	-1.4	-1.6	-0.6	-1.4	-1.6	-0.1	-1.4	-0.0	-1.6	-1.4	-1.7
Fluid intelligence score	1.2	2.4	5.7	2.0	2.3	2.2	-0.2	0.2	2.4	1.7	-1.6	0.3	1.5	1.6	0.3	1.1
Diabetes diagnosed by doctor	1.2	1.9	4.5	-1.2	-1.7	-1.4	-2.0	0.1	-1.2	-1.7	-1.0	-1.3	1.0	-1.2	-0.9	-2.1
Mineral and other dietary supplements	1.2	1.6	7.2	1.5	1.3	2.3	1.1	0.4	2.7	0.3	0.9	0.7	-0.6	0.5	0.6	1.0
Prostate Cancer	1.1	1.6	3.5	-1.1	-1.1	-1.9	-1.8	0.5	-1.7	-0.3	-1.2	-0.6	1.4	-0.3	-1.1	-1.7
Hearing difficulty/problems: Yes	1.1	1.7	6.4	-0.6	-1.5	0.3	-1.3	-2.5	0.4	-1.8	-0.3	-1.9	-0.6	-0.6	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.1	-1.5	-1.1	-1.8	-0.5	-0.5	-2.0	-0.8	0.6	-1.0	-0.5	-1.3	-1.6	-1.1
Hand grip strength (right)	1.1	3.1	6.2	-1.9	-1.6	-1.8	-1.0	-1.1	-2.4	-0.1	1.8	-1.7	-1.5	-2.2	-2.5	-1.9
Heart attack	1.1	1.4	2.9	-0.8	-1.0	-0.8	-1.3	-1.7	-1.0	-1.6	-0.8	-1.6	-0.2	-0.6	-1.5	-1.2
Pulse wave Arterial Stiffness index	1.1	1.3	3.1	-1.0	-1.7	-0.7	-1.7	-1.0	-0.6	-0.4	0.2	-1.5	-0.0	-1.0	-1.6	-1.6
Birth weight of first child	1.1	2.0	4.8	-1.4	-1.2	-1.5	-0.9	-1.7	-1.8	-1.0	0.2	-1.6	-1.0	-1.3	-2.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.5	-0.7	-1.5	-1.0	-1.6	-0.4	-0.3	-1.9	-1.1	-1.1	1.0	-0.6	-0.9	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.9	0.7	0.9	0.8	0.0	1.4	1.6	-0.7	-1.9	1.0	2.0	1.4	0.2	0.7
Bipolar Disorder or Schizophrenia	1.0	2.5	5.5	-1.4	-1.1	-2.1	-1.6	-1.0	-2.3	-1.6	0.4	-1.7	-0.2	-1.4	-2.1	-2.0
Past tobacco smoking	1.0	1.9	6.6	1.4	2.6	1.7	0.9	0.7	1.8	0.5	-0.4	1.2	0.3	1.4	1.2	1.7
Nervous feelings	1.0	1.9	4.1	-1.2	-0.1	-1.5	-1.8	-2.0	-1.0	-2.0	-1.5	-1.7	0.2	-0.3	-1.3	-1.3
Medication: Simvastatin	1.0	1.5	4.2	0.8	1.6	1.7	0.8	2.1	1.5	0.4	-0.2	1.5	0.8	0.6	1.3	0.9
Qualifications: A levels/AS levels or equivalent	1.0	2.3	8.1	1.4	2.6	1.2	0.1	1.3	1.5	2.8	-1.4	0.9	1.6	1.3	0.6	0.8
Breastfed as a baby	1.0	1.2	3.5	1.9	1.0	1.1	0.6	0.5	1.2	-0.2	-0.6	1.0	0.7	1.3	1.6	1.2
Blood clot in the leg (DVT)	1.0	1.3	3.0	-1.7	-0.7	-1.4	-0.5	-1.4	-1.5	-1.1	0.1	-1.2	-1.1	-1.1	-1.2	-0.8
Worry too long after embarrassment	1.0	1.7	4.0	-1.8	-1.1	-0.6	-1.5	-2.0	-0.1	-2.0	-0.4	-1.8	-0.2	-0.5	-1.2	-1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	6.0	-0.9	-1.0	0.1	-0.7	0.2	1.2	-0.7	-2.5	0.0	1.9	1.0	0.4	-0.0
Neck or shoulder pain in last month	1.0	1.4	3.9	-1.2	-1.3	-1.1	-1.5	-0.3	-0.4	-1.3	0.5	-1.2	0.1	-1.3	-2.0	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.6	0.4	0.9	1.2	0.5	-0.2	1.5	-0.8	-1.3	0.9	0.7	1.6	1.5	1.3
Knee pain experienced in last month	1.0	1.5	3.1	-1.2	-1.4	-1.3	-0.8	-0.8	-1.7	-0.8	0.8	-1.2	-1.0	-1.8	-1.1	-1.5
Commuting to job workplace: Public transport	1.0	1.2	3.6	-0.5	-0.0	-1.1	0.2	1.1	-1.5	1.7	1.9	0.1	-0.9	-1.4	-0.6	-0.5
Fractured/broken bones in last 5 years	1.0	1.3	3.4	-1.0	-0.6	-0.8	0.3	-0.2	-1.4	-0.2	1.8	-0.5	-1.6	-1.9	-1.6	-0.8
Myopia	1.0	1.4	3.6	-1.5	-1.9	-1.5	-1.5	-0.7	-0.8	0.4	-0.6	-1.3	1.0	-0.5	-1.2	-1.4
Supplements: Calcium	1.0	1.1	3.0	-1.7	-1.1	-1.6	-0.9	-0.9	-1.4	-0.6	0.0	-0.8	-0.3	-0.8	-1.2	-1.1
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.2	-0.9	-1.2	-0.9	-1.8	-0.8	-0.6	-0.1	-0.8	-1.4	0.9	-0.7	-1.2	-1.7
Systolic blood pressure, automated reading	0.9	2.6	5.7	2.1	1.5	2.4	2.0	0.4	2.1	-0.1	0.5	1.6	-0.6	1.3	1.9	2.0
Had menopause	0.9	1.2	2.7	-1.3	-1.6	-1.2	-0.4	-1.2	-1.4	-0.4	1.0	-0.9	-1.0	-1.2	-0.3	-1.0
Mouth/teeth dental problems	0.9	1.3	4.8	-0.4	0.0	-1.2	0.4	-0.9	-1.5	-0.4	1.9	-0.7	-2.2	-1.6	-0.7	-0.6
Allergy	0.9	2.0	6.4	0.9	0.4	1.7	2.1	0.4	0.8	1.8	2.5	1.0	-2.0	-0.5	0.9	1.1
Mood swings	0.9	1.7	4.1	-1.4	-0.5	-0.8	-2.0	-1.7	0.3	-2.0	-1.8	-1.5	0.9	0.3	-1.1	-0.8
Qualifications: nursing, teaching	0.9	1.4	3.2	-1.6	-1.0	-1.1	-1.8	-0.2	-1.0	1.1	-0.7	-1.2	1.1	-0.6	-1.4	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.6	-1.9	-1.2	-1.5	-0.7	-1.1	-1.2	-1.0	-0.3	-0.9	-0.1	-0.4	-0.7	-0.9
Back pain experienced in last month	0.9	1.4	3.6	0.3	1.9	1.0	1.3	1.7	1.0	0.6	-0.3	1.5	0.4	0.6	1.7	1.1
Medication: Lisinopril	0.9	1.2	6.1	-0.4	0.7	0.3	1.6	-0.8	-0.5	0.4	2.0	0.1	-2.5	-0.7	-0.5	0.5
Unable to work because of sickness or disability	0.9	1.2	4.8	1.2	0.5	1.0	0.0	-0.2	1.4	-0.6	-2.2	0.6	1.1	1.8	0.3	0.8
BMI	0.8	4.4	6.4	-2.5	-2.1	-2.4	-1.7	-2.3	-2.2	-2.5	0.5	-2.4	-1.3	-2.2	-1.9	-2.3
Waist Hip Ratio (WHR)	0.8	3.7	8.6	2.3	1.1	2.9	1.9	1.5	2.5	1.6	-0.0	2.1	0.3	1.9	2.3	2.3
Stomach or abdominal pain in last month	0.8	1.1	4.3	1.2	0.7	0.6	-0.5	1.5	1.0	0.4	-1.1	0.8	2.1	1.3	0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.8	-0.8	-0.4	-0.5	-1.5	-1.4	-0.0	-1.5	-2.2	-1.1	1.3	0.7	-0.1	-0.7
Eye problems/disorders: None of the above	0.8	0.9	2.7	0.1	-0.5	-0.2	1.1	1.6	-0.4	1.6	1.6	1.2	-0.7	-0.4	0.6	0.3
Leg fat mass (right)	0.8	3.0	7.5	-2.5	-2.3	-2.3	-0.7	-1.2	-2.7	-1.0	0.9	-1.4	-1.3	-1.7	-1.5	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	4.5	-0.2	-0.4	-0.8	-0.7	0.6	-0.1	-1.0	-1.8	0.4	2.1	1.4	0.1	0.2
Long-standing illness, disability or infirmity	0.8	1.3	3.4	-1.2	-0.5	-1.7	-0.9	0.5	-1.8	-1.4	0.0	-0.7	0.1	-1.4	-1.1	-1.5
Friendships satisfaction	0.8	1.0	4.3	0.9	0.6	2.1	0.9	-0.1	1.4	0.6	1.4	0.3	-1.1	-0.4	-0.5	0.6
Commuting to job workplace: Walk	0.8	0.9	3.3	0.3	0.8	-0.1	-1.4	-1.5	0.2	-1.8	-0.8	-1.3	-0.0	0.1	-0.6	-0.5
Medication for cholesterol	0.8	1.3	3.8	-0.5	-0.9	-1.1	-1.6	-0.1	-0.9	1.0	0.2	-1.3	0.5	-1.6	-1.3	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.9	-1.3	-0.4	-1.7	-1.7	0.7	-1.2	0.6	-2.0	-0.2	2.6	0.7	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.0	-0.5	-0.8	-0.4	-1.0	-1.7	-0.6	-1.6	-0.9	-1.3	-0.3	-0.3	-1.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.5	-1.6	-0.8	-1.4	-0.5	-1.2	-1.4	-0.8	-0.2	-0.9	-0.7	-0.7	-1.1	-0.6
Depressed Affect (Nagel 2018)	0.7	1.4	3.8	-0.5	-0.7	-0.1	-1.5	-1.9	0.8	-1.8	-0.2	-1.7	-0.2	-0.5	-1.9	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.8	7.2	1.1	2.7	2.0	-0.1	0.0	1.7	2.1	-0.6	0.1	0.8	1.0	-0.2	1.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.5	-0.9	-1.5	-0.7	-0.3	-1.6	-1.6	-0.6	0.2	-1.1	-1.2	-0.7	-0.7	-0.6
Schizophrenia (2014)	0.7	1.6	3.4	-1.2	-1.2	-1.0	-0.6	-1.9	-1.8	-1.7	0.8	-1.5	-1.1	-0.9	-1.3	-1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	0.3	-0.8	-0.0	-1.3	-1.4	0.4	-0.8	-1.3	-1.2	0.6	0.3	-0.8	-0.8
Smoking Status	0.7	1.7	5.9	-1.5	-2.4	-1.6	-1.6	-0.3	-1.4	-0.9	-0.5	-1.1	0.9	-0.7	-1.0	-1.6
Chronotype (morning person)	0.7	1.7	3.0	-1.6	-1.7	-1.3	-0.1	-1.5	-1.6	-0.8	1.0	-1.0	-1.7	-1.1	-1.5	-0.8
Ever had hysterectomy (womb removed)	0.7	0.8	2.5	-1.1	-1.0	-1.5	-0.6	-0.7	-1.6	-0.0	-1.0	-0.6	0.5	-0.2	-0.5	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.2	4.5	-0.7	-0.9	-1.1	-0.8	0.7	-2.1	1.0	1.0	-0.7	-0.2	-1.7	-1.0	-1.3
Lung cancer (father)	0.7	0.8	2.1	-0.9	-0.6	-0.8	-1.5	0.4	-0.3	-0.4	0.5	-1.0	0.1	-1.4	-0.7	-1.3
Tense / ‘highly strung’	0.7	1.1	2.3	-1.5	-0.2	-1.3	-0.2	-1.1	-1.5	-0.5	0.9	-0.9	-1.3	-1.0	-1.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.4	1.0	1.8	0.5	-0.7	0.1	0.9	1.5	-1.8	0.0	1.7	1.1	-0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.3	0.6	0.6	0.8	0.3	0.5	1.5	0.5	-1.1	0.8	1.1	1.4	1.4	0.9
Age at first live birth	0.7	1.3	4.6	0.4	0.3	0.3	-0.6	0.7	0.5	1.8	-2.1	0.6	2.1	1.4	0.9	0.3
Health satisfaction	0.7	0.9	2.7	1.6	0.5	1.5	0.7	0.0	1.4	-0.3	-0.7	0.8	0.2	1.2	0.4	1.0
Medication: Allopurinol	0.7	1.0	3.5	0.0	1.1	0.9	1.9	0.6	0.8	0.1	1.2	1.0	-1.4	-0.2	0.9	0.9
Overall health rating	0.7	1.6	3.8	-1.4	-1.5	-0.7	-1.0	-0.9	-0.3	-2.0	0.2	-1.4	-0.5	-1.3	-1.8	-1.6
Family relationship satisfaction	0.7	0.9	2.7	-0.4	-0.6	-0.4	-0.1	-0.8	-0.4	-0.0	1.6	-0.9	-1.4	-1.4	-1.6	-0.9
Hypertension (Self-reported)	0.7	1.9	3.3	1.7	1.7	1.3	1.6	0.8	1.4	0.7	-0.4	1.7	0.1	1.7	1.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	6.2	-1.1	-1.0	-1.6	-0.6	-0.3	-2.5	0.8	0.1	-0.9	-0.6	-0.9	-2.2	-1.0
Loneliness, isolation	0.7	1.0	4.7	1.2	0.8	2.0	0.1	0.3	2.2	0.1	-0.5	0.4	0.9	0.8	0.2	0.5
Osteoarthritis (self-reported)	0.7	0.9	2.8	-1.3	-0.7	-0.4	-0.5	-1.7	-0.7	-0.7	0.0	-1.1	-0.8	-0.6	-1.6	-0.4
Hearing aid user	0.7	0.8	2.6	-1.4	-0.9	-0.6	-0.0	-0.7	-0.7	-0.2	1.6	-0.6	-1.4	-1.1	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	-1.5	-1.1	-1.2	-0.3	-0.8	-0.9	-1.3	0.6	-0.7	-0.6	-0.9	-0.7	-0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.3	-0.9	-0.2	-0.4	0.0	-1.2	-1.3	-1.1	0.8	-0.7	-1.5	-1.1	-0.9	-0.6
Medication: Bendroflumethiazide	0.7	1.0	2.1	1.2	0.5	0.7	0.4	1.4	0.8	-0.5	-1.4	1.2	1.3	1.1	1.1	0.7
Medication: Atorvastatin	0.7	0.9	2.5	-1.2	-1.2	-1.0	-1.1	0.3	-0.9	-0.1	-1.1	-0.4	1.6	-0.0	-0.6	-0.9
Number of operations (self-reported)	0.7	1.1	4.7	1.0	2.2	0.4	1.6	0.3	-1.0	0.9	0.7	0.8	-1.1	0.2	0.2	1.1
Leg fat mass (left)	0.7	2.6	7.0	-2.4	-2.2	-2.1	-0.6	-1.1	-2.7	-0.8	0.9	-1.3	-1.3	-1.6	-1.4	-1.2
Fasting Glucose	0.6	0.7	2.7	1.1	-0.7	1.2	0.6	-0.5	1.6	-1.1	-0.2	0.1	-0.6	-0.2	0.6	0.1
HDL Cholesterol	0.6	1.0	2.4	1.0	0.9	1.3	0.9	1.6	1.2	1.2	0.6	1.1	0.4	0.6	0.8	0.8
Number of treatments/medications taken	0.6	1.0	3.4	-1.3	-0.1	-1.9	-1.2	-0.2	-1.4	-1.1	-0.9	-0.6	0.8	-0.4	-0.6	-1.0
Average weekly spirits intake	0.6	0.7	2.6	-0.6	-1.4	-0.8	-0.8	1.4	-0.3	0.4	-0.1	0.1	1.6	-0.3	0.5	-0.8
Vitamin and mineral supplements	0.6	0.8	3.3	0.5	0.2	1.8	0.8	-0.1	1.8	-0.6	-0.2	0.4	-0.1	0.7	0.8	0.9
Supplements: Zinc	0.6	0.7	1.6	-0.6	-0.6	-1.0	-1.3	-0.3	-1.2	0.5	-0.6	-0.8	0.7	-0.5	-0.4	-1.2
Diabetes (father)	0.6	0.8	2.7	-0.5	-1.2	-0.4	0.2	-0.7	-0.6	0.4	1.1	-0.7	-1.6	-1.5	-0.3	-0.7
Medication: Levothyroxine sodium	0.6	1.0	3.1	-0.4	0.1	-0.8	-1.8	-0.0	-0.0	-0.9	-0.1	-1.4	0.7	-1.6	-0.6	-1.8
Alcohol usually taken with meals	0.6	0.9	2.3	0.2	0.1	-0.5	-1.1	-1.1	-0.8	-0.2	0.6	-1.5	-0.9	-1.5	-0.9	-1.5
Financial difficulties in last 2 years	0.6	0.8	2.0	-1.0	-0.9	-1.2	-1.2	0.0	-0.5	-0.6	-0.3	-1.0	0.4	-1.1	-0.9	-1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.8	0.2	0.9	-0.7	-0.5	1.1	-0.3	-0.3	-1.6	0.6	1.9	1.0	0.5	0.1
Father’s age at death	0.6	0.7	2.2	0.0	0.3	0.1	1.5	0.9	-1.0	1.2	1.4	1.0	-0.8	-0.4	0.4	0.7
Arm fat mass (right)	0.6	2.5	7.2	-2.5	-1.8	-2.3	-0.7	-0.6	-2.7	-1.0	0.6	-1.1	-0.9	-1.5	-1.4	-1.2
High blood pressure (siblings)	0.6	0.9	1.7	1.1	1.0	0.6	0.5	1.3	0.5	-0.3	-1.0	1.1	0.7	1.3	1.1	1.0
Number of full brothers	0.6	0.8	2.1	0.9	0.5	1.2	0.8	-0.4	1.3	-0.5	-1.5	0.4	-0.1	1.4	0.3	1.0
Wheeze or whistling in the chest in last year	0.6	1.1	9.6	-0.3	-0.4	-0.0	-0.9	-0.9	0.7	-3.1	-1.1	-0.9	0.4	0.2	-0.4	-0.6
Number of full sisters	0.6	0.8	3.4	-1.1	-1.8	-0.4	-0.3	-0.4	-0.5	-1.3	0.7	-0.6	-0.8	-0.9	-0.7	-0.7
Suffer from ‘nerves’	0.6	0.9	3.0	-1.1	-0.2	-1.7	-0.8	-1.0	-1.6	-0.4	-0.2	-0.9	-0.2	-0.3	-1.1	-0.8
Chest pain or discomfort	0.6	0.9	3.8	-0.0	0.5	1.1	-0.8	-0.4	1.9	-1.7	-1.1	-0.7	0.4	-0.1	-0.5	-0.5
Arm fat mass (left)	0.6	2.5	7.9	-2.4	-1.9	-2.5	-0.7	-0.6	-2.8	-0.9	0.6	-1.1	-0.8	-1.4	-1.3	-1.2
Mother’s age at death	0.6	0.8	3.5	1.9	1.6	0.1	0.8	0.4	-0.3	-0.2	-0.2	0.9	0.2	0.8	0.8	1.1
Diastolic blood pressure, automated reading	0.6	2.0	4.3	2.1	1.2	1.7	1.7	0.8	1.9	0.3	0.3	1.6	-0.3	1.1	1.8	1.6
Alzheimer’s Disease (in father)	0.5	0.6	3.4	-0.1	1.8	-0.4	0.9	0.1	-0.8	-0.7	0.3	0.3	-0.5	0.6	0.4	1.1
Ovarian Cancer	0.5	0.7	2.5	-0.3	1.6	-0.7	-1.3	-0.5	-0.6	-0.5	-0.5	-1.1	0.5	-0.6	-0.6	-1.0
Primary Biliary Cirrhosis	0.5	0.7	2.0	-0.3	-0.2	0.0	-1.2	-0.6	0.3	-1.1	-1.0	-1.0	0.6	-0.6	-1.4	-1.1
Triglycerides	0.5	0.8	2.4	0.8	1.6	1.3	0.3	0.4	1.0	0.8	1.0	-0.0	-1.0	-0.8	-0.9	-0.1
Angina	0.5	0.6	1.5	-0.9	0.3	0.3	-1.2	-0.4	1.1	-1.1	-0.8	-0.9	0.6	-0.3	-0.7	-0.8
Townsend deprivation index at recruitment	0.5	0.7	5.4	-1.1	-2.3	-0.5	-0.2	-0.0	-0.1	-0.8	-0.6	-0.2	0.5	0.0	-0.3	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	3.2	0.1	-0.4	0.3	0.7	-0.3	0.3	-1.0	1.8	-0.1	-1.5	-0.9	0.1	0.2
Serious illness, injury or assault to yourself	0.5	0.6	2.5	-0.7	0.0	-0.6	-1.2	0.1	-0.1	-0.4	-1.4	-0.4	1.6	0.5	-0.7	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.3	-0.6	-0.4	-1.0	-1.3	0.6	0.1	-0.8	-1.9	-0.0	2.1	0.9	-0.5	-0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	0.1	1.2	0.1	1.1	1.2	-0.1	0.1	0.7	1.1	-0.5	-0.1	0.9	0.7
Trunk fat mass	0.5	2.0	7.1	-2.3	-1.8	-2.0	-0.3	-0.4	-2.7	-0.3	1.0	-0.6	-1.0	-1.2	-1.1	-0.7
Waist circumference	0.5	1.7	5.0	-1.6	-1.9	-1.7	-0.5	-0.7	-2.2	-0.7	0.6	-0.9	-0.8	-1.3	-1.1	-1.1
Diabetes (self-reported)	0.5	0.8	2.8	-0.2	-1.1	-0.2	-1.5	1.0	-0.1	-0.7	-1.1	-0.2	1.7	-0.1	0.0	-1.2
Neuroticism score	0.5	1.0	2.4	-1.1	-0.4	-1.0	-1.3	-1.6	-0.2	-1.3	-0.8	-1.3	0.0	-0.2	-1.2	-0.9
Worrier / anxious feelings	0.5	0.9	4.8	-2.2	-0.8	-0.6	-1.2	-1.2	-0.2	-0.7	-0.7	-0.9	0.3	-0.0	-0.6	-0.6
Depression (self-reported)	0.5	0.6	2.6	-1.0	-0.7	-0.3	-1.0	0.3	-0.2	0.0	0.1	-0.7	0.5	-0.9	-1.6	-1.1
Exposure to tobacco smoke at home	0.5	0.6	1.8	-1.4	-0.3	0.4	-0.6	0.2	1.2	-1.1	0.3	-0.6	-0.0	-0.9	-0.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	-1.3	-1.1	-0.9	-0.7	0.3	-0.4	-0.6	0.5	-0.6	-0.0	-1.0	-1.4	-1.1
Glaucoma (self-reported)	0.5	0.5	2.8	-0.1	-0.2	-0.3	-0.5	-0.1	0.4	-1.1	-1.7	-0.0	1.3	0.7	-0.0	-0.0
Number of children fathered	0.5	0.6	2.5	0.2	1.4	0.3	-0.0	1.6	0.7	0.3	-0.1	0.8	1.0	0.3	0.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	1.0	0.2	0.8	0.8	0.8	0.2	0.1	-0.7	1.0	0.7	1.0	1.1	1.0
Angina (self-reported)	0.5	0.7	1.6	-0.9	0.5	0.3	-1.3	-0.6	1.1	-1.1	-0.7	-1.0	0.6	-0.4	-0.8	-0.9
Whole body fat mass	0.5	2.0	7.5	-2.3	-1.9	-2.1	-0.3	-0.4	-2.7	-0.3	0.9	-0.7	-1.0	-1.2	-1.1	-0.8
Supplements: Vitamin C	0.5	0.6	2.7	1.6	0.9	0.4	0.8	0.8	0.3	0.2	-0.4	0.9	0.5	0.7	0.2	0.6
Average weekly red wine intake	0.5	0.8	2.8	0.2	0.4	0.1	-1.7	-1.2	0.1	-0.5	-0.5	-1.5	0.5	-0.7	-0.9	-1.3
Ever had bowel cancer screening	0.5	0.6	2.8	-0.2	-0.2	-0.5	-1.2	-0.3	-0.4	0.2	-1.6	-0.3	1.7	0.5	0.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.0	0.2	-0.3	0.1	1.3	0.7	-0.2	1.4	0.7	0.8	-0.8	-0.5	0.8	0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.1	-0.8	-1.5	-1.4	-1.1	-0.2	-1.0	-1.1	-0.7	-0.7	0.9	-0.1	-0.9	-1.0
Eye problems/disorders: Glaucoma	0.5	0.6	3.1	0.5	0.5	0.4	0.0	-0.2	0.8	-0.8	-1.8	0.3	0.9	1.2	-0.0	0.8
Average weekly beer plus cider intake	0.5	0.7	3.1	0.4	0.9	0.4	1.1	0.2	-0.3	-0.2	1.6	0.3	-1.8	-0.8	-0.7	0.4
Pack years of smoking	0.5	0.8	2.2	-1.0	-0.5	-0.5	0.4	-0.8	-1.3	-1.5	0.7	-0.6	-1.5	-0.7	-0.5	-0.2
Neuroticism (Nagel 2018)	0.4	0.9	2.8	-0.6	-0.6	-0.6	-1.0	-1.7	0.1	-1.6	-0.0	-1.3	-0.2	-0.3	-1.4	-0.9
Schizophrenia (2018)	0.4	0.9	2.4	-0.8	-1.6	-1.0	-0.3	-1.2	-1.3	-0.9	0.9	-1.0	-0.8	-0.5	-0.5	-0.7
Reaction Time	0.4	0.8	1.7	-0.9	-0.3	-0.6	-1.0	-1.3	-0.9	-0.5	0.6	-1.2	-0.9	-1.0	-0.7	-1.1
Hand grip strength (left)	0.4	1.1	3.0	-0.7	0.3	-0.5	0.2	-0.4	-1.5	-0.1	1.6	-0.7	-1.7	-1.4	-1.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	0.1	0.7	0.7	0.6	0.9	0.7	0.7	-0.3	1.0	0.4	0.7	0.5	0.8
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.7	-1.0	-0.5	0.5	-0.9	-0.8	-0.8	0.7	-0.2	-1.1	-0.1	-0.3	0.1
Pack years adult smoking proportion	0.4	0.6	2.8	-0.7	0.1	-0.0	0.9	-0.6	-0.8	-1.2	0.8	-0.2	-1.7	-0.4	0.1	0.3
Fed-up feelings	0.4	0.7	1.9	-0.2	-0.1	-0.2	-1.2	-1.0	1.0	-1.4	-0.3	-1.1	0.1	-0.4	-1.2	-0.8
Relative age voice broke	0.4	0.6	2.3	-0.7	0.8	-1.1	-0.4	-1.5	-1.0	-0.9	-0.4	-0.9	-0.6	-0.2	-0.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	-0.1	0.3	0.5	-0.1	-1.5	-0.3	-0.9	0.1	-0.8	-1.2	0.1	-0.5	-0.0
High blood pressure	0.4	1.1	2.1	1.5	1.0	1.3	1.4	0.6	1.1	0.4	-0.1	1.3	-0.2	1.2	1.2	1.4
Multivitamins +/- minerals	0.4	0.5	1.9	-0.5	-0.5	-1.4	-0.5	-0.4	-1.3	0.1	0.6	-0.5	-0.6	-0.7	-0.7	-0.6
Medication: Atenolol	0.4	0.5	2.4	0.0	1.0	0.1	-0.4	0.1	0.4	0.0	-1.6	0.1	1.2	1.0	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.6	-0.6	-0.3	-0.9	-0.7	0.8	-0.0	0.7	-0.5	-0.0	1.3	-0.3	-0.5	-0.8
Falls in the last year	0.4	0.6	1.6	0.8	-0.1	1.0	0.3	-0.8	1.0	-1.2	-0.9	0.1	-0.1	1.3	0.0	0.7
Pulse rate	0.4	0.6	1.8	-0.8	-0.7	-0.2	-1.3	-0.6	0.4	0.3	-1.0	-1.0	0.9	-0.3	-0.5	-1.0
Medication: Cholesterol lowering	0.4	0.6	3.3	0.1	0.9	0.6	-0.2	1.8	0.9	0.7	-0.1	0.7	1.1	-0.2	0.5	-0.3
Medication: Lansoprazole	0.4	0.5	1.7	-0.7	-0.3	-1.3	-1.0	0.2	-0.6	0.0	-0.2	-0.5	0.7	-0.3	-1.2	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	1.0	1.1	1.0	0.4	0.9	1.4	-0.3	-1.0	1.0	1.0	1.2	0.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	-1.0	-1.0	-0.8	-0.3	-1.4	-0.9	-0.4	0.8	-0.9	-1.1	-0.7	-0.5	-0.2
Gout (self-reported)	0.4	0.6	1.6	0.5	1.3	0.8	1.1	0.4	1.1	-0.6	-0.3	0.8	-0.2	0.4	0.8	0.8
Body fat percentage	0.4	1.4	4.7	0.4	0.1	0.9	1.8	0.7	0.9	0.1	0.2	1.7	-0.4	1.2	2.2	1.9
Exposure to tobacco smoke outside home	0.4	0.6	2.2	0.2	-0.6	1.2	1.0	0.4	1.5	0.1	0.9	0.5	-1.0	-0.2	0.5	0.4
Pulse wave peak to peak time	0.4	0.4	1.3	0.3	1.1	-0.1	1.1	0.5	-0.4	0.3	0.0	0.9	-0.3	0.5	0.8	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	2.1	0.3	-0.8	0.0	-1.0	-1.4	-0.4	-0.1	0.5	-1.4	-0.7	-0.7	-1.1	-0.8
Heart disease (mother)	0.4	0.4	2.1	-1.0	-0.9	0.0	-0.1	-1.4	-0.5	0.2	0.3	-0.8	-0.7	-0.4	0.2	-0.4
Average weekly champagne plus white wine intake	0.4	0.5	1.6	-0.5	-0.6	-0.9	-0.7	-1.3	-0.7	-0.1	-1.0	-0.8	0.4	0.2	-0.0	-0.7
Miserableness	0.4	0.7	2.5	0.4	-0.0	0.5	-0.6	-1.5	0.9	-1.6	-0.8	-1.0	-0.2	0.2	-1.0	-0.1
Irritability	0.4	0.7	3.0	-0.5	0.4	-0.5	0.8	-0.6	-0.3	-0.5	1.7	-0.1	-1.7	-0.8	-0.6	0.2
Commuting to job workplace: Cycle	0.4	0.5	1.8	0.8	1.4	0.4	-0.8	0.3	0.3	-0.8	-1.1	-0.4	0.7	-0.0	-0.7	-0.3
Alcohol drinker status: Previous	0.4	0.4	2.0	0.6	0.3	0.1	-0.1	0.3	0.1	-0.8	-1.4	0.4	0.9	0.9	0.6	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.1	-0.7	0.8	0.1	0.6	0.4	0.7	-0.7	0.5	1.0	0.9	0.4	0.5
Worry (Nagel 2018)	0.3	0.6	1.6	-0.7	-0.1	-1.1	-0.6	-1.0	-1.3	-0.7	-0.1	-0.8	-0.5	-0.4	-0.9	-0.8
Crohns Disease (2017)	0.3	0.6	1.5	0.3	-0.3	0.5	1.2	1.1	-0.0	0.6	-0.2	1.0	0.5	1.2	0.6	1.0
Irritable Bowel Disease (IBD)	0.3	0.7	2.9	0.7	-0.0	0.7	1.7	0.7	0.6	-0.2	-0.1	1.0	-0.0	1.2	0.6	1.3
Major Depression (MDD)	0.3	0.4	2.0	0.0	0.6	-0.2	-0.1	-0.2	0.3	-0.4	-1.4	0.1	0.5	0.6	-1.2	0.3
Bipolar Disorder (2011)	0.3	0.3	1.4	-0.4	-0.5	-0.9	-0.6	1.2	-0.8	-0.4	0.0	0.1	0.0	-0.3	0.0	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	1.1	0.8	-0.1	1.1	-0.1	0.1	1.0	-0.5	-0.8	0.1	0.3	0.2	-0.0	-0.1
Crohns Disease (2012)	0.3	0.5	1.9	0.1	0.4	0.1	1.4	1.0	-0.4	0.4	0.7	1.0	-0.5	0.3	0.4	0.8
Ulcerative Colitis	0.3	0.5	3.0	-0.1	0.0	-0.4	0.8	-0.5	0.2	-1.7	-0.6	0.2	-0.3	0.5	1.1	0.5
Blood Platelet Count	0.3	3.0	6.2	-1.5	-2.3	-2.5	0.5	1.1	-1.8	1.9	-2.0	1.4	2.2	1.6	1.8	0.1
Blood Red Count	0.3	3.1	7.2	2.1	0.5	1.1	0.9	0.4	2.0	0.3	-2.6	1.6	1.7	2.7	2.6	1.9
Blood White Count	0.3	2.1	8.3	1.5	0.0	2.1	-0.2	0.9	2.9	0.7	-1.6	1.0	1.8	1.6	1.0	0.6
Allergy or Eczema	0.3	0.8	3.5	-0.6	-0.2	-0.9	-1.3	0.4	0.2	-0.3	-1.8	-0.1	1.9	0.7	-0.4	-0.3
Relative age of first facial hair	0.3	0.7	2.1	-1.5	-0.8	-0.3	-1.1	-0.9	0.3	-0.4	-1.0	-0.9	0.8	-0.2	-0.7	-1.0
Trunk fat percentage	0.3	1.3	3.8	0.3	0.2	0.8	1.7	0.8	0.8	0.2	0.2	1.7	-0.3	1.3	2.0	1.9
Current tobacco smoking	0.3	0.5	1.9	-1.4	-1.1	-0.8	-0.9	-0.0	-0.3	-0.8	-0.1	-0.6	0.3	-0.3	-0.4	-0.7
Qualifications: None of the above	0.3	0.6	2.4	-0.1	-1.3	0.2	1.0	0.8	-0.2	-1.6	0.5	1.1	-0.3	0.5	0.4	0.8
Medication: Ramipril	0.3	0.4	2.1	0.3	0.7	0.4	-0.1	0.1	0.0	-1.4	-1.1	0.2	0.5	0.6	-0.0	0.4
Headache pain in last month	0.3	0.6	1.3	0.2	1.0	1.1	0.1	0.8	1.2	0.8	-1.0	0.6	1.0	0.5	-0.2	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.3	-0.3	0.2	0.3	0.4	-0.8	-0.0	-0.2	1.1	-0.4	-1.5	-0.5	-0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.5	0.0	-0.7	-0.1	-0.8	0.5	0.3	0.3	-0.8	-0.2	1.2	-0.2	-0.6	-0.7
Medication: Ibuprofen	0.3	0.4	1.0	-0.7	0.6	-1.0	-0.0	-0.3	-0.6	0.5	0.8	-0.2	-0.8	-0.9	-0.4	-0.4
Had major operations	0.3	0.3	1.1	-1.1	0.7	-0.5	-0.4	-0.0	-0.8	-0.8	-0.4	-0.5	0.1	-0.1	-0.8	-0.3
Age at last live birth	0.3	0.4	1.3	-1.0	-0.4	-0.2	-1.1	-0.2	0.0	0.1	-1.1	-0.6	1.0	0.1	-0.3	-0.7
Illnesses of father: Heart disease	0.3	0.4	1.6	0.0	0.2	-0.1	-0.8	1.0	1.0	0.0	-0.5	0.1	1.3	0.1	-0.5	-0.3
Breast cancer (self-reported)	0.3	0.3	1.2	-0.1	0.3	0.2	-0.3	-0.6	-0.4	-0.5	0.7	-0.5	-0.8	-1.1	-0.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.8	-0.1	-0.2	-0.9	-0.5	-0.0	-1.0	-0.1	-1.3	0.1	1.1	0.7	0.4	0.1
Alcohol drinker status: Never	0.3	0.4	1.1	0.7	-0.2	-0.8	-0.4	0.8	-1.0	0.4	-0.5	0.3	1.0	-0.1	0.6	-0.5
Ever depressed for a whole week	0.3	0.4	1.5	0.6	0.3	-0.5	-0.0	1.1	0.3	0.9	-0.5	0.6	1.2	0.3	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	-1.1	-0.8	-1.3	-1.0	-0.7	-1.3	-0.4	0.3	-1.1	-0.3	-1.2	-0.9	-1.1
Pain experienced in last month	0.3	0.6	1.4	1.1	1.0	0.5	1.1	-0.8	0.4	-0.1	0.4	0.2	-1.0	0.4	0.4	1.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.0	0.9	-0.8	-0.3	-0.4	-1.0	0.8	0.7	-0.6	-0.7	-0.5	-0.1	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.0	-0.1	1.5	0.3	-0.7	0.3	0.5	1.7	-0.2	-0.5	0.7	-0.1	-0.9	-0.2
Breast Cancer	0.2	0.4	1.8	0.1	0.2	-0.3	-0.4	1.3	-0.3	1.1	-0.4	0.5	1.1	-0.0	0.7	-0.3
Mean Putamen Volume	0.2	0.2	0.8	-0.1	-0.8	0.2	0.1	0.0	0.0	-0.2	-0.0	0.3	0.1	0.6	-0.9	0.7
LDL Cholesterol	0.2	0.3	1.6	-0.1	-0.4	0.2	0.1	1.3	0.0	0.5	1.0	0.5	0.2	-0.6	0.1	-0.1
Neuroticism (2016)	0.2	0.3	0.8	0.3	0.8	-0.0	0.4	0.4	0.1	0.0	-0.7	0.7	0.1	0.7	0.9	0.8
Hypothyroidism (self reported)	0.2	0.4	1.5	-0.2	0.6	-0.6	0.1	0.4	-0.5	-0.2	1.2	-0.1	-0.8	-1.2	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	-0.7	-0.9	-0.3	-0.7	-0.3	-0.6	-0.6	-0.1	-0.7	-0.0	-0.9	-0.4	-1.1
Neuroticism	0.2	0.4	1.0	-0.6	-0.6	-0.6	-0.6	-1.0	-0.1	-0.7	-0.8	-0.6	0.2	0.3	-0.7	-0.4
Severe depression (siblings)	0.2	0.2	0.4	-0.3	-0.6	-0.4	0.0	0.7	-0.2	-0.5	-0.5	0.4	0.5	0.2	-0.5	-0.2
Age when periods started (menarche)	0.2	0.4	1.7	0.0	-0.3	-0.5	-0.5	1.3	0.2	1.0	0.2	0.2	1.2	-0.4	0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.1	0.4	-0.3	0.7	-0.6	-0.8	0.0	-0.4	0.2	-0.5	0.5	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	0.7	-0.0	-0.1	0.4	-0.0	-0.2	0.1	0.9	-0.0	-0.8	-0.5	-0.1	-0.1
Body mass index (BMI)	0.2	0.9	2.8	-1.4	-1.7	-1.3	-0.4	-0.5	-1.1	-1.4	0.0	-0.7	-0.3	-0.8	-0.4	-0.7
Arm fat percentage (right)	0.2	0.7	2.2	-0.0	-0.2	0.4	1.5	0.4	0.4	-0.7	0.4	1.1	-0.8	0.4	1.5	1.2
Time employed in main current job	0.2	0.2	0.9	-0.9	-0.3	-0.9	0.1	-0.1	-0.3	-0.1	-0.2	0.4	0.1	0.7	0.5	0.5
Alcohol intake versus 10 years previously	0.2	0.2	0.8	0.2	-0.9	0.6	0.4	0.1	0.1	-0.4	-0.4	0.4	-0.3	0.7	0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.5	0.2	-0.4	0.8	0.3	-0.6	0.6	-1.2	-0.5	-0.0	-0.1	0.6	0.0	0.3
Happiness	0.2	0.2	1.1	0.3	0.3	-0.2	0.5	-0.1	0.0	0.4	1.1	0.3	-0.7	-0.1	0.5	0.3
Noisy workplace	0.2	0.3	1.0	0.1	0.9	0.1	0.8	-0.2	0.2	0.1	0.8	0.3	-1.0	-0.2	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.6	0.4	-0.5	-0.7	-0.1	0.5	-0.7	-0.4	-0.3	0.4	-0.3	-0.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.7	-0.9	0.0	-1.3	-0.3	0.1	-0.4	-0.3	0.3	-0.1	-0.2	-0.7	-0.2	-0.5
Prospective memory result	0.2	0.3	1.3	-0.2	-0.6	-0.5	-0.5	0.2	0.0	-0.2	-0.5	-0.2	0.6	-0.2	-1.1	-0.8
Length of working week for main job	0.2	0.2	0.7	0.3	0.5	-0.7	-0.6	0.2	0.2	0.2	-0.4	-0.1	0.9	0.3	-0.2	-0.2
Peak expiratory flow (PEF)	0.2	0.4	1.9	0.3	1.0	0.3	-0.3	-0.1	-0.5	1.1	-0.7	-0.1	0.0	-0.1	-1.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.4	0.0	-0.9	-1.1	0.3	-0.2	-0.6	0.2	-0.6	0.6	-0.8	0.0	-1.0
Leg fat percentage (right)	0.2	0.8	2.9	0.2	-0.5	1.0	1.3	-0.1	1.0	-0.6	0.2	0.8	-0.7	0.6	1.7	1.3
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.3	-0.4	-0.3	-0.5	0.1	0.2	-0.8	0.4	-0.3	0.1	-0.5	-0.4	-0.6
Qualifications: College or University degree	0.2	0.7	6.0	-0.3	0.0	0.3	0.0	-0.7	0.4	2.5	0.6	-0.5	-0.7	-0.4	-1.1	-0.4
Migraine (self-reported)	0.2	0.2	0.9	-0.4	0.5	0.1	0.6	-0.2	-0.1	-0.1	0.7	0.1	-0.9	-0.5	0.2	0.2
Alcohol intake frequency.	0.2	0.5	1.4	0.3	-0.1	-0.6	0.0	1.2	-1.0	-0.8	-1.0	0.6	0.9	0.2	0.9	0.0
Arm fat percentage (left)	0.2	0.9	3.3	0.2	-0.1	0.3	1.5	0.9	0.5	-0.4	0.2	1.4	-0.2	0.8	1.8	1.4
Osteoporosis (self-reported)	0.2	0.2	0.7	0.8	0.5	-0.1	0.6	0.2	-0.2	0.7	0.3	0.6	-0.3	0.4	0.4	0.5
Wears glasses or contact lenses	0.2	0.3	1.2	-0.4	-0.9	0.2	-0.5	-0.0	0.2	0.5	0.2	-0.4	0.1	-0.4	-1.1	-0.5
Ever smoked	0.2	0.3	1.5	-0.2	-1.2	-0.7	-0.4	0.3	-0.7	0.2	-0.1	-0.2	0.3	-0.4	-0.0	-0.7
Leg fat percentage (left)	0.2	0.9	3.0	0.3	-0.3	1.1	1.4	-0.0	1.0	-0.2	0.4	0.9	-0.8	0.5	1.7	1.4
Risk taking	0.2	0.3	0.6	-0.6	-0.7	0.0	-0.4	-0.4	0.4	-0.8	0.5	-0.7	-0.6	-0.7	-0.4	-0.8
Age started oral contraceptive pill	0.2	0.2	0.6	-0.6	0.6	-0.1	0.6	0.2	-0.6	0.3	0.7	0.4	-0.6	-0.0	0.8	0.4
Ulcerative Colitis (UC)	0.1	0.3	1.1	0.1	-0.6	0.0	0.9	-0.1	0.5	-1.1	-0.3	0.2	-0.1	0.6	0.0	0.5
Tanning	0.1	1.5	4.8	-2.2	-1.1	-1.7	-0.9	0.1	-1.9	-0.4	0.4	-0.8	0.6	-1.3	-1.2	-1.3
Pulse wave reflection index	0.1	0.2	0.7	0.3	-0.8	-0.4	0.2	-0.1	-0.5	-0.1	0.6	-0.1	-0.6	-0.5	0.2	-0.0
Medication: Amlodipine	0.1	0.2	0.6	0.7	-0.5	0.1	0.0	-0.5	0.1	0.8	-0.2	-0.2	-0.0	-0.0	0.5	-0.1
Emphysema/chronic bronchitis	0.1	0.2	0.7	0.1	0.1	-0.3	-0.1	-0.4	-0.4	-0.8	-0.0	-0.4	-0.7	-0.2	-0.4	-0.1
Medication: Blood pressure	0.1	0.2	0.6	0.3	-0.1	-0.5	-0.2	-0.3	-0.7	-0.3	-0.3	-0.4	-0.3	-0.4	-0.6	-0.8
Pulse rate, automated reading	0.1	0.2	0.7	-0.6	-0.8	-0.1	-0.2	0.1	0.6	0.2	-0.7	0.1	0.8	0.3	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.5	-0.1	-0.6	0.4	-0.1	-0.7	0.3	-0.7	-0.2	-0.2	0.1	0.4	-0.2	0.2
Smoking status: Current	0.1	0.2	0.9	-0.9	-0.6	-0.5	-0.5	0.1	-0.1	-0.7	0.1	-0.3	0.1	-0.1	-0.3	-0.3
High cholesterol (Self-reported)	0.1	0.1	0.4	0.1	0.2	-0.3	-0.5	0.6	-0.4	-0.2	0.2	-0.1	0.3	-0.5	-0.3	-0.5
Cholesterol lowering medication	0.1	0.2	0.8	-0.8	-0.6	-0.2	0.1	0.1	-0.7	-0.9	0.2	-0.1	-0.2	-0.2	-0.4	-0.1
Hair Pigment	0.0	0.4	1.7	-0.0	-1.3	-0.8	0.6	0.5	-0.7	1.0	0.3	0.6	-0.3	-0.1	0.8	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.2	0.0	-0.3	0.5	-0.1	-0.3	-0.0	0.2	-0.1	-0.2	-0.1	0.2	0.2	0.0

Hub : Genes

RPS20

Models

Trait associations