TWAS
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Models
Genes
Traits
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Traits
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Leg fat-free mass (left)
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chr12:131,872,850-133,778,796
Best TWAS P=3.69e-09 · Best GWAS P=1.98e-10 conditioned to 1
132M
132.5M
133M
133.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ANKLE2
0.04
0.02
lasso
2
0.02
5.8e-06
6.2
5.9
3.7e-09
0.96
0.00
1.00
TRUE
3
GTEx
Testis
EP400NL
0.37
0.30
lasso
5
0.36
6.0e-17
5.0
-5.4
6.0e-08
0.02
0.01
0.99
TRUE
1
GTEx
Adrenal Gland
ZNF605
0.23
0.07
lasso
9
0.06
4.5e-03
6.4
5.9
4.0e-09
0.96
0.01
0.96
FALSE
2
GTEx
Muscle Skeletal
ANKLE2
0.06
0.01
enet
17
0.03
8.8e-04
6.3
5.5
3.8e-08
0.74
0.00
0.95
FALSE
5
The Cancer Genome Atlas
Colon Adenocarcinoma
DDX51
0.05
0.04
lasso
2
0.05
8.1e-04
5.0
5.2
1.9e-07
0.00
0.01
0.89
FALSE