[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr12:121,453,962-124,591,385

Best TWAS P=4.91e-23 · Best GWAS P=8.79e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
68	GTEx	Testis	ABCB9	0.14	0.05	lasso	3	0.06	8.0e-04	8.5	-9.9	4.9e-23	0.33	0.22	0.18	TRUE
109	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	8.8	9.1	1.0e-19	-0.01	0.02	0.89	TRUE
30	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	9.2	8.7	4.7e-18	-0.05	0.70	0.29	TRUE
77	METSIM	Adipose	CLIP1	0.03	0.01	bslmm	372	0.01	3.3e-03	-6.1	7.1	1.6e-12	-0.65	0.37	0.41	TRUE
28	GTEx	Colon Transverse	CDK2AP1	0.17	0.19	enet	7	0.22	1.4e-10	6.6	-6.8	8.2e-12	0.01	0.21	0.79	TRUE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC43	0.03	0.03	enet	8	0.02	1.5e-03	-4.6	-6.6	3.1e-11	0.09	0.10	0.06	TRUE
79	METSIM	Adipose	WDR66	0.04	0.00	blup	341	0.01	1.4e-02	5.1	6.5	9.1e-11	-0.17	0.04	0.10	TRUE
15	GTEx	Brain Hippocampus	CLIP1	0.27	0.14	lasso	4	0.12	1.0e-03	-4.3	-6.5	1.1e-10	0.42	0.07	0.28	TRUE
89	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDK2AP1	0.07	0.07	blup	34	0.05	1.1e-03	5.9	-6.4	2.0e-10	-0.02	0.01	0.88	TRUE
35	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	2.7	6.0	1.7e-09	-0.31	0.59	0.08	TRUE
14	GTEx	Brain Cerebellum	TMEM120B	0.28	0.06	enet	18	0.04	2.6e-02	5.7	-6.0	1.9e-09	0.09	0.07	0.11	TRUE
116	The Cancer Genome Atlas	Thyroid Carcinoma	SBNO1	0.03	0.01	blup	59	0.02	9.4e-03	5.9	-5.9	2.8e-09	-0.06	0.01	0.66	TRUE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR81	0.07	0.02	blup	54	0.02	4.4e-03	5.8	5.8	6.9e-09	-0.36	0.04	0.20	TRUE
37	GTEx	Esophagus Muscularis	MPHOSPH9	0.18	0.18	enet	17	0.18	4.8e-11	5.8	5.6	1.9e-08	0.00	1.00	0.00	TRUE
81	YFS	Blood	PSMD9	0.04	0.03	bslmm	324	0.05	8.2e-15	-4.6	5.3	1.2e-07	-0.08	1.00	0.00	TRUE
11	GTEx	Artery Tibial	ZCCHC8	0.06	0.02	enet	14	0.01	2.5e-02	3.4	5.2	1.6e-07	-0.43	0.06	0.44	TRUE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	RILPL2	0.04	0.02	blup	43	0.02	6.1e-04	6.5	5.2	1.6e-07	0.01	0.01	0.94	TRUE
73	GTEx	Thyroid	WDR66	0.11	0.02	lasso	6	0.02	1.1e-02	-3.8	5.1	2.7e-07	-0.03	0.13	0.08	TRUE
2	GTEx	Adipose Subcutaneous	ZCCHC8	0.04	0.00	lasso	7	0.00	1.4e-01	6.4	9.7	2.5e-22	-0.41	0.12	0.36	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	9.2	9.1	1.3e-19	-0.02	0.02	0.88	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	9.1	8.8	1.6e-18	-0.01	0.02	0.94	FALSE
47	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-4.9	-8.4	6.2e-17	0.63	0.04	0.90	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC43	0.04	0.00	blup	58	0.01	6.9e-02	8.0	-7.9	3.9e-15	0.19	0.02	0.19	FALSE
117	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	6.4	-7.8	5.8e-15	0.16	0.06	0.93	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-282O18.3	0.14	0.11	enet	12	0.10	6.7e-06	6.6	-7.5	8.7e-14	0.03	0.19	0.81	FALSE
44	GTEx	Lung	CDK2AP1	0.08	0.03	lasso	4	0.00	2.0e-01	6.6	-7.2	5.0e-13	0.03	0.19	0.69	FALSE
5	GTEx	Adipose Visceral Omentum	MPHOSPH9	0.07	0.02	lasso	4	0.00	3.5e-01	6.6	7.2	6.5e-13	-0.03	0.14	0.08	FALSE
6	GTEx	Adipose Visceral Omentum	CDK2AP1	0.14	0.14	lasso	4	0.11	2.7e-06	6.6	-7.2	7.4e-13	0.05	0.18	0.82	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS33A	0.01	0.02	lasso	2	0.02	2.7e-04	7.0	-7.1	1.1e-12	0.25	0.15	0.65	FALSE
63	GTEx	Skin Sun Exposed Lower leg	WDR66	0.19	0.10	lasso	5	0.08	5.5e-07	5.3	7.1	1.2e-12	0.01	0.99	0.00	FALSE
9	GTEx	Artery Aorta	C12orf65	0.11	0.07	lasso	10	0.08	5.8e-05	6.0	-7.1	1.3e-12	0.06	0.37	0.53	FALSE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	VPS33A	0.04	0.05	lasso	1	0.04	3.0e-05	7.0	-7.0	2.2e-12	0.25	0.74	0.26	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CDK2AP1	0.07	0.06	enet	7	0.06	7.0e-05	6.6	-7.0	3.0e-12	-0.03	0.00	0.98	FALSE
75	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-5.0	-6.9	4.1e-12	0.53	0.12	0.52	FALSE
13	GTEx	Artery Tibial	SETD8	0.07	0.03	lasso	7	0.03	2.2e-03	6.8	6.9	5.0e-12	-0.02	0.02	0.96	FALSE
4	GTEx	Adipose Subcutaneous	RP11-282O18.3	0.15	0.14	lasso	7	0.15	2.0e-12	6.8	-6.9	5.1e-12	0.01	0.11	0.89	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS33A	0.03	0.05	lasso	1	0.05	4.4e-06	6.9	-6.9	5.4e-12	0.24	0.81	0.15	FALSE
46	GTEx	Lung	RP11-282O18.3	0.06	0.02	lasso	7	0.00	6.1e-01	6.6	-6.9	5.8e-12	0.01	0.13	0.70	FALSE
3	GTEx	Adipose Subcutaneous	CDK2AP1	0.20	0.18	lasso	11	0.19	1.0e-15	6.6	-6.9	5.9e-12	0.02	0.15	0.85	FALSE
38	GTEx	Esophagus Muscularis	CDK2AP1	0.17	0.10	enet	18	0.11	4.6e-07	6.5	-6.9	6.4e-12	0.02	0.19	0.81	FALSE
23	GTEx	Cells Transformed fibroblasts	C12orf65	0.07	0.05	lasso	4	0.04	5.8e-04	6.3	-6.8	9.1e-12	-0.01	0.21	0.66	FALSE
50	GTEx	Nerve Tibial	CDK2AP1	0.11	0.11	enet	25	0.09	4.4e-07	6.8	-6.8	1.0e-11	0.01	0.14	0.86	FALSE
49	GTEx	Nerve Tibial	MPHOSPH9	0.07	0.04	lasso	4	0.01	7.0e-02	6.1	6.8	1.3e-11	0.00	0.40	0.03	FALSE
58	GTEx	Pancreas	RP11-282O18.3	0.22	0.24	lasso	5	0.24	2.3e-10	6.6	-6.7	1.5e-11	0.00	0.17	0.83	FALSE
31	GTEx	Colon Transverse	RP11-282O18.3	0.18	0.19	enet	8	0.19	1.8e-09	6.6	-6.7	1.6e-11	0.00	0.21	0.79	FALSE
52	GTEx	Nerve Tibial	ABCB9	0.06	0.04	lasso	3	0.05	3.5e-04	6.8	6.7	1.6e-11	0.00	0.82	0.01	FALSE
54	GTEx	Nerve Tibial	RP11-282O18.3	0.10	0.10	enet	28	0.08	1.9e-06	6.8	-6.7	1.9e-11	0.02	0.12	0.88	FALSE
10	GTEx	Artery Aorta	RP11-282O18.3	0.18	0.19	lasso	9	0.16	4.3e-09	6.6	-6.7	2.0e-11	-0.01	0.29	0.71	FALSE
55	GTEx	Pancreas	CDK2AP1	0.24	0.27	lasso	3	0.26	3.1e-11	6.6	-6.7	2.0e-11	-0.01	0.20	0.80	FALSE
53	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-5.7	-6.7	2.2e-11	0.70	0.31	0.44	FALSE
74	GTEx	Thyroid	RP11-282O18.3	0.06	0.06	enet	6	0.06	3.6e-05	6.6	-6.7	2.3e-11	-0.02	0.25	0.73	FALSE
72	GTEx	Thyroid	CDK2AP1	0.08	0.09	enet	7	0.10	8.2e-08	6.6	-6.7	2.7e-11	-0.02	0.27	0.73	FALSE
8	GTEx	Artery Aorta	CDK2AP1	0.17	0.19	lasso	2	0.15	8.0e-09	6.6	-6.7	2.8e-11	0.00	0.28	0.72	FALSE
62	GTEx	Skin Sun Exposed Lower leg	CDK2AP1	0.21	0.22	lasso	5	0.22	3.4e-18	6.6	-6.7	2.8e-11	-0.02	0.28	0.72	FALSE
42	GTEx	Heart Left Ventricle	MPHOSPH9	0.06	0.04	lasso	5	0.04	4.2e-03	5.8	6.6	3.1e-11	-0.02	0.36	0.03	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	CDK2AP1	0.14	0.06	lasso	8	0.06	4.7e-03	6.4	-6.6	3.2e-11	0.02	0.09	0.21	FALSE
80	YFS	Blood	MPHOSPH9	0.05	0.07	enet	31	0.07	3.7e-23	6.2	6.6	4.5e-11	0.00	1.00	0.00	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	CDK2AP1	0.08	0.10	lasso	2	0.10	1.3e-09	6.6	-6.6	4.5e-11	-0.01	0.00	1.00	FALSE
34	GTEx	Esophagus Mucosa	CDK2AP1	0.30	0.36	lasso	5	0.38	1.9e-26	6.5	-6.6	4.6e-11	-0.01	0.32	0.68	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDK2AP1	0.12	0.14	blup	34	0.15	7.2e-07	5.6	-6.6	5.2e-11	-0.03	0.02	0.98	FALSE
16	GTEx	Breast Mammary Tissue	CDK2AP1	0.08	0.06	lasso	3	0.07	1.2e-04	6.4	-6.6	5.5e-11	0.00	0.28	0.57	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK2AP1	0.06	0.07	lasso	2	0.06	1.7e-06	6.6	-6.5	5.9e-11	-0.01	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDK2AP1	0.04	0.04	lasso	3	0.03	3.8e-04	6.6	-6.5	6.4e-11	0.00	0.00	0.99	FALSE
110	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDK2AP1	0.09	0.10	lasso	2	0.10	1.8e-07	6.6	-6.5	6.7e-11	0.00	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CDK2AP1	0.11	0.11	enet	5	0.11	1.2e-05	6.6	-6.5	6.9e-11	-0.01	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	RILPL2	0.02	0.01	enet	8	0.01	2.6e-02	6.7	6.5	8.1e-11	0.00	0.01	0.97	FALSE
57	GTEx	Pancreas	SETD8	0.20	0.12	lasso	5	0.13	3.4e-06	6.7	-6.5	8.4e-11	0.02	0.01	0.99	FALSE
71	GTEx	Thyroid	PITPNM2	0.04	0.07	lasso	2	0.06	1.6e-05	6.5	6.5	9.1e-11	0.01	0.84	0.01	FALSE
20	GTEx	Breast Mammary Tissue (Female)	RP11-282O18.3	0.09	0.07	enet	8	0.08	2.8e-03	5.8	-6.5	9.5e-11	0.00	0.28	0.20	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-282O18.3	0.25	0.29	enet	16	0.28	2.2e-21	6.6	-6.5	1.0e-10	-0.01	0.20	0.80	FALSE
18	GTEx	Breast Mammary Tissue (Female)	CDK2AP1	0.08	0.03	lasso	3	0.02	6.4e-02	6.6	-6.5	1.1e-10	-0.01	0.12	0.14	FALSE
22	GTEx	Cells Transformed fibroblasts	CDK2AP1	0.31	0.32	lasso	8	0.35	8.5e-27	6.6	-6.5	1.1e-10	-0.01	0.20	0.80	FALSE
64	GTEx	Skin Sun Exposed Lower leg	RP11-282O18.3	0.17	0.20	lasso	6	0.20	2.2e-16	6.6	-6.5	1.1e-10	-0.01	0.27	0.73	FALSE
36	GTEx	Esophagus Mucosa	RP11-282O18.3	0.29	0.34	lasso	4	0.34	1.9e-23	6.4	-6.4	1.3e-10	-0.01	0.42	0.58	FALSE
84	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDK2AP1	0.09	0.08	lasso	2	0.06	5.9e-06	6.4	-6.4	1.4e-10	-0.02	0.00	1.00	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDK2AP1	0.14	0.15	lasso	2	0.14	7.8e-16	6.4	-6.4	1.5e-10	-0.02	0.00	1.00	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK2AP1	0.03	0.04	lasso	1	0.04	1.2e-05	6.4	-6.4	1.5e-10	-0.02	0.00	1.00	FALSE
39	GTEx	Esophagus Muscularis	C12orf65	0.06	0.04	lasso	4	0.04	2.0e-03	6.8	-6.4	1.6e-10	0.01	0.19	0.74	FALSE
90	The Cancer Genome Atlas	Colon Adenocarcinoma	CDK2AP1	0.12	0.17	lasso	4	0.17	6.3e-10	6.4	-6.4	1.6e-10	-0.02	0.00	1.00	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDK2AP1	0.12	0.10	lasso	2	0.11	6.3e-07	6.4	-6.4	1.7e-10	-0.01	0.00	1.00	FALSE
12	GTEx	Artery Tibial	MPHOSPH9	0.05	0.03	lasso	3	0.03	2.2e-03	6.0	6.4	1.9e-10	0.02	0.60	0.02	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	RP11-282O18.3	0.13	0.10	lasso	6	0.09	1.9e-05	5.6	-6.4	1.9e-10	-0.01	0.63	0.37	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	CDK2AP1	0.17	0.12	lasso	10	0.12	3.4e-07	6.1	-6.3	2.2e-10	-0.02	0.59	0.41	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDK2AP1	0.11	0.13	lasso	5	0.14	5.9e-16	6.6	-6.3	2.2e-10	-0.01	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK2AP1	0.07	0.08	lasso	7	0.08	5.0e-16	6.4	-6.3	2.7e-10	-0.01	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	-4.8	-6.3	3.1e-10	-0.06	0.13	0.22	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	RP11-282O18.3	0.16	0.06	lasso	9	0.07	2.3e-03	6.4	-6.3	3.3e-10	-0.01	0.14	0.26	FALSE
17	GTEx	Breast Mammary Tissue	RP11-282O18.3	0.10	0.06	lasso	6	0.08	5.4e-05	6.4	-6.2	4.6e-10	0.00	0.38	0.55	FALSE
56	GTEx	Pancreas	ARL6IP4	0.07	0.07	lasso	2	0.07	9.6e-04	5.6	-6.2	7.0e-10	-0.01	0.27	0.10	FALSE
48	GTEx	Muscle Skeletal	SETD8	0.16	0.02	lasso	4	0.03	3.8e-04	6.8	6.2	7.4e-10	-0.03	0.01	0.98	FALSE
51	GTEx	Nerve Tibial	C12orf65	0.05	0.07	lasso	3	0.06	3.0e-05	6.0	-6.1	1.1e-09	-0.02	0.32	0.44	FALSE
65	GTEx	Stomach	MPHOSPH9	0.17	0.08	lasso	5	0.10	1.2e-05	6.4	6.1	1.2e-09	0.00	0.83	0.02	FALSE
70	GTEx	Thyroid	MPHOSPH9	0.10	0.08	enet	20	0.09	2.0e-07	5.7	6.1	1.3e-09	-0.03	1.00	0.00	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	MPHOSPH9	0.27	0.09	lasso	4	0.09	9.8e-09	6.3	6.1	1.3e-09	0.04	0.03	0.97	FALSE
83	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABCB9	0.05	0.04	enet	5	0.04	2.4e-04	5.8	6.0	1.6e-09	0.02	0.00	0.94	FALSE
41	GTEx	Esophagus Muscularis	RP11-282O18.3	0.19	0.11	lasso	6	0.10	2.1e-06	6.5	-6.0	1.9e-09	-0.02	0.26	0.74	FALSE
82	YFS	Blood	SBNO1	0.03	0.03	lasso	6	0.03	1.2e-09	6.4	-6.0	2.5e-09	0.02	0.29	0.71	FALSE
27	GTEx	Colon Sigmoid	ABCB9	0.18	0.16	lasso	6	0.15	4.8e-06	6.1	5.9	3.3e-09	-0.02	0.83	0.01	FALSE
76	METSIM	Adipose	CDK2AP1	0.11	0.14	enet	23	0.14	1.7e-20	6.0	-5.9	3.4e-09	-0.03	0.27	0.73	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	PITPNM2	0.04	0.03	enet	5	0.05	8.1e-06	5.0	5.9	3.7e-09	-0.01	0.03	0.96	FALSE
69	GTEx	Testis	RP11-282O18.3	0.18	0.09	lasso	9	0.12	7.8e-06	5.4	-5.9	4.4e-09	0.02	0.34	0.10	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	RILPL2	0.09	0.09	blup	43	0.08	3.1e-05	6.6	5.9	4.7e-09	-0.04	0.01	0.99	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PITPNM2	0.06	0.07	lasso	5	0.09	1.2e-05	6.0	-5.8	5.9e-09	-0.01	0.13	0.86	FALSE
29	GTEx	Colon Transverse	ABCB9	0.08	0.07	enet	5	0.09	5.3e-05	6.8	5.8	6.1e-09	-0.03	0.70	0.01	FALSE
78	METSIM	Adipose	MLXIP	0.08	0.07	enet	25	0.07	2.3e-10	-6.1	5.8	6.1e-09	0.02	0.91	0.09	FALSE
66	GTEx	Testis	MPHOSPH9	0.28	0.27	enet	23	0.32	1.3e-14	5.6	5.8	6.2e-09	0.01	1.00	0.00	FALSE
112	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CDK2AP1	0.13	0.10	blup	34	0.11	8.2e-05	5.4	-5.8	6.7e-09	0.00	0.02	0.95	FALSE
24	GTEx	Cells Transformed fibroblasts	SETD8	0.10	0.12	enet	9	0.09	1.4e-07	4.4	5.7	9.8e-09	-0.05	0.03	0.97	FALSE
67	GTEx	Testis	CDK2AP1	0.20	0.14	lasso	5	0.13	2.0e-06	5.4	-5.7	1.0e-08	0.01	0.78	0.15	FALSE
43	GTEx	Heart Left Ventricle	ABCB9	0.10	0.14	lasso	5	0.10	4.2e-06	5.6	5.7	1.6e-08	0.00	0.91	0.01	FALSE
45	GTEx	Lung	ABCB9	0.04	0.02	lasso	3	0.02	8.0e-03	5.8	5.7	1.6e-08	0.00	0.39	0.06	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	KNTC1	0.11	0.04	lasso	4	0.03	7.1e-03	5.6	-5.6	1.7e-08	0.30	0.21	0.06	FALSE
19	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-2.6	-5.4	5.8e-08	0.17	0.05	0.08	FALSE
21	GTEx	Cells Transformed fibroblasts	OGFOD2	0.10	0.07	lasso	7	0.07	3.1e-06	3.2	5.4	6.0e-08	-0.01	0.99	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC62	0.12	0.06	enet	21	0.06	3.3e-08	2.2	-5.4	6.8e-08	0.11	0.99	0.00	FALSE
40	GTEx	Esophagus Muscularis	ABCB9	0.10	0.08	lasso	6	0.05	3.8e-04	6.4	5.3	1.4e-07	0.03	0.78	0.01	FALSE
26	GTEx	Colon Sigmoid	C12orf65	0.08	0.04	enet	12	0.06	3.0e-03	3.8	-5.3	1.5e-07	0.02	0.24	0.41	FALSE