Best TWAS P=1.02e-08 · Best GWAS P=3.73e-07 conditioned to 0.381
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | CDC16 | 0.25 | 0.28 | lasso | 6 | 0.26 | 6.9e-14 | -5.1 | -5.3 | 1.3e-07 | 0.97 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | CDC16 | 0.23 | 0.08 | enet | 11 | 0.09 | 3.8e-03 | -4.5 | -5.5 | 3.5e-08 | 0.85 | 0.03 | 0.82 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CDC16 | 0.25 | 0.22 | enet | 28 | 0.22 | 3.6e-07 | -5.1 | -5.2 | 1.7e-07 | 0.92 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Colon Transverse | CDC16 | 0.18 | 0.23 | lasso | 5 | 0.21 | 3.2e-10 | -5.1 | -5.2 | 2.3e-07 | 0.98 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | CDC16 | 0.23 | 0.23 | enet | 19 | 0.26 | 9.5e-19 | -5.0 | -5.2 | 2.4e-07 | 0.95 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | CDC16 | 0.31 | 0.33 | lasso | 7 | 0.33 | 4.1e-28 | -4.9 | -5.1 | 3.0e-07 | 0.98 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Testis | CDC16 | 0.32 | 0.30 | enet | 26 | 0.35 | 4.4e-16 | -5.1 | -5.7 | 1.0e-08 | 0.94 | 0.01 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | CDC16 | 0.06 | 0.04 | lasso | 5 | 0.03 | 5.9e-03 | -5.0 | -5.4 | 7.4e-08 | 0.88 | 0.01 | 0.90 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CDC16 | 0.04 | 0.01 | blup | 49 | 0.03 | 7.7e-03 | -5.1 | -5.2 | 2.5e-07 | 0.96 | 0.02 | 0.93 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CDC16 | 0.11 | 0.09 | blup | 49 | 0.09 | 1.8e-04 | -5.0 | -5.4 | 6.4e-08 | 0.98 | 0.02 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC16 | 0.06 | 0.09 | lasso | 3 | 0.09 | 3.3e-09 | -5.1 | -5.4 | 8.8e-08 | 0.98 | 0.01 | 0.99 | FALSE |